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Cited by 1,930

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Oxidative Stress and Diabetic Vascular Complications

Giugliano, Dario, Ceriello, Anthonio, Paolisso, Giuseppe·1996·Diabetes Care
DOI 10.2337/diacare.19.3.257
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Abstract

Long-term vascular complications still represent the main cause of morbidity and mortality in diabetic patients. Although prospective randomized long-term clinical studies comparing the effects of conventional and intensive therapy have demonstrated a clear link between diabetic hyperglycemia and the development of secondary complications of diabetes, they have not defined the mechanism through which excess glucose results in tissue damage. Evidence has accumulated indicating that the generation of reactive oxygen species (oxidative stress) may play an important role in the etiology of diabetic complications. This hypothesis is supported by evidence that many biochemical pathways strictly associated with hyperglycemia (glucose autoxidation, polyol pathway, prostanoid synthesis, protein glycation) can increase the production of free radicals. Furthermore, exposure of endothelial cells to high glucose leads to augmented production of superoxide anion, which may quench nitric oxide, a potent endothelium-derived vasodilator that participates in the general homeostasis of the vasculature. In further support of the consequential injurious role of oxidative stress, many of the adverse effects of high glucose on endothelial functions, such as reduced endothelial-dependent relaxation and delayed cell replication, are reversed by antioxidants. A rational extension of this proposed role for oxidative stress is the suggestion that the different susceptibility of diabetic patients to microvascular and macrovascular complications may be a function of the endogenous antioxidant status.

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Metadata

Authors
Giugliano, D., Ceriello, A., & Paolisso, G.
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1996-03-01
Volume
19
Issue
3
Pages
257-267
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.19.3.257
OpenAlex
W2013529909
Cited by
1,930
References
1
FWCI
26.30
Type
journal article
Language
en
Open access
closed

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