Cited by 3,042Advanced Fluorescence Microscopy TechniquesNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

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Feng, Guoping, Mellor, Rebecca H., Bernstein, Michael, Keller-Peck, Cynthia, Nguyen, Quyen T., Wallace, Mia, Nerbonne, Jeanne M., Lichtman, Jeff W., Sanes, Joshua R.·2000·Neuron

DOI 10.1016/s0896-6273(00)00084-2

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Abstract

We generated transgenic mice in which red, green, yellow, or cyan fluorescent proteins (together termed XFPs) were selectively expressed in neurons. All four XFPs labeled neurons in their entirety, including axons, nerve terminals, dendrites, and dendritic spines. Remarkably, each of 25 independently generated transgenic lines expressed XFP in a unique pattern, even though all incorporated identical regulatory elements (from the thyl gene). For example, all retinal ganglion cells or many cortical neurons were XFP positive in some lines, whereas only a few ganglion cells or only layer 5 cortical pyramids were labeled in others. In some lines, intense labeling of small neuronal subsets provided a Golgi-like vital stain. In double transgenic mice expressing two different XFPs, it was possible to differentially label 3 neuronal subsets in a single animal.

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Background
Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice
Kelly, E. A., Russo, A. S., Jackson, C. D., Lamantia, C. E., & Majewska, A. K. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00369 · Cited by 48
Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4
Gomez, A. M., Froemke, R. C., & Burden, S. J. (2014) · eLife · doi:10.7554/elife.04287 · Cited by 47
Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy
McAuliffe, J. J., Bronson, S. L., Hester, M. S., Murphy, B. L., Dahlquist‐Topalá, R., Richards, D. A., & Danzer, S. C. (2011) · Hippocampus · doi:10.1002/hipo.20726 · Cited by 47
Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ
Meilandt, W. J., Maloney, J. A., Imperio, J., Lalehzadeh, G., Earr, T., Crowell, S., Bainbridge, T. W., Lu, Y., Ernst, J. A., Fuji, R. N., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0553-5 · Cited by 45
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
Sasmita, A. O., Ong, E. C., Nazarenko, T., Mao, S., Komarek, L., Thalmann, M., Hantakova, V., Spieth, L., Berghoff, S. A., Barr, H. J., et al. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.025 · Cited by 42
“34 Our ﬁndings underscore the need to stringently monitor breeding schemes of other widely used AD mouse models using the Thy1.”
Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith–Magenis syndrome
Huang, W.-H., Wang, D. C., Allen, W. E., Klope, M., Hu, H., Shamloo, M., & Luo, L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806796115 · Cited by 39
Primary cilia signaling in astrocytes mediates development and regional-specific functional specification
Wang, L., Guo, Q., Acharya, S., Zheng, X., Huynh, V., Whitmore, B., Yimit, A., Malhotra, M., Chatterji, S., Rosin, N., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01726-z · Cited by 33
Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age
McAvoy, K., Russo, C., Kim, S., Rankin, G., & Sahay, A. (2015) · Hippocampus · doi:10.1002/hipo.22464 · Cited by 36
Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau45-230 transgenic mice
Lang, A. E., Riherd Methner, D. N., & Ferreira, A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.017 · Cited by 35
Cell type-specific in vivo expression of genes encoding signalling molecules in the brain in response to chronic mild stress and chronic treatment with fluoxetine
Dong, L., Li, B., Verkhratsky, A., & Peng, L. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3921-2 · Cited by 32
Seizure-induced motility of differentiated dentate granule cells is prevented by the central Reelin fragment
Orcinha, C., Münzner, G., Gerlach, J., Kilias, A., Follo, M., Egert, U., & Haas, C. A. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00183 · Cited by 26
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Shao, L.-X., Liao, C., Gregg, I., Davoudian, P. A., Savalia, N. K., Delagarza, K., & Kwan, A. C. (2021) · doi:10.1101/2021.02.17.431629 · Cited by 628
“Multiple lines of evidence demonstrated that 5-HT 2A receptors are essential for serotonergic psychedelics’ psychotomimetic effects in humans (Vollenweider et al., 1998) and head-twitch responses in mice (Gonzalez-Maeso et al., 2007; Keiser et al., 2009).”
Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent
Vandenberg, A., Piekarski, D. J., Caporale, N., Munoz-Cuevas, F. J., & Wilbrecht, L. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00005 · Cited by 22
Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice.
Wyatt, R. M., Tring, E., & Trachtenberg, J. T. (2012) · Nature Neuroscience · doi:10.1038/nn.3134 · Cited by 22
Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer's disease
Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01637-3 · Cited by 20
“Cg-Tg(Thy1-YFP) HJrs/J ) [19] mice were purchased from the Jackson Laboratory and C57BL/6 mice via Orient Bio.”
Method
Adaptive Optical Two-Photon Microscopy for Surface-Profiled Living Biological Specimens
Yamaguchi, K., Otomo, K., Kozawa, Y., Tsutsumi, M., Inose, T., Hirai, K., Sato, S., Nemoto, T., & Uji-i, H. (2021) · ACS Omega · doi:10.1021/acsomega.0c04888 · Cited by 19
Developmentally divergent effects of Rho-kinase inhibition on cocaine- and BDNF-induced behavioral plasticity
DePoy, L. M., Noble, B., Allen, A. G., & Gourley, S. L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.004 · Cited by 20
The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis
Helgager, J., Liu, G., & McNamara, J. O. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23225 · Cited by 17
In vivo characterization of a bigenic fluorescent mouse model of Alzheimer’s disease with neurodegeneration
Crowe, S. E., & Ellis‐Davies, G. C. R. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23306 · Cited by 15
Shp2-mediated MAPK pathway regulates ΔNp63 in epithelium to promote corneal innervation and homeostasis
Okada, Y., Zhang, Y., Zhang, L., Yeh, L.-K., Wang, Y.-C., Saika, S., & Liu, C.-Y. (2020) · Laboratory Investigation · doi:10.1038/s41374-019-0338-2 · Cited by 13
The Duke Mouse Brain Atlas: MRI and light sheet microscopy stereotaxic atlas of the mouse brain
Mansour, H., Azrak, R., Cook, J. J., Hornburg, K. J., Qi, Y., Tian, Y., Williams, R. W., Yeh, F.-C., White, L. E., & Johnson, G. A. (2025) · Science Advances · doi:10.1126/sciadv.adq8089 · Cited by 11
Premature Aging Phenotype in Mice Lacking High-Affinity Nicotinic Receptors: Region-Specific Changes in Layer V Pyramidal Cell Morphology
Konsolaki, E., & Skaliora, I. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu019 · Cited by 9
The change of microglia numbers within the mice retina, optic nerve and chiasm following intravitreal AAV2-GFP injection
Ji, Y., Yu, B., Zhang, Y., & Wu, W. (2022) · European Journal of Ophthalmology · doi:10.1177/11206721211049001 · Cited by 3

