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Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

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Tchkonia, Tamara, Thomou, Thomas, Zhu, Yi, Karagiannides, Iordanes, Pothoulakis, Charalabos, Jensen, Michael D., Kirkland, James L.·2013·Cell Metabolism
DOI 10.1016/j.cmet.2013.03.008
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Abstract

Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex, genetic background, disease state, certain drugs and hormones, development, and aging. Preadipocyte replication and differentiation, developmental gene expression, susceptibility to apoptosis and cellular senescence, vascularity, inflammatory cell infiltration, and adipokine secretion vary among depots, as do fatty-acid handling and mechanisms of enlargement with positive-energy and loss with negative-energy balance. How interdepot differences in these molecular, cellular, and pathophysiological properties are related is incompletely understood. Whether fat redistribution causes metabolic disease or whether it is a marker of underlying processes that are primarily responsible is an open question.

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Metadata

Authors
Tchkonia, T., Thomou, T., Zhu, Y., Karagiannides, I., Pothoulakis, C., Jensen, M. D., & Kirkland, J. L.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2013-05
Volume
17
Issue
5
Pages
644-656
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2013.03.008
OpenAlex
W2148537305
Cited by
723
References
28
FWCI
26.73
Type
journal article
Language
en
Open access
bronze
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Tchkonia, T., Thomou, T., Zhu, Y., Karagiannides, I., Pothoulakis, C., Jensen, M. D., & Kirkland, J. L. (2013). Mechanisms and Metabolic Implications of Regional Differences among Fat Depots. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.03.008

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