Cited by 200Autism Spectrum Disorder ResearchMetabolomics and Mass Spectrometry StudiesFatty Acid Research and Health

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Open access

Thomas, Raymond H, Meeking, Melissa M, Mepham, Jennifer R, Tichenoff, Lisa, Possmayer, Fred, Liu, Suya, MacFabe, Derrick F·2012·Journal of Neuroinflammation

DOI 10.1186/1742-2094-9-153PMC PMC3472254

Open this paper in CoChat — free account Open PDF

Abstract

Gastrointestinal symptoms and altered blood phospholipid profiles have been reported in patients with autism spectrum disorders (ASD). Most of the phospholipid analyses have been conducted on the fatty acid composition of isolated phospholipid classes following hydrolysis. A paucity of information exists on how the intact phospholipid molecular species are altered in ASD. We applied ESI/MS to determine how brain and blood intact phospholipid species were altered during the induction of ASD-like behaviors in rats following intraventricular infusions with the enteric bacterial metabolite propionic acid. Animals were infused daily for 8 days, locomotor activity assessed, and animals killed during the induced behaviors. Propionic acid infusions increased locomotor activity. Lipid analysis revealed treatment altered 21 brain and 30 blood phospholipid molecular species. Notable alterations were observed in the composition of brain SM, diacyl mono and polyunsaturated PC, PI, PS, PE, and plasmalogen PC and PE molecular species. These alterations suggest that the propionic acid rat model is a useful tool to study aberrations in lipid metabolism known to affect membrane fluidity, peroxisomal function, gap junction coupling capacity, signaling, and neuroinflammation, all of which may be associated with the pathogenesis of ASD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/1742-2094-9-153

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Number of horizontal movements (A), number of vertical movements (B), counterclockwise revolutions (C), clockwise revolutions (D), number of stereotypic movements (E), horizontal movement time (F), and total distance travelled (G), representing abnormal animal behavior following ICV infusions with PPA and PBS. Animals received ICV infusions of PPA ( n = 12) and PBS ( n = 12) twice a day for 7 consecutive days. Behavioral measurements were monitored immediately after each infusion over 30 min. Values represent means ± SE over 7 days. Bars accompanied by asterisks indicate significant difference between treatments at LSD = 0.05, n = 12 per treatment group. PBS, phosphate buffered saline solution; PPA, propionic acid.CC BY · PubMed Central

Figure 2 Positive ion mass spectra of brain lipid extract. ( A) Full ion scan of all lipids present in positive ion mode. ( B) Detection of [M + H]+ ions of PC and SM molecular species by precursor scanning of m/z 184. IS, internal standard; PC, phosphatidylcholine; SM, sphingomyelin.CC BY · PubMed Central

Figure 3 Negative ion mass spectra of brain lipid extract. ( A) Detection of all [M-H] - ions of glycerophospholipids by precursor ion scan of m/z 153. ( B) Detection of PI molecular species by precursor ion scanning of m/z 241. ( C) Detection of PS molecular species by neutrol loss of 87 D. ( D) Detection of PE molecular species by precursor ion scanning of m/z 196. GPL, glycerophospholipids; IS, internal standard; PI, phosphatidylinositol; PS, phosphatidylserine; PE, phosphatidylethanolamine.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · cited 2×
“There is now emerging evidence that autism may be accompanied by abnormalities in the inflammatory response system [28], and that this abnormality may be related to the increases in oxidative stress [55-57], innate neuroinflammation [58], and altered lipid profiles [5,27,30,32,53] reported in ASD.”
Background
Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651
Pyrosequencing study of fecal microflora of autistic and control children
Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977
Autism and the pervasive developmental disorders
Volkmar, F. R., & Klin, A. (2012) · doi:10.1093/med/9780199696758.003.0214 · Cited by 931
Electrospray mass spectrometry of phospholipids
Pulfer, M. K., & Murphy, R. C. (2003) · Mass Spectrometry Reviews · doi:10.1002/mas.10061 · Cited by 909
Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry
Brügger, B., Erben, G., Sandhoff, R., Wieland, F., & Lehmann, W. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2339 · Cited by 882
Gastrointestinal Microflora Studies in Late‐Onset Autism
Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742
Handbook of Thin-Layer Chromatography
(2003) · CRC Press eBooks · doi:10.1201/9780203912430 · Cited by 703

