Cited by 322Tryptophan and brain disordersTreatment of Major DepressionAntioxidant Activity and Oxidative Stress

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Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment

Herken, Hasan, Gurel, Ahmet, Selek, Salih, Armutcu, Ferah, Ozen, Murat Eren, Bulut, Mahmut, Kap, Ozlem, Yumru, Mehmet, Savas, Haluk Asuman, Akyol, Omer·2007·Archives of Medical Research

DOI 10.1016/j.arcmed.2006.10.005

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Abstract

Background There has been much evidence in recent years that free oxygen radicals and nitric oxide (NO) may play an important role in the pathophysiology of neuropsychiatric disorders. In this study, we aimed to investigate whether NO, xanthine oxidase (XO), superoxide dismutase (SOD), and adenosine deaminase (ADA) levels are associated with major depression (MD) and to evaluate the impact of antidepressant treatments on NO, SOD, ADA and XO levels in MD.Methods Thirty-six patients who were diagnosed as MD according to DSM-IV criteria and 20 healthy controls were included. The serum levels of NO, XO, SOD, and ADA were measured by spectrophotometric methods both in patients and controls. Patients were treated with antidepressant drugs for 8 weeks. All patients were assessed by Hamilton Depression Rating Scale (HDRS) both before and after antidepressant treatment.Results ADA and XO levels of the patients were significantly higher than the controls. SOD level of the patients was significantly lower than the controls. Although NO levels of the patients were higher than the controls, the difference was not statistically significant. There was no correlation between HDRS and the parameters studied (SOD, ADA, XO, and NO) of the patients. After 8 weeks of antidepressant treatment, ADA and SOD activities were increased, whereas NO and, XO levels decreased significantly.Conclusions ADA, XO, and SOD activity may have a pathophysiological role in MD and may predict prognosis of MD. Activity of these enzymes may be used to monitor effects of the antidepressant treatment.

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2022) · doi:10.1176/appi.books.9780890425787 · Cited by 23,476
Methods of Enzymatic Analysis
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078
Methods of Enzymatic Analysis
(1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091304-6.x5001-0 · Cited by 6,786
A simple method for clinical assay of superoxide dismutase.
Sun, Y., Oberley, L. W., & Li, Y. (1988) · Clinical Chemistry · doi:10.1093/clinchem/34.3.497 · Cited by 4,537
Untitled work
Wilamowska (2010) · doi:10.1001/archpsyc.1988.01800320058007 · Cited by 2,115
Lipid peroxidation and antioxidants as biomarkers of tissue damage
Gutteridge, J. M. C. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.12.1819 · Cited by 1,849
Harper's Biochemistry
Murray, R. K. (1998) · Medical Entomology and Zoology · Cited by 905
Determination of Inorganic Nitrate in Serum and Urine by a Kinetic Cadmium-Reduction Method
Cortas, N. K., & Wakid, N. W. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.8.1440 · Cited by 894
Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718

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Gutteridge, 1995, Lipid peroxidation and antioxidants as biomarkers of tissue damage, Clin Chem, 41, 1819, 10.1093/clinchem/41.12.1819 · DOI

