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Immense Essence of Excellence: Marine Microbial Bioactive Compounds
Open accessAbstract
Oceans have borne most of the biological activities on our planet. A number of biologically active compounds with varying degrees of action, such as anti-tumor, anti-cancer, anti-microtubule, anti-proliferative, cytotoxic, photo protective, as well as antibiotic and antifouling properties, have been isolated to date from marine sources. The marine environment also represents a largely unexplored source for isolation of new microbes (bacteria, fungi, actinomycetes, microalgae-cyanobacteria and diatoms) that are potent producers of bioactive secondary metabolites. Extensive research has been done to unveil the bioactive potential of marine microbes (free living and symbiotic) and the results are amazingly diverse and productive. Some of these bioactive secondary metabolites of microbial origin with strong antibacterial and antifungal activities are being intensely used as antibiotics and may be effective against infectious diseases such as HIV, conditions of multiple bacterial infections (penicillin, cephalosporines, streptomycin, and vancomycin) or neuropsychiatric sequelae. Research is also being conducted on the general aspects of biophysical and biochemical properties, chemical structures and biotechnological applications of the bioactive substances derived from marine microorganisms, and their potential use as cosmeceuticals and nutraceuticals. This review is an attempt to consolidate the latest studies and critical research in this field, and to showcase the immense competence of marine microbial flora as bioactive metabolite producers. In addition, the present review addresses some effective and novel approaches of procuring marine microbial compounds utilizing the latest screening strategies of drug discovery.
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“Salinosporamide A, a novel long-lasting proteasome inhibitor isolated from a marine bacterium Salinispora tropica [230] in phase I clinical trials, has more efficacy against a wider range of hematologic malignancies and many solid tumor models, and less cytotoxicity to normal cells (Figure 8) [101].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [101]
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“Salinosporamide A, a novel long-lasting proteasome inhibitor isolated from a marine bacterium Salinispora tropica [230] in phase I clinical trials, has more efficacy against a wider range of hematologic malignancies and many solid tumor models, and less cytotoxicity to normal cells (Figure 8) [101].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [101]
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“Tasidotin, Synthadotin (ILX-651), derived from a marine bacterium in phase II clinical trials, and Soblidotin (TZT 1027), the bacterial peptide of marine origin in phase III clinical trials, are promising anticancer agents [101].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [101]
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“Tasidotin, Synthadotin (ILX-651), derived from a marine bacterium in phase II clinical trials, and Soblidotin (TZT 1027), the bacterial peptide of marine origin in phase III clinical trials, are promising anticancer agents [101].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [101]
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“Tasidotin, Synthadotin (ILX-651), derived from a marine bacterium in phase II clinical trials, and Soblidotin (TZT 1027), the bacterial peptide of marine origin in phase III clinical trials, are promising anticancer agents [101].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [101]
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“Salinosporamide A, a novel long-lasting proteasome inhibitor isolated from a marine bacterium Salinispora tropica [230] in phase I clinical trials, has more efficacy against a wider range of hematologic malignancies and many solid tumor models, and less cytotoxicity to normal cells (Figure 8) [101].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [101]
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Metadata
- Authors
- Bhatnagar, I., & Kim, S.-K.
- Affiliations
- Pukyong National University (KR)
- Corresponding author
- Kim, Se-Kwon
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2010-10-15
- Volume
- 8
- Issue
- 10
- Pages
- 2673-2701
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC2993000
- OpenAlex
- W2029997716
- Cited by
- 384
- References
- 124
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 21 · 2023: 23 · 2022: 28 · 2021: 18 · 2020: 39 · 2019: 26 · 2018: 25 · 2017: 26 · 2016: 32 · 2015: 28 · 2014: 30 · 2013: 23 · 2012: 27
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- marine microorganisms, bioactive secondary metabolites, marine natural products, antibacterial agents, antifungal agents, anticancer agents, marine bacteria, actinomycetes, cyanobacteria, diatoms, microbial symbionts, drug discovery screening, cosmeceuticals, nutraceuticals
- MeSH terms
- Cyanobacteria, Animals, Anti-Bacterial Agents, Antifungal Agents, Antineoplastic Agents, Bacteria, Clinical Trials as Topic, Fungi, Seawater, Symbiosis, Diatoms, Drug Discovery, Microalgae, Aquatic Organisms
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