Micro Total Analysis Systems for Cell Biology and Biochemical Assays

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250

Rapid Molecular Detection of Tuberculosis and Rifampin Resistance

Boehme, C. C., Nabeta, P., Hillemann, D., Nicol, M. P., Shenai, S., Krapp, F., Allen, J., Tahirli, R., Blakemore, R., Rustomjee, R., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907847 · Cited by 2,309

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

Taniguchi, Y., Choi, P. J., Li, G.-W., Chen, H., Babu, M., Hearn, J., Emili, A., & Xie, X. S. (2010) · Science · doi:10.1126/science.1188308 · Cited by 1,982

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

Stott, S. L., Hsu, C.-H., Tsukrov, D. I., Yu, M., Miyamoto, D. T., Waltman, B. A., Rothenberg, S. M., Shah, A. M., Smas, M. E., Korir, G. K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012539107 · Cited by 1,634

Ultrahigh-throughput screening in drop-based microfluidics for directed evolution

Agresti, J. J., Antipov, E., Abate, A. R., Ahn, K., Rowat, A. C., Baret, J.-C., Marquez, M., Klibanov, A. M., Griffiths, A. D., & Weitz, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910781107 · Cited by 1,149

Robust Growth of Escherichia coli

Wang, P., Robert, L., Pelletier, J., Dang, W. L., Taddei, F., Wright, A., & Jun, S. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.045 · Cited by 1,014

A synchronized quorum of genetic clocks

Danino, T., Mondragón-Palomino, O., Tsimring, L., & Hasty, J. (2010) · Nature · doi:10.1038/nature08753 · Cited by 992

Single-cell NF-κB dynamics reveal digital activation and analogue information processing

Tay, S., Hughey, J. J., Lee, T. K., Lipniacki, T., Quake, S. R., & Covert, M. W. (2010) · Nature · doi:10.1038/nature09145 · Cited by 789

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Xu, X., Nagarajan, H., Lewis, N. E., Pan, S., Cai, Z., Liu, X., Chen, W., Xie, M., Wang, W., Hammond, S., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1932 · Cited by 785

Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors

Peng, G., Hakim, M., Broza, Y. Y., Billan, S., Abdah-Bortnyak, R., Kuten, A., Tisch, U., & Haick, H. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605810 · Cited by 775

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry

Wang, H., Liu, J., Cooks, R. G., & Ouyang, Z. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906314 · Cited by 771

Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers

Wang, S., Liu, K., Liu, J., Yu, Z. T. ‐., Xu, X., Zhao, L., Lee, T., Lee, E. K., Reiss, J., Lee, Y., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201005853 · Cited by 620

Electrogenerated Chemiluminescence Detection in Paper-Based Microfluidic Sensors

Delaney, J. L., Hogan, C. F., Tian, J., & Shen, W. (2011) · Analytical Chemistry · doi:10.1021/ac102392t · Cited by 592

Label-free biomarker detection from whole blood

Stern, E., Vacic, A., Rajan, N. K., Criscione, J. M., Park, J., Ilic, B. R., Mooney, D. J., Reed, M. A., & Fahmy, T. M. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.353 · Cited by 543

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics

Pekin, D., Skhiri, Y., Baret, J.-C., Le Corre, D., Mazutis, L., Ben Salem, C., Millot, F., El Harrak, A., Hutchison, J. B., Larson, J. W., et al. (2011) · Lab on a Chip · doi:10.1039/c1lc20128j · Cited by 540

Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer

Stott, S. L., Lee, R. J., Nagrath, S., Yu, M., Miyamoto, D. T., Ulkus, L., Inserra, E. J., Ulman, M., Springer, S., Nakamura, Z., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000403 · Cited by 539

Interstitial flow influences direction of tumor cell migration through competing mechanisms

Polacheck, W. J., Charest, J. L., & Kamm, R. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103581108 · Cited by 509

High-throughput injection with microfluidics using picoinjectors

Abate, A. R., Hung, T., Mary, P., Agresti, J. J., & Weitz, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006888107 · Cited by 502

Integration of paper-based microfluidic devices with commercial electrochemical readers

Nie, Z., Deiss, F., Liu, X., Akbulut, O., & Whitesides, G. M. (2010) · Lab on a Chip · doi:10.1039/c0lc00237b · Cited by 481

