Cited by 1,441Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

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The Mitochondrial Basis of Aging

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Sun, Nuo, Youle, Richard J., Finkel, Toren·2016·Molecular Cell

DOI 10.1016/j.molcel.2016.01.028PMC PMC4779179

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Abstract

A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in mitochondria function contributes to aging. In particular, we discuss how mitochondria contribute to specific aspects of the aging process, including cellular senescence, chronic inflammation, and the age-dependent decline in stem cell activity. Signaling pathways regulating the mitochondrial unfolded protein response and mitophagy are also reviewed, with particular emphasis placed on how these pathways might, in turn, regulate longevity. Taken together, these observations suggest that mitochondria influence or regulate a number of key aspects of aging and suggest that strategies directed at improving mitochondrial quality and function might have far-reaching beneficial effects.

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Authors: Sun, N., Youle, R. J., & Finkel, T.
Affiliations: National Institutes of Health (US)
Corresponding author: Youle, Richard J.
Finkel, Toren
ORCID: Sun, Nuo
Youle, Richard J.
Finkel, Toren
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2016-03
Volume: 61
Issue: 5
Pages: 654-666
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2016.01.028
PMC: PMC4779179
OpenAlex: W2289876562
Cited by: 1,441
References: 143
Citations by year: 2026: 162 · 2025: 151 · 2024: 148 · 2023: 158 · 2022: 165 · 2021: 189 · 2020: 168 · 2019: 110 · 2018: 95 · 2017: 63 · 2016: 30
FWCI: 8.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Soochow University
National Institutes of Health
National Heart, Lung, and Blood Institute (ZIAHL005012)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial dysfunction, aging, cellular senescence, chronic inflammation, stem cell aging, mitochondrial unfolded protein response, mitophagy, longevity, age-related diseases, mitochondrial quality
MeSH terms: Age Factors, Aging, Animals, Humans, Inflammation, Longevity, Mitochondria, Stem Cells, Signal Transduction, Cellular Senescence, Unfolded Protein Response, Mitophagy

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