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Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis

Bickel, Marisa A., Csik, Boglarka, Gulej, Rafal, Ungvari, Anna, Nyul-Toth, Adam, Conley, Shannon M.·2023·Frontiers in Endocrinology
DOI 10.3389/fendo.2023.1087053
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Abstract

Age-related cerebrovascular pathologies, ranging from cerebromicrovascular functional and structural alterations to large vessel atherosclerosis, promote the genesis of vascular cognitive impairment and dementia (VCID) and exacerbate Alzheimer’s disease. Recent advances in geroscience, including results from studies on heterochronic parabiosis models, reinforce the hypothesis that cell non-autonomous mechanisms play a key role in regulating cerebrovascular aging processes. Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) exert multifaceted vasoprotective effects and production of both hormones is significantly reduced in aging. This brief overview focuses on the role of age-related GH/IGF-1 deficiency in the development of cerebrovascular pathologies and VCID. It explores the mechanistic links among alterations in the somatotropic axis, specific macrovascular and microvascular pathologies (including capillary rarefaction, microhemorrhages, impaired endothelial regulation of cerebral blood flow, disruption of the blood brain barrier, decreased neurovascular coupling, and atherogenesis) and cognitive impairment. Improved understanding of cell non-autonomous mechanisms of vascular aging is crucial to identify targets for intervention to promote cerebrovascular and brain health in older adults.

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Research works printed but not linked: 310

  1. Zlokovic, 2020, Vascular contributions to cognitive impairment and dementia (Vcid): A report from the 2018 national heart, lung, and blood institute and national institute of neurological disorders and stroke workshop, Alzheimers Dement, 16, 10.1002/Alz.12157 · DOI
  2. Gorelick, 2010, Advances in vascular cognitive impairment, Stroke, 41, 10.1161/Strokeaha.109.569921 · DOI
  3. Iadecola, 2019, Vascular cognitive impairment and dementia: Jacc scientific expert panel, J Am Coll Cardiol, 73, 10.1016/J.Jacc.2019.04.034 · DOI · Paper page
  4. Levit, 2020, Neurovascular unit dysregulation, white matter disease, and executive dysfunction: The shared triad of vascular cognitive impairment and Alzheimer disease, Geroscience, 42, 10.1007/S11357-020-00164-6 · DOI
  5. Tarantini, 2017, Demonstration of impaired neurovascular coupling responses in Tg2576 mouse model of alzheimer’s disease using functional laser speckle contrast imaging, Geroscience, 39, 10.1007/S11357-017-9980-Z · DOI
  6. Lamar, 2022, Complex profiles of cerebrovascular disease pathologies in the aging brain and their relationship with cognitive decline, Stroke, 53, 10.1161/Strokeaha.121.034814 · DOI
  7. Tarantini, 2021, Endothelial deficiency of insulin-like growth factor-1 receptor (Igf1r) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype, Geroscience, 43, 10.1007/S11357-021-00405-2 · DOI
  8. Daulatzai, 2016, Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and alzheimer’s disease, J Neurosci Res, 4, 10.1002/Jnr.23777 · DOI · Paper page
  9. Ighodaro, 2016, Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals, J Cereb Blood Flow Metab, 37, 10.1177/0271678x15621574 · DOI · Paper page
  10. Cooper, 2016, Cerebrovascular damage mediates relations between aortic stiffness and memory, Hypertension, 67, 10.1161/Hypertensionaha.115.06398 · DOI
  11. Jessen, 2015, Interneuron deficit associates attenuated network synchronization to mismatch of energy supply and demand in aging mouse brains, Cereb Cortex, 27, 10.1093/Cercor/Bhv261 · DOI
  12. Zlokovic, 2011, Neurovascular pathways to neurodegeneration in alzheimer’s disease and other disorders, Nat Rev Neurosci, 12, 10.1038/Nrn3114 · DOI · Paper page
  13. Hajdu, 1990, Effects of aging on mechanics and composition of cerebral arterioles in rats, Circ Res, 66, 10.1161/01.RES.66.6.1747 · DOI
  14. Mayhan, 1990, Effects of aging on responses of cerebral arterioles, Am J Physiol, 258, 10.1152/ajpheart.1990.258.4.H1138 · DOI
  15. Norling, 2020, The role of exercise in the reversal of igf-1 deficiencies in microvascular rarefaction and hypertension, Geroscience, 42, 10.1007/S11357-019-00139-2 · DOI
  16. Nyul-Toth, 2021, Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography, Am J Physiol Heart Circ Physiol, 320, 10.1152/ajpheart.00709.2020 · DOI