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

Ma, C., Fan, R., Ahmad, H., Shi, Q., Comin-Anduix, B., Chodon, T., Koya, R. C., Liu, C.-C., Kwong, G. A., Radu, C. G., et al. (2011) · Nature Medicine · doi:10.1038/nm.2375 · Cited by 441

High-throughput microfluidic single-cell RT-qPCR

White, A. K., VanInsberghe, M., Petriv, O. I., Hamidi, M., Sikorski, D., Marra, M. A., Piret, J., Aparicio, S., & Hansen, C. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019446108 · Cited by 440

Continuous separation of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP)

Moon, H.-S., Kwon, K., Kim, S.-I., Han, H., Sohn, J., Lee, S., & Jung, H.-I. (2011) · Lab on a Chip · doi:10.1039/c0lc00345j · Cited by 437

Micromachine‐Enabled Capture and Isolation of Cancer Cells in Complex Media

Balasubramanian, S., Kagan, D., Jack Hu, C., Campuzano, S., Lobo‐Castañon, M. J., Lim, N., Kang, D. Y., Zimmerman, M., Zhang, L., & Wang, J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201100115 · Cited by 426

Fabrication of microfluidic devices using polydimethylsiloxane

Friend, J., & Yeo, L. (2010) · Biomicrofluidics · doi:10.1063/1.3259624 · Cited by 425

Using buoyant mass to measure the growth of single cells

Godin, M., Delgado, F. F., Son, S., Grover, W. H., Bryan, A. K., Tzur, A., Jorgensen, P., Payer, K., Grossman, A. D., Kirschner, M. W., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1452 · Cited by 394

Chemoattraction to Dimethylsulfoniopropionate Throughout the Marine Microbial Food Web

Seymour, J. R., Simó, R., Ahmed, T., & Stocker, R. (2010) · Science · doi:10.1126/science.1188418 · Cited by 379

Controlled reagent transport in disposable 2D paper networks

Fu, E., Lutz, B., Kauffman, P., & Yager, P. (2010) · Lab on a Chip · doi:10.1039/b919614e · Cited by 363

Programmable diagnostic devices made from paper and tape

Martinez, A. W., Phillips, S. T., Nie, Z., Cheng, C.-M., Carrilho, E., Wiley, B. J., & Whitesides, G. M. (2010) · Lab on a Chip · doi:10.1039/c0lc00021c · Cited by 360

Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation

Bhagat, A. A. S., Hou, H. W., Li, L. D., Lim, C. T., & Han, J. (2011) · Lab on a Chip · doi:10.1039/c0lc00633e · Cited by 350

Size-Selective Microcavity Array for Rapid and Efficient Detection of Circulating Tumor Cells

Hosokawa, M., Hayata, T., Fukuda, Y., Arakaki, A., Yoshino, T., Tanaka, T., & Matsunaga, T. (2010) · Analytical Chemistry · doi:10.1021/ac101222x · Cited by 344

Microfluidic lab-on-a-foil for nucleic acid analysis based on isothermal recombinase polymerase amplification (RPA)

Lutz, S., Weber, P., Focke, M., Faltin, B., Hoffmann, J., Müller, C., Mark, D., Roth, G., Munday, P., Armes, N., et al. (2010) · Lab on a Chip · doi:10.1039/b921140c · Cited by 344

Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks

Osborn, J. L., Lutz, B., Fu, E., Kauffman, P., Stevens, D. Y., & Yager, P. (2010) · Lab on a Chip · doi:10.1039/c004821f · Cited by 338

Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays

Saliba, A.-E., Saias, L., Psychari, E., Minc, N., Simon, D., Bidard, F.-C., Mathiot, C., Pierga, J.-Y., Fraisier, V., Salamero, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001515107 · Cited by 337

Microfluidic paper-based chemiluminescence biosensor for simultaneous determination of glucose and uric acid

Yu, J., Ge, L., Huang, J., Wang, S., & Ge, S. (2011) · Lab on a Chip · doi:10.1039/c0lc00524j · Cited by 327

Whole-genome molecular haplotyping of single cells

Fan, H. C., Wang, J., Potanina, A., & Quake, S. R. (2011) · Nature Biotechnology · doi:10.1038/nbt.1739 · Cited by 325

Genome of a Low-Salinity Ammonia-Oxidizing Archaeon Determined by Single-Cell and Metagenomic Analysis

