The DOI matches its Crossref record; 58 of the 60 references it cites were found in a registry or an index.
Biomechanics of the Sensor-Tissue Interface—Effects of Motion, Pressure, and Design on Sensor Performance and Foreign Body Response—Part II: Examples and Application
Open accessAbstract
This article is the second part of a two-part review in which we explore the biomechanics of the sensor-tissue interface as an important aspect of continuous glucose sensor biocompatibility. Part I, featured in this issue of Journal of Diabetes Science and Technology, describes a theoretical framework of how biomechanical factors such as motion and pressure (typically micromotion and micropressure) affect tissue physiology around a sensor and in turn, impact sensor performance. Here in Part II, a literature review is presented that summarizes examples of motion or pressure affecting sensor performance. Data are presented that show how both acute and chronic forces can impact continuous glucose monitor signals. Also presented are potential strategies for countering the ill effects of motion and pressure on glucose sensors. Improved engineering and optimized chemical biocompatibility have advanced sensor design and function, but we believe that mechanical biocompatibility, a rarely considered factor, must also be optimized in order to achieve an accurate, long-term, implantable sensor.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Such behavior was attributed in part to blood occlusion due to pressures applied to tissue adjacent to the sensor.86–87”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [87]
Citations
Cites
Biological Responses to Materials
Anderson, J. M. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.81 · Cited by 1,465
A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
Weinbaum, S., Cowin, S. C., & Zeng, Y. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90010-8 · Cited by 1,266
Huiskes, R., Weinans, H., & van Rietbergen, B. (1992) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199201000-00014 · Cited by 1,227
Mechanical properties and Young's modulus of human skin in vivo
Agache, P. G., Monneur, C., Lévêque, J., & de Rigal, J. (1980) · Archives of Dermatological Research · doi:10.1007/bf00406415 · Cited by 742
Biophysical stimuli on cells during tissue differentiation at implant interfaces
Prendergast, P. J., Huiskes, R., & Søballé, K. (1997) · Journal of Biomechanics · doi:10.1016/s0021-9290(96)00140-6 · Cited by 637
Neovascularization of synthetic membranes directed by membrane microarchitecture
Brauker, J. H., Carr‐Brendel, V. E., Martinson, L. A., Crudele, J., Johnston, W. D., & Johnson, R. C. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820291208 · Cited by 517
Søballé, K., Hansen, E. S., Brockstedt-Rasmussen, H., Jørgensen, P. H., & Bünger, C. (1992) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100100216 · Cited by 506
The Healing of Rat Skin Wounds
Levenson, S. Μ., Geever, E. F., CHOWLEY, L. V., OATES, J. F., Berard, C. W., & ROSEN, H. (1965) · Annals of Surgery · doi:10.1097/00000658-196502000-00019 · Cited by 478
Handbook of non-invasive methods and the skin
Guy, R. H. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(96)01365-x · Cited by 414
Emerging synergy between nanotechnology and implantable biosensors: A review
Vaddiraju, S., Tomazos, I., Burgess, D. J., Jain, F., & Papadimitrakopoulos, F. (2009) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2009.12.001 · Cited by 383
Subbaroyan, J., Martin, D. C., & Kipke, D. R. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/4/006 · Cited by 368
A numerical‐experimental method to characterize the non‐linear mechanical behaviour of human skin
Hendriks, F. M., Brokken, D., Van Eemeren, J. T. W. M., Oomens, C. W. J., Baaijens, F. P. T., & Horsten, J. B. A. M. (2003) · Skin Research and Technology · doi:10.1034/j.1600-0846.2003.00019.x · Cited by 347
Brain micromotion around implants in the rodent somatosensory cortex
Gilletti, A., & Muthuswamy, J. (2006) · Journal of Neural Engineering · doi:10.1088/1741-2560/3/3/001 · Cited by 320
Tissue response to implanted polymers: The significance of sample shape
Matlaga, B. F., Yasenchak, L. P., & Salthouse, T. N. (1976) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820100308 · Cited by 295
Wu, K. S., van Osdol, W. W., & Dauskardt, R. H. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.06.019 · Cited by 229
Initial in vivo experience with steady‐state subzone‐based MR elastography of the human breast
Van Houten, E. E. W., Doyley, M. M., Kennedy, F. E., Weaver, J. B., & Paulsen, K. D. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10232 · Cited by 224
Ward, W. K., Slobodzian, E. P., Tiekotter, K. L., & Wood, M. D. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00160-6 · Cited by 176
Garg, S. K., Schwartz, S. L., & Edelman, S. V. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.734 · Cited by 161
Viscoelastic response of human skin to low magnitude physiologically relevant shear
Holt, B., Tripathi, A., & Morgan, J. (2008) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.06.008 · Cited by 161
Assessment of elastic parameters of human skin using dynamic elastography
Gennisson, J., Baldeweck, T., Tanter, M., Catheline, S., Fink, M., Sandrin, L., Cornillon, C., & Querleux, B. (2004) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2004.1324402 · Cited by 154
Intermittent micromotion inhibits bone ingrowth
Aspenberg, P., Goodman, S. B., Toksvig‐Larsen, S., Ryd, L., & Albrektsson, T. O. (1992) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679209154809 · Cited by 147
An In Vivo Method for Measuring the Mechanical Properties of the Skin Using Ultrasound
Diridollou, S., Berson, M., Vabre, V., Black, D., Karlsson, G., Conte-Auriol, F., Grégoire, J., Yvon, C., Vaillant, L., Gall, Y., et al. (1998) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(97)00237-8 · Cited by 145
Redepenning, J. G., Schlessinger, T., Burnham, S., Lippiello, L., & Miyano, J. (1996) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199603)30:3 · Cited by 145
Patel, P. N., Smith, C. K., & Patrick, C. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30291 · Cited by 144
Yu, B., Long, N., Moussy, Y., & Moussy, F. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2005.11.002 · Cited by 141
A subcutaneous glucose sensor with improved longevity, dynamic range, and stability of calibration.
