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MicroRNA-based therapeutics in central nervous system injuries

Sun, Ping, Liu, Da Zhi, Jickling, Glen C, Sharp, Frank R, Yin, Ke-Jie·2018·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1177/0271678x18773871
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Abstract

Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), are important causes of death and long-term disability worldwide. MicroRNA (miRNA), small non-coding RNA molecules that negatively regulate gene expression, can serve as diagnostic biomarkers and are emerging as novel therapeutic targets for CNS injuries. MiRNA-based therapeutics include miRNA mimics and inhibitors (antagomiRs) to respectively decrease and increase the expression of target genes. In this review, we summarize current miRNA-based therapeutic applications in stroke, TBI and SCI. Administration methods, time windows and dosage for effective delivery of miRNA-based drugs into CNS are discussed. The underlying mechanisms of miRNA-based therapeutics are reviewed including oxidative stress, inflammation, apoptosis, blood–brain barrier protection, angiogenesis and neurogenesis. Pharmacological agents that protect against CNS injuries by targeting specific miRNAs are presented along with the challenges and therapeutic potential of miRNA-based therapies.

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Metadata

Authors
Sun, P., Liu, D. Z., Jickling, G. C., Sharp, F. R., & Yin, K.-J.
Affiliations
  • Department of Neurology, Pittsburgh Institute of Brain Disorders &amp; Recovery, <!---->University of Pittsburgh School of Medicine<!---->, Pittsburgh, PA, USA
  • Department of Neurology and the M.I.N.D. Institute, University of California at Davis, Sacramento, CA, USA
  • Department of Neurology, University of Alberta, Edmonton, Alberta, Canada
Venue
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Published
2018-04-30
Volume
38
Issue
7
Pages
1125-1148
ISSN
  • 0271-678X
  • 1559-7016
DOI
10.1177/0271678x18773871
Cited by
228
References
11
Language
en
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

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