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Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease
Open accessAbstract
This report summarizes the consensus recommendations of a panel of neuropathologists from the United States and Europe to improve the postmortem diagnostic criteria for Alzheimer’s disease. The recommendations followed from a two-day workshop sponsored by the National Institute on Aging (NIA) and the Ronald and Nancy Reagan Institute of the Alzheimer’s Association to reassess the original NIA criteria for the postmortem diagnosis of Alzheimer’s disease published in 1985 [2] . The consensus recommendations for improving the neuropathological criteria for the postmortem diagnosis of Alzheimer’s disease are reported here, and the “position papers” by members of the Working Group that accompany this report elaborate on the research findings and concepts upon which these recommendations were based. Further, commentaries by other experts in the field also are included here to provide additional perspectives on these recommendations. Finally, it is anticipated that future meetings of the Working Group will reassess these recommendations and the implementation of postmortem diagnostic criteria for Alzheimer’s disease.
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In the citing paper
“there have been several changes in neuropathological diagnostic criteria, including the “Khachaturian criteria” of 1985 (27), the “Tierney” criteria of 1988 (28), The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria in 1991 (29), and the National Institute on Aging (NIA)-Reagan criteria in 1997 (30).”
From Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 (2012) · cites this paper as [30]
In the citing paper
“For the neuropathological diagnosis of AD, the NIA-Reagan criteria (30) are the most current guidelines”
From Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 (2012) · cites this paper as [30]
In the citing paper
“The neuropathological criteria for AD used by all NIA ADCs since 1997 have been the NIA-Reagan criteria (30).”
From Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 (2012) · cites this paper as [30]
In the citing paper
“The neuropathologic hallmarks of AD are neurofibrillary tangles (NFTs; including pretangles) and AβPs (including diffuse and neuritic plaques, which may also be referred to as “senile plaques” [2, 18, 19]; Fig. 1 and Table 1).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [2]
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Metadata
- Authors
- The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease
- Corresponding author
- The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 18
- Issue
- 4
- Pages
- S1-S2
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2725718031
- Cited by
- 981
- References
- 6
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 21 · 2023: 24 · 2022: 17 · 2021: 18 · 2020: 38 · 2019: 27 · 2018: 14 · 2017: 12 · 2016: 14 · 2015: 24 · 2014: 41 · 2013: 51 · 2012: 42
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurobiology of Aging (publishedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, postmortem diagnosis, consensus recommendations, neuropathology, diagnostic criteria revision
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