An estimate of the worldwide prevalence and disability associated with osteoporotic fractures

Epidemiology and outcomes of osteoporotic fractures

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Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

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European guidance for the diagnosis and management of osteoporosis in postmenopausal women

on behalf of the Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF), Kanis, J. A., Cooper, C., Rizzoli, R., & Reginster, J.-Y. (2019) · Osteoporosis International · doi:10.1007/s00198-018-4704-5 · Cited by 1,900

Mechanisms of diabetes mellitus-induced bone fragility

On behalf of the IOF Bone and Diabetes Working Group, Napoli, N., Chandran, M., Pierroz, D. D., Abrahamsen, B., Schwartz, A. V., & Ferrari, S. L. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.153 · Cited by 1,107

Excess mortality following hip fracture: a systematic epidemiological review

Abrahamsen, B., van Staa, T., Ariely, R., Olson, M., & Cooper, C. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0920-3 · Cited by 1,079

Interaction between bone and immune cells: Implications for postmenopausal osteoporosis

Fischer, V., & Haffner-Luntzer, M. (2022) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2021.05.014 · Cited by 759

Traumatic spinal injury: global epidemiology and worldwide volume

Kumar, R., Lim, J., Mekary, R. A., Rattani, A., Dewan, M. C., Sharif, S. Y., Osorio-Fonseca, E., & Park, K. B. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.02.033 · Cited by 657

Osteoporosis in Men: An Endocrine Society Clinical Practice Guideline

Watts, N. B., Adler, R. A., Bilezikian, J. P., Drake, M. T., Eastell, R., Orwoll, E. S., & Finkelstein, J. S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3045 · Cited by 611

Surgical vs Nonsurgical Treatment of Adults With Displaced Fractures of the Proximal Humerus: The PROFHER Randomized Clinical Trial

Rangan, A., Handoll, H., Brealey, S., Jefferson, L., Keding, A., Martin, B. C., Goodchild, L., Chuang, L.-H., Hewitt, C., & Torgerson, D. (2015) · JAMA · doi:10.1001/jama.2015.1629 · Cited by 556

Epidemiology of fracture risk with advancing age

Ensrud, K. E. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt092 · Cited by 456

Fracture risk and zoledronic acid therapy in men with osteoporosis

Boonen, S., Reginster, J.-Y., Kaufman, J.-M., Lippuner, K., Zanchetta, J., Langdahl, B., Rizzoli, R., Lipschitz, S., Dimai, H. P., Witvrouw, R., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1204061 · Cited by 359

Parathyroid hormone 1–84 accelerates fracture-healing in pubic bones of elderly osteoporotic women

Peichl, P., Holzer, L. A., Maier, R., & Holzer, G. (2011) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.j.01379 · Cited by 352

Sex Steroid Actions in Male Bone

Vanderschueren, D., Laurent, M. R., Claessens, F., Gielen, E., Lagerquist, M. K., Vandenput, L., Börjesson, A. E., & Ohlsson, C. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1024 · Cited by 327

Cellular senescence in bone

Farr, J. N., & Khosla, S. (2019) · Bone · doi:10.1016/j.bone.2019.01.015 · Cited by 263

Crucial Role of Vitamin D in the Musculoskeletal System

Wintermeyer, E., Ihle, C., Ehnert, S., Stöckle, U., Ochs, G., De Zwart, P., Flesch, I., Bahrs, C., & Nussler, A. (2016) · Nutrients · doi:10.3390/nu8060319 · Cited by 216

Pathophysiology and treatment of osteoporosis: Challenges for clinical practice in older people

Barnsley, J., Buckland, G., Chan, P. E., Ong, A., Ramos, A. S., Baxter, M., Laskou, F., Dennison, E. M., Cooper, C., & Patel, H. P. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01817-y · Cited by 199

Subclinical thyroid dysfunction and mortality: an estimate of relative and absolute excess all-cause mortality based on time-to-event data from cohort studies

Haentjens, P., Van Meerhaeghe, A., Poppe, K., & Velkeniers, B. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0110 · Cited by 174

The effects of whole body vibration therapy on bone mineral density and leg muscle strength in older adults: a systematic review and meta-analysis

Lau, R. W., Liao, L.-R., Yu, F., Teo, T., Chung, R. C., & Pang, M. Y. (2011) · Clinical Rehabilitation · doi:10.1177/0269215511405078 · Cited by 163

