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Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
Open accessAbstract
Background —Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse. Methods and Results —In a prospective study involving 14 916 apparently healthy men, we measured baseline plasma concentration of IL-6 in 202 participants who subsequently developed myocardial infarction (MI) and in 202 study participants matched for age and smoking status who did not report vascular disease during a 6-year follow-up. Median concentrations of IL-6 at baseline were higher among men who subsequently had an MI than among those who did not (1.81 versus 1.46 pg/mL; P =0.002). The risk of future MI increased with increasing quartiles of baseline IL-6 concentration ( P for trend <0.001) such that men in the highest quartile at entry had a relative risk 2.3 times higher than those in the lowest quartile (95% CI 1.3 to 4.3, P =0.005); for each quartile increase in IL-6, there was a 38% increase in risk ( P =0.001).This relationship remained significant after adjustment for other cardiovascular risk factors, was stable over long periods of follow-up, and was present in all low-risk subgroups, including nonsmokers. Although the strongest correlate of IL-6 in these data was C-reactive protein ( r =0.43, P <0.001), the relationship of IL-6 with subsequent risk remained after control for this factor ( P <0.001). Conclusions —In apparently healthy men, elevated levels of IL-6 are associated with increased risk of future MI. These data thus support a role for cytokine-mediated inflammation in the early stages of atherogenesis.
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“IL-6 is associated with a variety of age-related illnesses (10, 13-15, 38).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [38]
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Metadata
- Authors
- Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Circulation
- Published
- 2000-04-18
- Volume
- 101
- Issue
- 15
- Pages
- 1767-1772
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2067504868
- Cited by
- 2,429
- References
- 40
- Citations by year
- 2026: 41 · 2025: 48 · 2024: 55 · 2023: 56 · 2022: 57 · 2021: 74 · 2020: 64 · 2019: 64 · 2018: 82 · 2017: 85 · 2016: 96 · 2015: 99 · 2014: 118 · 2013: 101 · 2012: 107
- FWCI
- 33.08
- Type
- journal article
- Language
- en
- Open access
- green
- nrs.harvard.edu
- Licence
- cc-by
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (R01HL058755, HL-58755)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- interleukin-6, myocardial infarction, atherogenesis, inflammation, cytokines, C-reactive protein, cardiovascular risk, healthy men, plasma cytokine concentrations
- MeSH terms
- C-Reactive Protein, Coronary Artery Disease, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Risk Factors, Smoking, Interleukin-6, Case-Control Studies
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