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Postprandial hormone and metabolic responses in simulated shift work
Abstract
This study was designed to investigate postprandial responses to a mixed meal in simulated shift work conditions. Nine normal healthy subjects (six males and three females) were studied on two occasions at the same clock time (1330 h) after consuming test meals, first in their normal environment and secondly after a 9 h phase advance (body clock time 2230 h). Plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), triacylglycerol (TAG) and non-esterified fatty acids (NEFAs) were determined at intervals for 6 h after each test meal. Postprandial plasma glucose, insulin, GIP and GLP-1 profiles were evaluated by calculating areas under the curve (AUC) for the first 2 h and the last 4 h of the sampling together with total AUC. Significantly higher postprandial glucose responses (total AUC) were observed after the phase shift than before (AUC 0-360 min, 2.01 (1.51-2.19) vs 1.79 (1.56-2.04) mmol/l.min; P < 0.02; mean (range)). No significant difference was observed when the first 2 h of each response was compared, but significantly higher glucose levels were observed in the last 4 h of the study after the phase shift than before (AUC 120-360 min, 1.32 (1.08-1.42) vs 1.16 (1.00-1.28) mmol/l.min; P < 0.05). Similar results were obtained for insulin (AUC 0-360 min, 81.72 (30.75-124.97) vs 58.98 (28.03-92.57) pmol/l.min; P < 0.01; AUC 120-360 min, 40.73 (16.20-65.25) vs 25.71 (14.25-37.33) pmol/l.min; P < 0.02). No differences were observed in postprandial plasma GIP and GLP-1 responses before and after the phase shift. Postprandial circulating lipid levels were affected by phase shifting. Peak plasma TAG levels occurred 5 h postprandially before the phase shift. Postprandial rises in plasma TAG were significantly delayed after the phase shift and TAG levels continued to rise throughout the study. Plasma postprandial NEFA levels fell during the first 3 h both before and after the phase shift. Their rate of return to basal levels was significantly delayed after the phase shift compared with before. This study demonstrates that a simulated phase shift can significantly alter pancreatic B-cell responses and postprandial glucose and lipid metabolism.
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“Different forms of shift work are reported to induce multiple forms of circadian misalignment, which are believed to underlie the observed raised postprandial glucose (120) and insulin concentrations in shift workers (121), as well as the increased risk of impaired glucose tolerance (122) and type 2 diabetes observed in epidemiologic studies (81).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [120]
In the citing paper
“Important early studies have shown decreased glucose tolerance, a risk factor for diabetes, under simulated shift work conditions and in shift workers [e.g., Hampton et al. (67) and Lund et al. (68)].”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [67]
In the citing paper
“Moreover, a 9-h phase advance only had a detrimental effect on the average triglyceride response to a test meal when the pretest meal is a low- rather than high-fat meal (Hampton et al., 1996; Ribeiro et al., 1998).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Hampton et al., 1996
In the citing paper
“A 9-h phase advance of the circadian timing system—a simulation of shift work—increased the glucose and insulin response to a test meal given at the same clock time when the test meal was preceded by a high-fat but not low-fat meal (Hampton et al., 1996; Ribeiro et al., 1998).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Hampton et al., 1996
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Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
“Others have examined the effect of simulated night shift work on postprandial glucose and insulin with varied results (18, 19).”
BackgroundHealth disorders of shift workers
Knutsson, A. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg048 · Cited by 1,218
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
“Furthermore, post-prandial TAG levels are higher and the elevation more prolonged in subjects following a shift-work routin”
BackgroundKarlsson, B., Knutsson, A., & Lindahl, B. (2001) · Occupational and Environmental Medicine · doi:10.1136/oem.58.11.747 · Cited by 924
Rajaratnam, S. M., & Arendt, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06108-6 · Cited by 711
Self-citationCircadian regulation of glucose, lipid, and energy metabolism in humans
Poggiogalle, E., Jamshed, H., & Peterson, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.017 · Cited by 743
“[19] Hampton HS, Morgan LM, Lawrence N, Anastasiadou T, Norris F, Deacon S, et al.”
BackgroundInfluentialCircadian misalignment and health
Baron, K. G., & Reid, K. J. (2014) · International Review of Psychiatry · doi:10.3109/09540261.2014.911149 · Cited by 645
“…studies have used temporary phase shifts to study the effect of misalignment and demonstrate changes in leptin rhythm and glucose response to meals (Hampton et al., 1996; Schoeller, Cella, Sinha, & Caro, 1997) as well as increased depressed mood (Surridge-David, MacLean, Coulter, & Knowles, 1987).”
