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Cited by 563

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function

Open access
Csiszar, Anna, Ungvari, Zoltan, Edwards, John G., Kaminski, Pawel, Wolin, Michael S., Koller, Akos, Kaley, Gabor·2002·Circulation Research
DOI 10.1161/01.res.0000020401.61826.ea
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Abstract

We aimed to elucidate the possible role of phenotypic alterations and oxidative stress in age-related endothelial dysfunction of coronary arterioles. Arterioles were isolated from the hearts of young adult (Y, 14 weeks) and aged (A, 80 weeks) male Sprague-Dawley rats. For videomicroscopy, pressure-induced tone of Y and A arterioles and their passive diameter did not differ significantly. In A, arterioles L-NAME (a NO synthase blocker)–sensitive flow-induced dilations were significantly impaired (Y: 41±8% versus A: 3±2%), which could be augmented by superoxide dismutase (SOD) or Tiron (but not l -arginine or the TXA 2 receptor antagonist SQ29,548). For lucigenin chemiluminescence, O 2 ·− generation was significantly greater in A than Y vessels and could be inhibited with SOD and diphenyliodonium. NADH-driven O 2 ·− generation was also greater in A vessels. Both endothelial and smooth muscle cells of A vessels produced O 2 ·− (shown with ethidium bromide fluorescence). For Western blotting, expression of eNOS and COX-1 was decreased in A compared with Y arterioles, whereas expressions of COX-2, Cu/Zn-SOD, Mn-SOD, xanthine oxidase, and the NAD(P)H oxidase subunits p47 phox , p67 phox , Mox-1, and p22 phox did not differ. Aged arterioles showed an increased expression of iNOS, confined to the endothelium. Decreased eNOS mRNA and increased iNOS mRNA expression in A vessels was shown by quantitative RT-PCR. In vivo formation of peroxynitrite was evidenced by Western blotting, and immunohistochemistry showing increased 3-nitrotyrosine content in A vessels. Thus, aging induces changes in the phenotype of coronary arterioles that could contribute to the development of oxidative stress, which impairs NO-mediated dilations.

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Metadata

Authors
Csiszar, A., Ungvari, Z., Edwards, J. G., Kaminski, P., Wolin, M. S., Koller, A., & Kaley, G.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-06-14
Volume
90
Issue
11
Pages
1159-1166
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.0000020401.61826.ea
OpenAlex
W2097750015
Cited by
563
References
3
FWCI
9.55
Type
journal article
Language
en
Open access
bronze

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