Blainey, P. C., Mosier, A. C., Potanina, A., Francis, C. A., & Quake, S. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016626 · Cited by 305

Megapixel digital PCR

Heyries, K. A., Tropini, C., VanInsberghe, M., Doolin, C., Petriv, O. I., Singhal, A., Leung, K., Hughesman, C. B., & Hansen, C. L. (2011) · Nature Methods · doi:10.1038/nmeth.1640 · Cited by 305

Digital PCR on a SlipChip

Shen, F., Du, W., Kreutz, J. E., Fok, A., & Ismagilov, R. F. (2010) · Lab on a Chip · doi:10.1039/c004521g · Cited by 295

Microfluidic Local Perfusion Chambers for the Visualization and Manipulation of Synapses

Taylor, A. M., Dieterich, D. C., Ito, H. T., Kim, S. A., & Schuman, E. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.022 · Cited by 292

Loop-Mediated Isothermal Amplification Integrated on Microfluidic Chips for Point-of-Care Quantitative Detection of Pathogens

Fang, X., Liu, Y., Kong, J., & Jiang, X. (2010) · Analytical Chemistry · doi:10.1021/ac1000652 · Cited by 292

Thread as a Versatile Material for Low-Cost Microfluidic Diagnostics

Li, X., Tian, J., & Shen, W. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am9006148 · Cited by 275

A facile route for irreversible bonding of plastic-PDMS hybrid microdevices at room temperature

Tang, L., & Lee, N. Y. (2010) · Lab on a Chip · doi:10.1039/b924753j · Cited by 267

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

Cho, M., Xiao, Y., Nie, J., Stewart, R., Csordas, A. T., Oh, S. S., Thomson, J. A., & Soh, H. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009331107 · Cited by 267

Self-assembled artificial cilia

Vilfan, M., Potočnik, A., Kavčič, B., Osterman, N., Poberaj, I., Vilfan, A., & Babič, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906819106 · Cited by 262

Detection of EpCAM-Negative and Cytokeratin-Negative Circulating Tumor Cells in Peripheral Blood

Mikolajczyk, S. D., Millar, L. S., Tsinberg, P., Coutts, S. M., Zomorrodi, M., Pham, T., Bischoff, F. Z., & Pircher, T. J. (2011) · Journal of Oncology · doi:10.1155/2011/252361 · Cited by 254

A microfluidic platform for complete mammalian cell culture

Barbulovic-Nad, I., Au, S. H., & Wheeler, A. R. (2010) · Lab on a Chip · doi:10.1039/c002147d · Cited by 249

Multiplexed Real-Time Polymerase Chain Reaction on a Digital Microfluidic Platform

Hua, Z., Rouse, J. L., Eckhardt, A. E., Srinivasan, V., Pamula, V. K., Schell, W. A., Benton, J. L., Mitchell, T. G., & Pollack, M. G. (2010) · Analytical Chemistry · doi:10.1021/ac902510u · Cited by 248

Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing

Yu, L., Chen, M. C. W., & Cheung, K. C. (2010) · Lab on a Chip · doi:10.1039/c004590j · Cited by 247

High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments

Albrecht, D. R., & Bargmann, C. I. (2011) · Nature Methods · doi:10.1038/nmeth.1630 · Cited by 244

Biomimetic cilia arrays generate simultaneous pumping and mixing regimes

Shields, A. R., Fiser, B. L., Evans, E. E., Falvo, M. R., Washburn, S., & Superfine, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005127107 · Cited by 239

High-Performance Single Cell Genetic Analysis Using Microfluidic Emulsion Generator Arrays

Zeng, Y., Novak, R., Shuga, J., Smith, M. T., & Mathies, R. A. (2010) · Analytical Chemistry · doi:10.1021/ac902683t · Cited by 232

Probing Individual Environmental Bacteria for Viruses by Using Microfluidic Digital PCR

Tadmor, A. D., Ottesen, E. A., Leadbetter, J. R., & Phillips, R. (2011) · Science · doi:10.1126/science.1200758 · Cited by 230

Rails and anchors: guiding and trapping droplet microreactors in two dimensions

Abbyad, P., Dangla, R., Alexandrou, A., & Baroud, C. N. (2010) · Lab on a Chip · doi:10.1039/c0lc00104j · Cited by 225