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Maes, M. H. J., Kubera, M., Mihaylova, I., Geffard, M., Gałecki, P., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.039 · Cited by 87
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Kupper, N., Gidron, Y., Winter, J., & Denollet, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181bee6dc · Cited by 85
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Posser, T., Kaster, M. P., Baraúna, S. C., Rocha, J. B. T., Rodrigues, A. L. S., & Leal, R. B. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.055 · Cited by 86
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Camkurt, M. A., Fındıklı, E., İzci, F., Kurutaş, E. B., & Tuman, T. C. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.01.075 · Cited by 86
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Arora, V. K., & Chopra, K. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.08.032 · Cited by 85
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Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways
Anderson, G., Maes, M. H. J., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.016 · Cited by 86
Emerging Role of Flavonoids as the Treatment of Depression
Pannu, A. S., Sharma, P. C., Thakur, V. K., & Goyal, R. K. (2021) · Biomolecules · doi:10.3390/biom11121825 · Cited by 89
Music prevents stress-induced depression and anxiety-like behavior in mice
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Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder
Tsai, M.-C., & Huang, T. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.12.005 · Cited by 81
The NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium
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Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges
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Moonlighting Adenosine Deaminase: A Target Protein for Drug Development
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An intricate relationship between pain and depression: clinical correlates, coactivation factors and therapeutic targets
Chopra, K., & Arora, V. K. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.855720 · Cited by 77
Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention
Rossetti, A. C., Paladini, M. S., Riva, M. A., & Molteni, R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107520 · Cited by 73
Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study
Kuwano, N., Kato, T. A., Setoyama, D., Sato-Kasai, M., Shimokawa, N., Hayakawa, K., Ohgidani, M., Sagata, N., Kubo, H., Kishimoto, J., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.01.014 · Cited by 69
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Amadio, P., Zarà, M., Sandrini, L., Ieraci, A., & Barbieri, S. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207560 · Cited by 75
Elevated level of nitric oxide mediates the anti-depressant effect of rubidium chloride in mice
Kordjazy, N., Haj‐Mirzaian, A., Amiri, S., Ostadhadi, S., Kordjazy, M., Sharifzadeh, M. S., & Dehpour, A. R. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.06.030 · Cited by 70
Ferulic acid chronic treatment exerts antidepressant-like effect: role of antioxidant defense system
Lenzi, J., Rodrigues, A. F., Rós, A. D. S., de Castro, B. B., de Lima, D. D., Magro, D. D. D., & Zeni, A. L. B. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9725-6 · Cited by 68
Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review
Cecerska-Heryć, E., Polikowska, A., Serwin, N., Roszak, M., Grygorcewicz, B., Heryć, R., Michalczyk, A., & Dołęgowska, B. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2021.105269 · Cited by 68
α-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression
Lobato, K. R., Cardoso, C. C., Binfaré, R. W., Budni, J., Wagner, C. L. R., Brocardo, P. S., de Souza, L. F., Brocardo, C., Flesch, S., Freitas, A. E., et al. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.002 · Cited by 67
Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice
Dhingra, D., & Chhillar, R. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70875-7 · Cited by 66
DNA Damage in Major Psychiatric Diseases
Raza, M. U., Tufan, T., Wang, Y., Hill, C. P., & Zhu, M. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9621-9 · Cited by 70
2D-DIGE proteome analysis on the platelet proteins of patients with major depression
Huang, T., Sung, M.-L., & Chen, T. (2014) · Proteome Science · doi:10.1186/1477-5956-12-1 · Cited by 66
Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis
Li, X., Wu, T., Yu, Z., Li, T., Zhang, J., Zhang, Z., Cai, M., Zhang, W., Xiang, J. Y., & Cai, D. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.137 · Cited by 65
Vitamin E for the management of major depressive disorder: possible role of the anti-inflammatory and antioxidant systems
Manosso, L. M., Camargo, A., Dafré, A. L., & Rodrigues, A. L. S. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1853417 · Cited by 64

Authors: Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O.
Affiliations: Pamukkale University (TR)
Gaziantep University (TR)
ORCID: Selek, Salih
Bulut, Mahmut
Yumru, Mehmet
Venue: Archives of Medical Research
Publisher: Elsevier BV
Published: 2007-02
Volume: 38
Issue: 2
Pages: 247-252
ISSN: 0066-6769 (ISSN-L)
0188-4409
DOI: 10.1016/j.arcmed.2006.10.005
OpenAlex: W2069692485
Cited by: 322
References: 39
Citations by year: 2026: 8 · 2025: 12 · 2024: 11 · 2023: 17 · 2022: 22 · 2021: 18 · 2020: 23 · 2019: 15 · 2018: 17 · 2017: 17 · 2016: 21 · 2015: 23 · 2014: 25 · 2013: 23 · 2012: 21
FWCI: 4.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Archives of Medical Research (publishedVersion)
PubMed (publishedVersion)
Zonguldak Bülent Ecevit University Institutional Repository (submittedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: major depressive disorder, adenosine deaminase, nitric oxide, superoxide dismutase, xanthine oxidase, antidepressant treatment, oxidative stress, oxygen free radicals, depression pathophysiology, treatment response monitoring
MeSH terms: Adenosine Deaminase, Adolescent, Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Nitric Oxide, Prognosis, Superoxide Dismutase, Xanthine Oxidase

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Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment

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