The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C] raclopride study in healthy men
Abstract
Eight healthy men underwent two positron emission tomography (PET) [11C]raclopride scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, p.o.). PET data were analyzed using: (1) brain parametric maps to statistically generate regions of significant change; and (2) a priori identified regions of interest (ROI) manually drawn on each individual's co-registered magnetic resonance (MR) images. Compared with placebo, d-amphetamine decreased [11C]raclopride binding potential (BP) with significant effects in ventral but not dorsal striatum. Change in BP in the statistically generated cluster correlated with self-reported drug-induced 'drug wanting' (r = 0.83, p =.01) and the personality trait of Novelty Seeking-Exploratory Excitability (r = 0.79, p =.02). The same associations were seen in the manually drawn ROI in ventral striatum but not in dorsal putamen or caudate. Changes in extracellular dopamine (DA) did not correlate with mood. Mesolimbic DA might mediate interest in obtaining reward rather than reward, per se. Individual differences in amphetamine-induced DA release might be related to predispositions to drug and novelty seeking.
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In the citing paper
“Recruitment of brain regions and systems implicated in reward-processing (e.g., ventral striatum, orbitofrontal cortex) has been linked to measures of sensation seeking in humans and animals”
From Impact of socio-emotional context, brain development, and pubertal maturation on adolescent risk-taking (2013) · cites this paper as Leyton et al., 2002
In the citing paper
“Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Leyton et al., 2002
In the citing paper
“Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Leyton et al., 2002
In the citing paper
“Dopamine surges in nucleus accumbens evoked by addictive amphetamine or by L-DOPA correlate poorly with human subjective liking ratings of the drug - but do control their subjective wanting ratings to take more of that drug (Leyton et al., 2002; Evans et al., 2006).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Leyton et al., 2002
In the citing paper
“In humans, studies show that dopamine levels are more highly correlated with subjective ratings of ‘wanting’ a reward than with pleasure ratings of that same reward (Leyton et al., 2002; Volkow et al., 2002).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Leyton et al., 2002
In the citing paper
“Consistent with these data, in healthy humans, amphetamine-induced dopamine changes in ventral but not dorsal striatum were found to predict hedonic responses (Drevets et al., 2001; Leyton et al., 2002; Martinez et al., 2003).”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Leyton et al., 2002
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
A Systematic Method for Clinical Description and Classification of Personality Variants: A Proposal
Cloninger, C. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180093014 · Cited by 3,678
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · cited 2×
“1992), and linearly transformed into standardized stereotaxic space (Talairach and Tournoux 1988) using automated algorithms (Collins et al. 1994).”
MethodThe use of analogue scales in rating subjective feelings
BOND, A., & LADER, M. (1974) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1974.tb02285.x · Cited by 1,972
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355
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Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00233-9 · Cited by 1,869
Anatomically distinct dopamine release during anticipation and experience of peak emotion to music
Salimpoor, V. N., Benovoy, M., Larcher, K. M.-H., Dagher, A., & Zatorre, R. J. (2011) · Nature Neuroscience · doi:10.1038/nn.2726 · Cited by 1,842
Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730
Motivation concepts in behavioral neuroscience
Berridge, K. C. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.004 · Cited by 1,302
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254
Affective consciousness: core emotional feelings in animals and humans.
Panksepp, J. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2004.10.004 · Cited by 1,217
“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
Berridge, K. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.044 · Cited by 1,147
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935
The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873
The dual systems model: Review, reappraisal, and reaffirmation
Shulman, E. P., Smith, A. R., Silva, K., Icenogle, G., Duell, N., Chein, J., & Steinberg, L. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.12.010 · Cited by 867
“, ventral striatum, orbitofrontal cortex) has been linked to measures of sensation seeking in humans and other animals (Abler et al., 2006; Leyton et al., 2002; Lind et al., 2005).”
Pruessner, J. C., Champagne, F., Meaney, M. J., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3422-03.2004 · Cited by 709
From prediction error to incentive salience: mesolimbic computation of reward motivation.
