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Gliotransmitters Travel in Time and Space
Open accessAbstract
The identification of the presence of active signaling between astrocytes and neurons in a process termed gliotransmission has caused a paradigm shift in our thinking about brain function. However, we are still in the early days of the conceptualization of how astrocytes influence synapses, neurons, networks, and ultimately behavior. In this Perspective, our goal is to identify emerging principles governing gliotransmission and consider the specific properties of this process that endow the astrocyte with unique functions in brain signal integration. We develop and present hypotheses aimed at reconciling confounding reports and define open questions to provide a conceptual framework for future studies. We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons.
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“astrocyte interactions with synaptic circuits are multimodal and multiscale, occur under physiological conditions 2-5 and contribute to behavior 6-8 .”
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“Astrocytes contribute to synaptic plasticity by releasing fast mediators that directly modify synaptic function 2, 4 .”
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Metadata
- Authors
- Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A.
- Affiliations
- University of Minnesota (US)
- University of Padua (IT)
- Tufts University (US)
- Université de Bordeaux (FR)
- Université de Montréal (CA)
- University of Lausanne (CH)
- Corresponding author
- Carmignoto, Giorgio
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 81
- Issue
- 4
- Pages
- 728-739
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4107238
- OpenAlex
- W2042681276
- Cited by
- 1,308
- References
- 134
- Citations by year
- 2026: 73 · 2025: 101 · 2024: 115 · 2023: 125 · 2022: 116 · 2021: 153 · 2020: 116 · 2019: 95 · 2018: 105 · 2017: 84 · 2016: 86 · 2015: 105 · 2014: 32
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- HAL (submittedVersion)
- Funders
- National Science Foundation
- Sbarro Health Research Organization
- European Commission (202167, 340368)
- Institut National de la Santé et de la Recherche Médicale
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (140999, 31003A, 203729)
- LabEx BRAIN
- National Institutes of Health
- Canadian Institutes of Health Research (MOP‐14137, MOP‐111070)
- National Institute on Alcohol Abuse and Alcoholism (R01AA020183)
- National Institute of Mental Health (R01MH095385)
- National Institute on Drug Abuse (R01DA025967)
- National Institute of Neurological Disorders and Stroke (R01NS037585)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- gliotransmission, astrocytes, astrocyte-neuron communication, high-affinity receptor, spatiotemporal signaling, astrocyte function
- MeSH terms
- Animals, Astrocytes, Cell Communication, Humans, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses
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