Updike, S. J., Shults, M. C., Gilligan, B. J., & Rhodes, R. K. (2000) · Diabetes Care · doi:10.2337/diacare.23.2.208 · Cited by 135
Helton, K. L., Ratner, B. D., & Wisniewski, N. A. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500317 · Cited by 125
Self-citationSharkawy, A. A., Klitzman, B. M., Truskey, G. A., & Reichert, W. M. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19980615)40:4 · Cited by 110
The Theory of Early Loosening of Hip Prostheses
Mjöberg, B. (1997) · Orthopedics · doi:10.3928/0147-7447-19971201-12 · Cited by 108
A technique to prevent dural adhesions to chronically implanted microelectrode arrays
Maynard, E. M., Fernández, E., & Normann, R. A. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00159-x · Cited by 102
Sex‐ and site‐dependent variations in the thickness and mechanical properties of human skin in vivo
Diridollou, S., Black, D., Lagarde, J. M., Gall, Y., Berson, M., Vabre, V., Patat, F., & Vaillant, L. (2000) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2000.00037.x · Cited by 99
Amperometric Glucose Sensors: Sources of Error and Potential Benefit of Redundancy
Castle, J. R., & Ward, W. K. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400127 · Cited by 95
A new and evolving paradigm for biocompatibility
Hilborn, J. G., & Bjursten, L. M. (2007) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.4 · Cited by 91
Evaluation of a Subcutaneous Glucose Sensor out to 3 Months in a Dog Model
GILLIGAN, B. J., Shults, M. C., Rhodes, R. K., & Updike, S. J. (1994) · Diabetes Care · doi:10.2337/diacare.17.8.882 · Cited by 90
Sanders, J. E., Bale, S. D., & Neumann, T. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10285 · Cited by 82
A new amperometric glucose microsensor: in vitro and short-term in vivo evaluation
Ward, W. K., Jansen, L. B., Anderson, E., Reach, G., Klein, J.-C., & Wilson, G. S. (2002) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(01)00268-8 · Cited by 81
Feasibility of Continuous Long-Term Glucose Monitoring from a Subcutaneous Glucose Sensor in Humans
Gilligan, B. C., Shults, M., Rhodes, R. K., Jacobs, P. G., Brauker, J. H., Pintar, T. J., & Updike, S. J. (2004) · Diabetes Technology & Therapeutics · doi:10.1089/152091504774198089 · Cited by 71
Koschwanez, H. E., Yap, F. Y., Klitzman, B., & Reichert, W. M. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31824 · Cited by 69
Continuous Glucose Monitoring in Normal Mice and Mice with Prediabetes and Diabetes
Klueh, U., Liu, Z., Cho, B., Ouyang, T., Feldman, B., Henning, T. P., Kaur, M., & Kreutzer, D. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.402 · Cited by 63
Gant, R. M., Abraham, A. A., Hou, Y., Cummins, B. M., Grunlan, M. A., & Coté, G. L. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.01.039 · Cited by 58
Novak, M. T., Yuan, F., & Reichert, W. M. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4097-6 · Cited by 55
Ju, Y. M., Yu, B., West, L., Moussy, Y., & Moussy, F. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32400 · Cited by 52
Mahmud, J., Holt, C. A., & Evans, S. L. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.11.009 · Cited by 51
Does subcutaneous adipose tissue behave as an (anti-)thixotropic material?
