Cited by 483Antifungal resistance and susceptibilityBacterial biofilms and quorum sensingFungal and yeast genetics research

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Our Current Understanding of Fungal Biofilms

Ramage, Gordon, Mowat, Eilidh, Jones, Brian, Williams, Craig, Lopez-Ribot, Jose·2009·Critical Reviews in Microbiology

DOI 10.3109/10408410903241436

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Abstract

Gordon Ramage*a, Eilidh Mowata, Brian Jonesb, Craig Williamsc & Jose Lopez-Ribotda Section of Infection and Immunity, Glasgow Dental School and Hospital, Faculty of Medicine, University of Glasgow, UKb Microbiology Department, Glasgow Royal Infirmary, The University of Texas at San Antonio, San Antonio, Texas, USAc Microbiology Department, Royal Hospital for Sick Children, Yorkhill Division, The University of Texas at San Antonio, San Antonio, Texas, USAd Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USAAddress for Correspondence: Gordon Ramage, Section of Infection and Immunity, Glasgow Dental School, Faculty of Medicine, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, UK. Phone: +44(0)141 211 9752. Fax: +44(0) 141. e-mail: 0141 353 1593. e-mail: g.ramage@dental.gla.ac.ukFungal biofilms are an escalating clinical problem associated with significant rates of mortality. Candida albicans is the most notorious of all fungal biofilm formers. However, non-Candida species, yeasts such as Cryptococcus neoformans, and filamentous moulds such as Aspergillus fumigatus, have been shown to be implicated in biofilm-associated infections. Fungal biofilms have distinct developmental phases, including adhesion, colonisation, maturation and dispersal, which are governed by complex molecular events. Recalcitrance to antifungal therapy remains the greatest threat to patients with fungal biofilms. This review discusses our current understanding of the basic biology and clinical implications associated with fungal biofilms.

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Authors: Ramage, G., Mowat, E., Jones, B., Williams, C., & Lopez-Ribot, J.
Affiliations: University of Glasgow (GB)
The University of Texas at San Antonio (US)
The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Ramage, Gordon
ORCID: Ramage, Gordon
Jones, Brian
Williams, Craig
Lopez-Ribot, Jose
Venue: Critical Reviews in Microbiology
Publisher: Informa UK Limited
Published: 2009-10-28
Volume: 35
Issue: 4
Pages: 340-355
ISSN: 1040-841X (ISSN-L)
1549-7828
DOI: 10.3109/10408410903241436
OpenAlex: W2073130572
Cited by: 483
References: 201
Citations by year: 2026: 13 · 2025: 16 · 2024: 18 · 2023: 27 · 2022: 21 · 2021: 33 · 2020: 30 · 2019: 28 · 2018: 25 · 2017: 28 · 2016: 34 · 2015: 35 · 2014: 45 · 2013: 39 · 2012: 42
FWCI: 3.52
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Microbiology (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: fungal biofilms, Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, biofilm growth, biofilm dispersal, antifungal resistance, biofilm-associated infections
MeSH terms: Animals, Fungal Proteins, Fungi, Humans, Mycoses, Biofilms

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