  17. Thomas, 2021, Regional hyperperfusion in older adults with objectively-defined subtle cognitive decline, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20935171 · DOI
  18. Tomoto, 2020, Cerebral vasomotor reactivity during hypo- and hypercapnia across the adult lifespan, J Cereb Blood Flow Metab, 40, 10.1177/0271678x19828327 · DOI
  19. Trigiani, 2022, A functional cerebral endothelium is necessary to protect against cognitive decline, J Cereb Blood Flow Metab, 42, 74, 10.1177/0271678x211045438 · DOI
  20. Vestergaard, 2020, Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain, J Cereb Blood Flow Metab, 40, 10.1177/0271678x18818291 · DOI
  21. Liu, 2021, Age-related impairment of cerebral blood flow response to katp channel opener in alzheimer’s disease mice with presenilin-1 mutation, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20964233 · DOI
  22. Liu, 2021, Arterial elasticity, endothelial function and intracranial vascular health: A multimodal mri study, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20956950 · DOI
  23. Maasakkers, 2021, Hemodynamic and structural brain measures in high and low sedentary older adults, J Cereb Blood Flow Metab, 41, 10.1177/0271678x211009382 · DOI
  24. Milej, 2020, Quantification of cerebral blood flow in adults by contrast-enhanced near-infrared spectroscopy: Validation against mri, J Cereb Blood Flow Metab, 40, 10.1177/0271678x19872564 · doi:10.1177/0271678x19872564
  25. Pradillo, 2021, Influence of metabolic syndrome on post-stroke outcome, angiogenesis and vascular function in old rats determined by dynamic contrast enhanced mri, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20976412 · DOI
  26. Sweeney, 2018, Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders, Nat Rev Neurol, 14, 10.1038/Nrneurol.2017.188 · DOI · Paper page
  27. Verheggen, 2020, Increase in blood-brain barrier leakage in healthy, older adults, Geroscience, 42, 10.1007/S11357-020-00211-2 · DOI
  28. Montagne, 2022, Imaging subtle leaks in the blood-brain barrier in the aging human brain: Potential pitfalls, challenges, and possible solutions, Geroscience, 44, 10.1007/S11357-022-00571-X · DOI
  29. Li, 2020, Leaky memories: Impact of Apoe4 on blood-brain barrier and dementia, J Cereb Blood Flow Metab, 40, 10.1177/0271678x20938146 · DOI
  30. Moon, 2021, Hippocampal blood-brain barrier permeability is related to the Apoe4 mutation status of elderly individuals without dementia, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20952012 · DOI
  31. Lipecz, 2019, Age-related impairment of neurovascular coupling responses: A dynamic vessel analysis (Dva)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults, Geroscience, 41, 10.1007/S11357-019-00078-Y · DOI
  32. Zhang, 2021, Impaired cerebral vascular and metabolic responses to parametric n-back tasks in subjective cognitive decline, J Cereb Blood Flow Metab, 41, 10.1177/0271678x211012153 · DOI
  33. Poels, 2011, Incidence of cerebral microbleeds in the general population: The Rotterdam scan study, Stroke, 42, 10.1161/Strokeaha.110.607184 · DOI · Paper page
  34. Poels, 2012, Cerebral microbleeds are associated with worse cognitive function: The Rotterdam scan study, Neurology, 78, 10.1212/Wnl.0b013e3182452928 · DOI · Paper page
  35. Ungvari, 2017, Cerebral microhemorrhages: Mechanisms, consequences, and prevention, Am J Physiol Heart Circ Physiol, 312, 10.1152/Ajpheart.00780.2016 · DOI · Paper page
  36. Wiegertjes, 2021, Assessing cortical cerebral microinfarcts on iron-sensitive mri in cerebral small vessel disease, J Cereb Blood Flow Metab, 41, 10.1177/0271678x211039609 · DOI
  37. Ling, 2020, Incident cerebral lacunes: A review, J Cereb Blood Flow Metab, 40, 10.1177/0271678x20908361 · DOI
  38. Zhang, 2021, Cerebral microinfarcts affect brain structural network topology in cognitively impaired patients, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20902187 · DOI
  39. Zwartbol, 2021, Cortical cerebral microinfarcts on 7t mri: Risk factors, neuroimaging correlates and cognitive functioning - the medea-7t study, J Cereb Blood Flow Metab, 41, 10.1177/0271678x211025447 · DOI
  40. Zwartbol, 2021, Intracranial vessel wall lesions on 7t mri and mri features of cerebral small vessel disease: The smart-Mr study, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20958517 · DOI
  41. Shi, 2020, Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow, J Cereb Blood Flow Metab, 40, 85, 10.1177/0271678x18803956 · DOI
  42. Vikner, 2021, Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20980652 · DOI
  43. Vikner, 2020, Characterizing pulsatility in distal cerebral arteries using 4d flow mri, J Cereb Blood Flow Metab, 40, 10.1177/0271678x19886667 · DOI
