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Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
Abstract
Social relationships protect against the development of stress-related psychiatric disorders, yet little is known about the neurobiology that regulates this phenomenon. Recent evidence suggests that oxytocin (OT), a neuropeptide involved in social bond formation, may play a role. This experiment investigated the effects of chronic intranasal OT administration on acute stress-induced hypothalamic-pituitary-adrenal (HPA) axis activation in adult female squirrel monkeys. Subjects were randomized to one of two experimental conditions. Monkeys were intranasally administered either 50 microg oxytocin (N = 6 monkeys) or 0 microg oxytocin (N = 6 monkeys)/300 microl saline once a day for eight consecutive days. Immediately after drug administration on the eighth day, all monkeys were exposed to acute social isolation. Blood samples for determinations of adrenocorticotropic hormone (ACTH) and cortisol concentrations were collected after 30 and 90 min of stress exposure. Consistent with an anti-stress effect, OT-treated monkeys exhibited lower ACTH concentrations compared to saline-treated monkeys after 90 min of social isolation (F(1,7) = 6.891; P = 0.034). No drug-related differences in cortisol levels were observed, indicating that OT does not directly attenuate the adrenal stress response. Intranasal peptide administration has been shown to penetrate the central nervous system, and research must determine whether intranasally delivered OT exerts its effect(s) at a pituitary and/or brain level. This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders.
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In the citing paper
“When administered intranasally, OT also attenuates the neuroendocrine stress response in rodents and monkeys and alters emotion regulation in humans (Heinrichs et al., 2003; Parker et al., 2005; Windle et al., 2004).”
From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Parker et al., 2005
In the citing paper
“OT has an anti-stress effect in squirrel monkeys, with IN OT treated monkeys exhibiting lower ACTH concentrations compared to saline-treated monkeys 90 minutes following a social isolation stressors (Parker et al., 2005).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Parker et al., 2005
In the citing paper
“Such OT-mediated reduction in ACTH levels suggests that OT regulates social stress by acting through the hypothalamic-pituitary-adrenal (HPA) axis.”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Parker et al., 2005
In the citing paper
“Moreover, OT delivered intranasally to squirrel monkeys (Suimiri sciureus) attenuates stress responses by lowering adrenocorticotropic hormone (ACTH) (i.e., corticotropin) levels following 90 min of social isolation (Parker et al., 2005).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Parker et al., 2005
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Metadata
- Authors
- Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Parker, Karen J.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 30
- Issue
- 9
- Pages
- 924-929
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2001711371
- Cited by
- 204
- References
- 34
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 11 · 2021: 19 · 2020: 2 · 2019: 10 · 2018: 16 · 2017: 10 · 2016: 17 · 2015: 20 · 2014: 16 · 2013: 14 · 2012: 6
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-47573, R01MH047573)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, intranasal administration, ACTH, hypothalamic-pituitary-adrenal axis, acute stress, social isolation, cortisol, anti-stress effects, interpersonal relationships, stress-related psychiatric disorders, squirrel monkey, female primates
- MeSH terms
- Administration, Intranasal, Adrenocorticotropic Hormone, Animals, Female, Hydrocortisone, Oxytocin, Random Allocation, Saimiri, Social Isolation, Stress, Psychological
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