Authors: Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Sanes, Joshua R.
ORCID: Feng, Guoping
Bernstein, Michael
Keller-Peck, Cynthia
Nguyen, Quyen T.
Nerbonne, Jeanne M.
Lichtman, Jeff W.
Sanes, Joshua R.
Venue: Neuron
Publisher: Elsevier BV
Published: 2000-10
Volume: 28
Issue: 1
Pages: 41-51
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)00084-2
OpenAlex: W2127810309
Cited by: 3,042
References: 52
Citations by year: 2026: 42 · 2025: 102 · 2024: 105 · 2023: 126 · 2022: 128 · 2021: 132 · 2020: 153 · 2019: 133 · 2018: 149 · 2017: 132 · 2016: 164 · 2015: 175 · 2014: 173 · 2013: 180 · 2012: 164
FWCI: 25.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4672 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: transgenic mice, neuronal labeling, retinal ganglion cells, cortical pyramidal neurons, dendritic spines, axons, presynaptic terminals
MeSH terms: Animals, Axons, Cerebral Cortex, Color, Dendrites, Light, Luminescent Proteins, Mice, Transgenic, Microscopy, Fluorescence, Neuromuscular Junction, Neurons, Regulatory Sequences, Nucleic Acid, Retinal Ganglion Cells, Synapses, Presynaptic Terminals, Thy-1 Antigens, Cell Lineage, Transgenes, Green Fluorescent Proteins, Mice

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Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

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