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CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression
Open accessAbstract
While changes in gene expression are critical for many brain functions, including long-term memory, little is known about the cellular processes that mediate stimulus-transcription coupling at central synapses. In studying the signaling pathways by which synaptic inputs control the phosphorylation state of cyclic AMP-responsive element binding protein (CREB) and determine expression of CRE-regulated genes, we found two important Ca2+/calmodulin (CaM)-regulated mechanisms in hippocampal neurons: a CaM kinase cascade involving nuclear CaMKIV and a calcineurin-dependent regulation of nuclear protein phosphatase 1 activity. Prolongation of the synaptic input on the time scale of minutes, in part by an activity-induced inactivation of calcineurin, greatly extends the period over which phospho-CREB levels are elevated, thus affecting induction of downstream genes.
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Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052
Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
Petrif, F., Giles, R. H., Dauwerse, H. G., Saris, J. J., Hennekam, R. C. M., Masuno, M., Tommerup, N., van Ommen, G.-J. B., Goodman, R. H., Peters, D. J. M., et al. (1995) · Nature · doi:10.1038/376348a0 · Cited by 1,217
Ultrasensitivity in the mitogen-activated protein kinase cascade.
Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186
Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
Bading, H., Ginty, D. D., & Greenberg, M. E. (1993) · Science · doi:10.1126/science.8097060 · Cited by 1,157
Synaptic plasticity in the hippocampus: LTP and LTD
Malenka, R. C. (1994) · Cell · doi:10.1016/0092-8674(94)90517-7 · Cited by 655
Huang, Y.-Y., Kandel, E. R., Varshavsky, L., Brandont, E. P., Qi, M., Idzerda, R. L., Stanley McKnight, G., & Bourtchouladz, R. (1995) · Cell · doi:10.1016/0092-8674(95)90146-9 · Cited by 267
Cited by
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686
Voltage-Gated Calcium Channels
Catterall, W. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003947 · Cited by 1,628
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462
Variability, compensation and homeostasis in neuron and network function
Marder, E., & Goaillard, J.-M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1949 · Cited by 1,212
Transcription Factors in Long-Term Memory and Synaptic Plasticity
Alberini, C. M. (2009) · Physiological Reviews · doi:10.1152/physrev.00017.2008 · Cited by 991
Dolmetsch, R. E., Pajvani, U., Fife, K., Spotts, J. M., & Greenberg, M. E. (2001) · Science · doi:10.1126/science.1063395 · Cited by 900
CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation
Korzus, E., Rosenfeld, M. G., & Mayford, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.002 · Cited by 823
Invited review c-Fos as a transcription factor: a stressful (re)view from a functional map
Kovács, K. J. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(98)00023-0 · Cited by 740
Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior
Yap, E.-L., & Greenberg, M. E. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.013 · Cited by 706
Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression
Shieh, P. B., Hu, S.-C., Bobb, K., Timmusk, T., & Ghosh, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)81011-9 · Cited by 693
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
Wu, H., Kanatous, S. B., Thurmond, F. A., Gallardo, T., Isotani, E., Bassel-Duby, R., & Williams, R. S. (2002) · Science · doi:10.1126/science.1071163 · Cited by 684
Sakamoto, K., Karelina, K., & Obrietan, K. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07080.x · Cited by 543
Communication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease
Cohen, S., & Greenberg, M. E. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175235 · Cited by 400
Bartsch, D., Casadio, A., Karl, K. A., Serodio, P., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81752-3 · Cited by 373
Neuroplasticity Mediated by Altered Gene Expression
McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347
Oliveria, S. F., Dell'Acqua, M. L., & Sather, W. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.032 · Cited by 344
Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
Konradi, C., & Heckers, S. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00328-5 · Cited by 336
Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV
Impey, S., Fong, A. L., Wang, Y., Cardinaux, J.-R., Fass, D. M., Obrietan, K., Wayman, G. A., Storm, D. R., Soderling, T. R., & Goodman, R. H. (2002) · Neuron · doi:10.1016/s0896-6273(02)00654-2 · Cited by 335
Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ
Okuno, H., Akashi, K., Ishii, Y., Yagishita-Kyo, N., Suzuki, K., Nonaka, M., Kawashima, T., Fujii, H., Takemoto-Kimura, S., Abe, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.062 · Cited by 310
Self-citationClayton, D. F. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2000.3967 · Cited by 322
The role of CREB signaling in Alzheimer’s disease and other cognitive disorders
Saura, C. A., & Valero, J. (2011) · revneuro · doi:10.1515/rns.2011.018 · Cited by 312
Barco, A., Patterson, S., Alarcon, J. M., Gromova, P., Mata-Roig, M., Morozov, A., & Kandel, E. R. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.005 · Cited by 305
Tardito, D., Perez, J., Tiraboschi, E., Musazzi, L., Racagni, G., & Popoli, M. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.7 · Cited by 303
Beckhauser, T. F., Francis-Oliveira, J., & De Pasquale, R. (2016) · Journal of Experimental Neuroscience · doi:10.4137/jen.s39887 · Cited by 301
CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease
Bhat, S., Dao, D. T., Terrillion, C. E., Arad, M., Smith, R. J., Soldatov, N. M., & Gould, T. D. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.001 · Cited by 271
Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory
Suzuki, A., Fukushima, H., Mukawa, T., Toyoda, H., Wu, L.-J., Zhao, M.-G., Xu, H., Shang, Y., Endoh, K., Iwamoto, T., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3257-10.2011 · Cited by 250
Takao-Rikitsu, E., Mochida, S., Inoue, E., Deguchi-Tawarada, M., Inoue, M., Ohtsuka, T., & Takai, Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307101 · Cited by 221
Yamamoto-Sasaki, M., Ozawa, H., Saito, T., Rösler, M., & Riederer, P. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01220-2 · Cited by 198
Cellular and molecular mechanisms in the long-term action of antidepressants.