  44. Wartolowska, 2022, White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the uk biobank cohort study, J Cereb Blood Flow Metab, 42, 10.1177/0271678x211058803 · DOI
  45. Pahlavian, 2021, Cerebroarterial pulsatility and resistivity indices are associated with cognitive impairment and white matter hyperintensity in elderly subjects: A phase-contrast mri study, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20927101 · DOI
  46. Zeng, 2020, Severity of white matter hyperintensities: Lesion patterns, cognition, and microstructural changes, J Cereb Blood Flow Metab, 40, 10.1177/0271678x19893600 · DOI
  47. Zhang, 2021, Venous disruption affects white matter integrity through increased interstitial fluid in cerebral small vessel disease, J Cereb Blood Flow Metab, 41, 10.1177/0271678x20904840 · DOI
  48. Parodi-Rullan, 2020, Alzheimer’s amyloid beta heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis, Aging Cell, 19, E13258, 10.1111/Acel.13258 · DOI
  49. Castillo-Carranza, 2017, Cerebral microvascular accumulation of tau oligomers in alzheimer’s disease and related tauopathies, Aging Dis, 8, 10.14336/Ad.2017.0112 · DOI · Paper page
  50. Steinman, 2020, Microvascular alterations in alzheimer’s disease, Front Cell Neurosci, 14, 10.3389/Fncel.2020.618986 · DOI
  51. Vernooij, 2008, Prevalence and risk factors of cerebral microbleeds: The Rotterdam scan study, . Neurol, 70, 10.1212/01.Wnl.0000307750.41970.D9 · DOI · Paper page
  52. Kato, 2002, Silent cerebral microbleeds on T2*-weighted mri: Correlation with stroke subtype, stroke recurrence, and leukoaraiosis, Stroke, 33, 10.1161/01.STR.0000018012.65108.86 · DOI · Paper page
  53. Koton, 2020, Microvascular brain disease progression and risk of stroke: The aric study, Stroke, 51, 10.1161/Strokeaha.120.030063 · DOI
  54. Lin, 2020, Collateral recruitment is impaired by cerebral small vessel disease, Stroke, 51, 10.1161/Strokeaha.119.027661 · doi:10.1161/strokeaha.119.027661
  55. Sagnier, 2020, Normal-appearing white matter integrity is a predictor of outcome after ischemic stroke, Stroke, 51, 10.1161/Strokeaha.119.026886 · DOI
  56. Tarantini, 2019, Treatment with the Poly(Adp-ribose) polymerase inhibitor pj-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the nad+ depletion hypothesis of neurovascular aging, Geroscience, 41, 10.1007/S11357-019-00101-2 · DOI
  57. Kiss, 2020, Nicotinamide mononucleotide (Nmn) supplementation promotes neurovascular rejuvenation in aged mice: Transcriptional footprint of Sirt1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects, Geroscience, 42, 10.1007/S11357-020-00165-5 · DOI · Paper page
  58. Tarantini, 2019, Nicotinamide mononucleotide (Nmn) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice, Redox Biol, 24, 10.1016/J.Redox.2019.101192 · DOI · Paper page
  59. Yabluchanskiy, 2020, Cerebrovascular rejuvenation: Novel strategies for prevention of vascular cognitive impairment, Rejuvenation Res, 23, 10.1089/Rej.2020.2402 · DOI
  60. Hennebry, 2017, Igf1 stimulates greater muscle hypertrophy in the absence of myostatin in Male mice, J Endocrinol, 234, 187, 10.1530/Joe-17-0032 · DOI
  61. Kaur, 2021, The growth hormone-insulin like growth factor axis in pregnancy, J Endocrinol, 251, 10.1530/Joe-21-0087 · DOI
  62. Roberts, 2021, Liver is a primary source of insulin-like growth factor-1 in skin wound healing, J Endocrinol, 252, 59, 10.1530/Joe-21-0298 · DOI
  63. Shuang, 2021, Interaction among estrogen, igf-1, and H2s on smooth muscle cell proliferation, J Endocrinol, 248, 17, 10.1530/Joe-20-0190 · doi:10.1530/joe-20-0190
  64. Wood, 2022, Combined growth hormone and insulin-like growth factor-1 rescues growth retardation in glucocorticoid-treated mdxmice but does not prevent osteopenia, J Endocrinol, 253, 63, 10.1530/Joe-21-0388 · DOI
  65. Yan, 2020, Insulin-like growth factor 1 triggers salt secretion machinery in fish under acute salinity stress, J Endocrinol, 246, 10.1530/Joe-20-0053 · doi:10.1530/joe-20-0053
  66. Eichner, 2020, Relation of igf-I with subclinical cardiovascular markers including intima-media thickness, left ventricular mass index and nt-probnp, Eur J Endocrinol, 182, 79, 10.1530/Eje-19-0470 · doi:10.1530/eje-19-0470
  67. Van Den Beld, 2019, Igfbp-2 and aging: A 20-year longitudinal study on igfbp-2, igf-I, bmi, insulin sensitivity and mortality in an aging population, Eur J Endocrinol, 180, 10.1530/Eje-18-0422 · DOI
  68. Van Nieuwpoort, 2018, The relationship between serum igf-1, handgrip strength, physical performance and falls in elderly men and women, Eur J Endocrinol, 179, 73, 10.1530/Eje-18-0076 · DOI
