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Biosensors Based on Mechanical and Electrical Detection Techniques

Chalklen, Thomas, Jing, Qingshen, Kar-Narayan, Sohini·2020·Sensors
DOI 10.3390/s20195605
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Abstract

Biosensors are powerful analytical tools for biology and biomedicine, with applications ranging from drug discovery to medical diagnostics, food safety, and agricultural and environmental monitoring. Typically, biological recognition receptors, such as enzymes, antibodies, and nucleic acids, are immobilized on a surface, and used to interact with one or more specific analytes to produce a physical or chemical change, which can be captured and converted to an optical or electrical signal by a transducer. However, many existing biosensing methods rely on chemical, electrochemical and optical methods of identification and detection of specific targets, and are often: complex, expensive, time consuming, suffer from a lack of portability, or may require centralised testing by qualified personnel. Given the general dependence of most optical and electrochemical techniques on labelling molecules, this review will instead focus on mechanical and electrical detection techniques that can provide information on a broad range of species without the requirement of labelling. These techniques are often able to provide data in real time, with good temporal sensitivity. This review will cover the advances in the development of mechanical and electrical biosensors, highlighting the challenges and opportunities therein.

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Metadata

Authors
Chalklen, T., Jing, Q., & Kar-Narayan, S.
Venue
Sensors
Publisher
MDPI AG
Published
2020-09-30
Volume
20
Issue
19
Pages
5605
ISSN
1424-8220
DOI
10.3390/s20195605
Cited by
133
References
7
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • European Research Council (ERC-2014-STG-639526, NANOGEN)
  • Biotechnology and Biological Sciences Research Council (BB/R022283/1)
  • Centre of Advanced Materials for Integrated Energy Systems (EP/P007767/1)

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