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Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

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The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease·1997·Neurobiology of Aging

DOI 10.1016/s0197-4580(97)00057-2

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Abstract

This report summarizes the consensus recommendations of a panel of neuropathologists from the United States and Europe to improve the postmortem diagnostic criteria for Alzheimer’s disease. The recommendations followed from a two-day workshop sponsored by the National Institute on Aging (NIA) and the Ronald and Nancy Reagan Institute of the Alzheimer’s Association to reassess the original NIA criteria for the postmortem diagnosis of Alzheimer’s disease published in 1985 [2] . The consensus recommendations for improving the neuropathological criteria for the postmortem diagnosis of Alzheimer’s disease are reported here, and the “position papers” by members of the Working Group that accompany this report elaborate on the research findings and concepts upon which these recommendations were based. Further, commentaries by other experts in the field also are included here to provide additional perspectives on these recommendations. Finally, it is anticipated that future meetings of the Working Group will reassess these recommendations and the implementation of postmortem diagnostic criteria for Alzheimer’s disease.

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Authors: The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease
Corresponding author: The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1997-07
Volume: 18
Issue: 4
Pages: S1-S2
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(97)00057-2
OpenAlex: W2725718031
Cited by: 981
References: 6
Citations by year: 2026: 10 · 2025: 15 · 2024: 21 · 2023: 24 · 2022: 17 · 2021: 18 · 2020: 38 · 2019: 27 · 2018: 14 · 2017: 12 · 2016: 14 · 2015: 24 · 2014: 41 · 2013: 51 · 2012: 42
FWCI: 13.07
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 196 d)
Locations: Neurobiology of Aging (publishedVersion, cc-by-nc-nd)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, postmortem diagnosis, consensus recommendations, neuropathology, diagnostic criteria revision

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Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

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