  69. Ziagaki, 2019, Long-term growth hormone (Gh) replacement of adult gh deficiency (Ghd) benefits the heart, Eur J Endocrinol, 181, 79, 10.1530/Eje-19-0132 · DOI
  70. Smith, 2021, Insulin-like growth factor pathway and the thyroid, Front Endocrinol (Lausanne), 12, 10.3389/Fendo.2021.653627 · DOI
  71. Kraemer, 2020, Growth Hormone(S), testosterone, insulin-like growth factors, and cortisol: Roles and integration for cellular development and growth with exercise, Front Endocrinol (Lausanne), 11, 10.3389/Fendo.2020.00033 · DOI · Paper page
  72. Allard, 2018, Igf-binding proteins: Why do they exist and why are there so many, Front Endocrinol (Lausanne), 9, 10.3389/Fendo.2018.00117 · DOI · Paper page
  73. Reiter, 2021, Editorial: History of growth hormone: Animal to human, Front Endocrinol (Lausanne), 12, 10.3389/Fendo.2021.793272 · doi:10.3389/fendo.2021.793272
  74. Blum, 2018, The growth hormone-Insulin-Like growth factor-I axis in the diagnosis and treatment of growth disorders, Endocr Connect, 7, 10.1530/Ec-18-0099 · DOI
  75. Murray, 2000, Disorders of growth hormone in childhood
  76. Miller, 2022, The history of the insulin-like growth factor system, Horm Res Paediatr, 95, 10.1159/000527123 · doi:10.1159/000527123
  77. Toogood, 1996, Beyond the somatopause: Growth hormone deficiency in adults over the age of 60 years, J Clin Endocrinol Metab, 81, 10.1210/Jcem.81.2.8636250 · DOI
  78. Iranmanesh, 1991, Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (Gh) secretory bursts and the half-life of endogenous gh in healthy men, J Clin Endocrinol Metab, 73, 10.1210/Jcem-73-5-1081 · DOI · Paper page
  79. Sonntag, 2013, Insulin-like growth factor-1 in cns and cerebrovascular aging, Front In Aging Neurosci, 5, 10.3389/Fnagi.2013.00027 · DOI
  80. Tarantini, 2017, Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype, Aging Cell, 16, 10.1111/Acel.12583 · DOI · Paper page
  81. Toth, 2022, Age-related decline in circulating igf-1 associates with impaired neurovascular coupling responses in older adults, Geroscience, 44, 10.1007/S11357-022-00623-2 · DOI · Paper page
  82. Ungvari, 2012, The emerging role of igf-1 deficiency in cardiovascular aging: Recent advances, J Gerontol A Biol Sci Med Sci, 67, 599, 10.1093/Gerona/Gls072 · DOI
  83. Sonntag, 2005, Growth hormone and insulin-like growth factor-1 (Igf-1) and their influence on cognitive aging, Ageing Res Rev, 4, 195, 10.1016/J.Arr.2005.02.001 · DOI · Paper page
  84. Deak, 2012, Aging, synaptic dysfunction, and insulin-like growth factor (Igf)-1, J Gerontol A Biol Sci Med Sci, 67, 10.1093/Gerona/Gls118 · DOI
  85. Sonntag, 2012, Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: Progress and controversies, J Gerontol A Biol Sci Med Sci, 67, 10.1093/Gerona/Gls115 · DOI
  86. Khan, 2002, Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system, Cardiovasc Res, 54, 25, 10.1016/S0008-6363(01)00533-8 · DOI
  87. Ungvari, 2020, Mechanisms of vascular aging, a geroscience perspective: Jacc focus seminar, J Am Coll Cardiol, 75, 10.1016/J.Jacc.2019.11.061 · DOI · Paper page
  88. Giovannini, 2008, Modulation of Gh/Igf-1 axis: Potential strategies to counteract sarcopenia in older adults, Mech Ageing Dev, 129, 593, 10.1016/J.Mad.2008.08.001 · DOI
  89. Ashpole, 2016, Differential effects of igf-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice, Age (Dordr), 38, 38, 10.1007/S11357-016-9902-5 · DOI
  90. Ashpole, 2015, Igf-1 regulates vertebral bone aging through sex-specific and time-dependent mechanisms, J Bone Miner Res, 31, 10.1002/Jbmr.2689 · DOI
  91. Gong, 2014, Reductions in serum igf-1 during aging impair health span, Aging Cell, 13, 10.1111/Acel.12188 · DOI
  92. Farias Quipildor, 2019, Central igf-1 protects against features of cognitive and sensorimotor decline with aging in Male mice, Geroscience, 41, 185, 10.1007/S11357-019-00065-3 · DOI
  93. Abs, 2013, Prevalence of diabetes mellitus in 6050 hypopituitary patients with adult-onset gh deficiency before gh replacement: A kims analysis, Eur J Endocrinol, 168, 297, 10.1530/Eje-12-0807 · DOI
  94. Abs, 2006, Determinants of cardiovascular risk in 2589 hypopituitary gh-deficient adults - a kims database analysis, Eur J Endocrinol, 155, 79, 10.1530/Eje.1.02179 · DOI
  95. Quinlan, 2017, Low serum insulin-like growth factor-I (Igf-I) level is associated with increased risk of vascular dementia, Psychoneuroendocrinology, 86, 10.1016/J.Psyneuen.2017.09.018 · DOI
  96. Doi, 2015, Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed, Neurobiol Aging, 36, 10.1016/J.Neurobiolaging.2014.10.035 · DOI
