Cardiac Stem Cells and Mechanisms of Myocardial Regeneration

Muscle-derived hematopoietic stem cells are hematopoietic in origin

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Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.

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Mechanisms of tissue repair: from wound healing to fibrosis

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Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant

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The post‐natal heart contains a myocardial stem cell population

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Evidence for Cardiomyocyte Repopulation by Extracardiac Progenitors in Transplanted Human Hearts

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Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

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Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease

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The Clonal Origin of Myocardial Cells in Different Regions of the Embryonic Mouse Heart

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Myocyte Death in the Failing Human Heart Is Gender Dependent

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Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

Jalali, S., del Pozo, M. A., Chen, K.-D., Miao, H., Li, Y.-S., Schwartz, M. A., Shyy, J. Y.-J., & Chien, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1042 · Cited by 417

One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues

Prockop, D. J., Gregory, C. A., & Spees, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834138100 · Cited by 416

Clinical Applications of Stem Cells for the Heart

Wollert, K. C., & Drexler, H. (2005) · Circulation Research · doi:10.1161/01.res.0000155333.69009.63 · Cited by 415

Angiotensin II and Other Hypertrophic Stimuli Mediated by G Protein–Coupled Receptors Activate Tyrosine Kinase, Mitogen-Activated Protein Kinase, and 90-kD S6 Kinase in Cardiac Myocytes: The Critical Role of Ca 2+ -Dependent Signaling

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Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats

Min, J.-Y., Yang, Y., Converso, K. L., Liu, L., Huang, Q., Morgan, J. P., & Xiao, Y.-F. (2002) · Journal of Applied Physiology · doi:10.1152/jappl.2002.92.1.288 · Cited by 409

Lack of a Fusion Requirement for Development of Bone Marrow-Derived Epithelia

Harris, R. G., Herzog, E. L., Bruscia, E. M., Grove, J. E., Van Arnam, J. S., & Krause, D. S. (2004) · Science · doi:10.1126/science.1098925 · Cited by 407

How cells change their phenotype

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Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

Anversa, P., & Kajstura, J. (1998) · Circulation Research · doi:10.1161/01.res.83.1.1 · Cited by 390

Oct-3/4 and Sox2 Regulate Oct-3/4 Gene in Embryonic Stem Cells

Okumura-Nakanishi, S., Saito, M., Niwa, H., & Ishikawa, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410015200 · Cited by 387

Senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure

Chimenti, C., Kajstura, J., Torella, D., Urbanek, K., Heleniak, H., Colussi, C., Di Meglio, F., Nadal-Ginard, B., Frustaci, A., Leri, A., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000093985.76901.af · Cited by 386

Sizing up the heart: development redux in disease

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Cell Polyploidy: Its Relation to Tissue Growth and Function

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Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease: Part II: Cell-Based Therapies

Losordo, D. W., & Dimmeler, S. (2004) · Circulation · doi:10.1161/01.cir.0000128596.49339.05 · Cited by 380

Stem cell pluripotency and transcription factor Oct4

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Plasticity of Bone Marrow–Derived Stem Cells

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Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: Implications for myocardium regeneration

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The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila

Berdnik, D., Török, T., González-Gaitán, M., & Knoblich, J. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00215-0 · Cited by 366

Endothelial Cells Promote Cardiac Myocyte Survival and Spatial Reorganization: Implications for Cardiac Regeneration

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Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development

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Bone Marrow–Derived Cardiomyocytes Are Present in Adult Human Heart: A Study of Gender-Mismatched Bone Marrow Transplantation Patients

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Hepatic oval cells express the hematopoietic stem cell marker thy-1 in the rat

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Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

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Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease: Part I: Angiogenic Cytokines

Losordo, D. W., & Dimmeler, S. (2004) · Circulation · doi:10.1161/01.cir.0000128595.79378.fa · Cited by 357

The stem-cell niche theory: lessons from flies

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Local Implantation of Autologous Bone Marrow Cells for Therapeutic Angiogenesis in Patients With Ischemic Heart Disease. Clinical Trial and Preliminary Results.

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The stem cell niche: theme and variations

Ohlstein, B., Kai, T., Decotto, E., & Spradling, A. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.003 · Cited by 345

Hematopoietic Stem and Progenitor Cells: Clinical and Preclinical Regeneration of the Hematolymphoid System

Shizuru, J. A., Negrin, R. S., & Weissman, I. L. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152334 · Cited by 339

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.

