The DOI matches its Crossref record; 171 of the 173 references it cites were found in a registry or an index.
Microalgae for high-value compounds and biofuels production: A review with focus on cultivation under stress conditions
Abstract
Microalgal biomass as feedstock for biofuel production is an attracting alternative to terrestrial plant utilization for biofuels production. However, today the microalgal cultivation systems for energy production purposes seem not yet to be economically feasible. Microalgae, though cultivated under stress conditions, such as nutrient starvation, high salinity, high temperature etc. accumulate considerable amounts (up to 60-65% of dry weight) of lipids or carbohydrates along with several secondary metabolites. Especially some of the latter are valuable compounds with an enormous range of industrial applications. The simultaneous production of lipids or carbohydrates for biofuel production and of secondary metabolites in a biorefinery concept might allow the microalgal production to be economically feasible. This paper aims to provide a review on the available literature about the cultivation of microalgae for the accumulation of high-value compounds along with lipids or carbohydrates focusing on stress cultivation conditions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“carotenoids (β-Carotene) derived from Chlorella sp. are sold at USD 300–700 per kg in the open market [46].”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [46]
Citations
Cites
Commercial Applications of Microalgae
Spolaore, P., Joannis-Cassan, C., Duran, E., & Isambert, A. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.101.87 · Cited by 4,285
Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
Hu, Q., Sommerfeld, M., Jarvis, E., Ghirardi, M., Posewitz, M., Seibert, M., & Darzins, A. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03492.x · Cited by 3,745
Rodolfi, L., Chini Zittelli, G., Bassi, N., Padovani, G., Biondi, N., Bonini, G., & Tredici, M. R. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22033 · Cited by 2,879
Techniques for extraction of bioactive compounds from plant materials: A review
Azmir, J., Zaidul, I. S. M., Rahman, M. M., Sharif, K. M., Mohamed, A., Sahena, F., Jahurul, M. H. A., Ghafoor, K., Norulaini, N. A. N., & Omar, A. K. M. (2013) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2013.01.014 · Cited by 2,870
Micro-algae as a source of protein
Becker, E. W. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2006.11.002 · Cited by 2,311
Valuable Products from Biotechnology of Microalgae
Pulz, O., & Gross, W. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1647-x · Cited by 2,132
Heterotrophic cultures of microalgae: Metabolism and potential products
Perez‐Garcia, O., Escalante, F. M. E., de‐Bashan, L. E., & Yoav Bashan, A. (2010) · Water Research · doi:10.1016/j.watres.2010.08.037 · Cited by 1,820
From Glycerol to Value‐Added Products
Pagliaro, M., Ciriminna, R., Kimura, H., Rossi, M., & Pina, C. D. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604694 · Cited by 1,653
High-value products from microalgae—their development and commercialisation
Borowitzka, M. A. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9983-9 · Cited by 1,585
Cyanobacteria secondary metabolites—the cyanotoxins
Carmichael, W. W. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb01858.x · Cited by 1,457
Frank, H. A., & Cogdell, R. J. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb03022.x · Cited by 1,201
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190
Environmental Life Cycle Comparison of Algae to Other Bioenergy Feedstocks
Clarens, A. F., Resurreccion, E. P., White, M. A., & Colosi, L. M. (2010) · Environmental Science & Technology · doi:10.1021/es902838n · Cited by 1,118
Extraction of oil from microalgae for biodiesel production: A review
Halim, R., Danquah, M. K., & Webley, P. A. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.01.001 · Cited by 1,043
Metabolites from algae with economical impact
Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. D. R., Tonon, Â. P., Lopes, N. P., Campos, S. C. G., Torres, M. A., Souza, A. D. O., Colepicolo, P., et al. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.05.007 · Cited by 960
Handbook of microalgal culture: biotechnology and applied phycology.
RICHMOND, A. E. (2004) · Cited by 864
Carotenoids in Algae: Distributions, Biosyntheses and Functions
Takaichi, S. (2011) · Marine Drugs · doi:10.3390/md9061101 · Cited by 839
Microalgal production — A close look at the economics
Norsker, N.-H., Barbosa, M. J., Vermuë, M. H., & Wijffels, R. H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.08.005 · Cited by 819
Outdoor cultivation of microalgae for carotenoid production: Current state and perspectives
Del Campo, J. A., García-González, M., & Guerrero, M. G. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0844-9 · Cited by 739
Constraints to Commercialization of Algal Fuels
Chisti, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.07.020 · Cited by 719
Production of phycocyanin—a pigment with applications in biology, biotechnology, foods and medicine
Eriksen, N. T. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1542-y · Cited by 714
Bioethanol production using carbohydrate-rich microalgae biomass as feedstock
Ho, S.-H., Huang, S.-W., Chen, C.-Y., Hasunuma, T., Kondo, A., & Chang, J.-S. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.015 · Cited by 683
Renewable fuels from algae: An answer to debatable land based fuels
Singh, A., Nigam, P. S. N., & Murphy, J. D. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.06.032 · Cited by 661
Exocellular polysaccharides from cyanobacteria and their possible applications
Philippis, R. D., & Vincenzini, M. (1998) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1998.tb00365.x · Cited by 661
HANDBOOK OF MICROALGAL CULTURE: BIOTECHNOLOGY AND APPLIED PHYCOLOGY
Henry, E. C. (2004) · Journal of Phycology · doi:10.1111/j.1529-8817.2004.40502.x · Cited by 653
Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae
Yuan, J., Peng, J., Yin, K., & Wang, J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000414 · Cited by 649
Microalgae as sources of carotenoids
Guedes, A. C., Amaro, H. M., & Malcata, F. X. (2011) · Marine Drugs · doi:10.3390/md9040625 · Cited by 639
Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response
Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591
Phycobiliproteins as a commodity: Trends in applied research, patents and commercialization
Sekar, S., & Chandramohan, M. (2008) · Journal of Applied Phycology · doi:10.1007/s10811-007-9188-1 · Cited by 589
Markou, G., Angelidaki, I., & Georgakakis, D. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4398-0 · Cited by 549
Biorefineries: Current activities and future developments
Demirbaş, A. (2009) · Energy Conversion and Management · doi:10.1016/j.enconman.2009.06.035 · Cited by 529
Biorefinery of microalgae for food and fuel
Vanthoor-Koopmans, M., Wijffels, R. H., Barbosa, M. J., & Eppink, M. H. M. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.135 · Cited by 521
Methods of downstream processing for the production of biodiesel from microalgae
Kim, J., Yoo, G., Lee, H., Lim, J., Kim, K., Kim, C. W., Park, M. S., & Yang, J.-W. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.04.006 · Cited by 519
Astaxanthin Accumulation in the Green Alga Haematococcus pluvialis1
Boussiba, S., & Vonshak, A. (1991) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a078171 · Cited by 496
Second generation biofuels: Economics and policies
Carriquiry, M., Du, X., & Timilsina, G. R. (2011) · Energy Policy · doi:10.1016/j.enpol.2011.04.036 · Cited by 493
Microalgae—novel highly efficient starch producers
Brányiková, I., Maršálková, B., Doucha, J., Brányik, T., Bišová, K., Zachleder, V., & Vítová, M. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.23016 · Cited by 489
Mechanism and challenges in commercialisation of algal biofuels
Singh, A., Nigam, P. S., & Murphy, J. D. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2010.06.057 · Cited by 476
Phycobiliproteins — a family of valuable, widely used fluorophores
Glazer, A. N. (1994) · Journal of Applied Phycology · doi:10.1007/bf02186064 · Cited by 449
CHEMICAL PROFILE OF SELECTED SPECIES OF MICROALGAE WITH EMPHASIS ON LIPIDS1
Ben‐Amotz, A., Tornabene, T. G., & Thomas, W. H. (1985) · Journal of Phycology · doi:10.1111/j.0022-3646.1985.00072.x · Cited by 420
Biotechnological production of lutein and its applications
Fernández-Sevilla, J. M., Acién, F. G., & Grima, E. M. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2420-y · Cited by 406
Nutrient limitation as a strategy for increasing starch accumulation in microalgae
Dragone, G., Fernandes, B. D., Abreu, A. P., Vicente, A. A., & Teixeira, J. A. (2011) · Applied Energy · doi:10.1016/j.apenergy.2011.03.012 · Cited by 403
Advanced Biofuels and Bioproducts
(2013) · doi:10.1007/978-1-4614-3348-4 · Cited by 392
Secondary ketocarotenoid astaxanthin biosynthesis in algae: a multifunctional response to stress
Lemoine, Y., & Schoefs, B. (2010) · Photosynthesis Research · doi:10.1007/s11120-010-9583-3 · Cited by 384
Biotechnological and industrial significance of cyanobacterial secondary metabolites
Rastogi, R. P., & Sinha, R. P. (2009) · Biotechnology Advances · doi:10.1016/j.biotechadv.2009.04.009 · Cited by 371
Ben‐Amotz, A., & Avron, M. (1983) · PLANT PHYSIOLOGY · doi:10.1104/pp.72.3.593 · Cited by 365
Olaizola, M. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008159127672 · Cited by 359
Skjånes, K., Rebours, C., & Lindblad, P. (2013) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2012.681625 · Cited by 352
Mishra, A., & Jha, B. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.02.006 · Cited by 352
Functional properties of carotenoids originating from algae
Christaki, E., Bonos, E., Giannenas, I., & Florou‐Paneri, P. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5902 · Cited by 346
Dunaliella biotechnology: methods and applications
Hosseini Tafreshi, A., & Shariati, M. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04153.x · Cited by 343
Enigmatic Microorganisms and Life in Extreme Environments
Seckbach, J. (1999) · Springer eBooks · doi:10.1007/978-94-011-4838-2 · Cited by 337
Nobre, B. P., Villalobos, F., Barragán, B. E., Oliveira, A. C., Batista, A. P., Marques, P. A. S. S., Mendes, R. L., Sovová, H., Palavra, A. F., & Gouveia, L. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.11.084 · Cited by 333
Carpi, A. (2011) · InTech eBooks · doi:10.5772/771 · Cited by 326
Accumulation of astaxanthin and lutein in Chlorella zofingiensis (Chlorophyta)
Campo, J. A. D., Rodr�guez, H., Moreno, J., Vargas, M. A., Rivas, J., & Guerrero, M. G. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1510-5 · Cited by 324
Del Campo, J. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00178-9 · Cited by 323
Stehfest, K., Toepel, J., & Wilhelm, C. (2005) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2005.07.001 · Cited by 316
Recovery of pure B-phycoerythrin from the microalga Porphyridium cruentum
Román, R. B., Álvarez‐Pez, J. M., Acién, F. G., & Grima, E. M. (2002) · Journal of Biotechnology · doi:10.1016/s0168-1656(01)00385-6 · Cited by 314
Lipid analysis in Haematococcus pluvialis to assess its potential use as a biodiesel feedstock
Damiani, M. C., Popovich, C. A., Constenla, D., & Leonardi, P. I. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2009.12.136 · Cited by 301
Fu, W., Guðmundsson, Ó., Paglia, G., Herjólfsson, G., Andrésson, Ó. S., Palsson, B. Ø., & Brynjólfsson, S. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4502-5 · Cited by 289
Carotenoid and fatty acid metabolism in light‐stressed Dunaliella salina
Lamers, P. P., van de Laak, C. C. W., Kaasenbrood, P. S., Lorier, J., Janssen, M., de Vos, R. C. H., Bino, R. J., & Wijffels, R. H. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22725 · Cited by 288
Exopolysaccharide-producing cyanobacteria and their possible exploitation: A review
Philippis, R. D., Sili, C., Paperi, R., & Vincenzini, M. (2001) · Journal of Applied Phycology · doi:10.1023/a:1017590425924 · Cited by 280
Razón, L. F., & Tan, R. R. (2011) · Applied Energy · doi:10.1016/j.apenergy.2010.12.052 · Cited by 280
Zhekisheva, M., Boussiba, S., Khozin‐Goldberg, I., Zarka, A., & Cohen, Z. (2002) · Journal of Phycology · doi:10.1046/j.1529-8817.2002.01107.x · Cited by 267
Antioxidant activity of the polysaccharide of the red microalga Porphyridium sp
Tannin-Spitz, T., Bergman, M., van Moppes, D., Grossman, S., & Arad, S. M. (2005) · Journal of Applied Phycology · doi:10.1007/s10811-005-0679-7 · Cited by 265
Sánchez, J. F., Fernández, J. M., Acién, F. G., Rueda, A., Pérez-Parra, J., & Molina, E. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.01.004 · Cited by 264
Rabbani, S., Beyer, P., Lintig, J. V., Hugueney, P., & Kleinig, H. (1998) · PLANT PHYSIOLOGY · doi:10.1104/pp.116.4.1239 · Cited by 263
Anaerobic digestion of microalgae residues resulting from the biodiesel production process
Ehimen, E. A., Sun, Z., Carrington, C. G., Birch, E. J., & Eaton‐Rye, J. J. (2010) · Applied Energy · doi:10.1016/j.apenergy.2010.10.020 · Cited by 261
Sarada, R., Tripathi, U., & Ravishankar, G. A. (2002) · Process Biochemistry · doi:10.1016/s0032-9592(01)00246-1 · Cited by 249
Boussiba, S., Bing, W., Yuan, J.-P., Zarka, A., & Chen, F. (1999) · Biotechnology Letters · doi:10.1023/a:1005507514694 · Cited by 247
Adams, C., Godfrey, V., Wahlen, B., Seefeldt, L., & Bugbee, B. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.12.143 · Cited by 242
Neochloris oleabundans UTEX #1185: a suitable renewable lipid source for biofuel production
Gouveia, L., Marques, A. E., da Silva, T. L., & dos Reis, A. J. D. (2009) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-009-0559-2 · Cited by 236
Environmental Effects on Cell Composition
Hu, Q. (2013) · Handbook of Microalgal Culture · doi:10.1002/9781118567166.ch7 · Cited by 232
Borowitzka, M. A., Huisman, J. M., & Osborn, A. (1991) · Journal of Applied Phycology · doi:10.1007/bf02392882 · Cited by 226
Metabolite Profiling of Chlamydomonas reinhardtii under Nutrient Deprivation
Bölling, C., & Fiehn, O. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.071589 · Cited by 225
Aflalo, C., Meshulam, Y., Zarka, A., & Boussiba, S. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21391 · Cited by 220
Lamers, P. P., Janssen, M., De Vos, R. C. H., Bino, R. J., & Wijffels, R. H. (2012) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2012.04.018 · Cited by 216
Bioethanol Production by Carbohydrate-Enriched Biomass of Arthrospira (Spirulina) platensis
Μάρκου, Γ., Angelidaki, İ., Nerantzis, E. T., & Georgakakis, D. (2013) · Energies · doi:10.3390/en6083937 · Cited by 208
Self-citationFactors responsible for astaxanthin formation in the Chlorophyte Haematococcus pluvialis
Harker, M., Tsavalos, A. J., & Young, A. J. (1996) · Bioresource Technology · doi:10.1016/0960-8524(95)00002-x · Cited by 195
Dominguez-Bocanegra, A. R., Legarreta, I. G., Martı́nez-Jerónimo, F., & Tomasini-Campocosio, A. (2003) · Bioresource Technology · doi:10.1016/j.biortech.2003.04.001 · Cited by 184
Kobayashi, M., Kakizono, T., Yamaguchi, K., Nishio, N., & Nagai, S. (1992) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(92)90261-r · Cited by 178
Carballo-Cárdenas, E. C., Tuan, P. M., Janssen, M., & Wijffels, R. H. (2003) · Biomolecular Engineering · doi:10.1016/s1389-0344(03)00040-6 · Cited by 177
Effects of salinity increase on carotenoid accumulation in the green alga Dunaliella salina
Borowitzka, M. A., Borowitzka, L. J., & Kessly, D. (1990) · Journal of Applied Phycology · doi:10.1007/bf00023372 · Cited by 176
You, T., & Barnett, S. M. (2004) · Biochemical Engineering Journal · doi:10.1016/j.bej.2004.02.004 · Cited by 175
Young, G., Nippgen, F., Titterbrandt, S., & Cooney, M. J. (2010) · Separation and Purification Technology · doi:10.1016/j.seppur.2010.01.009 · Cited by 175
Biotechnological Applications of Microalgae
Chu, W.-L. (2012) · International e-Journal of Science, Medicine & Education · doi:10.56026/imu.6.suppl1.s24 · Cited by 174
Panda, B., Jain, P. K., Sharma, L., & Mallick, N. (2005) · Bioresource Technology · doi:10.1016/j.biortech.2005.05.013 · Cited by 165
Feng, P., Deng, Z., Fan, L., & Hu, Z. (2012) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2012.05.007 · Cited by 165
Durmaz, Y. (2007) · Aquaculture · doi:10.1016/j.aquaculture.2007.07.213 · Cited by 160
Iwamoto, H. (2003) · doi:10.1002/9780470995280.ch11 · Cited by 157
Hyper-accumulation of astaxanthin in a green algaHaematococcus pluvialis at elevated temperatures
Tjahjono, A. E., Hayama, Y., Kakizono, T., Terada, Y., Nishio, N., & Nagai, S. (1994) · Biotechnology Letters · doi:10.1007/bf01021659 · Cited by 151
Xie, Y., Ho, S.-H., Chen, C.-N. N., Chen, C.-Y., Ng, I.-S., Jing, K.-J., Chang, J.-S., & Lu, Y. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.06.064 · Cited by 151
Polysaccharides from cyanobacteria
Bertocchi, C., Navarini, L., Cesàro, A., & Anastasio, M. (1990) · Carbohydrate Polymers · doi:10.1016/0144-8617(90)90015-k · Cited by 149
Polyhydroxyalkanoate (PHA) synthesis by Spirulina subsalsa from Gujarat coast of India
Shrivastav, A., Mishra, S. K., & Mishra, S. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.01.001 · Cited by 142
Campenni’, L., Nobre, B. P., Santos, C. A., Oliveira, A. C., Aires-Barros, M. R., Palavra, A. M. F., & Gouveia, L. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4570-6 · Cited by 141
Sharma, L., & Mallick, N. (2004) · Bioresource Technology · doi:10.1016/j.biortech.2004.10.009 · Cited by 137
Panda, B., & Mallick, N. (2006) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.02048.x · Cited by 135
Coesel, S., Baumgartner, A., Teles, L. M., Ramos, A., Henriques, N., Cancela, M. L., & Varela, J. C. S. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9100-2 · Cited by 134
Cerón, M. C., García‐Malea, M. C., Rivas, J., Acién, F. G., Fernández-Sevilla, J. M., Río, E. D., Guerrero, M. G., & Molina, E. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0743-5 · Cited by 134
Hemlata, H., & Fatma, T. (2009) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-009-9837-y · Cited by 134
Exopolysaccharide production by a unicellular cyanobacterium isolated from a hypersaline habitat
Philippis, R. D., Margheri, M. C., Pelosi, E., & Ventura, S. (1993) · Journal of Applied Phycology · doi:10.1007/bf02182731 · Cited by 132
PHA Bioplastics, Biochemicals, and Energy from Crops
Somleva, M. N., Peoples, O. P., & Snell, K. D. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12039 · Cited by 127
Production of astaxanthin from Haematococcus in open pond by two-stage growth one-step process
Zhang, B. Y., Geng, Y., Li, Z. K., Hu, H. J., & Li, Y. G. (2009) · Aquaculture · doi:10.1016/j.aquaculture.2009.06.043 · Cited by 123
Biochemical methane potential of microalgae biomass after lipid extraction
Alzate, M. E., Muñoz, R., Rogalla, F., Fdz-Polanco, F., & Pérez-Elvira, S. I. (2013) · Chemical Engineering Journal · doi:10.1016/j.cej.2013.07.076 · Cited by 122
Chakraborty, M., Miao, C., McDonald, A. G., & Chen, S. (2011) · Fuel · doi:10.1016/j.fuel.2011.10.055 · Cited by 122
Saha, S. K., McHugh, E., Hayes, J., Moane, S., Walsh, D., & Murray, P. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.049 · Cited by 121
Evaluating industrial symbiosis and algae cultivation from a life cycle perspective
Soratana, K., & Landis, A. E. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.04.018 · Cited by 119
Heterotrophic cultivation of Euglena gracilis Z for efficient production of α-tocopherol
Ogbonna, J. C., Tomiyama, S., & Tanaka, H. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008011201437 · Cited by 115
Subhadra, B. G. (2010) · Energy Policy · doi:10.1016/j.enpol.2010.05.043 · Cited by 115
Accumulation of poly-β-hydroxybutyrate in cyanobacterium Synechocystis sp. PCC6803
Wu, G., Wu, Q., & Shen, Z. Y. (2001) · Bioresource Technology · doi:10.1016/s0960-8524(00)00099-7 · Cited by 115
Evolution of pigment composition in Chlorella vulgaris
Gouveia, L. (1996) · Bioresource Technology · doi:10.1016/0960-8524(96)00058-2 · Cited by 115
Μάρκου, Γ., Chatzipavlidis, I., & Georgakakis, D. (2012) · BioEnergy Research · doi:10.1007/s12155-012-9205-3 · Cited by 114
A new exopolysaccharide produced by marine Cyanothece sp. 113
Chi, Z., Su, C., & Lu, W. (2006) · Bioresource Technology · doi:10.1016/j.biortech.2006.05.001 · Cited by 112
Miao, C., Chakraborty, M., & Chen, S. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.01.047 · Cited by 108
Mishra, A., Mandoli, A., & Jha, B. (2008) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-008-0387-9 · Cited by 105
EFFECT OF TEMPERATURE AND IRRADIANCE ON GROWTH OF HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE)1
Fan, L., Vonshak, A., & Boussiba, S. (1994) · Journal of Phycology · doi:10.1111/j.0022-3646.1994.00829.x · Cited by 104
Enhancement of antioxidant production in Spirulina platensis under oxidative stress
El‐Baky, H. H. A., El-Baz, F. K., & El‐Baroty, G. S. (2009) · Acta Physiologiae Plantarum · doi:10.1007/s11738-009-0273-8 · Cited by 103
Extraction of proteins with ionic liquid aqueous two-phase system based on guanidine ionic liquid
Zeng, Q., Wang, Y., Li, N., Huang, X. F., Ding, X., Lin, X., Huang, S., & Liu, X. (2013) · Talanta · doi:10.1016/j.talanta.2013.06.011 · Cited by 103
Glycogen and poly- -hydroxybutyrate synthesis in Spirulina maxima
Philippis, R. D., Sili, C., & VINCENZINI, M. T. (1992) · Journal of General Microbiology · doi:10.1099/00221287-138-8-1623 · Cited by 99
Cerón-García, M. C., Sánchez, M. D. M., Sánchez‐Mirón, A., García-Camacho, F., & Grima, E. M. (2012) · Applied Energy · doi:10.1016/j.apenergy.2012.09.054 · Cited by 97
Fábregas, J., Domı́nguez, A., Maseda, A., & Otero, A. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1204-4 · Cited by 92
Enhanced production of lutein in heterotrophic Chlorella protothecoides by oxidative stress
Wei, D., Chen, F., Chen, G., Zhang, X., Liu, L., & Zhang, H. (2008) · Science in China Series C: Life Sciences · doi:10.1007/s11427-008-0145-2 · Cited by 91
Yao, C., Ai, J.-N., Cao, X., & Xue, S. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4983-x · Cited by 91
İmamoğlu, E., Dalay, M. C., & Sukan, F. V. (2009) · New Biotechnology · doi:10.1016/j.nbt.2009.08.007 · Cited by 89
Enrichment of vitamin E from Spirulina platensis microalga by SFE
Mendiola, J. A., García-Martínez, D. L., Rupérez, F. J., Martín‐Álvarez, P. J., Reglero, G., Cifuentes, A., Barbas, C., Ibáñez, E., & Señoráns, F. J. (2007) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2007.07.021 · Cited by 85
Lupi, F. M., Fernandes, H. M. L., Tomé, M., Sá‐Correia, I., & Novais, J. M. (1994) · Enzyme and Microbial Technology · doi:10.1016/0141-0229(94)90116-3 · Cited by 84
Gómez, P. I., & GONZÁLEZ, M. A. (2005) · Biological Research · doi:10.4067/s0716-97602005000200005 · Cited by 84
Oleic acid is the main fatty acid related with carotenogenesis in Dunaliella salina
Mendoza, H. M., Martel, A., del Río, M. J., & Reina, G. G. (1999) · Springer eBooks · doi:10.1007/978-94-011-4449-0_65 · Cited by 82
Hadi, M. R., Shariati, M., & Afsharzadeh, S. (2008) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-007-0185-7 · Cited by 80
Mogedas, B., Casal, C., Forján, E., & Vı́lchez, C. (2009) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2009.02.022 · Cited by 80
The accumulation and metabolism of astaxanthin in Scenedesmus obliquus (Chlorophyceae)
Qin, S., Liu, G., & Hu, Z. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.03.010 · Cited by 80
Kobayashi, M. (2003) · Biotechnology and Bioprocess Engineering · doi:10.1007/bf02949275 · Cited by 79
Microalgal biotechnology: Carotenoid production by the green algaeDunaliella salina
Jin, E., & Melis, A. (2003) · Biotechnology and Bioprocess Engineering · doi:10.1007/bf02949276 · Cited by 78
Río, E. D., Acién, F. G., García‐Malea, M. C., Rivas, J., Grima, E. M., & Guerrero, M. G. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21770 · Cited by 78
He, P., Duncan, J. A., & Barber, J. P. (2007) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2007.00468.x · Cited by 77
Ben‐Amotz, A. (1996) · Journal of Phycology · doi:10.1111/j.0022-3646.1996.00272.x · Cited by 76
Yin-Nin, R., & Chen, F. (2001) · Process Biochemistry · doi:10.1016/s0032-9592(01)00157-1 · Cited by 73
Kinetic modeling of lutein production by heterotrophic Chlorella at various pH and temperatures
Shi, X., Wu, Z., & Chen, F. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600037 · Cited by 73
A matter of detail: Assessing the true potential of microalgal biofuels
Klein‐Marcuschamer, D., Chisti, Y., Benemann, J. R., & Lewis, D. M. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.24967 · Cited by 72
Effect of nitrate and sulfate starvation on polysaccharide formation in rhodella reticulata
Arad, S. M., Lerental, Y., & Dubinsky, O. (1992) · Bioresource Technology · doi:10.1016/0960-8524(92)90073-7 · Cited by 69
Bhati, R., & Mallick, N. (2012) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.2737 · Cited by 68
Cysewski, G. R., & Lorenz, R. T. (2003) · doi:10.1002/9780470995280.ch14 · Cited by 66
Abalde, J., Fábregas, J., & Herrero, C. (1991) · Bioresource Technology · doi:10.1016/0960-8524(91)90142-7 · Cited by 65
Effects of growth conditions on exopolysaccharide production by Cyanospira capsulata
Philippis, R. D., Sili, C., Tassinato, G., VINCENZINI, M. T., & Materassi, R. (1991) · Bioresource Technology · doi:10.1016/0960-8524(91)90138-a · Cited by 64
Bergeron, C., Carrier, D. J., & Ramaswamy, S. (2012) · Wiley eBooks · doi:10.1002/9780470976692 · Cited by 62
Phadwal, K., & Singh, P. K. (2003) · Bioresource Technology · doi:10.1016/s0960-8524(03)00090-7 · Cited by 62
Effect of abiotic stress on the production of lutein and β-carotene by Chlamydomonas acidophila
Garbayo, I., Cuaresma, M., Vı́lchez, C., & Vega, J. M. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.06.012 · Cited by 60
Philippis, R. D., Ena, A., Guastiini, M., Sili, C., & Vincenzini, M. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05837.x · Cited by 60
Selection and optimisation of a method for efficient metabolites extraction from microalgae
Serive, B., Kaas, R., Bérard, J., Pasquet, V., Picot, L., & Cadoret, J. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.07.105 · Cited by 59
Ben‐Amotz, A. (1987) · Journal of Plant Physiology · doi:10.1016/s0176-1617(87)80290-0 · Cited by 59
Astaxanthin: A Comparative Case of Synthetic VS. Natural Production
Nguyen, K. D. (2013) · Cited by 58
Tripathi, U., Sarada, R., & Ravishankar, G. A. (2002) · Acta Physiologiae Plantarum · doi:10.1007/s11738-002-0058-9 · Cited by 56
Li, Z., Sun, M., Li, Q., Li, A., & Zhang, C. (2012) · Biotechnology Letters · doi:10.1007/s10529-012-0996-2 · Cited by 54
Exposure to Low Irradiances Favors the Synthesis of 9-cis β,β-Carotene in Dunaliella salina (Teod.)
Orset, S., & Young, A. J. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.2.609 · Cited by 52
Isolation of Dunaliella spp. from a hypersaline lake and their ability to accumulate glycerol
Kaçka, A., & Dönmez, G. (2008) · Bioresource Technology · doi:10.1016/j.biortech.2008.02.042 · Cited by 52
Sharma, L., & Mallick, N. (2005) · Biotechnology Letters · doi:10.1007/s10529-004-6586-1 · Cited by 51
Li, Z., Ma, X., Li, A., & Zhang, C. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.04.069 · Cited by 51
Lababpour, A., Hada, K., Shimahara, K., Katsuda, T., & Katoh, S. (2004) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(05)00311-7 · Cited by 51
Cao, H., Zhang, L., & Melis, A. (2001) · Journal of Applied Phycology · doi:10.1023/a:1008131412909 · Cited by 50
Evens, T. J., Niedz, R. P., & Kirkpatrick, G. J. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9277-1 · Cited by 39
Polysaccharide Produced by Anacystis nidulans: Its Ecological Implication
Sangar, V., & Dugan, P. R. (1972) · Applied Microbiology · doi:10.1128/am.24.5.732-734.1972 · Cited by 37
Biofuels from Microalgae: Towards Meeting Advanced Fuel Standards
Brennan, L., & Owende, P. M. O. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3348-4_24 · Cited by 36
Sixteenth International Seaweed Symposium
Kain, J. M., Brown, M. T., & Lahaye, M. (1999) · Springer eBooks · doi:10.1007/978-94-011-4449-0 · Cited by 36
Ben‐Amotz, A. (1999) · Springer eBooks · doi:10.1007/978-94-011-4838-2_31 · Cited by 34
Microalgal Biotechnology and Bioenergy in Dunaliella
Shariati, M., & Reza, M. (2011) · InTech eBooks · doi:10.5772/19046 · Cited by 32
Tran, N.-P., Park, J.-K., & Lee, C. (2009) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2009.07.006 · Cited by 29
Cai, M., Li, Z., & Qi, A. (2009) · Chinese Journal of Oceanology and Limnology · doi:10.1007/s00343-009-9176-1 · Cited by 25
Polysaccharide Produced by Anacystis nidulans: Its Ecological Implication
Sangar, V., & Dugan, P. R. (1972) · Applied Microbiology · doi:10.1128/aem.24.5.732-734.1972 · Cited by 23
Abiotic stress induced production of β-carotene, allophycocyanin and total lipids in Spirulina sp.
Hifney, A. F., Issa, A. A., & Fawzy, M. A. (2013) · Journal of Biology and Earth Sciences · Cited by 20
Marketing Omega-3 Products as Nutraceuticals
Clough, P. (2008) · Nutrition and Health · doi:10.1177/026010600801900313 · Cited by 13
Separation and Purification of Phytochemicals as Co‐Products in Biorefineries
Huang, H., & Ramaswamy, S. (2012) · doi:10.1002/9780470976692.ch3 · Cited by 12
Effect of increasing copper and salinity on glycerol production byDunaliella salina
Lustigman, B. K., McCormick, J. M., Dale, G., & McLaughlin, J. J. A. (1987) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf01606687 · Cited by 6
Research works printed but not linked: 2
- Del Campo, 2007, Outdoor cultivation of microalgae for carotenoid production: current state and perspectives, Appl Microbiol Biotechnol, 74, 1163, 10.1007/s00253-007-0844-9 · DOI · Paper page
- Yaşar, 2007, Vitamin E, (α-tocopherol) production by the marine microalgae Nannochloropsis oculata (Eustigmatophyceae) in nitrogen limitation, Aquaculture, 272, 717, 10.1016/j.aquaculture.2007.07.213 · DOI · Paper page
Cited by
Sorted by citations
Knothe, G., & Razón, L. F. (2016) · Progress in Energy and Combustion Science · doi:10.1016/j.pecs.2016.08.001 · Cited by 761
Carotenoids from microalgae: A review of recent developments
Gong, M., & Bassi, A. S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.10.005 · Cited by 747
Oxidative damage and antioxidative system in algae
Rezayian, M., Niknam, V., & Ebrahimzadeh, H. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.10.001 · Cited by 538
Production, extraction and characterization of microalgal and cyanobacterial exopolysaccharides
Delattre, C., Pierre, G., Laroche, C., & Michaud, P. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.08.001 · Cited by 500
Cuellar‐Bermudez, S. P., Aguilar‐Hernandez, I., Cardenas‐Chavez, D. L., Ornelas‐Soto, N., Romero‐Ogawa, M. A., & Parra‐Saldivar, R. (2015) · Microbial Biotechnology · doi:10.1111/1751-7915.12167 · Cited by 486
Metadata
- Authors
- Markou, G., & Nerantzis, E.
- Affiliations
- Technological Educational Institute of Athens (GR)
- ORCID
- Nerantzis, Elias
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 31
- Issue
- 8
- Pages
- 1532-1542
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W1995250319
- Cited by
- 815
- References
- 173
- Citations by year
- 2026: 41 · 2025: 53 · 2024: 36 · 2023: 66 · 2022: 86 · 2021: 80 · 2020: 85 · 2019: 89 · 2018: 83 · 2017: 73 · 2016: 48 · 2015: 60 · 2014: 15
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
- Keywords
- microalgae, biofuels, value-added chemicals, secondary metabolites, nutrient deprivation, salt stress, temperature stress, lipid accumulation, carbohydrate accumulation, biorefinery, microalgal biomass
- MeSH terms
- Biotechnology, Stress, Physiological, Cell Culture Techniques, Bioreactors, Biofuels, Microalgae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review