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Sexual dimorphism in skeletal muscle protein turnover

Smith, Gordon I., Mittendorfer, Bettina·2016·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00625.2015

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Abstract

Skeletal muscle is the major constituent of lean body mass and essential for the body's locomotor function. Women have less muscle mass (and more body fat) than men and are therefore not able to exert the same absolute maximal force as men. The difference in body composition between the sexes is evident from infancy but becomes most marked after puberty (when boys experience an accelerated growth spurt) and persists into old age. During early adulthood until approximately the fourth decade of life, muscle mass is relatively stable, both in men and women, but then begins to decline, and the rate of loss is slower in women than in men. In this review we discuss the underlying mechanisms responsible for the age-associated sexual dimorphism in muscle mass (as far as they have been elucidated to date) and highlight areas that require more research to advance our understanding of the control of muscle mass throughout life.

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See all 57

Authors: Smith, G. I., & Mittendorfer, B.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2016-03-15
Volume: 120
Issue: 6
Pages: 674-682
ISSN: 8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00625.2015
Cited by: 57
References: 35
Language: en
Funders: NIH (DK 94483, DK 56341, UL1 TR000448)

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Sexual dimorphism in skeletal muscle protein turnover

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