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The left-right axis in the mouse: from origin to morphology

Shiratori, Hidetaka, Hamada, Hiroshi·2006·Development

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Abstract

The past decade or so has seen rapid progress in our understanding of how left-right (LR) asymmetry is generated in vertebrate embryos. However, many important questions about this process remain unanswered. Although a leftward flow of extra-embryonic fluid in the node cavity (nodal flow) is likely to be the symmetry-breaking event, at least in the mouse embryo, it is not yet known how this flow functions or how the asymmetric signal generated in the node is transferred to the lateral plate. The final step in left-right patterning– translation of the asymmetric signal into morphology – is also little understood.

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Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
Yoshiba, S., Shiratori, H., Kuo, I. Y., Kawasumi, A., Shinohara, K., Nonaka, S., Asai, Y., Sasaki, G., Belo, J. A., Sasaki, H., et al. (2012) · Science · doi:10.1126/science.1222538 · Cited by 306
Self-citation
Cilia-Driven Leftward Flow Determines Laterality in Xenopus
Schweickert, A., Weber, T., Beyer, T., Vick, P., Bogusch, S., Feistel, K., & Blum, M. (2007) · Current Biology · doi:10.1016/j.cub.2006.10.067 · Cited by 280

See all 301

Authors: Shiratori, H., & Hamada, H.
Venue: Development
Publisher: The Company of Biologists
Published: 2006-06-01
Volume: 133
Issue: 11
Pages: 2095-2104
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.02384
OpenAlex: W2103899656
Cited by: 301
References: 91
FWCI: 8.10
Type: journal article
Language: en
Open access: closed

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

The left-right axis in the mouse: from origin to morphology

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