Spatial and temporal bias in the mitotic origins of somatostatin- and parvalbumin-expressing interneuron subgroups and the chandelier subtype in the medial ganglionic eminence
Open accessAbstract
GABAergic interneurons modulate cortical activity through the actions of distinct subgroups. Recent studies using interneuron transplants have shown tremendous promise as cell-based therapies for seizure disorders, Parkinson's disease, and in the study of neocortical plasticity. Previous reports identified a spatial bias for the origins of parvalbumin (PV)- and somatostatin (SST)-expressing interneuron subgroups within the medial ganglionic eminence (MGE). In the current study, the mitotic origins of these interneurons are examined by harvesting MGE cells at 2 time points and evaluating their neurochemical profiles after transplantation into neonatal mouse cortex. Although the dorsal MGE (dMGE)-SST and ventral MGE (vMGE)-PV bias were confirmed, both subgroups originate from progenitors located throughout the MGE. The dMGE bias was also found for SST subgroups that coexpress calretinin or reelin. In contrast, another major subgroup of SST interneuron, neuropeptide Y-expressing, does not appear to originate within the MGE. Finally, novel evidence is provided that a clinically important subtype of PV-expressing interneuron, the chandelier (axo-axonic) cell, is greatly enriched in transplants from the vMGE at embryonic day 15. These findings have important implications both for the study of interneuron fate determination and for studies that use interneuron precursor transplantation to alter cortical activity.
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Chandelier cells are most frequent in layers 2 and 6 although they are preferentially generated toward the end of neurogenesis.
“chandelier cells are most frequent in layers 2 and 6 of neocortex although they are preferentially generated toward the end of neurogenesis”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Inan et al., 2012
MGE progenitors generate most SST+ interneurons during the first half of the neurogenic period, whereas PV+ interneurons are produced at an almost constant rate throughout neurogenesis.
“MGE progenitors generate most SST+ interneurons during the first half of the neurogenic period, whereas PV+ interneurons are produced at an almost constant rate throughout neurogenesis”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Inan et al., 2012
The intermediate MGE produces both PV+ and SST+ interneurons with a rostral PV+ to caudal SST+ bias.
“The intermediate MGE produces both PV+ and SST+ interneurons with a rostral (PV+) to caudal (SST+) bias”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Inan et al., 2012
E13.5 MGE and E14.5 CGE/LGE correspond to peak neurogenesis in these structures.
“We manually dissected the embryonic day (E)13.5 MGE or E14.5 CGE and LGE from wild type mouse embryos, timepoints corresponding to peak neurogenesis in these structures7,8”
From Developmental diversification of cortical inhibitory interneurons (2018) · cites this paper as [7]
PV-expressing AAC neurogenesis preferentially occurs beyond E15.5, after the MGE has morphologically flattened into a ventral germinal zone.
“PV-expressing AAC neurogenesis preferentially occurs beyond E15.5 after the MGE has morphologically flattened out into a ventral germinal zone of the lateral ventricle”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [519]
Temporal dynamics significantly impact mature interneuron fate.
“Complementing the spatial control of interneuron specification within the GEs is a temporal dynamic that has significant impact on mature interneuron fate”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [519]
SST hub cells are generated from Nkx2.1 progenitors at E9.5, before the MGE is morphologically distinguishable.
“SST hub cells are generated from Nkx2.1 progenitors at the earliest time points of interneuron production (E9.5) before the MGE is even morphologically distinguishable”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [519]
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- Authors
- Inan, M., Welagen, J., & Anderson, S. A.
- Affiliations
- Cornell University (US)
- ORCID
- Anderson, S. A.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-21
- Volume
- 22
- Issue
- 4
- Pages
- 820-827
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC3450921
- OpenAlex
- W2163007828
- Cited by
- 161
- References
- 49
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 6 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 14 · 2019: 9 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 7 · 2014: 19 · 2013: 9 · 2012: 4
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K02MH070031, R01MH066912)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- medial ganglionic eminence, somatostatin interneurons, parvalbumin interneurons, chandelier cells, calretinin, reelin, GABAergic interneurons
- MeSH terms
- Reelin Protein, Analysis of Variance, Animals, Animals, Newborn, Bromodeoxyuridine, Cell Count, Cell Differentiation, Embryo, Mammalian, Female, Interneurons, Male, Mice, Transgenic, Nerve Tissue Proteins, Parvalbumins, Pregnancy, Somatostatin, Telencephalon, Time Factors, Gene Expression Regulation, Developmental, Neocortex, Green Fluorescent Proteins, Mice, Embryonic Stem Cells
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