Cited by 209Neuroendocrine regulation and behaviorStress Responses and CortisolAnimal Behavior and Reproduction

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Mechanisms underlying epigenetic effects of early social experience: The role of neuropeptides and steroids

CUSHING, B, KRAMER, K·2005·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2005.04.001

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Abstract

In mammals the neonatal period is a time of significant social interaction. This is true even in solitary species as females spend a significant amount of time nursing and caring for their offspring. In social species interactions may also include the father, older siblings and extended family members. This period is a time of significant development, including organization of the central nervous system, and therefore a time when the degree and type of social interaction influences the development and expression of social behavior in adulthood. The purpose of this review is to examine the possible mechanisms for the epigenetic effects of early social experience on the subsequent expression of social behavior. We propose that social interactions during the neonatal period organize the subsequent expression of behavior by altering sensitivity to neuropeptides and steroids. Both neuropeptides (e.g. oxytocin and arginine vasopressin) and steroids (e.g. estrogen) regulate or influence the expression of behaviors such as affiliation, aggression, sociosexual behavior, parental behavior, and responses to stress. Therefore, changes in sensitivity to these hormones via reorganization of receptors or changes in hormone production and secretion are potentially powerful mechanisms through which early social experience can mold subsequent social behaviors.

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Authors: CUSHING, B., & KRAMER, K.
Affiliations: University of Illinois Chicago (US)
Corresponding author: CUSHING, B
ORCID: CUSHING, B
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2005
Volume: 29
Issue: 7
Pages: 1089-1105
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2005.04.001
OpenAlex: W2048444812
Cited by: 209
References: 202
Citations by year: 2026: 3 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 13 · 2015: 14 · 2014: 15 · 2013: 18 · 2012: 13
FWCI: 14.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 01992, K01MH001992)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 41293, P01HD038490, HD38490, F32HD041293)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords: early social experience, epigenetic mechanisms, neuropeptides, oxytocin, vasopressin, estrogen, steroid hormones, social behavior development, receptor sensitivity, parental behavior, aggression, sociosexual behavior, stress response, affiliation
MeSH terms: Animals, Animals, Newborn, Behavior, Animal, Female, Humans, Limbic System, Male, Neurosecretory Systems, Oxytocin, Sex Characteristics, Social Behavior, Social Environment, Vasotocin, Gene Expression Regulation, Developmental, Epigenesis, Genetic

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Mechanisms underlying epigenetic effects of early social experience: The role of neuropeptides and steroids

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