Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

Dickstein, Dara L.; Walsh, Jessica; Brautigam, Hannah; Stockton, Steven D.; Gandy, Samuel; Hof, Patrick R.

doi:10.1002/msj.20155

Cited by 155

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Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

Dickstein, Dara L., Walsh, Jessica, Brautigam, Hannah, Stockton, Steven D., Gandy, Samuel, Hof, Patrick R.·2010·Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine

DOI 10.1002/msj.20155PMC PMC2918901

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Abstract

Recent findings indicate that vascular risk factors and neurovascular dysfunction play integral roles in the pathogenesis of Alzheimer's disease. In addition to aging, the most common risk factors for Alzheimer's disease are apolipoprotein e4 allele, hypertension, hypotension, diabetes, and hypercholesterolemia. All of these can be characterized by vascular pathology attributed to conditions such as cerebral amyloid angiopathy and subsequent blood‐brain barrier dysfunction. Many epidemiological, clinical, and pharmacotherapeutic studies have assessed the associations between such risk factors and Alzheimer's disease and have found positive associations between hypertension, hypotension, and diabetes mellitus. However, there are still many conflicting results from these population‐based studies, and they should be interpreted carefully. Recognition of these factors and the mechanisms by which they contribute to Alzheimer's disease will be beneficial in the current treatment regimens for Alzheimer's disease and in the development of future therapies. Here we discuss vascular factors with respect to Alzheimer's disease and dementia and review the factors that give rise to vascular dysfunction and contribute to Alzheimer's disease. Mt Sinai J Med 77:82&–102, 2010. © 2010 Mount Sinai School of Medicine

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Vascular risk factors and neurovascular dysfunction play integral roles in the pathogenesis of AD.
“Atherosclerosis has been associated with AD and cerebral angiopathy in humans [43], [44], and recent findings indicate that vascular risk factors and neurovascular dysfunction play integral roles in the pathogenesis of AD [45].”
From ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage (2011) · cites this paper as [45]

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Sorted by citations

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“Clinical and pathological studies suggest that concomitant vascular disease is common and determines the time of onset of clinical symptoms in persons with Alzheimer's disease pathology [62-66].”
Background
ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage
Ramírez, C., Sierra, S., Tercero, I., Vázquez, J. A., Pineda, A., Manrique, T., & Burgos, J. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022712 · Cited by 31
Association between bone mineral density and brain parenchymal atrophy and ventricular enlargement in healthy individuals
Bae, I.-S., Kim, J. M., Cheong, J. H., Ryu, J. I., & Han, M.-H. (2019) · Aging · doi:10.18632/aging.102316 · Cited by 22

Authors: Dickstein, D. L., Walsh, J., Brautigam, H., Stockton, S. D., Gandy, S., & Hof, P. R.
Venue: Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine
Publisher: Wiley
Published: 2010-01
Volume: 77
Issue: 1
Pages: 82-102
ISSN: 0027-2507
1931-7581
DOI: 10.1002/msj.20155
PMC: PMC2918901
Cited by: 155
References: 40
Language: en
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 24 d)

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Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

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