The GLUT4 Glucose Transporter

Obesity is associated with macrophage accumulation in adipose tissue

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Insulin signalling and the regulation of glucose and lipid metabolism

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

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Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

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Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

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Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins

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Mechanisms of Insulin Action and Insulin Resistance

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Fiber Types in Mammalian Skeletal Muscles

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The PI3K Pathway in Human Disease

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Exercise, GLUT4, and skeletal muscle glucose uptake

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The SLC2 (GLUT) family of membrane transporters

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Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

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Insulin resistance: review of the underlying molecular mechanisms

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Biochemical and cellular properties of insulin receptor signalling

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Tumor Necrosis Factor‐Alpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus

Akash, M. S. H., Rehman, K., & Liaqat, A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26174 · Cited by 690

The roles of vitamin D in skeletal muscle: form, function, and metabolism

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Glucose transporters in brain in health and disease

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Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

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A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives

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Role of Insulin Resistance in MAFLD

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Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

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The protein family of glucose transport facilitators: It's not only about glucose after all

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Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-γ agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions

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Insulin resistance in the nervous system

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Regulation of Glucose Transporter Translocation in Health and Diabetes

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Hepatic Selective Insulin Resistance at the Intersection of Insulin Signaling and Metabolic Dysfunction-Associated Steatotic Liver Disease

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Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

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Insulin Signal Transduction Perturbations in Insulin Resistance

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Chapter 21 Interleukin‐6 and Insulin Resistance

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Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

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Muscular weakness and muscle wasting in the critically ill

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Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training

Evans, P. L., McMillin, S. L., Weyrauch, L. A., & Witczak, C. A. (2019) · Nutrients · doi:10.3390/nu11102432 · Cited by 190

Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice

Manna, P., Achari, A. E., & Jain, S. K. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.01.002 · Cited by 181

Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

Wang, C., Wang, C., Huang, H., & Wei, Y. (2013) · The FEBS Journal · doi:10.1111/febs.12096 · Cited by 165

Hypoxia-inducible factors and diabetes

Gunton, J. E. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137556 · Cited by 159

Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle

Hunter, R. W., Treebak, J. T., Wojtaszewski, J. F. P., & Sakamoto, K. (2011) · Diabetes · doi:10.2337/db10-1148 · Cited by 151

Gut Microbiota in Obesity and Undernutrition

de Clercq, N. C., Groen, A. K., Romijn, J. A., & Nieuwdorp, M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012914 · Cited by 140

Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129

Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials

Bergouignan, A., Latouche, C., Heywood, S., Grace, M. S., Reddy-Luthmoodoo, M., Natoli, A. K., Owen, N., Dunstan, D. W., & Kingwell, B. A. (2016) · Scientific Reports · doi:10.1038/srep32044 · Cited by 121

Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle

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Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle

Treebak, J. T., Pehmøller, C., Kristensen, J. M., Kjøbsted, R., Birk, J. B., Schjerling, P., Richter, E. A., Goodyear, L. J., & Wojtaszewski, J. F. P. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.266338 · Cited by 113

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Chen, X.-W., Leto, D., Xiong, T., Yu, G., Cheng, A., Decker, S., & Saltiel, A. R. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-08-0665 · Cited by 108

The effects of postprandial exercise on glucose control in individuals with type 2 diabetes: a systematic review

Borror, A., Zieff, G., Battaglini, C., & Stoner, L. (2018) · Sports Medicine · doi:10.1007/s40279-018-0864-x · Cited by 106

Reciprocal Regulation of Endocytosis and Metabolism

Antonescu, C. N., McGraw, T. E., & Klip, A. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016964 · Cited by 104

Insulin-stimulated Phosphorylation of the Rab GTPase-activating Protein TBC1D1 Regulates GLUT4 Translocation

Peck, G. R., Chavez, J. A., Roach, W. G., Budnik, B. A., Lane, W. S., Karlsson, H. K. R., Zierath, J. R., & Lienhard, G. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.035568 · Cited by 95

Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes

Pan, X., Zaarur, N., Singh, M., Morin, P., & Kandror, K. V. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-11-0777 · Cited by 89

Efficient pathway enrichment and network analysis of GWAS summary data using GSA-SNP2

Yoon, S., Nguyen, H. C. T., Yoo, Y. J., Kim, J., Baik, B., Kim, S., Kim, J., Kim, S., & Nam, D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky175 · Cited by 81

Rab GTPases implicated in inherited and acquired disorders

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Exocyst function regulated by effector phosphorylation

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Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics

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RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis

Gulbranson, D. R., Davis, E. M., Demmitt, B. A., Ouyang, Y., Ye, Y., Yu, H., & Shen, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712176114 · Cited by 67

Brain glucose metabolism in health, obesity, and cognitive decline-does insulin have anything to do with it? A narrative review

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Modulation of myocellular fat stores: lipid droplet dynamics in health and disease

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Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men

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Ca2+ and insulin-mediated glucose uptake

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Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase

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p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity

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TBC1D13 is a RAB35 Specific GAP that Plays an Important Role in GLUT4 Trafficking in Adipocytes

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The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle

Howlett, K. F., Mathews, A., Garnham, A., & Sakamoto, K. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00542.2007 · Cited by 47

Developmental Programming: Prenatal Testosterone Excess and Insulin Signaling Disruptions in Female Sheep1

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Insulin Receptor Plasma Membrane Levels Increased by the Progesterone Receptor Membrane Component 1

Hampton, K. K., Anderson, K., Frazier, H., Thibault, O., & Craven, R. J. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.110510 · Cited by 39

Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle

Ducommun, S., Wang, H. Y., Sakamoto, K., MacKintosh, C., & Chen, S. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00379.2011 · Cited by 35

Reconstructing the transport cycle in the sugar porter superfamily using coevolution-powered machine learning

Mitrovic, D., McComas, S. E., Alleva, C., Bonaccorsi, M., Drew, D., & Delemotte, L. (2023) · eLife · doi:10.7554/elife.84805 · Cited by 31

Skeletal muscle fiber type-selective effects of acute exercise on insulin-stimulated glucose uptake in insulin-resistant, high-fat-fed rats

Pataky, M. W., Yu, C. S., Nie, Y., Arias, E. B., Singh, M., Mendias, C. L., Ploutz-Snyder, R. J., & Cartee, G. D. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00482.2018 · Cited by 26

Astrocytic transporters in Alzheimer's disease

Ugbode, C., Hu, Y., Whalley, B., Peers, C., Rattray, M., & Dallas, M. L. (2017) · Biochemical Journal · doi:10.1042/bcj20160505 · Cited by 25

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes

Hamilton, D. L., Findlay, J. A., Montagut, G., Meakin, P. J., Bestow, D., Jalicy, S. M., & Ashford, M. L. J. (2014) · Diabetologia · doi:10.1007/s00125-014-3269-x · Cited by 20

Novel dual PPARα/γ agonists protect against liver steatosis and improve insulin sensitivity while avoiding side effects

Guru, B., Tamrakar, A. K., Manjula, S. N., & Prashantha Kumar, B. R. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175322 · Cited by 18