Utility of the trabecular bone score (TBS) in secondary osteoporosis

Ulivieri, F. M., Silva, B. C., Sardanelli, F., Hans, D., Bilezikian, J. P., & Caudarella, R. (2014) · Endocrine · doi:10.1007/s12020-014-0280-4 · Cited by 161

MRI assessment of bone structure and microarchitecture

Chang, G., Boone, S., Martel, D., Rajapakse, C. S., Hallyburton, R. S., Valko, M., Honig, S., & Regatte, R. R. (2017) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25647 · Cited by 151

High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly

Wassenaar, M. J. E., Biermasz, N. R., Hamdy, N. A. T., Zillikens, M. C., van Meurs, J. B. J., Rivadeneira, F., Hofman, A., Uitterlinden, A. G., Stokkel, M. P. M., Roelfsema, F., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-1005 · Cited by 144

The Association of Gut Microbiota With Osteoporosis Is Mediated by Amino Acid Metabolism: Multiomics in a Large Cohort

Ling, C.-W., Miao, Z., Xiao, M.-L., Zhou, H., Jiang, Z., Fu, Y., Xiong, F., Zuo, L.-S.-Y., Liu, Y.-P., Wu, Y.-Y., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab492 · Cited by 138

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

Khosla, S., Farr, J. N., & Kirkland, J. L. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02694 · Cited by 130

The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity

Ali, D., Tencerova, M., Figeac, F., Kassem, M., & Jafari, A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.981487 · Cited by 122

Automatic opportunistic osteoporosis screening in routine CT: improved prediction of patients with prevalent vertebral fractures compared to DXA

Löffler, M. T., Jacob, A., Scharr, A., Sollmann, N., Burian, E., El Husseini, M., Sekuboyina, A., Tetteh, G., Zimmer, C., Gempt, J., et al. (2021) · European Radiology · doi:10.1007/s00330-020-07655-2 · Cited by 120

Salpingo-oophorectomy at the Time of Benign Hysterectomy: A Systematic Review

Evans, E. C., Matteson, K. A., Orejuela, F. J., Alperin, M., Balk, E. M., El-Nashar, S., Gleason, J. L., Grimes, C., Jeppson, P., Mathews, C., et al. (2016) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000001592 · Cited by 116

X-ray-based quantitative osteoporosis imaging at the spine

Löffler, M. T., Sollmann, N., Mei, K., Valentinitsch, A., Noël, P. B., Kirschke, J. S., & Baum, T. (2020) · Osteoporosis International · doi:10.1007/s00198-019-05212-2 · Cited by 114

Therapies for Musculoskeletal Disease: Can we Treat Two Birds with One Stone?

Girgis, C. M., Mokbel, N., & DiGirolamo, D. J. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0204-5 · Cited by 110

Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial

Emaus, N., Gjesdal, C. G., Almås, B., Christensen, M., Grimsgaard, A. S., Berntsen, G. K. R., Salomonsen, L., & Fønnebø, V. (2010) · Osteoporosis International · doi:10.1007/s00198-009-1126-4 · Cited by 102

Bone Remodeling and the Microbiome

Pacifici, R. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031203 · Cited by 101

Microarchitecture Influences Microdamage Accumulation in Human Vertebral Trabecular Bone

Arlot, M. E., Burt-Pichat, B., Roux, J.-P., Vashishth, D., Bouxsein, M. L., & Delmas, P. D. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080517 · Cited by 89

Depression and risk of fracture and bone loss: an updated meta-analysis of prospective studies

Wu, Q., Liu, B., & Tonmoy, S. (2018) · Osteoporosis International · doi:10.1007/s00198-018-4420-1 · Cited by 87

Early Surgery Confers 1-Year Mortality Benefit in Hip-Fracture Patients

Maheshwari, K., Planchard, J., You, J., Sakr, W. A., George, J., Higuera-Rueda, C. A., Saager, L., Turan, A., & Kurz, A. (2018) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000001043 · Cited by 84

Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

Bassett, J. H. D., Gogakos, A., White, J. K., Evans, H., Jacques, R. M., van der Spek, A. H., Sanger Mouse Genetics Project, Ramirez-Solis, R., Ryder, E., Sunter, D., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002858 · Cited by 82

The relationship between vitamin A and risk of fracture: Meta-analysis of prospective studies

