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PreprintCited by 4Memory and Neural MechanismsMemory Processes and InfluencesNeurogenesis and neuroplasticity mechanisms

Neural Mechanisms of Memory

Open access
Amer, Tarek, Davachi, Lila·2022·Oxford University Press eBooks
DOI 10.31234/osf.io/32egy
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Abstract

The ability to form and access memories of our experiences involves complex neural mechanisms at both the cellular and systems levels. Animal and human (including lesion and neuroimaging) studies have evidenced a critical role for the hippocampus and connected brain regions in these processes. The current chapter will review the role of the hippocampus in the different stages of long-term memory, namely, encoding, consolidation, and retrieval. Specifically, this chapter will illustrate how the hippocampus, in conjunction with other brain regions, supports these processes, giving rise to our rich experience of remembering.

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Crossref · 10.31234/osf.io/32egy

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162 of 162 references verified0 citation errors · 0 not checkable

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  • According to some theories of memory, regions with a relative specialization in particular modalities are also responsible for storing their respective modality-specific components of a particular memory.

    “According to some theories of memory, regions with a relative specialization in particular modalities (e.g. vision) are also responsible for storing their respective modality-specific components of a particular memory [67].”

    From Episodic Memory in AI Agents Poses Risks that Should be Studied and Mitigated (2025) · cites this paper as [67]

    The Systems Level Memory and the Medial Temporal Lobe section describes an account in which different cortical regions process distinct features of an episode and provide those inputs to the hippocampus. The Episodic retrieval: A brain-wide function section also describes reinstatement of studied content in cortical regions. Neither passage says that regions specialized for a sensory modality store that modality’s components of a memory; page numbers were not available in our copy. (LLM, conf=0.76)

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Cites

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6 of the 168 references couldn’t be matched to a known paper.

Research works printed but not linked: 11

  1. Amaral, D., & Lavenex, P. (2007). Hippocampal neuroanatomy. P. Andersen, R. Morris, D. Amaral, T. Bliss, J. O'Keefe (Eds.), The Hippocampus Book, Oxford University Press, New York (2007), p. 872
  2. Dobbins, I. G., Foley, H., Schacter, D. L., & Wagner, A. D. (2002). Executive control during episodic retrieval: multiple prefrontal processes subserve source memory. Neuron, 35(5), 989-996.
  3. Knierim, J. J. (2015). The hippocampus. Current Biology, 25(23), R1116-R1121.
  4. Lashley, K. S. (1950). In search of the engram. In Society for Experimental Biology, Physiological mechanisms in animal behavior. (Society's Symposium IV.) (pp. 454-482). Academic Press.
  5. Lisman, J. E. (1999). Relating hippocampal circuitry to function: recall of memory sequences by reciprocal dentate-CA3 interactions. Neuron, 22(2), 233-242.
  6. Malenka, R. C., & Bear, M. F. (2004). LTP and LTD: An embarrassment of riches. Neuron, 44(1), 5-21.
  7. Mishkin, M. (1982). A memory system in the monkey. Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 298(1089), 85-95.
  8. Miyashita, Y., & Chang, H. S. (1988). Neuronal correlate of pictorial short-term memory in the primate temporal cortex. Nature, 331(6151), 68-70.
  9. Nadel, L., Samsonovich, A., Ryan, L., & Moscovitch, M. (2000). Multiple trace theory of human memory: Computational, neuroimaging, and neuropsychological results. Hippocampus, 10(4), 352-368.
  10. Tulving, E., & Thompson, D. (1973). Encoding specificity and retrieval process in episodic process. Journal of Experimental Psychology, 87, 353-373.
  11. Zola-Morgan, S., & Squire, L. R. (1990). The neuropsychology of memory: Parallel findings in humans and nonhuman primates. Annals of the New York Academy of Sciences, 608, 434- 456.

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Authors
Amer, T., & Davachi, L.
Affiliations
Columbia University (US)
ORCID
Venue
Oxford University Press eBooks
Publisher
Center for Open Science
Published
2022-06-29
Pages
94-112
DOI
10.31234/osf.io/32egy
OpenAlex
W4400773630
Cited by
3
References
168
Citations by year
2025: 1 · 2023: 1 · 2012: 1
FWCI
1.79
Type
book chapter
Language
en
Open access
Locations
  • Oxford University Press eBooks (publishedVersion)
  • PsyArXiv (OSF Preprints) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
memory, hippocampus, long-term memory, memory encoding, memory consolidation, memory retrieval, neural mechanisms of memory, brain regions, lesion studies, neuroimaging

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