Cited by 313Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Diabetes mellitus and the Risk of Dementia, Alzheimer’s Disease and Vascular Cognitive Impairment in the Canadian Study of Health and Aging

MacKnight, Chris, Rockwood, Kenneth, Awalt, Erin, McDowell, Ian·2002·Dementia and Geriatric Cognitive Disorders

Abstract

Background: Conflicting results have been reported about the status of diabetes mellitus as a risk for Alzheimer’s disease. We investigated the relationship between diabetes and incident dementia (including Alzheimer’s disease and vascular cognitive impairment) in a 5-year longitudinal study. Methods: Secondary analysis of the Canadian Study of Health and Aging, a representative cohort study of dementia in older Canadians. Results: 5,574 subjects without cognitive impairment at baseline participated in 5-year follow-up. Diabetes mellitus at baseline was associated with incident vascular cognitive impairment (RR: 1.62; 95% CI: 1.12–2.33) and its subtypes, vascular dementia (RR: 2.03; 95% CI: 1.15–3.57), and vascular cognitive impairment not dementia (RR: 1.68; 95% CI: 1.01–2.78). Diabetes was not associated with mixed Alzheimer’s/vascular dementia (RR: 0.87; 95% CI: 0.34–2.21), incident Alzheimer’s disease (RR: 1.30; 95% CI: 0.83–2.03) or all dementias (RR: 1.26; 95% CI: 0.90–1.76). Conclusions: Despite increased recognition of the role of vascular factors in Alzheimer’s disease, we did not find an association between diabetes and incident Alzheimer’s disease, even though diabetes was associated with incident vascular cognitive impairment.

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Crossref · 10.1159/000064928

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Metadata

Authors
MacKnight, C., Rockwood, K., Awalt, E., & McDowell, I.
Affiliations
  • Dalhousie University (CA)
  • University of Ottawa (CA)
Venue
Dementia and Geriatric Cognitive Disorders
Publisher
S. Karger AG
Published
2002
Volume
14
Issue
2
Pages
77-83
ISSN
  • 1420-8008 (ISSN-L)
  • 1421-9824
OpenAlex
W2050640530
Cited by
313
References
40
Citations by year
2026: 3 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 19 · 2018: 12 · 2017: 13 · 2016: 15 · 2015: 12 · 2014: 21 · 2013: 20 · 2012: 12
FWCI
5.77
Type
journal article
Language
en
Open access
closed
Locations
  • Dementia and Geriatric Cognitive Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
diabetes mellitus, Alzheimer's disease, dementia, vascular cognitive impairment, vascular dementia, incident dementia risk, older adults, Canadian Study of Health and Aging
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Diabetes Mellitus, Female, Humans, Male, Risk Factors, Dementia, Vascular, Cohort Studies

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