Wu, A.-M., Huang, C.-Q., Lin, Z.-K., Tian, N.-F., Ni, W.-F., Wang, X.-Y., Xu, H.-Z., & Chi, Y.-L. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2237 · Cited by 72

Osteoprotective effect of extract from Achyranthes bidentata in ovariectomized rats

He, C.-C., Hui, R.-R., Tezuka, Y., Kadota, S., & Li, J.-X. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.11.016 · Cited by 67

Potential mechanisms linking psychological stress to bone health

Ng, J.-S., & Chin, K.-Y. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.50680 · Cited by 66

Bone densitometry worldwide: a global survey by the ISCD and IOF

on behalf of the International Society for Clinical Densitometry (ISCD) and the International Osteoporosis Foundation (IOF), Clynes, M. A., Westbury, L. D., Dennison, E. M., Kanis, J. A., Javaid, M. K., Harvey, N. C., Fujita, M., Cooper, C., Leslie, W. D., et al. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05435-8 · Cited by 64

Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism

Behera, J., Kelly, K. E., Voor, M. J., Metreveli, N., Tyagi, S. C., & Tyagi, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-33149-9 · Cited by 59

Hypogonadism and low bone mineral density in patients on long-term intrathecal opioid delivery therapy

Duarte, R. V., Raphael, J. H., Southall, J. L., Labib, M. H., Whallett, A. J., & Ashford, R. L. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002856 · Cited by 55

Areal and volumetric bone mineral density and risk of multiple types of fracture in older men

Chalhoub, D., Orwoll, E. S., Cawthon, P. M., Ensrud, K. E., Boudreau, R., Greenspan, S., Newman, A. B., Zmuda, J., Bauer, D., Cummings, S., et al. (2016) · Bone · doi:10.1016/j.bone.2016.08.014 · Cited by 54

Fracture Risk Assessment: State of the Art, Methodologically Unsound, or Poorly Reported?

Collins, G. S., & Michaëlsson, K. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0108-1 · Cited by 51

FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends

Melčová, V., Svoradová, K., Menčík, P., Kontárová, S., Rampichová, M., Hedvičáková, V., Sovková, V., Přikryl, R., & Vojtová, L. (2020) · Polymers · doi:10.3390/polym12122806 · Cited by 50

Estrogen deficiency and its effect on the jaw bones

Ejiri, S., Tanaka, M., Watanabe, N., Anwar, R. B., Yamashita, E., Yamada, K., & Ikegame, M. (2008) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-008-0870-4 · Cited by 49

Dietary patterns and bone mineral density in Brazilian postmenopausal women with osteoporosis: a cross-sectional study

de França, N. A. G., Camargo, M. B. R., Lazaretti-Castro, M., Peters, B. S. E., & Martini, L. A. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.27 · Cited by 49

Chronic myeloproliferative neoplasms and risk of osteoporotic fractures; a nationwide population‐based cohort study

Farmer, S., Horváth‐Puhó, E., Vestergaard, H., Hermann, A. P., & Frederiksen, H. (2013) · British Journal of Haematology · doi:10.1111/bjh.12581 · Cited by 45

The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model

Hambright, W. S., Mu, X., Gao, X., Guo, P., Kawakami, Y., Mitchell, J., Mullen, M., Nelson, A.-L., Bahney, C., Nishimura, H., et al. (2023) · Journal of Osteoporosis · doi:10.1155/2023/5572754 · Cited by 44

Does coffee drinking have beneficial effects on bone health of Taiwanese adults? A longitudinal study

Chang, H.-C., Hsieh, C.-F., Lin, Y.-C., Tantoh, D. M., Ko, P.-C., Kung, Y.-Y., Wang, M.-C., Hsu, S.-Y., Liaw, Y.-C., & Liaw, Y.-P. (2018) · BMC Public Health · doi:10.1186/s12889-018-6168-0 · Cited by 39

Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study

Veronese, N., Stubbs, B., Koyanagi, A., Hébert, J. R., Cooper, C., Caruso, M. G., Guglielmi, G., Reginster, J. Y., Rizzoli, R., Maggi, S., et al. (2018) · Osteoporosis International · doi:10.1007/s00198-017-4251-5 · Cited by 36

Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration

Deng, L., Liu, Y., Wu, Q., Lai, S., Yang, Q., Mu, Y., & Dong, M. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04024-4 · Cited by 32

Selective Serotonin Reuptake Inhibitors (SSRIs) and Markers of Bone Turnover in Men