BackgroundRoles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 632
“, “jet lag”), and shift work rotations are highly prevalent conditions in modern society, and their hormonal and metabolic implications have only begun to be recognized (3).”
BackgroundMorris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418955112 · Cited by 523
“, SCN lesions, clock gene mutations, continuous light exposure, and simulated shift work) can impair glucose metabolism (19, 20, 26, 28, 29).”
BackgroundEating and shift work - effects on habits, metabolism and performance
Lowden, A., Moreno, C., Holmbäck, U., Lennernäs, M., & Tucker, P. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2898 · Cited by 492
“For example, participants in a simulated shift work study were given a late evening meal (22:30 hours) and consequently exhibited elevated postprandial glucose and insulin responses (63).”
BackgroundSleep disorders, health, and safety in police officers
Rajaratnam, S. M. W., Barger, L. K., Lockley, S. W., Shea, S. A., Wang, W., Landrigan, C. P., O’Brien, C. S., Qadri, S., Sullivan, J. P., Cade, B. E., et al. (2011) · JAMA · doi:10.1001/jama.2011.1851 · Cited by 405
Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403
Workhours in relation to work stress, recovery and health
Härmä, M. (2006) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1055 · Cited by 387
“Differences in the circadian timing of meals among shift workers have also been shown to influence postprandial levels of lipids and glucose (89, 90).”
BackgroundEffects of Health Care Provider Work Hours and Sleep Deprivation on Safety and Performance
Lockley, S. W., Barger, L. K., Ayas, N., Rothschild, J. M., Czeisler, C. A., & Landrigan, C. P. (2007) · The Joint Commission Journal on Quality and Patient Safety · doi:10.1016/s1553-7250(07)33109-7 · Cited by 399
Sleep and Cardiovascular Disease
Wolk, R. A., Gami, A. S., García‐Touchard, A., & Somers, V. K. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.07.002 · Cited by 340
Metabolic disturbances in male workers with rotating three-shift work. Results of the WOLF study
Karlsson, B. H., Knutsson, A., Lindahl, B., & Alfredsson, L. S. (2003) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-003-0440-y · Cited by 316
“This interpretation is supported by findings of Hampton et al. (1996) .”
BackgroundResultMeta‐analysis on night shift work and risk of metabolic syndrome
Wang, F., Zhang, L., Zhang, Y., Zhang, B., He, Y., Xie, S., Li, M., Miao, X., Chan, E. Y. Y., Tang, J. L., et al. (2014) · Obesity Reviews · doi:10.1111/obr.12194 · Cited by 302
Health Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291
Sleep and Metabolism: An Overview
Sharma, S., & Kavuru, M. S. (2010) · International Journal of Endocrinology · doi:10.1155/2010/270832 · Cited by 296
“revealed that when subjects were made to simulate shift work it resulted in alterations in postprandial glucose and lipid metabolism [15].”
BackgroundMorris, C. J., Purvis, T. E., Mistretta, J., & Scheer, F. A. J. L. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3924 · Cited by 262
Circadian rhythms, metabolism, and chrononutrition in rodents and humans
Johnston, J. D., Ordovás, J. M., Scheer, F. A., & Turek, F. W. (2016) · Advances in Nutrition · doi:10.3945/an.115.010777 · Cited by 258
Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health
Almoosawi, S., Vingeliene, S., Gachon, F., Voortman, T., Palla, L., Johnston, J. D., Van Dam, R. M., Darimont, C., & Karagounis, L. G. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy070 · Cited by 247
“…shift work are reported to induce multiple forms of circadian misalignment, which are believed to underlie the observed raised postprandial glucose (120) and insulin concentrations in shift workers (121), as well as the increased risk of impaired glucose tolerance (122) and type 2 diabetes…”
Efficacy of Melatonin Treatment in Jet Lag, Shift Work, and Blindness
Arendt, J., Skene, D. J., Middleton, B., Lockley, S. W., & Deacon, S. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200616 · Cited by 245
Self-citationEffects of circadian disruption on the cardiometabolic system
Rüger, M., & Scheer, F. A. J. L. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9122-8 · Cited by 232
“One of the first laboratory studies to investigate potential metabolic changes due to circadian disruption/misalignment was by Hampton and co-workers [144] in a simulated shift work study.”
