Early adverse life events are associated with altered brain network architecture in a sex- dependent manner
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Early adverse life events (EALs) increase the risk for chronic medical and psychiatric disorders by altering early neurodevelopment. The aim of this study was to examine associations between EALs and network properties of core brain regions in the emotion regulation and salience networks, and to test the influence of sex on these associations. Resting-state functional and diffusion tensor magnetic resonance imaging were obtained in healthy individuals (61 men, 63 women). Functional and anatomical network properties of centrality and segregation were calculated for the core regions of the two networks using graph theory. Moderator analyses were applied to test hypotheses. The type of adversity experienced influences brain wiring differently, as higher general EALs were associated with decreased functional and anatomical centrality in salience and emotion regulation regions, while physical and emotional EALs were associated with increased anatomical centrality and segregation in emotion regulation regions. Sex moderated the associations between EALs and measures of centrality; with decreased centrality of salience and emotion regulation regions with increased general EALs in females, and increased centrality in salience regions with higher physical and emotional EALs in males. Increased segregation of salience regions was associated with increased general EALs in males. Centrality of the amygdala was associated with physical symptoms, and segregation of salience regions was correlated with higher somatization in men only. Emotion regulation and salience regions are susceptible to topological brain restructuring associated with EALs. The male and female brains appear to be differently affected by specific types of EALs.
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Salience and emotion regulation brain networks are especially susceptible to topological restructuring associated with ELAs.
“Furthermore, salience and emotion regulation brain networks are especially susceptible to topological restructuring associated with ELAs 11.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [11]
A history of ELA can have a sustained impact on the integrity and function of the brain, with brain regions associated with emotional regulation, cognitive modulation and feeding behaviours frequently implicated.
“Evidence from neuroimaging studies suggests that a history of ELA can have a sustained impact on the integrity and function of the brain 9, 10, 11, 12, with brain regions associated with emotional regulation, cognitive modulation and feeding behaviours frequently implicated 12, 13, 14, 15, 16.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [11]
Sex‐specific brain alterations have also been reported in obesity and ELA studies.
“sex‐specific brain alterations have also been reported in obesity and ELA studies 11, 51, 52, 53, 54, 55, 56, 57.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [11]
ELA (general) may not be as severe or personal in nature as other ELAs and may actually serve as a source of increased resilience.
“ELA (general) may not be as severe or personal in nature as other ELAs and may actually serve as a source of increased resilience 11.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [11]
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Sex differences in the emotional brain
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Self-citationLabus, J. S., Naliboff, B. D., Kilpatrick, L. A., Liu, X. C., Ashe-McNalley, C., dos Santos, I., Alaverdyan, M., Woodworth, D. C., Gupta, A., Ellingson, B. M., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.018 · Cited by 31 · see citing works
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Flagged first, then by citations
Research works printed but not linked: 1
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Cited by
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A Distinct Brain-Gut-Microbiome Profile Exists for Females with Obesity and Food Addiction
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Self-citationHelpman, L., Zhu, X., Suarez-Jimenez, B., Lazarov, A., Monk, C., & Neria, Y. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0854-y · Cited by 82 · see citing works
Tiwari, A., & Gonzalez, A. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.01.006 · Cited by 71 · see citing works
Blume, S. R., Padival, M., Urban, J. H., & Rosenkranz, J. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-48683-3 · Cited by 71 · see citing works
Schroeder, A., Notaras, M., Du, X., & Hill, R. A. (2018) · Brain Sciences · doi:10.3390/brainsci8070121 · Cited by 50 · see citing works
Osadchiy, V., Mayer, E. A., Bhatt, R., Labus, J. S., Gao, L., Kilpatrick, L. A., Liu, C., Tillisch, K., Naliboff, B., Chang, L., et al. (2019) · Obesity Science & Practice · doi:10.1002/osp4.362 · Cited by 44 · see citing works
Self-citation
- Authors
- Gupta, A., Mayer, E. A., Acosta, J. R., Hamadani, K., Torgerson, C., van Horn, J. D., Chang, L., Naliboff, B., Tillisch, K., & Labus, J. S.
- Affiliations
- University of California, Los Angeles (US)
- University of Southern California (US)
- Corresponding author
- Gupta, Arpana
- ORCID
- Venue
- Neurobiology of Stress
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 7
- Pages
- 16-26
- ISSN
- 2352-2895 (ISSN-L)
- PMC
- PMC5318542
- OpenAlex
- W2588455380
- Cited by
- 56
- References
- 99
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 2
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neurobiology of Stress (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (K23 DK106528, R01 DK048351, P50 DK64539, P30 DK041301, R01 AT007137, R01 HD076756, R03 DK084169)
- Ahmanson-Lovelace Brain Mapping Center
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- brain network architecture, sex differences, salience network, network centrality, network segregation, graph theory, amygdala, somatization, brain development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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