Berridge, K. C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07990.x · Cited by 700
The dopamine theory of addiction: 40 years of highs and lows
Nutt, D., Lingford-Hughes, A. R., Erritzøe, D., & Stokes, P. R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3939 · Cited by 696
The Rewarding Aspects of Music Listening Are Related to Degree of Emotional Arousal
Salimpoor, V. N., Benovoy, M., Longo, G., Cooperstock, J. R., & Zatorre, R. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007487 · Cited by 634
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632
Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631
Alcohol promotes dopamine release in the human nucleus accumbens
Boileau, I., Assaad, J., Pihl, R. O., Benkelfat, C., Leyton, M., Diksic, M., Tremblay, R. E., & Dagher, A. (2003) · Synapse · doi:10.1002/syn.10226 · Cited by 591
Self-citationHyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
Peciña, S., Cagniard, B., Berridge, K. C., Aldridge, J. W., & Zhuang, X. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09395.2003 · Cited by 551
Ventral pallidum roles in reward and motivation
Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.038 · Cited by 548
Thobois, S., Ardouin, C., Lhommée, E., Klinger, H., Lagrange, C., Xie, J., Fraix, V., Braga, M.-C. C., Hassani, R., Kistner, A., et al. (2010) · Brain · doi:10.1093/brain/awq032 · Cited by 546
Compulsive drug use linked to sensitized ventral striatal dopamine transmission.
Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P. (2006) · Annals of Neurology · doi:10.1002/ana.20822 · Cited by 473
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Bastide, M. F., Meissner, W. G., Picconi, B., Fasano, S., Fernagut, P., Feyder, M. T., Francardo, V., Alcacer, C., Ding, Y., Brambilla, R., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.07.002 · Cited by 492
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Wood, P. B., Schweinhardt, P., Jaeger, E., Dagher, A., Hakyemez, H., Rabiner, E. A., Bushnell, M. C., & Chizh, B. A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05623.x · Cited by 406
Wacker, J., Dillon, D. G., & Pizzagalli, D. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.058 · Cited by 405
Dopaminergic mechanisms of individual differences in human effort-based decision-making
Treadway, M. T., Buckholtz, J. W., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Kessler, R. M., & Zald, D. H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6459-11.2012 · Cited by 385
Kaar, S. J., Natesan, S., McCutcheon, R. A., & Howes, O. D. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107704 · Cited by 404
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Craving's place in addiction theory: Contributions of the major models
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Bódi, N., Kéri, S., Nagy, H., Moustafa, A. A., Myers, C. E., Daw, N. D., Dibó, G., Takáts, A., Bereczki, D., & Gluck, M. A. (2009) · Brain · doi:10.1093/brain/awp094 · Cited by 356
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Dagher, A., & Robbins, T. W. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.031 · Cited by 339
Epstein, L. H., Temple, J. L., Neaderhiser, B. J., Salis, R. J., Erbe, R. W., & Leddy, J. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.5.877 · Cited by 324
Oswald, L. M., Wong, D. F., McCaul, M., Zhou, Y., Kuwabara, H., Choi, L., Brasic, J., & Wand, G. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300667 · Cited by 314
George, O., & Koob, G. F. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.05.002 · Cited by 322
Boileau, I., Dagher, A., Leyton, M., Gunn, R. N., Baker, G. B., Diksic, M., & Benkelfat, C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1386 · Cited by 305
Self-citationCompulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?