BackgroundChua, E. C.-P., Shui, G., Lee, I. T.-G., Lau, P., Tan, L.-C., Yeo, S.-C., Lam, B. D., Bulchand, S., Summers, S. A., Puvanendran, K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222647110 · Cited by 221
“Postprandial TAG levels are higher for meals taken during the night versus the day (10, 11), coinciding with a circadian increase in plasma TAG concentrations, as shown here and in other studies (5, 36).”
BackgroundResultShiftwork and Cardiovascular Disease: Review of Disease Mechanisms
Knutsson, A., & Bøggild, H. (2000) · Reviews on Environmental Health · doi:10.1515/reveh.2000.15.4.359 · Cited by 221
Moreno, C. R. D. C., Marqueze, E. C., Sargent, C., Wright, K. P., Ferguson, S. A., & Tucker, P. (2019) · Industrial Health · doi:10.2486/indhealth.sw-1 · Cited by 246
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Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215
“Moreover, a 9-h phase advance only had a detrimental effect on the average triglyceride response to a test meal when the pretest meal is a low- rather than high-fat meal (Hampton et al., 1996; Ribeiro et al., 1998).”
BackgroundPostprandial hormone and metabolic responses amongst shift workers in Antarctica
Lund, J., Arendt, J., Hampton, S., English, J., & Morgan, L. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1710557 · Cited by 206
“An increased incidence of cardiovascular disease (CVD) is well documented (Knutsson et al. 1986, Kristensen 1989, Kawachi et al. 1996).”
BackgroundResultInfluentialSelf-citationCircadian Adaptation to Night-Shift Work by Judicious Light and Darkness Exposure
Boivin, D. B., & James, F. O. (2002) · Journal of Biological Rhythms · doi:10.1177/0748730402238238 · Cited by 205
“…including cardiovascular disease, gastrointestinal discomfort, reproductive difficulties, and breast cancer (Knutsson et al., 1999; Nakamura et al., 1997; Harrington, 1994; Romon and Bertin Lebrette, 1998; Hampton et al., 1996; Nurminen, 1998; Hansen, 2001; Koller et al., 1978; Koller, 1983).”
BackgroundHuman circadian rhythms: physiological and therapeutic relevance of light and melatonin
Skene, D. J., & Arendt, J. (2006) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/000456306778520142 · Cited by 210
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The effects of shift work on body weight change − a systematic review of longitudinal studies
van Drongelen, A., Boot, C., Merkus, S., Smid, T., & Beek, A. J. (2011) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.3143 · Cited by 197
“4 insulin sensitivity as a result of nocturnal eating (48,51-55).”
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Gozal, D., Dumin, M., & Koren, D. (2016) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s95120 · Cited by 204
Visual impairment and circadiam rhythm disorders
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Self-citationSleep and the metabolic syndrome
Wolk, R. A., & Somers, V. K. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033787 · Cited by 193
“Other metabolic effects of shift work include abdominal obesity, dyslipidaemia (lower HDL cholesterol and higher triglycerides) and changes in glucose tolerance (Hampton et al. 1996; Karlsson et al. 2001, 2003; Nagaya et al. 2002; Di Lorenzo et al. 2003), all suggestive of the possibility that shift work may contribut…”
BackgroundMeasurement of, and Some Reasons for, Differences in Eating Habits Between Night and Day Workers
Waterhouse, J. M., Buckley, P., Edwards, B., & Reilly, T. P. (2003) · Chronobiology International · doi:10.1081/cbi-120025536 · Cited by 182
“In this regard, night work is associated with altered plasma lipids (Cella et al., 1995; Romon et al., 1990) and glucose tolerance (Hampton et al., 1996; Lund et al., 2001; Ribeiro et al., 1998), and it has been shown that there is a direct relationship between the amount of carbohydrates taken in…”
BackgroundCircadian regulation of lipid metabolism
Gooley, J. J. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000288 · Cited by 194
The trouble with circadian clock dysfunction: Multiple deleterious effects on the brain and body
Zelinski, E. L., Deibel, S. H., & McDonald, R. J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.007 · Cited by 189
Chrononutrition in the management of diabetes
Henry, C. J., Kaur, B., & Quek, R. Y. C. (2020) · Nutrition & Diabetes · doi:10.1038/s41387-020-0109-6 · Cited by 174
Markers of insulin resistance in day and shift workers aged 30-59 years
Nagaya, T., Yoshida, H., Takahashi, H., & Kawai, M. (2002) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-002-0370-0 · Cited by 158
Physiological responses to food intake throughout the day
Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158
“In comparable experiments, the exaggerated postprandial response following a test meal in shifted subjects was reduced for glucose and insulin but increased for TAG following a low-fat pre-meal((150)) rather than a high-fat pre-meal((151)).”