  97. Vidal, 2016, Low serum insulin-like growth factor-I predicts cognitive decline in alzheimer’s disease, J Alzheimers Dis, 52, 10.3233/Jad-151162 · DOI
  98. Watanabe, 2004, Influence of insulin-like growth factor-1 and hepatocyte growth factor on carotid atherosclerosis and cognitive function in the elderly, Dement Geriatr Cognit Disord, 18, 67, 10.1159/000077812 · DOI
  99. Xie, 2021, Association between circulating insulin-like growth factor 1 and risk of all-cause and cause-specific mortality, Eur J Endocrinol, 185, 10.1530/Eje-21-0573 · DOI
  100. Miller, 2022, Increased susceptibility to cerebral microhemorrhages is associated with imaging signs of microvascular degeneration in the retina in an insulin-like growth factor 1 deficient mouse model of accelerated aging, Front In Aging Neurosci, 14, 10.3389/Fnagi.2022.788296 · DOI · Paper page
  101. Fulop, 2019, Igf-1 deficiency promotes pathological remodeling of cerebral arteries: A potential mechanism contributing to the pathogenesis of intracerebral hemorrhages in aging, J Gerontol A Biol Sci Med Sci, 74, 10.1093/Gerona/Gly144 · DOI
  102. Toth, 2014, Igf-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice, J Cereb Blood Flow Metab, 34, 10.1038/Jcbfm.2014.156 · DOI · Paper page
  103. Toth, 2015, Igf-1 deficiency impairs neurovascular coupling in mice: Implications for cerebromicrovascular aging, Aging Cell, 14, 10.1111/Acel.12372 · DOI
  104. Tarantini, 2016, Igf-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering mirna-mediated post-transcriptional gene regulation: Implications for the developmental origins of health and disease hypothesis, Age (Dordr), 38, 10.1007/S11357-016-9943-9 · DOI
  105. Podlutsky, 2017, The Gh/Igf-1 axis in a critical period early in life determines cellular dna repair capacity by altering transcriptional regulation of dna repair-related genes: Implications for the developmental origins of cancer, Geroscience, 39, 10.1007/S11357-017-9966-X · DOI
  106. Bailey-Downs, 2012, Growth hormone and igf-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: Implications for vascular aging, J Gerontol A Biol Sci Med Sci, 67, 10.1093/Gerona/Glr197 · DOI
  107. Ashpole, 2017, Igf-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan, Geroscience, 39, 10.1007/S11357-017-9971-0 · DOI
  108. Bailey-Downs, 2012, Liver-specific knockdown of igf-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: A novel model of vascular aging, J Gerontol A Biol Sci Med Sci, 67, 10.1093/Gerona/Glr164 · DOI
  109. D’costa, 1995, Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats, Neuroscience, 65, 10.1016/0306-4522(94)00495-Q · DOI
  110. Grill, 2005, Dendritic stability in a model of adult-onset igf-I deficiency, Growth Horm Igf Res, 15, 10.1016/J.Ghir.2005.07.002 · DOI
  111. Groban, 2011, Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation, Growth Horm Igf Res, 21, 10.1016/J.Ghir.2011.01.003 · DOI
  112. Hua, 2009, Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum, Glia, 57, 10.1002/Glia.20829 · DOI · Paper page
  113. Khan, 2001, Growth hormone increases regional coronary blood flow and capillary density in aged rats, J Gerontol A Biol Sci Med Sci, 56, 10.1093/gerona/56.8.B364 · DOI
  114. Lichtenwalner, 2001, Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis, Neuroscience, 107, 10.1016/S0306-4522(01)00378-5 · DOI · Paper page
  115. Lichtenwalner, 2006, Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: Insights into the regulation of adult hippocampal neurogenesis, J Neurosci Res, 83, 199, 10.1002/Jnr.20719 · DOI
  116. Logan, 2018, Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-beta uptake in astrocytes, Mol Metab, 9, 10.1016/J.Molmet.2018.01.013 · DOI
  117. Nieves-Martinez, 2010, Early-onset gh deficiency results in spatial memory impairment in mid-life and is prevented by gh supplementation, J Endocrinol, 204, 10.1677/Joe-09-0323 · DOI
  118. Poe, 2001, Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area Ca3 of hippocampus, Neuroscience, 107, 10.1016/S0306-4522(01)00341-4 · DOI
  119. Shi, 2005, Differential effects of aging and insulin-like growth factor-1 on synapses in Ca1 of rat hippocampus, Cereb Cortex, 15, 10.1093/Cercor/Bhh158 · DOI
  120. Bartke, 2021, Benefits of living without growth hormone, J Gerontol A Biol Sci Med Sci, 76, 10.1093/Gerona/Glab147 · DOI
  121. Dixit, 2021, Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging, Aging Cell, 20, E13505, 10.1111/Acel.13505 · DOI
  122. Fang, 2020, Lifespan of long-lived growth hormone receptor knockout mice was not normalized by housing At 30 degrees c since weaning, Aging Cell, 19, E13123, 10.1111/Acel.13123 · DOI
