Molecular Engineering of an Organic NIR‐II Fluorophore with Aggregation‐Induced Emission Characteristics for In Vivo Imaging

Wu, Wei; Yang, Yanqing; Yang, Yang; Yang, Yuming; Zhang, Kaiyuan; Guo, Li; Ge, Hongfei; Chen, Xiaowei; Liu, Jie; Feng, Hua

doi:10.1002/smll.201805549

Cited by 122Luminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionLuminescence Properties of Advanced Materials

Molecular Engineering of an Organic NIR‐II Fluorophore with Aggregation‐Induced Emission Characteristics for In Vivo Imaging

Wu, Wei, Yang, Yanqing, Yang, Yang, Yang, Yuming, Zhang, Kaiyuan, Guo, Li, Ge, Hongfei, Chen, Xiaowei +2 more·2019·Small

DOI 10.1002/smll.201805549

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Abstract

Design and synthesis of new fluorophores with emission in the second near‐infrared window (NIR‐II, 1000–1700 nm) have fueled the advancement of in vivo fluorescence imaging. Organic NIR‐II probes particularly attract tremendous attention due to excellent stability and biocompatibility, which facilitate clinical translation. However, reported organic NIR‐II fluorescent agents often suffer from low quantum yield and complicated design. In this study, the acceptor unit of a known NIR‐I aggregation‐induced emission (AIE) luminogen (AIEgen) is molecularly engineered by varying a single atom from sulfur to selenium, leading to redshifted absorption and emission spectra. After formulation of the newly prepared AIEgen, the resultant AIE nanoparticles (referred as L897 NPs) have an emission tail extending to 1200 nm with a high quantum yield of 5.8%. Based on the L897 NPs, noninvasive vessel imaging and lymphatic imaging are achieved with high signal‐to‐background ratio and deep penetration. Furthermore, the L897 NPs can be used as good contrast agents for tumor imaging and image‐guided surgery due to the high tumor/normal tissue ratio, which peaks at 9.0 ± 0.6. This work suggests a simple strategy for designing and manufacturing NIR‐II AIEgens and demonstrates the potential of NIR‐II AIEgens in vessel, lymphatic, and tumor imaging.

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Authors: Wu, W., Yang, Y., Yang, Y., Yang, Y., Zhang, K., Guo, L., Ge, H., Chen, X., Liu, J., & Feng, H.
Affiliations: Army Medical University (CN)
Nanjing Tech University (CN)
Corresponding author: Chen, Xiaowei
Liu, Jie
Feng, Hua
ORCID: Yang, Yanqing
Yang, Yuming
Zhang, Kaiyuan
Guo, Li
Ge, Hongfei
Chen, Xiaowei
Liu, Jie
Feng, Hua
Venue: Small
Publisher: Wiley
Published: 2019-03-29
Volume: 15
Issue: 20
Pages: e1805549-e1805549
ISSN: 1613-6810 (ISSN-L)
1613-6829
DOI: 10.1002/smll.201805549
OpenAlex: W2935041328
Cited by: 122
References: 54
Citations by year: 2026: 6 · 2025: 9 · 2024: 15 · 2023: 18 · 2022: 17 · 2021: 31 · 2020: 19 · 2019: 7
FWCI: 6.68
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Small (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (21402219, 81700880)
Nanjing Tech University (38274017115)
China Postdoctoral Science Foundation (2018M643859)
Southwest Hospital (SWH2016ZDCX1011)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
Keywords: NIR-II fluorescence, aggregation-induced emission, organic fluorophores, selenium substitution, AIEgens, in vivo imaging, vascular imaging, lymphatic imaging, tumor imaging, image-guided surgery, contrast media, quantum yield
MeSH terms: Animals, Biocompatible Materials, Brain, Cell Line, Fluorescent Dyes, Hindlimb, Humans, Infrared Rays, Mice, Inbred C57BL, Mice, Nude, Neoplasms, Organic Chemicals, Thiadiazoles, Tissue Distribution, Nanoparticles, Optical Imaging

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Molecular Engineering of an Organic NIR‐II Fluorophore with Aggregation‐Induced Emission Characteristics for In Vivo Imaging

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