BackgroundBiological Rhythms During Residence in Polar Regions
Arendt, J. (2012) · Chronobiology International · doi:10.3109/07420528.2012.668997 · Cited by 172
“…time (for example, in the middle of the biological night) are followed by abnormal postprandial metabolism, with evidence of insulin resistance and slow clearance of blood lipids, i.e., triglycerides (Hampton et al., 1996; Holmback et al., 2002; Ribeiro et al., 1998; Sopowski et al., 2001).”
BackgroundSelf-citationLipid metabolism around the body clocks
Petrenko, V., Sinturel, F., Riezman, H., & Dibner, C. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101235 · Cited by 171
“Consistently, previous studies proposed that night eating resulted in increased postprandial glucose, insulin and TAG levels in comparison to daytime meals [109,110].”
BackgroundCircadian clocks in the digestive system
Segers, A., & Depoortere, I. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00401-5 · Cited by 165
Altered postprandial hormone and metabolic responses in a simulated shift work environment
Ribeiro, D., Hampton, S., Morgan, L., Deacon, S., & Arendt, J. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1580305 · Cited by 155
“The aim of this study was to extend the observations from our previous work (Hampton et al. 1996) on postprandial hormone and metabolic responses during simulated shift work.”
InfluentialHow to Trick Mother Nature into Letting You Fly Around or Stay Up All Night
Revell, V. L., & Eastman, C. I. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277233 · Cited by 151
“In addition, consuming meals at an unusual circadian phase, after transmeridian travel and during the night shift, can result in inappropriate metabolic responses that are risk factors for cardiovascular disease and type II diabetes mellitus (Hampton et al., 1996).”
BackgroundAtypical Work Hours and Metabolic Syndrome Among Police Officers
Violanti, J. M., Burchfiel, C. M., Hartley, T. A., Mnatsakanova, A., Fekedulegn, D. B., Andrew, M. E., Charles, L. E., & Vila, B. J. (2009) · Archives of Environmental & Occupational Health · doi:10.1080/19338240903241259 · Cited by 150
Treatment of Circadian Rhythm Disorders–Melatonin
Arendt, J., & Deacon, S. (1997) · Chronobiology International · doi:10.3109/07420529709001155 · Cited by 138
Self-citationDiurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics
Gooley, J. J., & Chua, E. C.-P. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.04.001 · Cited by 140
Al-Naimi, S., Hampton, S. M., Richard, P., Tzung, C., & Morgan, L. M. (2004) · Chronobiology International · doi:10.1081/cbi-200037171 · Cited by 134
“This is in contrast with previous findings (Hampton et al., 1996; Knutsson et al., 2002; Lund et al., 2001; Ribeiro et al., 1998).”
ResultHow to Travel the World Without Jet Lag
Eastman, C. I., & Burgess, H. J. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.02.006 · Cited by 134
“Following transmeridian travel it is likely that meals will be eaten at inappropriate circadian phases, and repeated occurrence of this could increase the risk of cardiovascular disease and type II diabetes [15].”
BackgroundCircadian Aspects of Postprandial Metabolism
Morgan, L., Hampton, S. M., Gibbs, M. A., & Arendt, J. (2003) · Chronobiology International · doi:10.1081/cbi-120024218 · Cited by 129
“, 1997) and in a more recent study, shift workers have been shown to have a higher prevalence of metabolic syndrome (Hampton et al., 1996).”
BackgroundSelf-citationGonnissen, H. K. J., Rutters, F., Mazuy, C., Martens, E. A. P., Adam, T. C., & Westerterp‐Plantenga, M. S. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037192 · Cited by 127
Effects of the endogenous clock and sleep time on melatonin, insulin, glucose and lipid metabolism
Morgan, L., Arendt, J., Owens, D., Folkard, S., Hampton, S., Deacon, S., English, J., Ribeiro, D., & Taylor, K. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570443 · Cited by 124
“…9-h phase advance, such as might be found in rotating shift work or after Eastward time zone change, postprandial insulin and glucose responses to a standard mixed meal were significantly greater than to the same meal at the same external clock time before the phase shift (Hampton et al. 1996).”