Phaseguides: a paradigm shift in microfluidic priming and emptying

Vulto, P., Podszun, S., Meyer, P., Hermann, C., Manz, A., & Urban, G. A. (2011) · Lab on a Chip · doi:10.1039/c0lc00643b · Cited by 222

Whole-Teflon microfluidic chips

Ren, K., Dai, W., Zhou, J., Su, J., & Wu, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100356108 · Cited by 219

A high-throughput label-free nanoparticle analyser

Fraikin, J.-L., Teesalu, T., McKenney, C. M., Ruoslahti, E., & Cleland, A. N. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.24 · Cited by 218

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

Douville, N. J., Zamankhan, P., Tung, Y.-C., Li, R., Vaughan, B. L., Tai, C.-F., White, J., Christensen, P. J., Grotberg, J. B., & Takayama, S. (2011) · Lab Chip · doi:10.1039/c0lc00251h · Cited by 216

Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples

Haun, J. B., Castro, C. M., Wang, R., Peterson, V. M., Marinelli, B. S., Lee, H., & Weissleder, R. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002048 · Cited by 214

An integrated, self-contained microfluidic cassette for isolation, amplification, and detection of nucleic acids

Chen, D., Mauk, M., Qiu, X., Liu, C., Kim, J., Ramprasad, S., Ongagna, S., Abrams, W. R., Malamud, D., Corstjens, P. L. A. M., et al. (2010) · Biomedical Microdevices · doi:10.1007/s10544-010-9423-4 · Cited by 213

Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans

Hulme, S. E., Shevkoplyas, S. S., McGuigan, A. P., Apfeld, J., Fontana, W., & Whitesides, G. M. (2010) · Lab Chip · doi:10.1039/b919265d · Cited by 213

Stepwise Synthesis of Giant Unilamellar Vesicles on a Microfluidic Assembly Line

Matosevic, S., & Paegel, B. M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja109137s · Cited by 205

Microbots Swimming in the Flowing Streams of Microfluidic Channels

Sanchez, S., Solovev, A. A., Harazim, S. M., & Schmidt, O. G. (2011) · Journal of the American Chemical Society · doi:10.1021/ja109627w · Cited by 205

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

van Midwoud, P. M., Merema, M. T., Verpoorte, E., & Groothuis, G. M. M. (2010) · Lab on a Chip · doi:10.1039/c0lc00043d · Cited by 203

Metering the Capillary-Driven Flow of Fluids in Paper-Based Microfluidic Devices

Noh, H., & Phillips, S. T. (2010) · Analytical Chemistry · doi:10.1021/ac100431y · Cited by 203

Fully integrated lab-on-a-disc for simultaneous analysis of biochemistry and immunoassay from whole blood

Lee, B. S., Lee, Y. U., Kim, H.-S., Kim, T.-H., Park, J., Lee, J.-G., Kim, J., Kim, H., Lee, W. G., & Cho, Y.-K. (2011) · Lab Chip · doi:10.1039/c0lc00205d · Cited by 200

Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics

Ferguson, B. S., Buchsbaum, S. F., Wu, T.-T., Hsieh, K., Xiao, Y., Sun, R., & Soh, H. T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203981w · Cited by 192

High-throughput combinatorial cell co-culture using microfluidics

Tumarkin, E., Tzadu, L., Csaszar, E., Seo, M., Zhang, H., Lee, A., Peerani, R., Purpura, K., Zandstra, P. W., & Kumacheva, E. (2011) · Integrative Biology · doi:10.1039/c1ib00002k · Cited by 192

De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis

Fordyce, P. M., Gerber, D., Tran, D., Zheng, J., Li, H., DeRisi, J. L., & Quake, S. R. (2010) · Nature Biotechnology · doi:10.1038/nbt.1675 · Cited by 184

Fabrication of microfluidic channels with a circular cross section using spatiotemporally focused femtosecond laser pulses

He, F., Xu, H., Cheng, Y., Ni, J., Xiong, H., Xu, Z., Sugioka, K., & Midorikawa, K. (2010) · Optics Letters · doi:10.1364/ol.35.001106 · Cited by 183

High-Throughput Selection, Enumeration, Electrokinetic Manipulation, and Molecular Profiling of Low-Abundance Circulating Tumor Cells Using a Microfluidic System

Dharmasiri, U., Njoroge, S. K., Witek, M. A., Adebiyi, M. G., Kamande, J. W., Hupert, M. L., Barany, F., & Soper, S. A. (2011) · Analytical Chemistry · doi:10.1021/ac103172y · Cited by 181