  123. Saccon, 2021, Circulating microrna profile in humans and mice with congenital gh deficiency, Aging Cell, 20, E13420, 10.1111/Acel.13420 · DOI
  124. Schneider, 2021, The interconnections between somatic and ovarian aging in murine models, J Gerontol A Biol Sci Med Sci, 76, 10.1093/Gerona/Glaa258 · DOI
  125. Yuan, 2020, Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice, Aging Cell, 19, E13263, 10.1111/Acel.13263 · DOI
  126. Wiesenborn, 2020, The role of Ames dwarfism and calorie restriction on gut microbiota, J Gerontol A Biol Sci Med Sci, 75, 10.1093/Gerona/Glz236 · DOI
  127. Icyuz, 2021, Physiological and metabolic characteristics of novel double-mutant female mice with targeted disruption of both growth hormone-releasing hormone and growth hormone receptor, Aging Cell, 20, E13339, 10.1111/Acel.13339 · DOI
  128. Holzenberger, 2003, Igf-1 receptor regulates lifespan and resistance to oxidative stress in mice, Nature, 421, 10.1038/Nature01298 · DOI · Paper page
  129. Flurkey, 2001, Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production, Proc Natl Acad Sci U.S.A., 98, 10.1073/pnas.111158898 · DOI · Paper page
  130. Liang, 2003, Genetic mouse models of extended lifespan, Exp Gerontol, 38, 10.1016/j.exger.2003.10.019 · DOI
  131. Hill, 2016, Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditure, Aging Cell, 15, 10.1111/Acel.12467 · DOI
  132. Gesing, 2016, A long-lived mouse lacking both growth hormone and growth hormone receptor: A new animal model for aging studies, J Gerontol A Biol Sci Med Sci, 24, 10.1093/Gerona/Glw193 · DOI
  133. Panici, 2010, Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice, FASEB J, 24, 1, 10.1096/Fj.10-163253 · DOI
  134. Bokov, 2009, Long-lived Ames dwarf mice are resistant to chemical stressors, J Gerontol A Biol Sci Med Sci, 64, 10.1093/Gerona/Glp052 · DOI
  135. Bartke, 2004, Life extension in the dwarf mouse, Curr Top Dev Biol, 63, 189, 10.1016/S0070-2153(04)63006-7 · DOI · Paper page
  136. Mattison, 2000, Studies of aging in Ames dwarf mice: Effects of caloric restriction, J Am Aging Assoc, 23, 9, 10.1007/S11357-000-0002-0 · DOI
  137. Sun, 2017, Longevity is impacted by growth hormone action during early postnatal period, Elife, 6, e24059, 10.7554/Elife.24059 · DOI
  138. Kuramoto, 2010, Spontaneous dwarf rat: a novel model for aging research, Geriatr Gerontol Int, 10, 94, 10.1111/J.1447-0594.2009.00559.X · DOI
  139. Ungvari, 2010, Vasoprotective effects of life span-extending peripubertal gh replacement in Lewis dwarf rats, J Gerontol A Biol Sci Med Sci, 65, 10.1093/Gerona/Glq147 · DOI
  140. Zhang, 2021, The antagonistic pleiotropy of insulin-like growth factor 1, Aging Cell, 20, E13443, 10.1111/Acel.13443 · DOI · Paper page
  141. Milman, 2014, Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity, Aging Cell, 13, 10.1111/Acel.12213 · DOI
  142. Zhang, 2020, Insulin-like growth factor-1 and igf binding proteins predict all-cause mortality and morbidity in older adults, Cells, 9, 10.3390/Cells9061368 · DOI · Paper page
  143. Bartke, 2013, Somatotropic signaling: Trade-offs between growth, reproductive development, and longevity, Physiol Rev, 93, 10.1152/Physrev.00006.2012 · DOI · Paper page
  144. Tatar, 2003, The endocrine regulation of aging by insulin-like signals, Sci (New York Ny, 299, 10.1126/science.1081447 · DOI · Paper page
  145. Colon, 2019, The enigmatic role of growth hormone in age-related diseases, cognition, and longevity, Geroscience, 41, 10.1007/S11357-019-00096-W · DOI
  146. Fang, 2017, Differential effects of early-life nutrient restriction in long-lived ghr-ko and normal mice, Geroscience, 39, 10.1007/S11357-017-9978-6 · DOI
  147. Ouarné, 2021, From remodeling to quiescence: The transformation of the vascular network, Cells Dev, 168, 10.1016/J.Cdev.2021.203735 · DOI
  148. Silpanisong, 2013, Vasotrophic regulation of age-dependent hypoxic cerebrovascular remodeling, Curr Vasc Pharmacol, 11, 10.2174/1570161111311050002 · DOI
  149. Bonnans, 2014, Remodelling the extracellular matrix in development and disease, Nat Rev Mol Cell Biol, 15, 786, 10.1038/Nrm3904 · DOI · Paper page
  150. Sonbol, 2018, Extracellular matrix remodeling in human disease, J Microsc Ultrastruct, 6, 10.4103/Jmau.Jmau_4_18 · DOI
  151. Phillip, 2015, The mechanobiology of aging, Annu Rev BioMed Eng, 17, 10.1146/Annurev-Bioeng-071114-040829 · DOI · Paper page
  152. Tarantini, 2021, Effect of genetic depletion of mmp-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice, Geroscience, 43, 10.1007/S11357-021-00402-5 · DOI