BackgroundTiming of food intake during simulated night shift impacts glucose metabolism: A controlled study
Grant, C. L., Coates, A. M., Dorrian, J., Kennaway, D. J., Wittert, G., Heilbronn, L. K., Pajcin, M., Vedova, C. B. D., Gupta, C. C., & Banks, S. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1335318 · Cited by 105
“Findings of the current study extend previous carefully controlled, laboratory studies using either circadian misalignment or sleep restriction protocols, which demonstrated that eating meals during the biological night impairs immediate postprandial glucose metabolism or glucose tolerance to test meals (Hampton et al…”
BackgroundResultCrowley, S. J., & Eastman, C. I. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.12.004 · Cited by 99
“In laboratory studies that experimentally imposed severe acute circadian misalignment, healthy participants showed adverse metabolic responses that are risk factors for cardiovascular disease and type 2 diabetes [1, 8, 9].”
BackgroundBarnes, R. G., Deacon, S., Forbes, M. J., & Arendt, J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00965-8 · Cited by 98
Self-citationGibbs, M. A., Hampton, S., Morgan, L., & Arendt, J. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00247-1 · Cited by 95
Self-citationSchiavo‐Cardozo, D., Lima, M. M. O., Pareja, J. C., & Geloneze, B. (2013) · Clinical Endocrinology · doi:10.1111/cen.12114 · Cited by 96
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Gonnissen, H. K. J., Hulshof, T., & Westerterp‐Plantenga, M. S. (2013) · Obesity Reviews · doi:10.1111/obr.12019 · Cited by 93
“The effects of a phase shift, regardless of advance or delay, on glucose and insulin secretion indicate a disturbed glucose and insulin metabolism (57,81,101,103).”
BackgroundThe Roles of Time of Day and Sleep Quality in Modulating Glucose Regulation: Clinical Implications
Scheen, A. J., & Cauter, E. V. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023170 · Cited by 80
“Voluntary sleep curtailment, rapid travel across time zones (i.e. ‘jet lag’) and shift work rotations are highly prevalent conditions in modern society, and their hormonal and metabolic implications have been only begun to be recognized [”
BackgroundThe influence of sleep and sleep loss upon food intake and metabolism
Crispim, C. A., Zimberg, I. Z., Dattilo, M., Padilha, H. G., Edwards, B., Waterhouse, J. M., Tufik, S., & de Mello, M. T. (2007) · Nutrition Research Reviews · doi:10.1017/s0954422407810651 · Cited by 80
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Prasai, M., George, J. T., & SCOTT, E. M. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.015 · Cited by 76
METABOLIC RESPONSES ON THE EARLY SHIFT
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Shiftwork and metabolic dysfunction
Tucker, P., Marquié, J.-C., Folkard, S., Ansiau, D., & Esquirol, Y. (2012) · Chronobiology International · doi:10.3109/07420528.2012.675259 · Cited by 69
“Shiftworkers show a lowered tolerance to glucose and lipids following a change from day work to night work (Hampton et al., 1996; Lund et al., 2001; Riberio et al., 1998).”
BackgroundCombined effects of high-fat feeding and circadian desynchronization
Bartol-Munier, I., Gourmelen, S., Pévet, P., & Challet, É. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803048 · Cited by 66
Biancolin, A. D., Martchenko, A., Mitova, E., Gurges, P., Michalchyshyn, E., Chalmers, J. A., Doria, A., Mychaleckyj, J. C., Adriaenssens, A. E., Reimann, F. M., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.004 · Cited by 62
“However, similar differences have been noted in humans, wherein a phase delay of 3 27 h has been reported to impair GLP-1 release, whereas a 9-hour phase advance has been reported to have no effect [54,55].”
BackgroundGonnissen, H. K. J., Mazuy, C., Rutters, F., Martens, E. A. P., Adam, T. C., & Westerterp-Plantenga, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072877 · Cited by 59
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Heden, T. D., & Kanaley, J. A. (2018) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000172 · Cited by 63
Subjective Poor Sleep and White Blood Cell Count in Male Japanese Workers
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Self-citationThe prevention and treatment of jet lag
Haimov, I. (1999) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(99)90004-7 · Cited by 50
Wehrens, S. M. T., Hampton, S. M., Finn, R. E., & Skene, D. J. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0077 · Cited by 47
“In previous studies reporting postprandial differences, meals were given at an abnormal clock time (Hampton et al .”
