Cited by 72Exercise and Physiological ResponsesMuscle Physiology and DisordersSeaweed-derived Bioactive Compounds

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Microalgae Produce Antioxidant Molecules with Potential Preventive Effects on Mitochondrial Functions and Skeletal Muscular Oxidative Stress

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Vignaud, Jordi, Loiseau, Céline, Hérault, Josiane, Mayer, Claire, Côme, Martine, Martin, Isabelle, Ulmann, Lionel·2023·Antioxidants

DOI 10.3390/antiox12051050PMC PMC10215861

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Abstract

In recent years, microalgae have become a source of molecules for a healthy life. Their composition of carbohydrates, peptides, lipids, vitamins and carotenoids makes them a promising new source of antioxidant molecules. Skeletal muscle is a tissue that requires constant remodeling via protein turnover, and its regular functioning consumes energy in the form of adenosine triphosphate (ATP), which is produced by mitochondria. Under conditions of traumatic exercise or muscular diseases, a high production of reactive oxygen species (ROS) at the origin of oxidative stress (OS) will lead to inflammation and muscle atrophy, with life-long consequences. In this review, we describe the potential antioxidant effects of microalgae and their biomolecules on mitochondrial functions and skeletal muscular oxidative stress during exercises or in musculoskeletal diseases, as in sarcopenia, chronic obstructive pulmonary disease (COPD) and Duchenne muscular dystrophy (DMD), through the increase in and regulation of antioxidant pathways and protein synthesis.

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Authors: Vignaud, J., Loiseau, C., Hérault, J., Mayer, C., Côme, M., Martin, I., & Ulmann, L.
Affiliations: Le Mans Université (FR)
BiOSSE (Biology of Organisms, Stress, Health, Environment), Institut Universitaire de Technologie, Département Génie Biologique, Le Mans Université, F-53020 Laval, France
Corresponding author: Ulmann, Lionel
ORCID: Vignaud, Jordi
Loiseau, Céline
Mayer, Claire
Ulmann, Lionel
Venue: Antioxidants
Publisher: MDPI AG
Published: 2023-05-05
Volume: 12
Issue: 5
Pages: 1050
ISSN: 2076-3921 (ISSN-L)
DOI: 10.3390/antiox12051050
PMC: PMC10215861
OpenAlex: W4372347288
Cited by: 72
References: 213
Citations by year: 2026: 19 · 2025: 31 · 2024: 16 · 2023: 6
FWCI: 2.44
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Antioxidants (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Collectivités Locales Mayennaises
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords: microalgae, antioxidants, mitochondrial function, reactive oxygen species, sarcopenia, chronic obstructive pulmonary disease, Duchenne muscular dystrophy, exercise-induced muscle damage, muscle atrophy, antioxidant pathways, protein synthesis, carotenoids

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Microalgae Produce Antioxidant Molecules with Potential Preventive Effects on Mitochondrial Functions and Skeletal Muscular Oxidative Stress

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