The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

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Akt Phosphorylates the Yes-Associated Protein, YAP, to Induce Interaction with 14-3-3 and Attenuation of p73-Mediated Apoptosis

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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

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TEAD mediates YAP-dependent gene induction and growth control

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Hippo pathway in organ size control, tissue homeostasis, and cancer

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YAP/TAZ at the Roots of Cancer

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Mechanisms of Hippo pathway regulation

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Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP

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Mechanobiology of YAP and TAZ in physiology and disease

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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP

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The Hippo Pathway: Biology and Pathophysiology

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YAP1 increases organ size and expands undifferentiated progenitor cells

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The Hippo pathway: regulators and regulations.

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The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

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Yap1 acts downstream of α-catenin to control epidermal proliferation

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Transduction of mechanical and cytoskeletal cues by YAP and TAZ

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The Hippo Signaling Pathway in Development and Disease

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The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

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Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

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The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

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The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

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Mechanical regulation of bone remodeling

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The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control

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The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network

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The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

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The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase

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The DREAM complex: master coordinator of cell cycle-dependent gene expression

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YAP/TAZ Signaling and Resistance to Cancer Therapy

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YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

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Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

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Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65

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The Drosophila embryo at single-cell transcriptome resolution

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YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

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Aerobic glycolysis tunes YAP/TAZ transcriptional activity

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Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

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Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate

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Characterization of Hippo Pathway Components by Gene Inactivation

Plouffe, S. W., Meng, Z., Lin, K. C., Lin, B., Hong, A. W., Chun, J. V., & Guan, K.-L. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.034 · Cited by 275

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

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Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

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Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors

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Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

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PTPN14 interacts with and negatively regulates the oncogenic function of YAP

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PTPN14 is required for the density-dependent control of YAP1

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The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance.

Emoto, K., Parrish, J. Z., Jan, L. Y., & Jan, Y.-N. (2006) · Nature · doi:10.1038/nature05090 · Cited by 194

KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases

Xiao, L., Chen, Y., Ji, M., & Dong, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173468 · Cited by 190

dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells

Ziosi, M., Baena-López, L. A., Grifoni, D., Froldi, F., Pession, A., Garoia, F., Trotta, V., Bellosta, P., Cavicchi, S., & Pession, A. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001140 · Cited by 184

YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human diseaseThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

Wang, K., Degerny, C., Xu, M., & Yang, X.-J. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-114 · Cited by 180

Genetic Control of Programmed Cell Death During Animal Development

Conradt, B. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091533 · Cited by 173

Polyploidy in tissue homeostasis and regeneration

Øvrebø, J. I., & Edgar, B. A. (2018) · Development · doi:10.1242/dev.156034 · Cited by 171

The Evolutionary History of YAP and the Hippo/YAP Pathway

Hilman, D., & Gat, U. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr065 · Cited by 166

A Feed-Forward Circuit Linking Wingless, Fat-Dachsous Signaling, and the Warts-Hippo Pathway to Drosophila Wing Growth

Zecca, M., & Struhl, G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000386 · Cited by 148

Modularity in the Hippo signaling pathway

Sudol, M., & Harvey, K. F. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.010 · Cited by 149

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells

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YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

Tanaka, H., Homma, H., Fujita, K., Kondo, K., Yamada, S., Jin, X., Waragai, M., Ohtomo, G., Iwata, A., Tagawa, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14353-6 · Cited by 119

TEAD family transcription factors in development and disease

Currey, L., Thor, S., & Piper, M. (2021) · Development · doi:10.1242/dev.196675 · Cited by 120

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

Doggett, K., Grusche, F. A., Richardson, H. E., & Brumby, A. M. (2011) · BMC Developmental Biology · doi:10.1186/1471-213x-11-57 · Cited by 119

Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways

Konsavage, W. M., & Yochum, G. S. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms084 · Cited by 94

The Hippo signal transduction network in skeletal and cardiac muscle

Wackerhage, H., Del Re, D. P., Judson, R. N., Sudol, M., & Sadoshima, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005096 · Cited by 92

The Hippo Signaling Pathway in Drug Resistance in Cancer

Zeng, R., & Dong, J. (2021) · Cancers · doi:10.3390/cancers13020318 · Cited by 89

An Ectopic Network of Transcription Factors Regulated by Hippo Signaling Drives Growth and Invasion of a Malignant Tumor Model

Atkins, M., Potier, D., Romanelli, L., Jacobs, J., Mach, J., Hamaratoglu, F., Aerts, S., & Halder, G. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.035 · Cited by 88

Nuclear signaling from cadherin adhesion complexes

McCrea, P. D., Maher, M. T., & Gottardi, C. J. (2015) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.018 · Cited by 85

LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap

Nguyen, H. B., Babcock, J. T., Wells, C. D., & Quilliam, L. A. (2013) · Oncogene · doi:10.1038/onc.2012.431 · Cited by 84

A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth

Vissers, J. H. A., Manning, S. A., Kulkarni, A., & Harvey, K. F. (2016) · Nature Communications · doi:10.1038/ncomms10368 · Cited by 70

The MST4–MOB4 complex disrupts the MST1–MOB1 complex in the Hippo–YAP pathway and plays a pro-oncogenic role in pancreatic cancer

Chen, M., Zhang, H., Shi, Z., Li, Y., Zhang, X., Gao, Z., Zhou, L., Ma, J., Xu, Q., Guan, J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003279 · Cited by 70

YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling

Coggins, G. E., Farrel, A., Rathi, K. S., Hayes, C. M., Scolaro, L., Rokita, J. L., & Maris, J. M. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1415 · Cited by 66

Planarian yorkie/YAP functions to integrate adult stem cell proliferation, organ homeostasis and maintenance of axial patterning

Lin, A. Y. T., & Pearson, B. J. (2014) · Development · doi:10.1242/dev.101915 · Cited by 57

Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation

Lin, Z., & Pu, W. T. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.04.010 · Cited by 52

The Hippo signal transduction network for exercise physiologists

Gabriel, B. M., Hamilton, D. L., Tremblay, A. M., & Wackerhage, H. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01076.2015 · Cited by 48

Hippo signaling controls cell cycle and restricts cell plasticity in planarians

de Sousa, N., Rodríguez-Esteban, G., Rojo-Laguna, J. I., Saló, E., & Adell, T. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2002399 · Cited by 41

The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye

Wittkorn, E., Sarkar, A., Garcia, K., Kango-Singh, M., & Singh, A. (2015) · Development · doi:10.1242/dev.117358 · Cited by 39

Yorkie is required to restrict the injury responses in planarians

Lin, A. Y. T., & Pearson, B. J. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006874 · Cited by 38

Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways

Duhart, J. C., & Raftery, L. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00161 · Cited by 33

Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways

Ma, T., Ruan, H., Lv, L., Wei, C., Yu, Y., Jia, L., Song, X., Zhang, J., & Li, Y. (2023) · Food & Function · doi:10.1039/d3fo01902k · Cited by 26

Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation

Tyra, L. K., Nandi, N., Tracy, C., & Krämer, H. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.011 · Cited by 26

LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein

Yang, S., Xu, W., Liu, C., Jin, J., Li, X., Jiang, Y., Zhang, L., Meng, X., Zhan, J., & Zhang, H. (2022) · Science China Life Sciences · doi:10.1007/s11427-020-1914-3 · Cited by 24

Untitled work

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Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription

Tokamov, S. A., Su, T., Ullyot, A., & Fehon, R. G. (2021) · eLife · doi:10.7554/elife.62326 · Cited by 15

Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells

Waghmare, I., & Kango-Singh, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158081 · Cited by 14

Expression patterns of Yes-associated protein 1 in the developing mouse liver

Wei, W., Lotto, J., & Hoodless, P. A. (2018) · Gene Expression Patterns · doi:10.1016/j.gep.2018.04.003 · Cited by 3