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Cited by 437

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Lifestyle Intervention in Overweight Individuals With a Family History of Diabetes

Wing, Rena R, Venditti, Elizabeth, Jakicic, John M, Polley, Betsy A, Lang, Wei·1998·Diabetes Care
DOI 10.2337/diacare.21.3.350
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Abstract

OBJECTIVE: To assess the effect of lifestyle intervention over 2 years on changes in weight, coronary heart disease (CHD) risk factors, and incidence of diabetes in overweight individuals with a parental history of diabetes. RESEARCH DESIGN AND METHODS: Participants (n = 154), who were 30–100% over ideal body weight, had one or both parents with diabetes, and were currently nondiabetic, were randomly assigned to 2-year treatments focused on diet (decreasing calories and fat intake), exercise (goal of 1,500 kcal/week of moderate activity), or the combination of diet plus exercise or to a no-treatment control group. Subjects were reassessed at 6 months, 1 year, and 2 years. RESULTS: At 6 months, the groups differed significantly on measures of eating, exercise, and fitness; weight losses in the diet and diet-plus-exercise groups were significantly > in the exercise and control conditions. Weight losses were associated with positive changes in CHD risk factors. After 6 months, there was gradual deterioration of behavioral and physiological changes, so that at 2 years, almost no between-group differences were maintained. Differences between groups in risk of developing diabetes were of borderline significance (P = 0.08). Strongest predictors were impaired glucose tolerance at baseline, which was positively related to risk of developing diabetes, and weight loss from baseline to 2 years, which was negatively related; in all treatment groups, a modest weight loss of 4.5 kg reduced the risk of type 2 diabetes by ∼ 30% compared with no weight loss. CONCLUSIONS: Although initially successful, the interventions studied here were not effective in producing long-term changes in behavior, weight, or physiological parameters. However, weight loss from 0 to 2 years reduced the risk of developing type 2 diabetes. Since modest weight loss significantly reduced risk of type 2 diabetes, further research is needed to determine how best to increase the percentage of subjects achieving at least a modest weight loss.

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Metadata

Authors
Wing, R. R., Venditti, E., Jakicic, J. M., Polley, B. A., & Lang, W.
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1998-03-01
Volume
21
Issue
3
Pages
350-359
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.21.3.350
OpenAlex
W2044964910
Cited by
437
References
8
FWCI
10.00
Type
journal article
Language
en
Open access
closed

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