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Gallant, A. R., Lundgren, J. D., & Drapeau, V. (2013) · Current Obesity Reports · doi:10.1007/s13679-013-0081-8 · Cited by 50
Cardiovascular risk in operators under radiofrequency electromagnetic radiation
Vangelova, K. K., Deyanov, C., & Israel, M. S. (2005) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2005.09.008 · Cited by 47
Bonham, M. P., Kaias, E., Zimberg, I. Z., Leung, G. K. W., Davis, R., Sletten, T. L., Windsor-Aubrey, H., & Huggins, C. E. (2019) · Journal of Biological Rhythms · doi:10.1177/0748730418824214 · Cited by 47
Crowley, S. J., & Eastman, C. I. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2869-8 · Cited by 45
“Even short-term circadian misalignment in healthy participants impairs metabolic responses that are risk factors for cardiovascular disease and type II diabetes mellitus (Hampton et al. 1996; Scheer et al. 2009).”
Genetic variants in MTNR1B affecting insulin secretion
Müssig, K., Staiger, H., Machicao, F., Häring, H.-U., & Fritsche, A. (2010) · Annals of Medicine · doi:10.3109/07853890.2010.502125 · Cited by 38
“simulated phase shift signifi cantly alters pancreatic β -cell responses, postprandial glucose levels, and lipid metabolism (23), and circadian misalignment results in postprandial glucose responses in the range characteristic of a prediabetic state (24).”
BackgroundMcDonald, R. J., Zelinski, E. L., Keeley, R. J., Sutherland, D., Fehr, L., & Hong, N. S. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.04.010 · Cited by 39
“Normal rats show a preference, measured by dwell time, for the context previously associated with the food or a specific food type [56].”
BackgroundResultBalakrishnan, A., Stearns, A. T., Ashley, S. W., Tavakkolizadeh, A., & Rhoads, D. B. (2010) · Journal of Nutrition · doi:10.3945/jn.109.116749 · Cited by 38
“In light of reports that SGLT1 expression is increased in obesity and diabetes (29,30), it would be interesting to assess the functional consequences of our observation by comparing glucose homeostasis in light- and dark-fed rats as well as measuring SGLT1 expression in shift workers who are forced to eat off schedule…”
BackgroundMavroudis, P. D., Corbett, S., Calvano, S. E., & Androulakis, I. P. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00026.2014 · Cited by 36
Chronotype and cardio metabolic health in obesity: does nutrition matter?
Muscogiuri, G., Barrea, L., Aprano, S., Framondi, L., Matteo, R. D., Altieri, B., Laudisio, D., Pugliese, G., Savastano, S., & Colao, A. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1885017 · Cited by 39
Knutsson, A., Karlsson, B., Örnkloo, K., Landström, U., Lennernäs, M. A. ‐., & Eriksson, K. (2002) · Nutrition and Health · doi:10.1177/026010600201600207 · Cited by 36
The osmotic laxative magnesium sulphate activates the ileal brake
Vu, Nouwens, Biemond, Lamers, & Masclee (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00746.x · Cited by 35
Dyslipidemia in industrial workers in hot environments
Vangelova, K., Deyanov, C., & Ivanova, M. (2006) · Central European Journal of Public Health · doi:10.21101/cejph.b0049 · Cited by 33
Postprandial Triacylglycerol Responses in Simulated Night and Day Shift: Gender Differences
Sopowski, M. J., Hampton, S., Ribeiro, D. C. O., Morgan, L. D., & Arendt, J. (2001) · Journal of Biological Rhythms · doi:10.1177/074873040101600310 · Cited by 36
“In previous studies conducted in our laboratory using a simulated shift work environment and healthy volunteers, elevated postprandial TAG levels were reported at night compared with the day (Hampton et al., 1996; Ribeiro et al., 1998).”
BackgroundResultInfluentialSelf-citationMolzof, H. E., Peterson, C. M., Thomas, S. J., Gloston, G. F., Johnson, R. L., & Gamble, K. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.876752 · Cited by 32
“HDL cholesterol (mg/dl) 45 (10) 58 (13) 0.”