Geerligs, M., Peters, G. G., Ackermans, P. A. J., Oomens, C. W. J., & Baaijens, F. F. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.11.037 · Cited by 44
Assessment of Chronically Implanted Subcutaneous Glucose Sensors in Dogs
Ward, W. K., & Troupe, J. E. (1999) · ASAIO Journal · doi:10.1097/00002480-199911000-00009 · Cited by 43
The Diabetes Research in Children Network (DirecNet) Study Group (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.03.042 · Cited by 39
Biocompatibility of Electrochemical Glucose Sensors Implanted in the Subcutis of Pigs
Kvist, P. H., Iburg, T. M., Bielecki, M., Gerstenberg, M., Buch‐Rasmussen, T., Hasselager, E., & Jensen, H. E. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.463 · Cited by 38
Sanders, J. E., & Rochefort, J. R. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.20027 · Cited by 32
Wu, J. Z., Cutlip, R. G., Welcome, D. E., & Dong, R. G. (2006) · PubMed · Cited by 29
PETROFSKY, J. S., McLellan, K. C. P., Prowse, M., Bains, G. S., Berk, L., & Lee, S. D. (2010) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2009.0123 · Cited by 29
Epple, M., & Herzberg, O. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199822)43:2 · Cited by 24
Continuous glucose monitoring in the free-moving rat
Thomé-Duret, V., Aussedat, B., Reach, G., Gangnerau, M.-N., Lemonnier, F., Klein, J. C., Zhang, Y., Hu, Y., & Wilson, G. S. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90115-9 · Cited by 21
Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance
Koschwanez, H. E., Reichert, W. M., & Klitzman, B. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32630 · Cited by 15
Strategies for Testing Long-Term Transcutaneous Amperometric Glucose Sensors
Long, N., Yu, B., Moussy, Y., & Moussy, F. G. (2005) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2005.7.927 · Cited by 14
Commercially Available Continuous Glucose Monitoring Systems
Henning, T. P. (2009) · doi:10.1002/9780470567319.ch5 · Cited by 9
Bioluminescence Imaging of Glucose in Tissue Surrounding Polyurethane and Glucose Sensor Implants
Prichard, H. L., Schroeder, T., Reichert, W. M., & Klitzman, B. M. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400504 · Cited by 8
Effect of Subcutaneous Glucose Sensor Implantation on Skin mRNA Expression in Pigs
Kvist, P. H., Iburg, T. M., Dawson, H. D., & Jensen, H. E. (2010) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2010.0041 · Cited by 6
Research works printed but not linked: 7
- Breton MD, 2011, Diabetes Technol Ther., 13, 176
- Renard EM, Farret A, Place J, Cobelli C, Kovatchev BP, Breton MD. Closed-loop insulin delivery using subcutaneous infusion and glucose sensing, and equipped with a dedicated safety supervision algorithm, improves safety of glucose control in type 1 diabetes. Proceedings of the 46th Annual Meeting of the European Association for the Study of Diabetes; 2010 Sep 20–24; Stockholm, Sweden.
- Von Recum A, 1990, New aspects of biocompatibility: Motion at the interface
- 10.1046/j.1467-2494.2000.00037.x · DOI · Paper page
- Wu JZ, 2006, Biomedical Mater Eng., 16, 53
- Marshall AJ, 2004, Polym Prepr., 45, 100
- 10.2337/diacare.23.2.208 · DOI · Paper page
Cited by
Sorted by citations
Continuous glucose monitoring and metrics for clinical trials: an international consensus statement
Battelino, T., Alexander, C. M., Amiel, S. A., Arreaza-Rubin, G., Beck, R. W., Bergenstal, R. M., Buckingham, B. A., Carroll, J., Ceriello, A., Chow, E., et al. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00319-9 · Cited by 831
Biocompatible Materials for Continuous Glucose Monitoring Devices
Nichols, S. P., Koh, A., Storm, W. L., Shin, J. H., & Schoenfisch, M. H. (2013) · Chemical Reviews · doi:10.1021/cr300387j · Cited by 347
Advanced strategies to thwart foreign body response to implantable devices
Capuani, S., Malgir, G., Chua, C. Y. X., & Grattoni, A. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10300 · Cited by 204
Challenges and recent progress in the development of a closed-loop artificial pancreas
Bequette, B. W. (2012) · Annual Reviews in Control · doi:10.1016/j.arcontrol.2012.09.007 · Cited by 184
Heinemann, L., Schoemaker, M., Schmelzeisen-Redecker, G., Hinzmann, R., Kassab, A., Freckmann, G., Reiterer, F., & Del Re, L. (2020) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819855670 · Cited by 170
Metadata
- Authors
- Helton, K. L., Ratner, B. D., & Wisniewski, N. A.
- Affiliations
- University of Washington (US)
- Profusa (United States) (US)
- Corresponding author
- Wisniewski, Natalie A.
- ORCID
- Ratner, Buddy D.
- Venue
- Journal of Diabetes Science and Technology
- Publisher
- SAGE Publications
- Published
- 2011-05
- Volume
- 5
- Issue
- 3
- Pages
- 647-656
- ISSN
- 1932-2968 (ISSN-L)
- PMC
- PMC3192630
- OpenAlex
- W2092619316
- Cited by
- 102
- References
- 60
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 4
- Type
- conference abstract
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Diabetes Science and Technology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- continuous glucose monitoring, micromotion, foreign body reaction, implantable glucose sensor, sensor design
- MeSH terms
- Animals, Biocompatible Materials, Biomechanical Phenomena, Blood Glucose, Diabetes Mellitus, Dogs, Equipment Design, Glucose, Humans, Motion, Pressure, Self Care, Swine, Blood Glucose Self-Monitoring, Reproducibility of Results, Porosity, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review