Lawrence, A. D., Evans, A. H., & Lees, A. J. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00529-5 · Cited by 287
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Tridimensional personality of adolescents with Internet addiction and substance use experience
Ko, C.-H., Yen, J.-Y., Chen, C.-C., Chen, S.-H., Wu, K., & Yen, C.-F. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605101404 · Cited by 265
Roles of "wanting" and "liking" in motivating behavior: gambling, food, and drug addictions
Robinson, M. J. F., Fischer, A. M., Ahuja, A., Lesser, E. N., & Maniates, H. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_387 · Cited by 247
Zald, D. H., Cowan, R. L., Riccardi, P., Baldwin, R. M., Ansari, M. S., Li, R., Shelby, E. S., Smith, C. E., McHugo, M., & KESSLER, R. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2423-08.2008 · Cited by 239
Dopamine Transmission in the Human Striatum during Monetary Reward Tasks
Zald, D. H., Boileau, I., El-Dearedy, W., Gunn, R., McGlone, F., Dichter, G. S., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4643-03.2004 · Cited by 238
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Self-citationTen good reasons to consider biological processes in prevention and intervention research
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Self-citationFactors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease
Evans, A. H., Lawrence, A. D., Potts, J., Appel, S., & Lees, A. J. (2005) · Neurology · doi:10.1212/01.wnl.0000184487.72289.f0 · Cited by 207
Krank, M. D., Stewart, S. H., O’Connor, R. M., Woicik, P. B., Wall, A.-M., & Conrod, P. (2010) · Addictive Behaviors · doi:10.1016/j.addbeh.2010.08.010 · Cited by 223
Evans, A. H. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.065417 · Cited by 184
Wand, G. S., Oswald, L. M., McCaul, M. E., Wong, D. F., Johnson, E., Zhou, Y., Kuwabara, H., & Kumar, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301373 · Cited by 178
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Barrett, S. P., Boileau, I., Okker, J., Pihl, R. O., & Dagher, A. (2004) · Synapse · doi:10.1002/syn.20066 · Cited by 177
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Self-citationIndividual variation in resisting temptation: Implications for addiction
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Norbury, A., & Husain, M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.015 · Cited by 142
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The Cambridge Handbook of Personality Psychology
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Self-citationGatzke-Kopp, L. M., Beauchaine, T. P., Shannon, K. E., Chipman, J., Fleming, A. P., Crowell, S. E., Liang, O., Johnson, L. C., & Aylward, E. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0014378 · Cited by 137
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Differential effects of acute stress on anticipatory and consummatory phases of reward processing
Kumar, P., Berghorst, L. H., Nickerson, L. D. H., Dutra, S. J., Goer, F., Greve, D. N., & Pizzagalli, D. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.058 · Cited by 146
Rosa-Neto, P., Lou, H. C., Cumming, P., Pryds, O., Karrebaek, H., Lunding, J., & Gjedde, A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.031 · Cited by 135
Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans
Riccardi, P., Li, R., Ansari, M. S., Zald, D., Park, S., Dawant, B., Anderson, S., Doop, M., Woodward, N., Schoenberg, E., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300916 · Cited by 134
Pei, Y., Asif-Malik, A., & Canales, J. J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00148 · Cited by 134
Marchand, W. R. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0280-y · Cited by 137
Narendran, R., Frankle, W. G., Mason, N. S., Rabiner, E. A., Gunn, R. N., Searle, G. E., Vora, S., Litschge, M. Y., Kendro, S., Cooper, T. B., et al. (2009) · Synapse · doi:10.1002/syn.20628 · Cited by 132
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Self-citationDopamine ups and downs in vulnerability to addictions: a neurodevelopmental model
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Metadata
- Authors
- Leyton, M.
- Affiliations
- McGill University (CA)
- Corresponding author
- Leyton, M
- ORCID
- Leyton, M
- Venue
- Neuropsychopharmacology
- Published
- 2002-12
- Volume
- 27
- Issue
- 6
- Pages
- 1027-1035
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2071825212
- Cited by
- 476
- References
- 60
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 21 · 2022: 7 · 2021: 9 · 2020: 95 · 2019: 8 · 2018: 16 · 2017: 14 · 2016: 24 · 2015: 23 · 2014: 27 · 2013: 26 · 2012: 34
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (36429, MOP–36429)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amphetamine, extracellular dopamine, novelty seeking, [11C]raclopride, ventral striatum, mesolimbic dopamine system, individual differences, reward seeking, personality traits
- MeSH terms
- Adult, Amphetamine, Analysis of Variance, Corpus Striatum, Dopamine, Exploratory Behavior, Extracellular Space, Humans, Magnetic Resonance Imaging, Male, Tomography, Emission-Computed, Behavior, Addictive, Raclopride
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