ResultCircadian Misalignment and Metabolic Consequences
Banks, S., Dorrian, J., Grant, C., & Coates, A. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420168-2.00017-x · Cited by 30
Misalignment of Circadian Rhythms in Diet-Induced Obesity
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_2 · Cited by 35
Varcoe, T. J., Gatford, K. L., Voultsios, A., Salkeld, M. D., Boden, M. J., Rattanatray, L., & Kennaway, D. J. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.080630 · Cited by 26
The real-world association between digital markers of circadian disruption and mental health risks
Lee, M. P., Kim, D. W., Fang, Y., Kim, R., Bohnert, A. S. B., Sen, S., & Forger, D. B. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01348-6 · Cited by 29
“This matches previous experimental studies demonstrating that circadian misalignment induces dysregulation of appetite-stimulating hormonesand glucose metabolism, leading to changes in feeding behaviors 9,34,44,45 .”
Methodological and metabolic considerations in the study of caffeine-containing energy drinks
Shearer, J. (2014) · Nutrition Reviews · doi:10.1111/nure.12131 · Cited by 26
Waterhouse, J. M., Jones, K., Edwards, B., Harrison, Y. D., Nevill, A. M., & Reilly, T. (2004) · Chronobiology International · doi:10.1081/cbi-120038628 · Cited by 24
“This results in an altered glucose response curve and in altered lipid profiles in the blood following a meal (Hampton et al., 1996; Holmback et al., 2002; Lennernas et al., 1994; Lund et al., 2001; Morgan et al., 1998; Owens et al., 1996; Scheen and Van Cauter, 1998; Trotti et al., 2002; Van Cauter et al., 1989, 1991…”
BackgroundInfluentialSleep Disruption in Jet Lag and Other Circadian Rhythm-Related Disorders
Arendt, J., Stone, B. M., & Skene, D. J. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50062-8 · Cited by 24
Self-citationHa, J., Kim, S. G., Paek, D., & Park, J. (2011) · Safety and Health at Work · doi:10.5491/shaw.2011.2.1.70 · Cited by 24
Loss of prokineticin receptor 2 signaling predisposes mice to torpor
Jethwa, P. H., I’Anson, H., Warner, A., PROSSER, H., Hastings, M. H., Maywood, E. S., & Ebling, F. J. P. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00778.2007 · Cited by 23
“One line of evidence for this link comprises observations of altered insulin production, and glucose and lipid metabolism in humans (9) and laboratory animals (2) subjected to enforced changes in environmental light-dark cycles.”
Noisy and individual, but doable
Kantermann, T., Wehrens, S. M. T., Ulhôa, M. A., Moreno, C. R. D. C., & Skene, D. J. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00022-8 · Cited by 24
“Shift-work simulation studies (Hampton et al., 1996; Ribeiro et al., 1998), for example, were able to demonstrate that glucose, insulin, and lipid levels following food intake were dependent on a person’s internal time.”
BackgroundThomas, C., & Power, C. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyp365 · Cited by 22
Enhancing the metabolic benefits of exercise: Is timing the key?
Bennett, S. E., & Sato, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.987208 · Cited by 29
“Whilst correlation does not necessarily equal causality, it must be noted that simulated shift work experiments have revealed transcriptomic (11), endocrine (12, 13) and metabolic (14) circadian misalignment following relatively short intervention periods.”
Background
Metadata
- Authors
- Hampton, S. M., Morgan, L. M., Lawrence, N., Anastasiadou, T., Norris, F., Deacon, S., Ribeiro, D., & Arendt, J.
- Affiliations
- University of Surrey (GB)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1996-11-01
- Volume
- 151
- Issue
- 2
- Pages
- 259-267
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W1996486968
- Cited by
- 155
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 14 · 2013: 10 · 2012: 7
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- shift work, circadian phase advance, postprandial blood glucose, insulin response, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, triglycerides, free fatty acids, mixed meal, circadian rhythm, meal timing, lipid metabolism, jet lag, sleep deprivation
- MeSH terms
- Adult, Blood Glucose, Fatty Acids, Nonesterified, Female, Gastric Inhibitory Polypeptide, Glucagon, Humans, Insulin, Islets of Langerhans, Lipids, Male, Peptide Fragments, Protein Precursors, Triglycerides, Work Schedule Tolerance, Postprandial Period, Glucagon-Like Peptide 1
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