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

Imura, Y., Sato, K., & Yoshimura, E. (2010) · Analytical Chemistry · doi:10.1021/ac100806x · Cited by 172

Rapid Prototyping of Arrayed Microfluidic Systems in Polystyrene for Cell-Based Assays

Young, E. W. K., Berthier, E., Guckenberger, D. J., Sackmann, E., Lamers, C., Meyvantsson, I., Huttenlocher, A., & Beebe, D. J. (2011) · Analytical Chemistry · doi:10.1021/ac102897h · Cited by 172

Magnetically-actuated artificial cilia for microfluidic propulsion

Khaderi, S. N., Craus, C. B., Hussong, J., Schorr, N., Belardi, J., Westerweel, J., Prucker, O., Rühe, J., den Toonder, J. M. J., & Onck, P. R. (2011) · Lab on a Chip · doi:10.1039/c0lc00411a · Cited by 171

Comprehensive microRNA expression profiling of the hematopoietic hierarchy

Petriv, O. I., Kuchenbauer, F., Delaney, A. D., Lecault, V., White, A., Kent, D., Marmolejo, L., Heuser, M., Berg, T., Copley, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009320107 · Cited by 170

Integrated DNA purification, PCR, sample cleanup, and capillary electrophoresis microchip for forensic human identification

Liu, P., Li, X., Greenspoon, S. A., Scherer, J. R., & Mathies, R. A. (2011) · Lab on a Chip · doi:10.1039/c0lc00533a · Cited by 169

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

Shin, Y., Jeon, J. S., Han, S., Jung, G.-S., Shin, S., Lee, S.-H., Sudo, R., Kamm, R. D., & Chung, S. (2011) · Lab on a Chip · doi:10.1039/c1lc20039a · Cited by 166

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

Liu, T., Lin, B., & Qin, J. (2010) · Lab on a Chip · doi:10.1039/c000022a · Cited by 162

Clinical microfluidics for neutrophil genomics and proteomics

Program, T. I. A. T. H. R. T. I. C. R., Kotz, K. T., Xiao, W., Miller-Graziano, C., Qian, W.-J., Russom, A., Warner, E. A., Moldawer, L. L., De, A., Bankey, P. E., et al. (2010) · Nature Medicine · doi:10.1038/nm.2205 · Cited by 161

A microfluidic platform for probing small artery structure and function

Günther, A., Yasotharan, S., Vagaon, A., Lochovsky, C., Pinto, S., Yang, J., Lau, C. H., Voigtlaender‐Bolz, J., & Bolz, S. (2010) · Lab on a Chip · doi:10.1039/c004675b · Cited by 156

A software-programmable microfluidic device for automated biology

Fidalgo, L. M., & Maerkl, S. J. (2011) · Lab on a Chip · doi:10.1039/c0lc00537a · Cited by 155

A Cancer Detection Platform Which Measures Telomerase Activity from Live Circulating Tumor Cells Captured on a Microfilter

Xu, T., Lü, B., Tai, Y., & Goldkorn, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0686 · Cited by 150

On-chip electro membrane extraction

Petersen, N. J., Jensen, H. M., Hansen, S. H., et al. (2010) · Microfluidics and Nanofluidics · doi:10.1007/s10404-010-0603-6 · Cited by 145

A microfluidic array for large-scale ordering and orientation of embryos

Chung, K., Kim, Y., Kanodia, J., Gong, E. S., Shvartsman, S. Y., & Lu, H. (2010) · Nature Methods · doi:10.1038/nmeth.1548 · Cited by 144

Single-sided continuous optoelectrowetting (SCOEW) for droplet manipulation with light patterns

Park, S.-Y., Teitell, M. A., & Chiou, E. P. Y. (2010) · Lab on a Chip · doi:10.1039/c001324b · Cited by 142

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing

Gambin, Y., VanDelinder, V., Ferreon, A. C. M., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1568 · Cited by 140

Parallel microfluidic surface plasmon resonance imaging arrays

Ouellet, E., Lausted, C. G., Lin, T., Yang, C. W. T., Hood, L., & Lagally, E. T. (2010) · Lab on a Chip · doi:10.1039/b920589f · Cited by 135

Long-term high-resolution imaging and culture of C. elegans in chip-gel hybrid microfluidic device for developmental studies