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Metabolic co-operation between biochemically marked mammalian cells in tissue culture

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Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells

Yuasa, S., Itabashi, Y., Koshimizu, U., Tanaka, T., Sugimura, K., Kinoshita, M., Hattori, F., Fukami, S.-I., Shimazaki, T., Okano, H., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1093 · Cited by 326

Promotion of Collateral Growth by Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Coronary Artery Disease: A Randomized, Double-Blind, Placebo-Controlled Study

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A Sense of Danger from Radiation1

McBride, W. H., Chiang, C.-S., Olson, J. L., Wang, C.-C., Hong, J.-H., Pajonk, F., Dougherty, G. J., Iwamoto, K. S., Pervan, M., & Liao, Y.-P. (2004) · Radiation Research · doi:10.1667/rr3196 · Cited by 323

Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human

Hart, A. H., Hartley, L., Ibrahim, M., & Robb, L. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20034 · Cited by 322

BMP-6 Enhances Chondrogenesis in a Subpopulation of Human Marrow Stromal Cells

Sekiya, I., Colter, D. C., & Prockop, D. J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4898 · Cited by 316

Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes

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Embryoid bodies: an in vitro model of mouse embryogenesis

Desbaillets, I., Ziegler, U., Groscurth, P., & Gassmann, M. (2000) · Experimental Physiology · doi:10.1017/s0958067000021047 · Cited by 313

Origin and Differentiation of Human and Murine Stroma

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β1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

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Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death

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Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: A review

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The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

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Remodeling of the postnatal mouse testis is accompanied by dramatic changes in stem cell number and niche accessibility

Shinohara, T., Orwig, K. E., Avarbock, M. R., & Brinster, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158198 · Cited by 301

Direct cadherin-activated cell signaling

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Genetic Dissection of Cardiac Growth Control Pathways

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Circulating mesenchymal stem cells

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Asymmetric cell division

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Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium?

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Isolation of Mouse Marrow Mesenchymal Progenitors by a Novel and Reliable Method

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Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats

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Cellular basis of chronic ventricular remodeling after myocardial infarction in rats.

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The cellular basis of dilated cardiomyopathy in humans

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Myocardial Akt Activation and Gender: Increased Nuclear Activity in Females Versus Males

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Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite of extensive proliferation

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Bone Marrow–Derived Cells for Enhancing Collateral Development: Mechanisms, Animal Data, and Initial Clinical Experiences

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From teratocarcinomas to embryonic stem cells

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Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration

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Aging, stem cells and tissue regeneration: lessons from muscle.

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The skeletal muscle satellite cell: stem cell or son of stem cell?

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Stem cell plasticity

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Pluripotential competence of cells associated with Nanog activity

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Progenitor cells of the testosterone-producing Leydig cells revealed

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Hepatic polyploidy and liver growth control

Gupta, S. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0317 · Cited by 251

Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors

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Forming a Multinucleated Cell: Molecules That Regulate Myoblast Fusion

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Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners

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Heart regeneration in adult MRL mice

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Stable benefit of embryonic stem cell therapy in myocardial infarction

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Cells, Matrix, Growth Factors, and the Surgeon The Biology of Scarless Fetal Wound Repair

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Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors

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Selective permeability of gap junction channels

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Human embryonic stem cells: prospects for development

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Stem cells and repair of the heart

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DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary

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Retinoic Acid Signaling Restricts the Cardiac Progenitor Pool

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G1 tetraploidy checkpoint and the suppression of tumorigenesis

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Smooth Muscle Cell Transplantation into Myocardial Scar Tissue Improves Heart Function

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Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events

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Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells

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Aging, Cardiac Hypertrophy and Ischemic Cardiomyopathy Do Not Affect the Proportion of Mononucleated and Multinucleated Myocytes in the Human Heart

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Isolation of a Highly Clonogenic and Multipotential Subfraction of Adult Stem Cells from Bone Marrow Stroma

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Heterogeneity among human bone marrow-derived mesenchymal stem cells and neural progenitor cells.

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Cardiomyocytes of Noncardiac Origin in Myocardial Biopsies of Human Transplanted Hearts

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The immunogenicity of human embryonic stem-derived cells

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Nuclear Targeting of Akt Enhances Kinase Activity and Survival of Cardiomyocytes

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Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.

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Epigenetic control of neural stem cell fate

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Cell fusion causes confusion

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