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FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task
Abstract
Comparative studies have implicated striatal and mesial forebrain circuitry in the generation of autonomic, endocrine, and behavioral responses for incentives. Using blood oxygen level-dependent functional magnetic resonance imaging, we sought to visualize functional activation of these regions in 12 normal volunteers as they anticipated and responded for monetary incentives. Both individual and group analyses of time-series data revealed significant activation of striatal and mesial forebrain structures (including insula, caudate, putamen, and mesial prefrontal cortex) during trials involving both monetary rewards and punishments. In addition to these areas, during trials involving punishment, group analysis revealed activation foci in the anterior cingulate and thalamus. These results corroborate comparative studies which implicate striatal and mesial forebrain circuitry in the elaboration of incentive-driven behavior. This report also introduces a new paradigm for probing the functional integrity of this circuitry in humans.
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“Both tasks have two phases, an anticipation phase, in which the subject is given information about the potential for reward, and a delivery phase, in which the reward is received. By measuring brain activity during the anticipation and delivery phases, a motivational component and a reward responsiveness component can be inferred, respectively (Knutson et al., 2000; Lutz and Widmer, 2014; Wang et”
From The effects of early life stress on reward processing (2018) · cites this paper as Knutson et al., 2000
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“The VS plays a role in affective reactivity (Knutson, Westdorp, Kaiser, & Hommer, 2000; Sescousse, Caldu, Segura, & Dreher, 2013; Jensen et al., 2003; Levita et al., 2009)”
From Feeling left out or just surprised? Neural correlates of social exclusion and overinclusion in adolescence (2020) · cites this paper as Knutson, Westdorp, Kaiser, & Hommer, 2000
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“This region is known for processing both rewarding (Knutson et al., 2000; Sescousse et al., 2013) and aversive stimuli (Jensen et al., 2003; Levita et al., 2009), and increases in VS responses to social stimuli have been associated with reduced susceptibility to peer influences (Pfeifer et al., 2011).”
From Feeling left out or just surprised? Neural correlates of social exclusion and overinclusion in adolescence (2020) · cites this paper as Knutson et al., 2000
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Metadata
- Authors
- Knutson, B., Westdorp, A., Kaiser, E., & Hommer, D.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Knutson, Brian
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 12
- Issue
- 1
- Pages
- 20-27
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1967922673
- Cited by
- 1,414
- References
- 36
- Citations by year
- 2026: 65 · 2025: 62 · 2024: 68 · 2023: 103 · 2022: 101 · 2021: 82 · 2020: 85 · 2019: 86 · 2018: 71 · 2017: 68 · 2016: 64 · 2015: 56 · 2014: 67 · 2013: 55 · 2012: 59
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- monetary incentive delay task, incentive processing, striatum, insula, caudate nucleus, putamen, anterior cingulate cortex, thalamus, reward, punishment, brain activation
- MeSH terms
- Adult, Brain, Brain Mapping, Cerebrovascular Circulation, Corpus Striatum, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Oxygen, Photic Stimulation, Punishment, Reaction Time, Reward, Thalamus, Prosencephalon
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