Krajniak, J., & Lu, H. (2010) · Lab on a Chip · doi:10.1039/c001986k · Cited by 135

‘Fab-Chips’: a versatile, fabric-based platform for low-cost, rapid and multiplexed diagnostics

Bhandari, P., Narahari, T., & Dendukuri, D. (2011) · Lab on a Chip · doi:10.1039/c1lc20373h · Cited by 134

Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices

Butler, K. L., Ambravaneswaran, V., Agrawal, N., Bilodeau, M., Toner, M., Tompkins, R. G., Fagan, S. P., & Irimia, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011921 · Cited by 134

Spinning Disk Platform for Microfluidic Digital Polymerase Chain Reaction

Sundberg, S. O., Wittwer, C. T., Gao, C., & Gale, B. K. (2010) · Analytical Chemistry · doi:10.1021/ac902398c · Cited by 133

Paper-Based Microfluidic Surface Acoustic Wave Sample Delivery and Ionization Source for Rapid and Sensitive Ambient Mass Spectrometry

Ho, J., Tan, M. K., Go, D. B., Yeo, L. Y., Friend, J. R., & Chang, H. (2011) · Analytical Chemistry · doi:10.1021/ac200380q · Cited by 130

Integrated Microfluidic System for Rapid Forensic DNA Analysis: Sample Collection to DNA Profile

Hopwood, A. J., Hurth, C., Yang, J., Cai, Z. Q., Moran, N., Lee‐Edghill, J. G., Nordquist, A. R., Lenigk, R., Estes, M. D., Haley, J. P., et al. (2010) · Analytical Chemistry · doi:10.1021/ac101355r · Cited by 125

Microstructuring of polymer films for sensitive genotyping by real-time PCR on a centrifugal microfluidic platform

Focke, M., Stumpf, F., Faltin, B., Reith, P., Bamarni, D., Wadle, S., Müller, C., Reinecke, H., Schrenzel, J., François, P., et al. (2010) · Lab on a Chip · doi:10.1039/c004954a · Cited by 124

Co-culture of neurons and glia in a novel microfluidic platform

Majumdar, D., Gao, Y., Li, D., & Webb, D. J. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.12.024 · Cited by 121

Single-molecule spectroscopy of protein folding in a chaperonin cage

Hofmann, H., Hillger, F., Pfeil, S. H., Hoffmann, A., Streich, D., Haenni, D., Nettels, D., Lipman, E. A., & Schuler, B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002356107 · Cited by 118

Nanoliter Multiplex PCR Arrays on a SlipChip

Shen, F., Du, W., Davydova, E. K., Karymov, M. A., Pandey, J., & Ismagilov, R. F. (2010) · Analytical Chemistry · doi:10.1021/ac1007249 · Cited by 118

Phononic crystal structures for acoustically driven microfluidic manipulations

Wilson, R., Reboud, J., Bourquin, Y., Neale, S. L., Zhang, Y., & Cooper, J. M. (2010) · Lab on a Chip · doi:10.1039/c0lc00234h · Cited by 117

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

Tavana, H., Zamankhan, P., Christensen, P. J., Grotberg, J. B., & Takayama, S. (2011) · Biomedical Microdevices · doi:10.1007/s10544-011-9543-5 · Cited by 117

Microfluidics made of yarns and knots: from fundamental properties to simple networks and operations

Safavieh, R., Zhou, G., & Juncker, D. (2011) · Lab on a Chip · doi:10.1039/c1lc20336c · Cited by 116

Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture

Lee, K. S., Boccazzi, P., Sinskey, A. J., & Ram, R. J. (2011) · Lab on a Chip · doi:10.1039/c1lc20019d · Cited by 113

A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of Clinical Brain Tumor Specimens

Sun, J., Masterman-Smith, M. D., Graham, N. A., Jiao, J., Mottahedeh, J., Laks, D. R., Ohashi, M., DeJesus, J., Kamei, K., Lee, K., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0076 · Cited by 111

In situ monitoring of antibiotic susceptibility of bacterial biofilms in a microfluidic device

Kim, K. P., Kim, Y., Choi, C., et al. (2010) · Lab on a Chip · doi:10.1039/c0lc00154f · Cited by 110

Responses of Escherichia coli Bacteria to Two Opposing Chemoattractant Gradients Depend on the Chemoreceptor Ratio

