Cited by 3,042Advanced Fluorescence Microscopy TechniquesNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

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Feng, Guoping, Mellor, Rebecca H., Bernstein, Michael, Keller-Peck, Cynthia, Nguyen, Quyen T., Wallace, Mia, Nerbonne, Jeanne M., Lichtman, Jeff W., Sanes, Joshua R.·2000·Neuron

DOI 10.1016/s0896-6273(00)00084-2

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Abstract

We generated transgenic mice in which red, green, yellow, or cyan fluorescent proteins (together termed XFPs) were selectively expressed in neurons. All four XFPs labeled neurons in their entirety, including axons, nerve terminals, dendrites, and dendritic spines. Remarkably, each of 25 independently generated transgenic lines expressed XFP in a unique pattern, even though all incorporated identical regulatory elements (from the thyl gene). For example, all retinal ganglion cells or many cortical neurons were XFP positive in some lines, whereas only a few ganglion cells or only layer 5 cortical pyramids were labeled in others. In some lines, intense labeling of small neuronal subsets provided a Golgi-like vital stain. In double transgenic mice expressing two different XFPs, it was possible to differentially label 3 neuronal subsets in a single animal.

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Authors: Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Sanes, Joshua R.
ORCID: Feng, Guoping
Bernstein, Michael
Keller-Peck, Cynthia
Nguyen, Quyen T.
Nerbonne, Jeanne M.
Lichtman, Jeff W.
Sanes, Joshua R.
Venue: Neuron
Publisher: Elsevier BV
Published: 2000-10
Volume: 28
Issue: 1
Pages: 41-51
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)00084-2
OpenAlex: W2127810309
Cited by: 3,042
References: 52
Citations by year: 2026: 42 · 2025: 102 · 2024: 105 · 2023: 126 · 2022: 128 · 2021: 132 · 2020: 153 · 2019: 133 · 2018: 149 · 2017: 132 · 2016: 164 · 2015: 175 · 2014: 173 · 2013: 180 · 2012: 164
FWCI: 25.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4672 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: transgenic mice, neuronal labeling, retinal ganglion cells, cortical pyramidal neurons, dendritic spines, axons, presynaptic terminals
MeSH terms: Animals, Axons, Cerebral Cortex, Color, Dendrites, Light, Luminescent Proteins, Mice, Transgenic, Microscopy, Fluorescence, Neuromuscular Junction, Neurons, Regulatory Sequences, Nucleic Acid, Retinal Ganglion Cells, Synapses, Presynaptic Terminals, Thy-1 Antigens, Cell Lineage, Transgenes, Green Fluorescent Proteins, Mice

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Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

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