Show all 68 references

Sorted by citations

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
The Intestinal Microbiome in Early Life: Health and Disease
Arrieta, M.-C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00427 · Cited by 1,024
The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis
Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891
The role of microbiome in central nervous system disorders
Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637
Gastrointestinal microbiota in children with autism in Slovakia
Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.033 · Cited by 632
Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation
Petra, A. I., Panagiotidou, S., Hatziagelaki, E., Stewart, J. M., Conti, P., & Theoharides, T. C. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.002 · Cited by 592
Autism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484
The Gut Microbiota and Autism Spectrum Disorders
Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462
Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder
Liu, S., Li, E., Sun, Z., Fu, D., Duan, G., Jiang, M., Yu, Y., Mei, L., Yang, P., Tang, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36430-z · Cited by 457
Self-citation
Neuropeptides and the Microbiota-Gut-Brain Axis
Holzer, P., & Farzi, A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_9 · Cited by 451
Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders
MacFabe, D. F. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.19260 · Cited by 438
Self-citation
Influence of gut microbiota on neuropsychiatric disorders
Cénit, M. C., Sanz, Y., & Codoñer‐Franch, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i30.5486 · Cited by 433
The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality
Montiel-Castro, A. J., González-Cervantes, R. M., Bravo-Ruiseco, G., & Pacheco-López, G. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00070 · Cited by 413
Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders
Kang, D.-W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., Lozupone, C. A., Hahn, J., Adams, J. B., & Krajmalnik-Brown, R. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2017.12.007 · Cited by 381
Bacterial Neuroactive Compounds Produced by Psychobiotics
Wall, R., Cryan, J. F., Ross, R. P., Fitzgerald, G. F., Dinan, T. G., & Stanton, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_10 · Cited by 373
Understanding the Molecular Mechanisms of the Interplay Between Herbal Medicines and Gut Microbiota
Xu, J., Chen, H., & Li, S. (2017) · Medicinal Research Reviews · doi:10.1002/med.21431 · Cited by 346
Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder
Wang, Y., Li, N., Yang, J.-J., Zhao, D.-M., Chen, B., Zhang, G.-Q., Chen, S., Cao, R.-F., Yu, H., Zhao, C.-Y., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104784 · Cited by 324
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model
Brandscheid, C., Schuck, F., Reinhardt, S., Schäfer, K.-H., Pietrzik, C. U., Grimm, M., Hartmann, T., Schwiertz, A., & Endres, K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160926 · Cited by 318
Autism spectrum disorders and intestinal microbiota
De Angelis, M., Francavilla, R., Piccolo, M., De Giacomo, A., & Gobbetti, M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1035855 · Cited by 311
The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease
Morris, G., Berk, M., Carvalho, A. F., Caso, J. R., Sanz, Y., Walder, K. R., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0004-2 · Cited by 318
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300
May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry
Sherwin, E., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0370-3 · Cited by 308
Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders
Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103740 · Cited by 294
Self-citation
Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases
Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 308
Cross talk: the microbiota and neurodevelopmental disorders
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271
Effects of electromagnetic fields exposure on the antioxidant defense system
Kıvrak, E. G., Yurt, K., Kaplan, A., Alkan, I., & Altun, G. (2017) · Journal of Microscopy and Ultrastructure · doi:10.1016/j.jmau.2017.07.003 · Cited by 268
Desulfovibrio in the Gut: The Enemy within?
Singh, S., Carroll‐Portillo, A., & Lin, H. C. (2023) · Microorganisms · doi:10.3390/microorganisms11071772 · Cited by 279
Gut Microbiota Features in Young Children With Autism Spectrum Disorders
Coretti, L., Paparo, L., Riccio, M. P., Amato, F., Cuomo, M., Natale, A., Borrelli, L., Corrado, G., De Caro, C., Comegna, M., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03146 · Cited by 266
Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders
MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.28177 · Cited by 263
Self-citation
Gut Microbiota and Their Metabolites in Stroke: A Double-Edged Sword
Peh, A., O’Donnell, J. A., Broughton, B. R. S., & Marques, F. Z. (2022) · Stroke · doi:10.1161/strokeaha.121.036800 · Cited by 260
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism
Gevi, F., Zolla, L., Gabriele, S., & Persico, A. M. (2016) · Molecular Autism · doi:10.1186/s13229-016-0109-5 · Cited by 251
Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder
Frye, R. E., Melnyk, S., & MacFabe, D. F. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.143 · Cited by 239
Self-citation
Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder
Rose, S., Niyazov, D. M., Rossignol, D. A., Goldenthal, M. J., Kahler, S. G., & Frye, R. E. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0352-x · Cited by 237
Gut microbiota and autism: key concepts and findings
Ding, H. T., Taur, Y., & Walkup, J. T. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2960-9 · Cited by 232
Microbiome disturbances and autism spectrum disorders
Rosenfeld, C. S. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.063826 · Cited by 229
Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
Rose, S., Bennuri, S. C., Davis, J. E., Wynne, R., Slattery, J. C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S. G., MacFabe, D. F., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0089-z · Cited by 226
Self-citation
Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions
Ristori, M. V., Quagliariello, A., Reddel, S., Ianiro, G., Vicari, S., Gasbarrini, A., & Putignani, L. (2019) · Nutrients · doi:10.3390/nu11112812 · Cited by 214
Gut Dysbiosis in Animals Due to Environmental Chemical Exposures
Rosenfeld, C. S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00396 · Cited by 217
Gut Microbiota and Psychiatric Disorders: A Two-Sample Mendelian Randomization Study
Ni, J., Xu, Q., Yan, S., Han, B., Zhang, H., Wei, X., Feng, G.-J., Zhao, M., Pei, Y., & Zhang, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.737197 · Cited by 184
Implications of the Gut Microbiome in Parkinson's Disease
Elfil, M., Kamel, S., Kandil, M. A., Koo, B. B., & Schaefer, S. M. (2020) · Movement Disorders · doi:10.1002/mds.28004 · Cited by 160
Microbiota‐gut‐brain axis as a regulator of reward processes
García‐Cabrerizo, R., Carbia, C., O’Riordan, K. J., Schellekens, H., & Cryan, J. F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15284 · Cited by 150
Microbiome and nutrition in autism spectrum disorder: Current knowledge and research needs
Berding, K., & Donovan, S. M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw048 · Cited by 146
Diet can impact microbiota composition in children with autism spectrum disorder
Berding, K., & Donovan, S. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00515 · Cited by 144
Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome
Frye, R. E., Rose, S., Slattery, J. M., & MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.27458 · Cited by 145
Self-citation
Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota
Madore, C., Leyrolle, Q., Lacabanne, C., Benmamar-Badel, A., Joffre, C., Nadjar, A., & Layé, S. (2016) · Neural Plasticity · doi:10.1155/2016/3597209 · Cited by 141
Pathophysiological and neurobehavioral characteristics of a propionic acid-mediated autism-like rat model
Choi, J., Lee, S., Won, J., Jin, Y., Hong, Y., Hur, T.-Y., Kim, J.-H., Lee, S.-R., & Hong, Y. (2018) · PLOS ONE · doi:10.1371/journal.pone.0192925 · Cited by 139
Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?
Stilling, R. M., Bordenstein, S. R., Dinan, T. G., & Cryan, J. F. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00147 · Cited by 139
Autism: Metabolism, Mitochondria, and the Microbiome
Macfabe, D. (2013) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2013.089 · Cited by 131
Self-citation
Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines
Frye, R. E., Rose, S., Chacko, J., Wynne, R., Bennuri, S. C., Slattery, J. C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S. G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.189 · Cited by 130
Self-citation
Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis
Frye, R. E., Rincon, N., McCarty, P. J., Brister, D., Scheck, A. C., & Rossignol, D. A. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106520 · Cited by 132
Microbial ecosystems therapeutics: a new paradigm in medicine?
Petrof, E., Claud, E. C., Gloor, G. B., & Allen‐Vercoe, E. (2012) · Beneficial Microbes · doi:10.3920/bm2012.0039 · Cited by 127
Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II – contemporary contextual research
Bested, A. C., Logan, A. C., & Selhub, E. M. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-3 · Cited by 121
The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder
Alharthi, A., Alhazmi, S., Alburae, N. A., & Bahieldin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031363 · Cited by 126
The role of the gut microbiome in the development of schizophrenia
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G. A., & Dinan, T. G. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.02.010 · Cited by 121
Microbiota, immunoregulatory old friends and psychiatric disorders
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_15 · Cited by 117
Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: Implications for autism spectrum disorders
Foley, K. A., MacFabe, D. F., Vaz, A., Ossenkopp, K., & Kavaliers, M. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.04.001 · Cited by 116
Self-citation
Genetic and non-genetic animal models for autism spectrum disorders (ASD)
Ergaz, Z., Weinstein‐Fudim, L., & Ornoy, A. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.04.024 · Cited by 121
Autism Spectrum Disorder Associated With Gut Microbiota at Immune, Metabolomic, and Neuroactive Level
García-Gutiérrez, E., Narbad, A., & Rodríguez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.578666 · Cited by 118
Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products
Carter, C., & Blizard, R. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.10.011 · Cited by 116
Recent progress on hybrid fibrous electromagnetic shields: Key protectors of living species against electromagnetic radiation
Hashemi, S. A., Ghaffarkhah, A., Hosseini, E., Bahrani, S., Najmi, P., Omidifar, N., Mousavi, S. M., Amini, M., Ghaedi, M., Ramakrishna, S., et al. (2022) · Matter · doi:10.1016/j.matt.2022.09.012 · Cited by 112
Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives
Mehra, A., Arora, G., Sahni, G., Kaur, M., Singh, H. B., Singh, B., & Kaur, S. (2022) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2022.03.001 · Cited by 116
An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders
Borrego-Ruiz, A., & Borrego, J. J. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110861 · Cited by 111
The neurobiology of autism spectrum disorders
Parellada, M., Penzol, M. J., Pina‐Camacho, L., Moreno, C., González‐Vioque, E., Zalsman, G., & Arango, C. (2013) · European Psychiatry · doi:10.1016/j.eurpsy.2013.02.005 · Cited by 115
Walnut‐Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice
Wang, M., Amakye, W. K., Guo, L., Gong, C., Zhao, Y., Yao, M., & Ren, J. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900326 · Cited by 99
Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: Relevance to autism spectrum disorders
Foley, K. A., MacFabe, D. F., Kavaliers, M., & Ossenkopp, K. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.032 · Cited by 100
Self-citation
Visceral Inflammation and Immune Activation Stress the Brain
Holzer, P., Farzi, A., Hassan, A. M., Zenz, G., Jačan, A., & Reichmann, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01613 · Cited by 84
Targeting Modified Lipids during Routine Lipidomics Analysis using HILIC and C30 Reverse Phase Liquid Chromatography coupled to Mass Spectrometry
Pham, T. H., Zaeem, M., Fillier, T. A., Nadeem, M., Vidal, N. P., Manful, C. F., Cheema, S. K., Cheema, M., & Thomas, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-41556-9 · Cited by 80
Self-citation
The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism
Parker, W., Hornik, C. D., Bilbo, S. D., Holzknecht, Z. E., Gentry, L., Rao, R., Lin, S. S., Herbert, M. R., & Nevison, C. D. (2017) · Journal of International Medical Research · doi:10.1177/0300060517693423 · Cited by 87
Neuroprotective Effect of α-Mangostin in Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats
Tiwari, A., Khera, R., Rahi, S., Mehan, S., Makeen, H. A., Khormi, Y. H., Rehman, M. U., & Khan, A. (2021) · Brain Sciences · doi:10.3390/brainsci11030288 · Cited by 73
The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood
Slattery, J. M., MacFabe, D. F., & Frye, R. E. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38338 · Cited by 72
Self-citation
Altered Gut Microbiota and Short-chain Fatty Acids in Chinese Children with Constipated Autism Spectrum Disorder
He, J., Gong, X., Hu, B., Lin, L., Lin, X., Gong, W., Zhang, B., Cao, M., Xu, Y., Xia, R., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-46566-2 · Cited by 74
Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats
Shultz, S. R., aziz, N. A., Yang, L., Sun, M., MacFabe, D. F., & O'Brien, T. J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.050 · Cited by 70
Self-citation
The Gut–Brain Axis in the Neuropsychological Disease Model of Obesity: A Classical Movie Revised by the Emerging Director “Microbiome”
Niccolai, E., Boem, F., Russo, E., & Amedei, A. (2019) · Nutrients · doi:10.3390/nu11010156 · Cited by 70
Microbiome to Brain: Unravelling the Multidirectional Axes of Communication
Aidy, S. E., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-20215-0_15 · Cited by 65
The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders
Marzal, L. N. P., Prince, N., Bajić, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810052 · Cited by 67
A review of probiotics in the treatment of autism spectrum disorders: Perspectives from the gut–brain axis
Feng, P., Zhao, S., Zhang, Y., & Li, E. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1123462 · Cited by 62
The microbiome and disorders of the central nervous system
Felice, V. D., & O'Mahony, S. M. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.016 · Cited by 60
A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress
Mirza, R., & Sharma, B. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108758 · Cited by 60
Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model
Duque, A. L. R. F., Demarqui, F. M., Santoni, M. M., Zanelli, C. F., Adorno, M. Â. T., Milenković, D., Mesa, V., & Sivieri, K. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110657 · Cited by 62
Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats
Meeking, M. M., MacFabe, D. F., Mepham, J. R., Foley, K. A., Tichenoff, L. J., Boon, F. H., Kavaliers, M., & Ossenkopp, K. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109794 · Cited by 60
Self-citation
Neuropeptides, Microbiota, and Behavior
Holzer, P. D. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.005 · Cited by 57
Interplay Between Peripheral and Central Inflammation in Autism Spectrum Disorders: Possible Nutritional and Therapeutic Strategies
Cristiano, C., Lama, A., Lembo, F., Mollica, M. P., Calignano, A., & Raso, G. M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00184 · Cited by 60
Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats
Mirza, R., & Sharma, B. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.10.045 · Cited by 55
Potential Role of L-Carnitine in Autism Spectrum Disorder
Kępka, A., Ochocińska, A., Chojnowska, S., Borzym‐Κluczyk, M., Skorupa, E., Knaś, M., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061202 · Cited by 56
Dietary polyunsaturated fatty acids influence flight muscle oxidative capacity but not endurance flight performance in a migratory songbird
Dick, M. F., & Guglielmo, C. G. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00206.2018 · Cited by 50
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure
Sharma, A. R., Batra, G., Saini, L. K., Sharma, S., Mishra, A., Singla, R., Singh, A. K., Singh, R. S., Jain, A., Bansal, S., et al. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210806165430 · Cited by 49
Gut-to-Brain Axis in Autism Spectrum Disorders
Kraneveld, A. D., Szklany, K., de Theije, C. G. M., & Garssen, J. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.09.001 · Cited by 47
A systematic review of gut‐immune‐brain mechanisms in Autism Spectrum Disorder
Azhari, A., Azizan, F., & Esposito, G. (2018) · Developmental Psychobiology · doi:10.1002/dev.21803 · Cited by 52
RETRACTED ARTICLE: PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats
Sharma, A., Bhalla, S., & Mehan, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01026-0 · Cited by 47
Retracted
The Microbiota-Gut Axis in Premature Infants: Physio-Pathological Implications
Bresesti, I., Salvatore, S., Valetti, G., Baj, A., Giaroni, C., & Agosti, M. A. (2022) · Cells · doi:10.3390/cells11030379 · Cited by 51
Propionate relieves pentylenetetrazol-induced seizures, consequent mitochondrial disruption, neuron necrosis and neurological deficits in mice
Cheng, Y., Mai, Q., Zeng, X., Wang, H., Xiao, Y., Tang, L., Li, J., Zhang, Y., & Ding, H. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.08.009 · Cited by 45
Review article: bugs, inflammation and mood—a microbiota‐based approach to psychiatric symptoms in inflammatory bowel diseases
Thomann, A., Mak, J. W. Y., Zhang, J., Wüstenberg, T., Ebert, M. P., Sung, J. J. �., Bernstein, C. N., Reindl, W., & Ng, S. C. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15787 · Cited by 44
Mini-review: Brain energy metabolism and its role in animal models of depression, bipolar disorder, schizophrenia and autism
Kolář, D., Kletečková, L., Brožka, H., & Valeš, K. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136003 · Cited by 46
Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder
Zhu, J., Hua, X., Yang, T., Guo, M., Li, Q., Xiao, L., Li, L., Chen, J., & Li, T. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05066-w · Cited by 44
The role of microbiota in autism spectrum disorders
Campion, D., Ponzo, P., Alessandria, C., Saracco, G. M., & Balzola, F. A. (2018) · Minerva Gastroenterologica e Dietologica · doi:10.23736/s1121-421x.18.02493-5 · Cited by 40
Can microbiology affect psychiatry? A link between gut microbiota and psychiatric disorders
Gulas, E., Wysiadecki, G., Strzelecki, D., Gawlik-Kotelnicka, O., & Polguj, M. (2018) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/81103 · Cited by 40
Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism
Lobzhanidze, G., Japaridze, N. J., Lordkipanidze, T. G., Rzayev, F., MacFabe, D. F., & Zhvania, M. G. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10011 · Cited by 38
Self-citation
Enhancing Clinical Efficacy through the Gut Microbiota: A New Field of Traditional Chinese Medicine
Lu, Y., Xie, J., Peng, C., Wang, B., Wang, K., & Li, L. (2018) · Engineering · doi:10.1016/j.eng.2018.11.013 · Cited by 37
Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals
Rahi, S., & Mehan, S. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01010-1 · Cited by 38

Authors: Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F.
Affiliations: Western University (CA)
Corresponding author: Thomas, Raymond H
ORCID: Thomas, Raymond H
Possmayer, Fred
Liu, Suya
Venue: Journal of Neuroinflammation
Publisher: Springer Science and Business Media LLC
Published: 2012-07-02
Volume: 9
Issue: 1
Pages: 153-153
ISSN: 1742-2094 (ISSN-L)
DOI: 10.1186/1742-2094-9-153
PMC: PMC3472254
OpenAlex: W2103294794
Cited by: 200
References: 68
Citations by year: 2026: 9 · 2025: 9 · 2024: 6 · 2023: 10 · 2022: 17 · 2021: 22 · 2020: 19 · 2019: 17 · 2018: 17 · 2017: 10 · 2016: 22 · 2015: 15 · 2014: 11 · 2013: 12 · 2012: 4
FWCI: 6.88
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.creativecommons.org/licenses/by/2.0 (unspecified)
Locations: Journal of Neuroinflammation (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Autism Research Institute
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: autism spectrum disorder, propionic acid, gut-brain axis, phospholipid molecular species, brain phospholipids, plasma phospholipids, intraventricular infusion, locomotor activity, sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, plasmalogens, lipid metabolism, neuroinflammation, membrane fluidity
MeSH terms: Animals, Brain, Child Development Disorders, Pervasive, Child, Preschool, Disease Models, Animal, Enterobacteriaceae, Humans, Motor Activity, Phospholipids, Propionates, Biomarkers, Rats, Long-Evans, Rats, Infusions, Intraventricular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks