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Inflammation, Sanitation, and Consternation: Loss of Contact With Coevolved, Tolerogenic Microorganisms and the Pathophysiology and Treatment of Major Depression
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CONTEXT: Inflammation is increasingly recognized as contributing to the pathogenesis of major depressive disorder (MDD), even in individuals who are otherwise medically healthy. Most studies in search of sources for this increased inflammation have focused on factors such as psychosocial stress and obesity that are known to activate inflammatory processes and increase the risk for depression. However, MDD may be so prevalent in the modern world not just because proinflammatory factors are widespread, but also because we have lost contact with previously available sources of anti-inflammatory, immunoregulatory signaling. OBJECTIVE: To examine evidence that disruptions in coevolved relationships with a variety of tolerogenic microorganisms that were previously ubiquitous in soil, food, and the gut, but that are largely missing from industrialized societies, may contribute to increasing rates of MDD in the modern world. DATA SOURCES: Relevant studies were identified using PubMed and Ovid MEDLINE. STUDY SELECTION: Included were laboratory animal and human studies relevant to immune functioning, the hygiene hypothesis, and major depressive disorder identified via PubMed and Ovid MEDLINE searches. DATA EXTRACTION: Studies were reviewed by all authors, and data considered to be potentially relevant to the contribution of hygiene-related immune variables to major depressive disorder were extracted. DATA SYNTHESIS: Significant data suggest that a variety of microorganisms (frequently referred to as the "old friends") were tasked by coevolutionary processes with training the human immune system to tolerate a wide array of non-threatening but potentially proinflammatory stimuli. Lacking such immune training, vulnerable individuals in the modern world are at significantly increased risk of mounting inappropriate inflammatory attacks on harmless environmental antigens (leading to asthma), benign food contents and commensals in the gut (leading to inflammatory bowel disease), or self-antigens (leading to any of a host of autoimmune diseases). Loss of exposure to the old friends may promote MDD by increasing background levels of depressogenic cytokines and may predispose vulnerable individuals in industrialized societies to mount inappropriately aggressive inflammatory responses to psychosocial stressors, again leading to increased rates of depression. CONCLUSION: Measured exposure to the old friends or their antigens may offer promise for the prevention and treatment of MDD in modern industrialized societies.
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“these organisms (often referred to as ‘old friends’) share a tendency to reduce inflammation and suppress effector immune cells through the induction of IL-10 and transforming growth factor-β (TGFβ) while promoting the development of anti-inflammatory immune cell populations, such as alternatively activated (also referred to as ‘M2’) macrophages and regulatory T (TReg) cells and regulatory B cells”
From The role of inflammation in depression: from evolutionary imperative to modern treatment target (2016) · cites this paper as [13]
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“Consequently, we find ourselves in a condition of an exacerbated inflammatory bias, with the particular conditions afflicting any given individual largely the result of genetic predisposition and environmental (for example, psychosocial) exposures13,14, ultimately accounting for the high co-morbidity between depression and autoimmune, allergic and inflammatory disorders13,15.”
From The role of inflammation in depression: from evolutionary imperative to modern treatment target (2016) · cites this paper as [13]
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“Environmental risk factors for the development of depression (that is, psychosocial stress, early life adversity, obesity and processed-food diet) are uniformly pro-inflammatory13.”
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“The prevalence of autoimmune, allergic and inflammatory diseases has markedly increased in the past 100 years, and rates of these conditions follow a similar upward trajectory in societies transitioning from traditional (that is, rural) to modern (that is, urban) ways of life13.”
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Citations
Cites
Projections of Global Mortality and Burden of Disease from 2002 to 2030
Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
The Logic of Scientific Discovery
Bhaskar, R. (2013) · Routledge eBooks · doi:10.4324/9780203090732-9 · Cited by 7,765
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322
Asher, M. I., Montefort, S., Björkstén, B., Lai, C. K., Strachan, D. P., Weiland, S. K., & Williams, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69283-0 · Cited by 4,223
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070
The Prevalence of Comorbid Depression in Adults With Diabetes
Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1069 · Cited by 3,926
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
Self-citationBeasley, R. W. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07302-9 · Cited by 3,794
Cellular and Molecular Immunology
Abbas, A. K., Lichtman, A. H., & Pillai, S. S. (1994) · Cited by 3,571
Anterior Cingulate Cortex, Error Detection, and the Online Monitoring of Performance
Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998) · Science · doi:10.1126/science.280.5364.747 · Cited by 3,273
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Nothing in Biology Makes Sense except in the Light of Evolution
Dobzhansky, T. (1973) · The American Biology Teacher · doi:10.2307/4444260 · Cited by 3,219
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168
Physical Activity and Public Health in Older Adults
Nelson, M. E., Rejeski, W. J., Blair, S. N., Duncan, P. W., Judge, J. O., King, A. C., Macera, C. A., & Castaneda‐Sceppa, C. (2007) · Circulation · doi:10.1161/circulationaha.107.185650 · Cited by 3,057
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Self-citationWang, Y., & Beydoun, M. A. (2007) · Epidemiologic Reviews · doi:10.1093/epirev/mxm007 · Cited by 2,854
Cellular and Molecular Immunology
Denman, A. M. (1992) · Postgraduate Medical Journal · doi:10.1136/pgmj.68.798.305 · Cited by 2,807
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,723
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
Cross-national epidemiology of major depression and bipolar disorder
Weissman, M. M. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540040037030 · Cited by 2,302
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068
Kendler, K. S., Prescott, C. A., Myers, J., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.929 · Cited by 1,868
Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults
Breslau, N., Roth, T., Rosenthal, L., & Andreski, P. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00188-3 · Cited by 1,831
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655
Hasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1097 · Cited by 1,645
Eder, W., Ege, M. J., & von Mutius, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054308 · Cited by 1,621
Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey
Riedler, J., Braun-Fahrländer, C., Eder, W., Schreuer, M., Waser, M., Maisch, S., Carr, D., Schierl, R., Nowak, D., & von Mutius, E. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06252-3 · Cited by 1,520
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346
Association between obesity and psychiatric disorders in the US adult population
Simon, G. E., Von Korff, M., Saunders, K., Miglioretti, D. L., Crane, P. K., van Belle, G., & Kessler, R. C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.824 · Cited by 1,338
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267 · cited 1×
“In the last decade, numerous studies have demonstrated that psychosocial stress activates innate immune cytokines and intracellular inflammatory elements such as nuclear factor- .(11-17,57-59) Psychosocial stress may also impair acquired immune processes that normally regulate inflammation.”
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197
Self-citationParoxetine for the prevention of depression induced by high-dose interferon alfa.
Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120
Mood disorders in the medically ill: scientific review and recommendations
Evans, D. L., Charney, D. S., Lewis, L., Golden, R. N., Gorman, J. M., Krishnan, K. R. R., Nemeroff, C. B., Bremner, J. D., Carney, R. M., Coyne, J. C., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.001 · Cited by 1,071
The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review
Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., McCorkle, R., Seligman, D. A., & Schmidt, K. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0597 · Cited by 995
Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952
A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 927
Vega, W. A., Kolody, B., Aguilar‐Gaxiola, S., Alderete, E., Catalano, R. A., & Caraveo-Anduaga, J. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.9.771 · Cited by 910
Social Isolation and Health, with an Emphasis on Underlying Mechanisms
Cacioppo, J. T., & Hawkley, L. C. (2003) · Perspectives in Biology and Medicine · doi:10.1353/pbm.2003.0049 · Cited by 887
Sleep Deprivation and Activation of Morning Levels of Cellular and Genomic Markers of Inflammation
Irwin, M. R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1756 · Cited by 850
Miller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., Cole, S., & Kobor, M. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902971106 · Cited by 822
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810
Increasing Rates of Depression
Klerman, G. L. (1989) · JAMA · doi:10.1001/jama.1989.03420150079041 · Cited by 787
The age of anxiety? The birth cohort change in anxiety and neuroticism, 1952-1993.
Twenge, J. M. (2000) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.79.6.1007 · Cited by 786
Smits, H. H., Engering, A. J., van der Kleij, D., de Jong, E. C., Schipper, K., van Capel, T. M. M., Zaat, B. A. J., Yazdanbakhsh, M., Wierenga, E. A., & van Kooyk, Y. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.03.036 · Cited by 778
Trichuris suis therapy in Crohn’s disease
Summers, R. W., Elliott, D. E., Urban, J. F., Thompson, R., & Weinstock, J. V. (2005) · Gut · doi:10.1136/gut.2004.041749 · Cited by 762
Variation and trends in incidence of childhood diabetes in Europe
(2000) · The Lancet · doi:10.1016/s0140-6736(99)07125-1 · Cited by 755
Social regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745
Trichuris suis therapy for active ulcerative colitis: A randomized controlled trial
Summers, R. W., Elliott, D. E., Urban, J. F., Thompson, R. A., & Weinstock, J. V. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.01.005 · Cited by 739
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1243 · Cited by 721
Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L., & Glaser, R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.12.1377 · Cited by 715
Andrade, L. H., Caraveo-Anduaga, J. J., Berglund, P. A., Bijl, R. C., Kessler, R. C., Demler, O., Walters, E. E., Kylyc, C., Offord, D. R., Üstün, T. B., et al. (2000) · Europe PMC (PubMed Central) · Cited by 711
Matricardi, P. M. (2000) · BMJ · doi:10.1136/bmj.320.7232.412 · Cited by 694
The rise of childhood type 1 diabetes in the 20th century.
Gale, E. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3353 · Cited by 673
Personality and Major Depression: A Swedish Longitudinal, Population-Based Twin Study
Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.10.1113 · Cited by 663
Kendler, K., Kuhn, J. W., Vittum, J., Prescott, C., & Riley, B. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.529 · Cited by 647
Social Isolation and Health, with an Emphasis on Underlying Mechanisms
Cacioppo, J. T., & Hawkley, L. C. (2003) · Perspectives in biology and medicine · doi:10.1353/pbm.2003.0063 · Cited by 624
Steptoe, A., Owen, N., Kunz-Ebrecht, S. R., & Brydon, L. (2004) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00086-6 · Cited by 620
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612
Maes, M. H. J., Kubera, M., & Leunis, J. (2008) · PubMed · Cited by 609
A Novel Host-Parasite Lipid Cross-talk
van der Kleij, D., Latz, E., Brouwers, J. F. H. M., Kruize, Y. C. M., Schmitz, M., Kurt-Jones, E. A., Espevik, T., de Jong, E. C., Kapsenberg, M. L., Golenbock, D. T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206941200 · Cited by 587
Rao, A. V., Bested, A. C., Beaulne, T. M., Katzman, M. A., Iorio, C., Berardi, J. M., & Logan, A. C. (2009) · Gut Pathogens · doi:10.1186/1757-4749-1-6 · Cited by 577
Balducci, S., Zanuso, S., Nicolucci, A., Fernando, F., Cavallo, S., Cardelli, P., Fallucca, S., Alessi, E., Letizia, C., Jimenez, A., et al. (2010) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.04.015 · Cited by 566
Gimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., Kumari, M., Lowe, G. D. O., Rumley, A., Marmot, M. G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708003723 · Cited by 561
Sex differences in rates of depression: cross-national perspectives
Weissman, M. M. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90025-f · Cited by 553
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., Ma, R., & Cole, S. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.017 · Cited by 552
SILK, D. B. A., DAVIS, A., VULEVIC, J., TZORTZIS, G., & GIBSON, G. R. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03911.x · Cited by 551
Zuany‐Amorim, C., Sawicka, E., Manlius, C., Moine, A. L., Brunet, L. R., Kemeny, D. M., Bowen, G., Rook, G. A. W., & Walker, C. (2002) · Nature Medicine · doi:10.1038/nm0602-625 · Cited by 514
Self-citationCytokine Dysregulation, Inflammation and Well-Being
Elenkov, I. J., Iezzoni, D. G., Daly, A., Harris, A. G., & Chrousos, G. P. (2005) · NeuroImmunoModulation · doi:10.1159/000087104 · Cited by 513
Time trends in adolescent mental health
Collishaw, S., Maughan, B., Goodman, R., & Pickles, A. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00335.x · Cited by 508
O’Connor, M.-F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., Hoyt, M. A., Martin, J. L., Robles, T. F., Sloan, E. K., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.04.005 · Cited by 500 · cited 1×
“* Conversely, interventions that reduce depressive symptoms have been reported to lower inflammatory and/or increase anti-inflammatory, immunoregulatory activity in the body and brain (Table).(18-22,25-27,31,32,35-38)”
Selective Alteration of Personality and Social Behavior by Serotonergic Intervention
Knutson, B., Wolkowitz, O. M., Cole, S. W., Chan, T., Moore, E. A., Johnson, R. C., Terpstra, J., Turner, R. A., & Reus, V. I. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.3.373 · Cited by 500
Sleep Loss Activates Cellular Inflammatory Signaling
Irwin, M. R., Wang, M., Ribeiro, D., Cho, H. J., Olmstead, R., Breen, E. C., Martinez-Maza, O., & Cole, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.004 · Cited by 467
Association between parasite infection and immune responses in multiple sclerosis
Correale, J. D., & Farez, M. (2007) · Annals of Neurology · doi:10.1002/ana.21067 · Cited by 461
Sympathetic Nervous System Activity in Major Depression
Veith, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950050071008 · Cited by 457
Cross-national epidemiology of major depression and bipolar disorder
Weissman, M. M. (1996) · JAMA · doi:10.1001/jama.276.4.293 · Cited by 452
Compton, W. M., Conway, K. P., Stinson, F. S., & Grant, B. F. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.12.2141 · Cited by 445
Grangette, C., Nutten, S., Palumbo, E., Morath, S., Hermann, C., Dewulf, J., Pot, B., Härtung, T., Pascal Hols, A., & Mercenier, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504084102 · Cited by 443
Kohut, M. L., McCann, D. A., Russell, D. W., Konopka, D. N., Cunnick, J. E., Franke, W. D., Castillo, M. C., Reighard, A. E., & Vanderah, E. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.12.002 · Cited by 436
Zautra, A. J., Davis, M. C., Reich, J. W., Nicassario, P., Tennen, H., Finan, P., Kratz, A., Parrish, B., & Irwin, M. R. (2008) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.76.3.408 · Cited by 430 · cited 1×
“* Conversely, interventions that reduce depressive symptoms have been reported to lower inflammatory and/or increase anti-inflammatory, immunoregulatory activity in the body and brain (Table).(18-22,25-27,31,32,35-38)”
Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.058 · Cited by 429
Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
Brietzke, E., Stertz, L., Fernandes, B. S., Kauer-Sant’Anna, M., Mascarenhas, M., Escosteguy Vargas, A., Chies, J. A., & Kapczinski, F. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.12.001 · Cited by 423
Blumenthal, J. A., Sherwood, A., Babyak, M. A., Watkins, L. L., WAUGH, R. A., Georgiades, A., Bacon, S., Hayano, J., Coleman, R. E., & Hinderliter, A. L. (2005) · JAMA · doi:10.1001/jama.293.13.1626 · Cited by 414
Eisenberger, N. I., Inagaki, T. K., Mashal, N. M., & Irwin, M. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.12.009 · Cited by 413
Having a word with yourself: neural correlates of self-criticism and self-reassurance.
Longe, O., Maratos, F. A., Gilbert, P., Evans, G., Volker, F., Rockliff, H., & Rippon, G. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.019 · Cited by 403
Give us this day our daily germs
Rook, G. A. W., & Stanford, J. L. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)80008-x · Cited by 393
Self-citationTuglu, C., Kara, S. H., Caliyurt, O., Vardar, E., & Abay, E. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1566-z · Cited by 391
Prospective survey of childhood inflammatory bowel disease in the British Isles
Sawczenko, A., Sandhu, B., Logan, R., Jenkins, H., Taylor, C., Mian, S., & Lynn, R. M. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04309-9 · Cited by 388
Maes, M., Lin, A.-H., Delmeire, L., Van Gastel, A., Kenis, G., De Jongh, R., & Bosmans, E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00131-0 · Cited by 387
Personality Change During Depression Treatment: A Placebo-Controlled Trial
Tang, T. Z., DeRubeis, R. J., Hollon, S. D., Amsterdam, J., Shelton, R., & Schalet, B. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.166 · Cited by 384
Brydon, L., Harrison, N. A., Walker, C., Steptoe, A., & Critchley, H. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.007 · Cited by 381 · cited 1×
“In addition to these correlative data, both immediate and longterm administration of proinflammatory cytokines (or substances that induce these cytokines) cause behavioral symptoms that overlap with those found in MDD and respond to standard antidepressant therapy.(86-91) Consistent with evidence that proinflammatory…”
Th1, Th2, and Th3 cytokine alterations in major depression
MYINT, A., LEONARD, B., STEINBUSCH, H., & KIM, Y. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.07.008 · Cited by 371
Fish Consumption and Depressive Symptoms in the General Population in Finland
Tanskanen, A. J., Hibbeln, J. R., Tuomilehto, J., Uutela, A. K., Haukkala, A., Viinamäki, H. T., Lehtonen, J., & Vartiainen, E. (2001) · Psychiatric Services · doi:10.1176/appi.ps.52.4.529 · Cited by 360
Neural Origins of Human Sickness in Interoceptive Responses to Inflammation
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., Dolan, R. J., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.007 · Cited by 345
Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder
Hoge, E. A., Brandstetter, K., Moshier, S., Pollack, M. H., Wong, K. K., & Simon, N. M. (2009) · Depression and Anxiety · doi:10.1002/da.20564 · Cited by 343
Ursu, S., Stenger, V. A., Shear, M. K., Jones, M. R., & Carter, C. S. (2003) · Psychological Science · doi:10.1111/1467-9280.24411 · Cited by 341
Prenatal Stress Alters Bacterial Colonization of the Gut in Infant Monkeys
Bailey, M. T., Lubach, G. R., & Coe, C. L. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200404000-00009 · Cited by 339
Omega-3 fatty acids: a comprehensive review of their role in health and disease
Yashodhara, B. M., Umakanth, S., Pappachan, J. M., Bhat, S. K., Kamath, R., & Choo, B. H. (2009) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.073338 · Cited by 335
Bailey, M. T., Dowd, S. E., Parry, N. M. A., Galley, J. D., Schauer, D. B., & Lyte, M. (2010) · Infection and Immunity · doi:10.1128/iai.00862-09 · Cited by 335
Rook, G. A. W. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2010.04133.x · Cited by 332
Self-citationVgontzas, A. N., Zoumakis, M., Papanicolaou, D. A., Bixler, E. O., Prolo, P., Lin, H.-M., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2002) · Metabolism · doi:10.1053/meta.2002.33357 · Cited by 329
McDade, T. W., Hawkley, L. C., & Cacioppo, J. T. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000221371.43607.64 · Cited by 326
Do birth cohorts matter? Age-period-cohort analyses of the obesity epidemic in the United States
Reither, E. N., Hauser, R. M., & Yang, Y. (2009) · Social Science & Medicine · doi:10.1016/j.socscimed.2009.08.040 · Cited by 323
Cytokine imbalance in the pathophysiology of major depressive disorder
Kim, Y., Na, K.-S., Shin, K.-H., Jung, H., Choi, S., & Kim, J.-B. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.004 · Cited by 319
Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
Sutcigil, L., Oktenli, C., Musabak, U., Bozkurt, A., Cansever, A., Uzun, O., Sanisoglu, S. Y., Yesilova, Z., Ozmenler, N., Ozsahin, A., et al. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/76396 · Cited by 315
Associations Between Anxiety, Depression, and the Metabolic Syndrome
Skilton, M. R., Moulin, P., Terra, J., & Bonnet, F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.012 · Cited by 310
Vulnerability before, during, and after a major depressive episode: a 3-wave population-based study.
Ormel, J., Oldehinkel, A. J., & Vollebergh, W. (2004) · PubMed · doi:10.1001/archpsyc.61.10.990 · Cited by 310
Depression During Pegylated Interferon-Alpha Plus Ribavirin Therapy
Raison, C. L., Borisov, A. S., Broadwell, S. D., Capuron, L., Woolwine, B. J., Jacobson, I. M., Nemeroff, C. B., & Miller, A. H. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0106 · Cited by 300
Self-citationRook, G. A. W. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.03007.x · Cited by 295
Self-citationPro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
Eller, T., Vasar, V., Shlik, J., & Maron, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.015 · Cited by 290
Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases
Bernstein, C. N., & Shanahan, F. (2008) · Gut · doi:10.1136/gut.2007.122143 · Cited by 290
Commensal microbiota is fundamental for the development of inflammatory pain
Amaral, F. A., Sachs, D., Costa, V. V., Fagundes, C. T., Cisalpino, D., Cunha, T. M., Ferreira, S. H., Cunha, F. Q., Silva, T. A., Nicoli, J. R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711891105 · Cited by 289
Andrade, L. H., Berglund, P. A., Bijl, R. C., Walters, E. E., Offord, D. R., & Üstün, T. B. (2000) · Europe PMC (PubMed Central) · Cited by 288
Zuroff, D. C., Blatt, S. J., Sotsky, S. M., KRUPNICK, J. L., Martin, D. J., A., I. S. C., & Simmens, S. J. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.68.1.114 · Cited by 279
Upton, M. N. (2000) · BMJ · doi:10.1136/bmj.321.7253.88 · Cited by 275
Lundgren, A., Strömberg, E., Sjöling, Å., Lindholm, C., Enarsson, K., Edebo, A., Johnsson, E., Suri‐Payer, E., Larsson, P., Rudin, A., et al. (2004) · Infection and Immunity · doi:10.1128/iai.73.1.523-531.2005 · Cited by 268
Pathways linking depression, adiposity, and inflammatory markers in healthy young adults
Miller, G. E., Freedland, K. E., Carney, R. M., Stetler, C., & Banks, W. A. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00057-6 · Cited by 252
Rohleder, N., Marin, T. J., Ma, R., & Miller, G. E. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7435 · Cited by 252
Time trends in adolescent mental health
Collishaw, S., Maughan, B., Goodman, R., & Pickles, A. R. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00842.x · Cited by 247
Psychiatric Symptoms in Patients With Chronic Hepatitis C Receiving Interferon Alfa-2b Therapy
Kraus, M. R., Schafer, A., Faller, H., Csef, H., & Scheurlen, M. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0614 · Cited by 245
Butland, B. K., Strachan, D. P., Lewis, S., Bynner, J., Butler, N., & Britton, J. (1997) · BMJ · doi:10.1136/bmj.315.7110.717 · Cited by 237
50 years of asthma: UK trends from 1955 to 2004
Anderson, H. R., Gupta, R., Strachan, D. P., & Limb, E. S. (2006) · Thorax · doi:10.1136/thx.2006.066407 · Cited by 237
Major depression in the transition to adulthood: Risks and impairments.
Reinherz, H. Z., Giaconia, R. M., Hauf, A. M. C., Wasserman, M. S., & Silverman, A. B. (1999) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.108.3.500 · Cited by 234
Ghia, J.-E., Blennerhassett, P., & Collins, S. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32849 · Cited by 233
Udupa, K., Sathyaprabha, T. N., Thirthalli, J., Kishore, K., Lavekar, G. S., Raju, T. R., & Gangadhar, B. N. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.10.007 · Cited by 231
Evolutionary, historical and political economic perspectives on health and disease
Armelagos, G. J., Brown, P. J., & Turner, B. (2004) · Social Science & Medicine · doi:10.1016/j.socscimed.2004.08.066 · Cited by 230
Fourlanos, S., Varney, M., Tait, B., Morahan, G., Honeyman, M., Colman, P., & Harrison, L. (2008) · Diabetes Care · doi:10.2337/dc08-0239 · Cited by 229
Bull, S. J., Huezo-Diaz, P., Binder, E. B., Cubells, J. F., Ranjith, G., Maddock, C., Miyazaki, C., Alexander, N., Hotopf, M., Cleare, A. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.48 · Cited by 228
Benn, C. S., Melbye, M., Wohlfahrt, J., Björkstén, B., & Aaby, P. (2004) · BMJ · doi:10.1136/bmj.38069.512245.fe · Cited by 227
Dhabhar, F. S., Burke, H. M., Epel, E. S., Mellon, S. H., Rosser, R., Reus, V. I., & Wolkowitz, O. M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.05.010 · Cited by 225
Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment
Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B. J., Nemeroff, C. B., Berns, G. S., & Miller, A. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.033 · Cited by 222
Vega, W. A., Sribney, W. M., Aguilar‐Gaxiola, S., & Kolody, B. (2004) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000135477.57357.b2 · Cited by 220
Looking on the bright side: biased attention and the human serotonin transporter gene
Fox, E., Ridgewell, A., & Ashwin, C. (2009) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2008.1788 · Cited by 220
Depression, inflammation, and pain in patients with rheumatoid arthritis.
Kojima, M., Kojima, T., Suzuki, S., Oguchi, T., Oba, M., Tsuchiya, H., Sugiura, F., Kanayama, Y., Furukawa, T. A., Tokudome, S., et al. (2009) · Arthritis Care & Research · doi:10.1002/art.24647 · Cited by 217
Reber, S. O., Birkeneder, L., Veenema, A. H., Obermeier, F., Falk, W., Straub, R. H., & Neumann, I. (2006) · Endocrinology · doi:10.1210/en.2006-0983 · Cited by 212
van den Biggelaar, A. H. J., Gussekloo, J., de Craen, A. J. M., Frölich, M., Stek, M. L., van der Mast, R. C., & Westendorp, R. G. J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.011 · Cited by 209
Cizza, G., Marques, A. H., Eskandari, F., Christie, I. C., Torvik, S., Silverman, M. N., Phillips, T. M., & Sternberg, E. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.035 · Cited by 208
Spitzer, C., Barnow, S., Völzke, H., Wallaschofski, H., John, U., Freyberger, H. J., Löwe, B., & Grabe, H. J. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.06.002 · Cited by 205
Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study Group.
(2000) · PubMed · Cited by 202
Give us this day our daily germs
Rook, G. A. W. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01204-8 · Cited by 202
Self-citationLowry, C. A., Hollis, J. H., de Vries, A., Pan, B., Brunet, L. R., Hunt, J. R. F., Paton, J. F. R., van Kampen, E., Knight, D. M., Evans, A. K., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.067 · Cited by 199
Self-citationMiller, G. E., Rohleder, N., & Cole, S. W. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318190d7de · Cited by 197
Zuroff, D. C., Blatt, S. J., Sotsky, S. M., KRUPNICK, J. L., Martin, D. J., Sanislow, C. A., & Simmens, S. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.1.114 · Cited by 194
Soenens, B., Luyckx, K., Vansteenkiste, M., Luyten, P., Duriez, B., & Goossens, L. (2008) · Journal of Family Psychology · doi:10.1037/0893-3200.22.3.465 · Cited by 193
Knowles, S. R., Nelson, E. A., & Palombo, E. A. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.010 · Cited by 192
Inflammatory Bowel Disease in Children and Adolescents in Sweden, 1984–1995
Lindberg, E., Lindquist, B. L., Holmquist, L., & Hildebrand, H. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200003000-00009 · Cited by 190
Immunomodulation by commensal and probiotic bacteria
Forsythe, P., & Bienenstock, J. (2010) · Immunological Investigations · doi:10.3109/08820131003667978 · Cited by 189
Socioeconomic status and C-reactive protein levels in the US population: NHANES IV
Alley, D. E., Seeman, T. E., Kim, J. K., Karlamangla, A. S., Hu, P., & Crimmins, E. M. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.10.003 · Cited by 186
EISENBERGER, N. I., LIEBERMAN, M. D., & SATPUTE, A. B. (2005) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.5.2.169 · Cited by 184
Pervanidou, P., Kolaitis, G., Charitaki, S., Margeli, A., Ferentinos, S., Bakoula, C., Lazaropoulou, C., Papassotiriou, I., Tsiantis, J., & Chrousos, G. P. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.07.001 · Cited by 183
Multiple sclerosis and the hygiene hypothesis
Fleming, J. O., & Cook, T. D. (2006) · Neurology · doi:10.1212/01.wnl.0000247663.40297.2d · Cited by 182
Helminth‐induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation
Wilson, M. S., Taylor, M. D., O’Gorman, M. T., Balic, A., Barr, T. A., Filbey, K. J., Anderton, S. M., & Maizels, R. M. (2010) · European Journal of Immunology · doi:10.1002/eji.200939721 · Cited by 179
The neuropsychiatry of multiple sclerosis: Focus on disorders of mood, affect and behaviour
Paparrigopoulos, T. J., Ferentinos, P. P., Kouzoupis, A. B., Koutsis, G., & Papadimitriou, G. N. (2010) · International Review of Psychiatry · doi:10.3109/09540261003589323 · Cited by 173
Fuligni, A. J., Telzer, E. H., Bower, J., Cole, S. W., Kiang, L., & Irwin, M. R. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181921b1f · Cited by 170
Effect of Dietary Fatty Acids on Inflammatory Gene Expression in Healthy Humans
Weaver, K. L., Ivester, P., Seeds, M. C., Case, L. D., Arm, J. P., & Chilton, F. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004861 · Cited by 167
Increasing rates of depression
Klerman, G. L. (1989) · JAMA · doi:10.1001/jama.261.15.2229 · Cited by 166
WICKRAMARATNE, P. J., Weissman, M. M., Leaf, P. J., & Holford, T. R. (1989) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(89)90038-3 · Cited by 165
Li, Y., Xiao, B., Qiu, W., Yang, L., Hu, B., Tian, X., & Yang, H. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.018 · Cited by 163
Marin, T. J., Chen, E., Munch, J. A., & Miller, G. E. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318199dbc3 · Cited by 159
Gonda, X., Fountoulakis, K. Ν., Juhász, G., Rihmer, Z., Lazáry, J., Lászik, A., Akiskal, H. S., & Bagdy, G. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0842-7 · Cited by 156
Monagas, M., Khan, N., Andrés‐Lacueva, C., Urpí-Sardà, M., Vázquez-Agell, M., Lamuela-Raventós, R. M., & Estruch, R. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114508162110 · Cited by 155
Promoting physical activity: the new imperative for public health
Sparling, P. B. (2000) · Health Education Research · doi:10.1093/her/15.3.367 · Cited by 152
Mood Alterations During Interferon-Alfa Therapy in Patients With Chronic Hepatitis C
Constant, A., Castéra, L., Dantzer, R., Couzigou, P., de Lédinghen, V., Demotes‐Mainard, J., & Henry, C. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0814 · Cited by 151
Suarez, E. C. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000138281.73634.67 · Cited by 151
The role of IL-12 and TGF-β1 in the pathophysiology of major depressive disorder
Lee, K.-M., & Kim, Y.-K. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.03.015 · Cited by 150
Genetic variation in 5HTTLPR is associated with emotional resilience
Stein, M. B., Campbell‐Sills, L., & Gelernter, J. E. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30916 · Cited by 148
Prevalence and incidence of depressive disorder: the Baltimore ECA follow-up, 1981–2004
Eaton, W. W., Kalaydjian, A., Scharfstein, D. O., Mezuk, B., & Ding, Y. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01017.x · Cited by 146
Dai, J., Miller, A. H., Bremner, J. D., Goldberg, J., Jones, L., Shallenberger, L., Buckham, R., Murrah, N. V., Veledar, E., Wilson, P. W., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.710699 · Cited by 145
RAISON, C. L., WOOLWINE, B. J., DEMETRASHVILI, M. F., BORISOV, A. S., WEINREIB, R., STAAB, J. P., ZAJECKA, J. M., BRUNO, C. J., HENDERSON, M. A., REINUS, J. F., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03316.x · Cited by 142
Self-citationWichers, M. C., Barge-Schaapveld, D. Q. C. M., Nicolson, N. A., Peeters, F., de Vries, M., Mengelers, R., & van Os, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.66 · Cited by 139
O’Brien, M. E. R., Anderson, H., Kaukel, E., O’Byrne, K., Pawlicki, M., von Pawel, J., & Reck, M. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh220 · Cited by 139
Vaccarino, V., Brennan, M., Miller, A. H., Bremner, J. D., Ritchie, J., Lindau, F., Veledar, E., Su, S., Murrah, N. V., Jones, L. R., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.023 · Cited by 137
Hamer, M., & Steptoe, A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318148c4c0 · Cited by 137
The normal intestinal microbiota
Marchesi, J. R., & Shanahan, F. (2007) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3282a56a99 · Cited by 136
Lotrich, F. E., Ferrell, R. E., Rabinovitz, M., & Pollock, B. G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.009 · Cited by 135
Increased heart rate in depressed subjects in spite of unchanged autonomic balance?
Moser, M., Lehofer, M., Hoehn‐Saric, R., McLeod, D. R., Hildebrandt, G., Steinbrenner, B., Voica, M., Liebmann, P. M., & Zapotoczky, H. G. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00164-x · Cited by 134
Het, S., & Wolf, O. T. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.1.11 · Cited by 134
Bailey, M. T., Engler, H., & Sheridan, J. F. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.09.008 · Cited by 133 · cited 1×
“Stress paradigms in adult animals produce similar changes in the microflora and reliably increase various measures of inflammation in the gut, as well as increased translocation of potentially pathogenic bacteria across the gut wall.(188,189) Interestingly, these changes are mediated in part by reduced vagal parasympa…”
The Extant Works of Aretæus the Cappadocian.
(1857) · Europe PMC (PubMed Central) · Cited by 133
The hygiene hypothesis and the increasing prevalence of chronic inflammatory disorders
Rook, G. A. W. (2007) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2007.05.014 · Cited by 126
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Metadata
- Authors
- Raison, C. L., Lowry, C. A., & Rook, G. A. W.
- Affiliations
- Emory University (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-12-06
- Volume
- 67
- Issue
- 12
- Pages
- 1211
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC3724429
- OpenAlex
- W2077672919
- Cited by
- 169
- References
- 259
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 13 · 2020: 13 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 18 · 2015: 13 · 2014: 15 · 2013: 20 · 2012: 20
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Science Foundation (0845550, 0921969)
- Bill and Melinda Gates Foundation
- Eli Lilly and Company
- European Commission
- Silence Therapeutics
- National Institutes of Health (UL1TR000454, RR025008)
- Centers for Disease Control and Prevention
- National Institute of Mental Health (R21 MH0771172, R01MH070553, R01MH086539, R01MH065702)
- National Center for Research Resources (UL1RR025008, M01RR000039, M01-RR-0039)
- National Center for Advancing Translational Sciences
- National Center for Complementary and Integrative Health (R01AT004698, RC1AT005728)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- major depressive disorder, inflammation, hygiene hypothesis, old friends, microbial exposure, psychosocial stress, cytokines, autoimmune disease, inflammatory bowel disease, asthma, industrial society
- MeSH terms
- Animals, Anti-Inflammatory Agents, Major Depressive Disorder, Environmental Microbiology, Humans, Inflammation, Organic Chemicals, Sanitation, Social Environment, Stress, Psychological, Cytokines
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