Kalinin, Y. V., Neumann, S., Sourjik, V., & Wu, M. (2010) · Journal of Bacteriology · doi:10.1128/jb.01507-09 · Cited by 110

Endothelial Cell Culture Model for Replication of Physiological Profiles of Pressure, Flow, Stretch, and Shear Stress in Vitro

Estrada, R., Giridharan, G. A., Nguyen, M.-D., Roussel, T. J., Shakeri, M., Parichehreh, V., Prabhu, S. D., & Sethu, P. (2011) · Analytical Chemistry · doi:10.1021/ac2002998 · Cited by 106

Self-Digitization of Sample Volumes

Cohen, D. E., Schneider, T., Wang, M. Y., & Chiu, D. T. (2010) · Analytical Chemistry · doi:10.1021/ac100713u · Cited by 106

Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites

Cohen, M. S., Orth, C. B., Kim, H. J., Jeon, N. L., & Jaffrey, S. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012401108 · Cited by 105

A parallel microfluidic flow cytometer for high-content screening

McKenna, B. K., Evans, J. G., Cheung, M. C., & Ehrlich, D. J. (2011) · Nature Methods · doi:10.1038/nmeth.1595 · Cited by 103

Electrically-driven hydrogel actuators in microfluidic channels: fabrication, characterization, and biological application

Kwon, G. H., Choi, Y. Y., Park, J. Y., Woo, D., Lee, K. B., Kim, J., & Lee, S. (2010) · Lab on a Chip · doi:10.1039/b926443d · Cited by 102

A Microfluidic Pipette for Single-Cell Pharmacology

Ainla, A., Jansson, E. T., Stepanyants, N., Orwar, O., & Jesorka, A. (2010) · Analytical Chemistry · doi:10.1021/ac100480f · Cited by 100

Detection of Proteins in Serum by Micromagnetic Aptamer PCR (MAP) Technology

Csordas, A. T., Gerdon, A. E., Adams, J. D., Qian, J., Oh, S. S., Xiao, Y., & Soh, H. T. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200904846 · Cited by 100

Production of reactive oxygen species in endothelial cells under different pulsatile shear stresses and glucose concentrations

Chin, L. K., Yu, J. Q., Fu, Y. H., Yu, T., Liu, A. Q., & Luo, K. Q. (2011) · Lab on a Chip · doi:10.1039/c0lc00651c · Cited by 98

Continuous microfluidic DNA extraction using phase-transfer magnetophoresis

Karle, M., Miwa, J., Czilwik, G., Auwärter, V., Roth, G. D., Zengerle, R., & von Stetten, F. (2010) · Lab on a Chip · doi:10.1039/c0lc00129e · Cited by 97

Rapid, cost-efficient fabrication of microfluidic reactors in thermoplastic polymers by combining photolithography and hot embossing

Greener, J., Li, W., Ren, J., Voicu, D., Pakharenko, V., Tang, T. J., & Kumacheva, E. (2009) · Lab on a Chip · doi:10.1039/b918834g · Cited by 96

Rapid Detection of Urinary Tract Infections Using Isotachophoresis and Molecular Beacons

Bercovici, M., Kaigala, G. V., Mach, K. E., Han, C. M., Liao, J. C., & Santiago, J. G. (2011) · Analytical Chemistry · doi:10.1021/ac200253x · Cited by 96

Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans

Shi, W., Wen, H., Lu, Y., Shi, Y., Lin, B., & Qin, J. (2010) · Lab on a Chip · doi:10.1039/c0lc00256a · Cited by 95

In Vitro Fertilization on a Single-Oocyte Positioning System Integrated with Motile Sperm Selection and Early Embryo Development

Ma, R., Xie, L., Han, C., Su, K., Qiu, T., Wang, L., Huang, G., Xing, W., Qiao, J., Wang, J., et al. (2011) · Analytical Chemistry · doi:10.1021/ac103063g · Cited by 94

Extremely slow intramolecular diffusion in unfolded protein L

Waldauer, S. A., Bakajin, O., & Lapidus, L. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005415107 · Cited by 93

A self-powered, one-step chip for rapid, quantitative and multiplexed detection of proteins from pinpricks of whole blood

Wang, J., Ahmad, H. M. N., Ma, C., Shi, Q., Vermesh, O., Vermesh, U., & Heath, J. R. (2010) · