Cited by 3,960Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop

McKeith, I.G., Galasko, D., Kosaka, K., Perry, E.K., Dickson, D.W., Hansen, L.A., Salmon, D.P., Lowe, J., Mirra, S.S., Byrne, E.J., Lennox, G., Quinn, N.P., Edwardson, J.A., Ince, P.G., Bergeron, C., Burns, A., Miller, B.L., Lovestone, S., Collerton, D., Jansen, E.N.H., Ballard, C., de Vos, R.A.I., Wilcock, G.K., Jellinger, K.A., Perry, R.H.·1996·Neurology

DOI 10.1212/wnl.47.5.1113

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Abstract

Recent neuropathologic autopsy studies found that 15 to 25% of elderly demented patients have Lewy bodies (LB) in their brainstem and cortex, and in hospital series this may constitute the most common pathologic subgroup after pure Alzheimer's disease (AD). The Consortium on Dementia with Lewy bodies met to establish consensus guidelines for the clinical diagnosis of dementia with Lewy bodies (DLB) and to establish a common framework for the assessment and characterization of pathologic lesions at autopsy. The importance of accurate antemortem diagnosis of DLB includes a characteristic and often rapidly progressive clinical syndrome, a need for particular caution with neuroleptic medication, and the possibility that DLB patients may be particularly responsive to cholinesterase inhibitors. We identified progressive disabling mental impairment progressing to dementia as the central feature of DLB. Attentional impairments and disproportionate problem solving and visuospatial difficulties are often early and prominent. Fluctuation in cognitive function, persistent well-formed visual hallucinations, and spontaneous motor features of parkinsonism are core features with diagnostic significance in discriminating DLB from AD and other dementias. Appropriate clinical methods for eliciting these key symptoms are described. Brainstem or cortical LB are the only features considered essential for a pathologic diagnosis of DLB, although Lewy-related neurites, Alzheimer pathology, and spongi…

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Authors: McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., Lennox, G., Quinn, N. P., Edwardson, J. A., Ince, P. G., Bergeron, C., Burns, A., Miller, B. L., Lovestone, S., Collerton, D., Jansen, E. N. H., Ballard, C., de Vos, R. A. I., Wilcock, G. K., Jellinger, K. A., & Perry, R. H.
Affiliations: Newcastle upon Tyne Hospital (GB)
ORCID: McKeith, I.G.
Galasko, D.
Dickson, D.W.
Salmon, D.P.
Lowe, J.
Quinn, N.P.
Ince, P.G.
Burns, A.
Miller, B.L.
Lovestone, S.
Collerton, D.
Ballard, C.
Jellinger, K.A.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-11
Volume: 47
Issue: 5
Pages: 1113-1124
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.47.5.1113
OpenAlex: W2123056519
Cited by: 3,960
References: 2
Citations by year: 2026: 28 · 2025: 38 · 2024: 46 · 2023: 50 · 2022: 51 · 2021: 72 · 2020: 72 · 2019: 105 · 2018: 106 · 2017: 130 · 2016: 129 · 2015: 119 · 2014: 135 · 2013: 148 · 2012: 160
FWCI: 72.06
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: dementia with Lewy bodies, diagnosis, neuropathology, Lewy bodies, cortical Lewy bodies, Alzheimer's disease, parkinsonism, visual hallucinations, cognitive fluctuations, cholinesterase inhibitors, antipsychotic drugs, frozen tissue storage
MeSH terms: Dementia, Humans, Parkinson Disease

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Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop

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