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Non-invasive optical spectroscopy and imaging of human brain function

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Villringer, Arno, Chance, Britton·1997·Trends in Neurosciences
DOI 10.1016/s0166-2236(97)01132-6
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Abstract

Brain activity is associated with changes in optical properties of brain tissue. Optical measurements during brain activation can assess haemoglobin oxygenation, cytochrome-c-oxidase redox state, and two types of changes in light scattering reflecting either membrane potential (fast signal) or cell swelling (slow signal), respectively. In previous studies of exposed brain tissue, optical imaging of brain activity has been achieved at high temporal and microscopical spatial resolution. Now, using near-infrared light that can penetrate biological tissue reasonably well, it has become possible to assess brain activity in human subjects through the intact skull non-invasively. After early studies employing single-site near-infrared spectroscopy, first near-infrared imaging devices are being applied successfully for low-resolution functional brain imaging. Advantages of the optical methods include biochemical specificity, a temporal resolution in the millisecond range, the potential of measuring intracellular and intravascular events simultaneously and the portability of the devices enabling bedside examinations.

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Metadata

Authors
Villringer, A., & Chance, B.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
1997-10
Volume
20
Issue
10
Pages
435-442
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/s0166-2236(97)01132-6
OpenAlex
W1973638771
Cited by
1,618
References
2
FWCI
1.53
Type
journal article
Language
en
Open access
hybrid
Licence

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Villringer, A., & Chance, B. (1997). Non-invasive optical spectroscopy and imaging of human brain function. Trends in Neurosciences. https://doi.org/10.1016/s0166-2236(97)01132-6

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