  153. Reed, 2019, The extracellular matrix of the blood-brain barrier: Structural and functional roles in health, aging, and alzheimer’s disease, Tissue Barriers, 7, 10.1080/21688370.2019.1651157 · DOI
  154. Behmoaras, 2005, Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains, Am J Physiol Heart Circ Physiol, 288, 10.1152/Ajpheart.00544.2004 · DOI
  155. Kiss, 2019, Nicotinamide mononucleotide (Nmn) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: A potential mechanism for the prevention of vascular cognitive impairment, Geroscience, 41, 10.1007/S11357-019-00074-2 · DOI
  156. Ungvari, 2010, Mechanisms of vascular aging: New perspectives, J Gerontol A Biol Sci Med Sci, 65, 10.1093/Gerona/Glq113 · DOI · Paper page
  157. Feihl, 2006, Hypertension: A disease of the microcirculation, Hypertension, 48, 10.1161/01.Hyp.0000249510.20326.72 · DOI
  158. Schager, 2020, Susceptibility to capillary plugging can predict brain region specific vessel loss with aging, J Cereb Blood Flow Metab, 40, 10.1177/0271678x19895245 · DOI
  159. Riddle, 2003, Microvascular plasticity in aging, Ageing Res Rev, 2, 10.1016/S1568-1637(02)00064-8 · DOI · Paper page
  160. Ingraham, 2008, Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus, J Gerontol A Biol Sci Med Sci, 63, 12, 10.1093/gerona/63.1.12 · DOI
  161. Sardone, 2021, Retinal vascular density on optical coherence tomography angiography and age-related central and peripheral hearing loss in a southern Italian older population, J Gerontol A Biol Sci Med Sci, 76, 10.1093/Gerona/Glaa269 · DOI
  162. Anversa, 1994, Effects of aging on quantitative structural properties of coronary vasculature and microvasculature in rats, Am J Physiol, 267, 10.1152/ajpheart.1994.267.3.H1062 · DOI
  163. Faber, 2011, Aging causes collateral rarefaction and increased severity of ischemic injury in multiple tissues, Arterioscler Thromb Vac Biol, 31, 10.1161/Atvbaha.111.227314 · DOI
  164. Kang, 2001, Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and thrombospondin-1 in renal disease, Am J Kidney Dis, 37, 10.1053/ajkd.2001.22087 · doi:10.1053/ajkd.2001.22087 · Paper page
  165. Kiss, 2022, Old blood from heterochronic parabionts accelerates vascular aging in young mice: Transcriptomic signature of pathologic smooth muscle remodeling, Geroscience, 44, 10.1007/S11357-022-00519-1 · DOI
  166. Kiss, 2020, Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: Transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood, Geroscience, 42, 10.1007/S11357-020-00180-6 · DOI
  167. Pan, 2013, Platelet-secreted microrna-223 promotes endothelial cell apoptosis induced by advanced glycation end products Via targeting the insulin-like growth factor 1 receptor, J Of Immunol (Baltimore Md: 1950), 192, 10.4049/Jimmunol.1301790 · DOI
  168. Lopez-Lopez, 2004, Insulin-like growth factor I is required for vessel remodeling in the adult brain, Proc Natl Acad Sci U.S.A., 101, 10.1073/Pnas.0400337101 · DOI · Paper page
  169. Zhu, 2009, Postischemic igf-1 gene transfer promotes neurovascular regeneration after experimental stroke, J Cereb Blood Flow Metab, 29, 10.1038/Jcbfm.2009.75 · DOI
  170. Hayes, 2021, Preclinical and clinical evidence of igf-1 as a prognostic marker and acute intervention with ischemic stroke, J Cereb Blood Flow Metab, 41, 10.1177/0271678x211000894 · DOI
  171. Fuchtbauer, 2020, Increased number of retinal vessels in acromegaly, Eur J Endocrinol, 182, 293, 10.1530/Eje-19-0778 · DOI
  172. Gallo, 2020, Igf-1 is an independent predictor of retinal arterioles remodeling in subjects with uncontrolled acromegaly, Eur J Endocrinol, 182, 10.1530/Eje-19-0390 · doi:10.1530/eje-19-0390
  173. Tarnawski, 2010, Pten silencing reverses aging-related impairment of angiogenesis in microvascular endothelial cells, Biochem Biophys Res Commun, 394, 10.1016/J.Bbrc.2010.02.161 · DOI
  174. Bach, 2005, Defects in activation of nitric oxide synthases occur during delayed angiogenesis in aging, Mech Ageing Dev, 126, 10.1016/J.Mad.2004.10.005 · DOI
  175. Sadoun, 2003, Impaired angiogenesis in aging is associated with alterations in vessel density, matrix composition, inflammatory response, and growth factor expression, J Histochem Cytochem, 51, 10.1177/002215540305100902 · DOI
  176. Ahluwalia, 2011, Activation of the metabolic sensor - amp activated protein kinase reverses impairment of angiogenesis in aging myocardial microvascular endothelial cells. implications for the aging heart, J Physiol Pharmacol, 62
  177. Delafontaine, 2004, Expression, regulation, and function of igf-1, igf-1r, and igf-1 binding proteins in blood vessels, Arterioscler Thromb Vac Biol, 24, 10.1161/01.Atv.0000105902.89459.09 · DOI · Paper page