Racagni, G., & Popoli, M. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.4/gracagni · Cited by 192
The absence of a major Ca 2+ signaling pathway in GABAergic neurons of the hippocampus
Sík, A., Hájos, N., Gulácsi, A., Mody, I., & Freund, T. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3245 · Cited by 186
GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis
Purwana, I., Zheng, J., Li, X., Deurloo, M., Son, D. O., Zhang, Z., Liang, C., Shen, E., Tadkase, A., Feng, Z.-P., et al. (2014) · Diabetes · doi:10.2337/db14-0153 · Cited by 183
Du, J., Feng, L., Yang, F., & Lu, B. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1423 · Cited by 178
Ploughman, M., Granter-Button, S., Chernenko, G., Attwood, Z., Tucker, B. A., Mearow, K. M., & Corbett, D. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.065 · Cited by 170
A new era for functional labeling of neurons: activity-dependent promoters have come of age
Kawashima, T., Okuno, H., & Bito, H. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00037 · Cited by 165
Self-citationBito, H., & Takemoto-Kimura, S. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00140-4 · Cited by 135
Self-citationStephenson, J. R., Wang, X., Perfitt, T. L., Parrish, W. P., Shonesy, B. C., Marks, C. R., Mortlock, D. P., Nakagawa, T., Sutcliffe, J. S., & Colbran, R. J. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2068-16.2017 · Cited by 127
Kobro-Flatmoen, A., Lagartos-Donate, M. J., Aman, Y., Edison, P., Witter, M. P., & Fang, E. F. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101307 · Cited by 119
Kong, H., Sha, L.-L., Fan, Y., Xiao, M., Ding, J.-H., Wu, J., & Hu, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.185 · Cited by 115
Cohen, S. M., Ma, H., Kuchibhotla, K. V., Watson, B. O., Buzsáki, G., Froemke, R. C., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.001 · Cited by 100
Self-citationJoseph, A., & Turrigiano, G. G. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0618-17.2017 · Cited by 94
GABAergic system in the endocrine pancreas: a new target for diabetes treatment
Wang, Q., Prud'homme, G., & Wan, Y. (2015) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s50642 · Cited by 100
Schwartz, N., Schohl, A., & Ruthazer, E. S. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.007 · Cited by 94
Yuan, Q., Harley, C. W., Bruce, J. C., Darby-King, A., & McLean, J. H. (2000) · Learning & Memory · doi:10.1101/lm.35900 · Cited by 73
Epigenetic Mechanisms of Rubinstein–Taybi Syndrome
Park, E., Kim, Y., Ryu, H., Kowall, N. W., Lee, J., & Ryu, H. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8285-3 · Cited by 63
Calmodulin-Stimulated Adenylyl Cyclase Gene Deletion Affects Morphine Responses
Li, S., Lee, M. L., Bruchas, M. R., Chan, G. C., Storm, D. R., & Chavkin, C. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.025783 · Cited by 56
In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons
Najm, R., Zalocusky, K. A., Zilberter, M., Yoon, S. Y., Hao, Y., Koutsodendris, N., Nelson, M., Rao, A., Taubes, A., Jones, E. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107962 · Cited by 52
Sirianni, R. W., Olausson, P., Chiu, A. S., Taylor, J. R., & Saltzman, W. M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.041 · Cited by 51
“Phosphorylation of CREB is known to regulate gene transcription (Chrivia et al., 1993; Bito et al., 1996; Shaywitz and Greenberg, 1999), and this regulation of gene transcription by phosphorylated CREB produces complex downstream effects in gene translation that are believed to be necessary for the…”
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Pozzi, L., Baviera, M., Sacchetti, G., Calcagno, E., Balducci, C., Invernizzi, R. W., & Carli, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.060 · Cited by 49
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Abbas, A.-K., Dozmorov, M., Li, R., Huang, F.-S., Hellberg, F., Danielson, J., Tian, Y., Ekström, J., Sandberg, M., & Wigström, H. (2009) · Neuroscience Research · doi:10.1016/j.neures.2008.10.008 · Cited by 42
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Baar (2009) · doi:10.1139/h09-035 · Cited by 36
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Egan, A. E., Thompson, A. M. K., Buesing, D., Fourman, S. M., Packard, A. E. B., Terefe, T., Li, D., Wang, X., Song, S., Solomon, M. B., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.030 · Cited by 19
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Hopp, S. C., Bihlmeyer, N. A., Corradi, J. P., Vanderburg, C., Cacace, A. M., Das, S., Clark, T. W., Betensky, R. A., Hyman, B. T., & Hudry, E. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14469 · Cited by 20
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Metadata
- Authors
- Bito, H., Deisseroth, K., & Tsien, R. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 87
- Issue
- 7
- Pages
- 1203-1214
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2049134173
- Cited by
- 1,122
- References
- 8
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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