Williams, L. J., Berk, M., Hodge, J. M., Kotowicz, M. A., Stuart, A. L., Chandrasekaran, V., Cleminson, J., & Pasco, J. A. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0398-0 · Cited by 30

Depression as a risk factor for fracture in women: A 10 year longitudinal study

Williams, L. J., Pasco, J. A., Jackson, H., Kiropoulos, L., Stuart, A. L., Jacka, F. N., & Berk, M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.048 · Cited by 29

Hepatitis C virus infection and risk of osteoporosis: a meta-analysis

Wijarnpreecha, K., Thongprayoon, C., Panjawatanan, P., Phatharacharukul, P., & Ungprasert, P. (2017) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_452_16 · Cited by 29

Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone

Wang, Y.-J., Zhan, J.-K., Huang, W., Wang, Y., Liu, Y., Wang, S., Tan, P., Tang, Z.-Y., & Liu, Y.-S. (2013) · International Journal of Endocrinology · doi:10.1155/2013/570413 · Cited by 29

Understanding osteoporosis

Javaid, M. K., & Holt, R. I. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107087955 · Cited by 28

Association of osteoporotic fracture with smoking, alcohol consumption, tea consumption and exercise among Chinese nonagenarians/centenarians

Du, F., Qiukui, H., Birong, D., Changquan, H., Hongmei, W., Yanling, Z., Wen, Z., & Li, L. (2011) · The Journal of nutrition, health and aging · doi:10.1007/s12603-010-0270-z · Cited by 26

Effectiveness of Spironolactone in Reducing Osteoporosis and Future Fracture Risk in Middle-Aged and Elderly Hypertensive Patients

Song, S., Cai, X., Hu, J., Zhu, Q., Shen, D., Ma, H., Zhang, Y., Ma, R., Yang, W., Hong, J., et al. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s466904 · Cited by 25

Muscle mass, muscle morphology and bone health among community-dwelling older men: Findings from the Hertfordshire Sarcopenia Study (HSS)

Patel, H. P., Dawson, A., Westbury, L. D., Hasnaoui, G., Syddall, H. E., Shaw, S., Sayer, A. A., Cooper, C., & Dennison, E. M. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0388-2 · Cited by 24

Osteoporosis Imaging in the Geriatric Patient

Heilmeier, U., Youm, J., Torabi, S., & Link, T. M. (2016) · Current Radiology Reports · doi:10.1007/s40134-016-0144-1 · Cited by 21

Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts

Tanaka, K., Kondo, H., Hamamura, K., & Togari, A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.069 · Cited by 21

Kyphoplasty increases vertebral height, decreases both pain score and opiate requirements while improving functional status

Tolba, R., Bolash, R. B., Shroll, J., Costandi, S., Dalton, J. E., Sanghvi, C., & Mekhail, N. (2014) · Pain Practice · doi:10.1111/papr.12131 · Cited by 21

Assessment of Bone Mineral Density From a Computed Tomography Topogram of Photon-Counting Detector Computed Tomography—Effect of Phantom Size and Tube Voltage

Euler, A., Nowak, T., Bucher, B., Eberhard, M., Schmidt, B., Flohr, T. G., Frey, D., Distler, O., & Alkadhi, H. (2021) · Investigative Radiology · doi:10.1097/rli.0000000000000781 · Cited by 19

Trends in opioid use following balloon kyphoplasty or vertebroplasty for the treatment of vertebral compression fractures

Ni, W., Ricker, C., Quinn, M., Gasquet, N., Janardhanan, D., Gilligan, C. J., & Hirsch, J. A. (2022) · Osteoporosis International · doi:10.1007/s00198-021-06163-3 · Cited by 10

The Impact of Age and Body Composition on Bone Density among Office Worker Women in Hungary

Vári, B., Győri, F., Katona, Z., & Berki, T. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20115976 · Cited by 9

The association between osteocalcin and C-reactive protein; A relation of bone with inflammation: A systematic review and meta-analysis

Fatahi, S., Ghaedi, E., Mousavi, S. M., Bawadi, H., Rahmani, J., Pezeshki, M., & Varkaneh, H. K. (2019) · Hormone and Metabolic Research · doi:10.1055/a-0897-844 · Cited by 6

The Ambivalent Role of miRNA-21 in Trauma and Acute Organ Injury

Ritter, A., Han, J., Bianconi, S., Henrich, D., Marzi, I., Leppik, L., & Weber, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011282 · Cited by 6