  178. Humpert, 2008, Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by igf-1 receptor-dependent signaling, Mol Med, 14, 10.2119/2007-00052.Humpert · DOI
  179. Oomen, 2002, Reduced capillary permeability and capillary density in the skin of gh-deficient adults: Improvement after 12 months gh replacement, Clin Endocrinol (Oxf), 56, 10.1046/J.1365-2265.2002.01517.X · DOI
  180. Viana, 2015, Combined effect of insulin-like growth factor-1 and cc chemokine ligand 2 on angiogenic events in endothelial cells, PloS One, 10, E0121249, 10.1371/Journal.Pone.0121249 · DOI
  181. Banki, 2015, Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells, J Gerontol A Biol Sci Med Sci, 70, 10.1093/Gerona/Glu116 · DOI
  182. Wagatsuma, 2006, Effect of aging on expression of angiogenesis-related factors in mouse skeletal muscle, Exp Gerontol, 41, 49, 10.1016/J.Exger.2005.10.003 · DOI
  183. Ryan, 2006, Lower skeletal muscle capillarization and vegf expression in aged vs. young men, J Appl Physiol (1985), 100, 10.1152/Japplphysiol.00827.2005 · DOI
  184. Iemitsu, 2006, Exercise training improves aging-induced downregulation of vegf angiogenic signaling cascade in hearts, Am J Physiol Heart Circ Physiol, 291, 10.1152/Ajpheart.00820.2005 · DOI
  185. Mieno, 2006, Aging is associated with an impaired coronary microvascular response to vascular endothelial growth factor in patients, J Thorac Cardiovasc Surg, 132, 10.1016/J.Jtcvs.2006.08.043 · DOI
  186. Yu, 2021, Protein signatures from blood plasma and urine suggest changes in vascular function and il-12 signaling in elderly with a history of chronic diseases compared with an age-matched healthy cohort, Geroscience, 43, 593, 10.1007/S11357-020-00269-Y · DOI
  187. Dilley, 1989, Vascular remodeling in the growth hormone transgenic mouse, Circ Res, 65, 10.1161/01.Res.65.5.1233 · DOI
  188. Chen, 1998, Insulin-like growth factor-1 stimulates vascular smooth muscle cell proliferation in rat aorta In vivo, Growth Horm Igf Res, 8, 299, 10.1016/S1096-6374(98)80125-1 · doi:10.1016/s1096-6374(98)80125-1
  189. Kobayashi, 2003, Possible involvement of igf-1 receptor and igf-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta, Br J Pharmacol, 140, 10.1038/Sj.Bjp.0705438 · DOI
  190. Claassen, 2021, Regulation of cerebral blood flow in humans: Physiology and clinical implications of autoregulation, Physiol Rev, 101, 10.1152/Physrev.00022.2020 · DOI · Paper page
  191. Linde, 2012, Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats, Am J Physiol Heart Circ Physiol, 302, 10.1152/Ajpheart.00950.2011 · DOI
  192. Springo, 2015, Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries, J Cereb Blood Flow Metab, 35, 10.1038/Jcbfm.2014.256 · DOI
  193. Wang, 2020, Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats, Geroscience, 42, 10.1007/S11357-020-00233-W · DOI
  194. Tarumi, 2014, Cerebral hemodynamics in normal aging: Central artery stiffness, wave reflection, and pressure pulsatility, J Cereb Blood Flow Metab, 34, 10.1038/Jcbfm.2014.44 · DOI · Paper page
  195. Brayden, 2008, Transient receptor potential (Trp) channels, vascular tone and autoregulation of cerebral blood flow, Clin Exp Pharmacol Physiol, 35, 10.1111/J.1440-1681.2007.04855.X · DOI
  196. Toth, 2013, Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin ii-induced hypertension, J Cereb Blood Flow Metab, 33, 10.1038/Jcbfm.2013.143 · DOI
  197. Ungvari, 2003, High pressure induces superoxide production in isolated arteries Via protein kinase c-dependent activation of Nad(P)H oxidase, Circulation, 108, 10.1161/01.Cir.0000079165.84309.4d · DOI
  198. Toth, 2015, Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: Role of resveratrol treatment in vasoprotection, Aging Cell, 14, 10.1111/Acel.12315 · DOI · Paper page
  199. Yu, 2020, Neurovascular unit dysfunction and neurodegenerative disorders, Front Neurosci, 14, 10.3389/Fnins.2020.00334 · DOI · Paper page
  200. Hendrikx, 2019, Measurement of neurovascular coupling in neonates, Front Physiol, 10, 10.3389/Fphys.2019.00065 · DOI

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Metadata

Authors
Bickel, M. A., Csik, B., Gulej, R., Ungvari, A., Nyul-Toth, A., & Conley, S. M.
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2023-01-23
Volume
14
ISSN
1664-2392
DOI
10.3389/fendo.2023.1087053
Cited by
29
References
32
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • National Institutes of Health (R01AG070915, T32AG052363, 1P20GM125228)
  • American Heart Association (AHA83433, AHA916225)

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