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Cited by 612

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The microbiota–gut–brain axis in obesity

Open access
Torres-Fuentes, Cristina, Schellekens, Harriët, Dinan, Timothy G, Cryan, John F·2017·The Lancet Gastroenterology & Hepatology
DOI 10.1016/s2468-1253(17)30147-4
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Abstract

Changes in microbial diversity and composition are increasingly associated with several disease states including obesity and behavioural disorders. Obesity-associated microbiota alter host energy harvesting, insulin resistance, inflammation, and fat deposition. Additionally, intestinal microbiota can regulate metabolism, adiposity, homoeostasis, and energy balance as well as central appetite and food reward signalling, which together have crucial roles in obesity. Moreover, some strains of bacteria and their metabolites might target the brain directly via vagal stimulation or indirectly through immune-neuroendocrine mechanisms. Therefore, the gut microbiota is becoming a target for new anti-obesity therapies. Further investigations are needed to elucidate the intricate gut-microbiota-host relationship and the potential of gut-microbiota-targeted strategies, such as dietary interventions and faecal microbiota transplantation, as promising metabolic therapies that help patients to maintain a healthy weight throughout life.

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Metadata

Authors
Torres-Fuentes, C., Schellekens, H., Dinan, T. G., & Cryan, J. F.
Venue
The Lancet Gastroenterology & Hepatology
Publisher
Elsevier BV
Published
2017-10
Volume
2
Issue
10
Pages
747-756
ISSN
  • 2468-1156 (ISSN-L)
  • 2468-1253
DOI
10.1016/s2468-1253(17)30147-4
OpenAlex
W2747197555
Cited by
612
References
32
FWCI
14.17
Type
journal article
Language
en
Open access
green
Licence
Funders
  • Science Foundation Ireland (SFI/12/RC/2273)
  • Seventh Framework Programme (FP7/2007–2013)

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