Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies

Hokanson, John E.; Austin, Melissa A.

doi:10.1097/00043798-199604000-00014

Cited by 1,706Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies

Hokanson, John E., Austin, Melissa A.·1996·Journal of Cardiovascular Risk

DOI 10.1097/00043798-199604000-00014

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Crossref · 10.1097/00043798-199604000-00014

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Adjustment for HDL cholesterol and other cardiovascular risk factors attenuated the relative risk attributed to triglycerides, although they remained significant (1.14 and 1.37, respectively).
“Adjustment for HDL cholesterol and other cardiovascular risk factors attenuated the relative risk attributed to triglycerides, although they remained significant (1.14 and 1.37, respectively) (132).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [132]
A meta-analysis of Western population-based prospective studies, including 46,413 men and 10,864 women, showed an overall relative risk for CVD of 1.32 for men and 1.76 for women per 1 mmol/liter (88.5 mg/dl) increase of triglycerides.
“A meta-analysis of Western population-based prospective studies, including 46,413 men and 10,864 women, showed an overall relative risk for CVD of 1.32 for men and 1.76 for women per 1 mmol/ liter (88.5 mg/dl) increase of triglycerides (132).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [132]
Several meta-analyses from studies performed in the general population have shown a modest but independent effect of triglycerides on CVD.
“Several meta-analyses from studies performed in the general population have shown a modest but independent effect of triglycerides on CVD.”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [132]
Observational cohorts demonstrate that higher TG and remnant cholesterol predict cardiovascular events independently of LDL-C.
“Observational cohorts demonstrate that higher TG and remnant cholesterol predict cardiovascular events independently of LDL-C, while Mendelian randomization analyses confirm a causal relationship between lifelong TRL elevation and ASCVD.”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [43]
In meta-analyses, triglycerides have been shown to be an independent risk factor.
“In a number of meta-analyses, TGs has been shown to be an independent risk factor. 96,97”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [97]

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Authors: Hokanson, J. E., & Austin, M. A.
ORCID: Hokanson, John E.
Austin, Melissa A.
Venue: Journal of Cardiovascular Risk
Publisher: SAGE Publications
Published: 1996-04
Volume: 3
Issue: 2
Pages: 213-219
ISSN: 1350-6277 (ISSN-L)
DOI: 10.1097/00043798-199604000-00014
OpenAlex: W4232807629
Cited by: 1,706
References: 7
Citations by year: 2026: 11 · 2025: 22 · 2024: 25 · 2023: 28 · 2022: 31 · 2021: 53 · 2020: 35 · 2019: 55 · 2018: 55 · 2017: 48 · 2016: 67 · 2015: 55 · 2014: 63 · 2013: 64 · 2012: 76
FWCI: 10.11
Type: journal article
Language: en
Open access: closed
Locations: Journal of Cardiovascular Risk (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: plasma triglycerides, cardiovascular risk, HDL cholesterol, independent risk factor, prospective cohort

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Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies

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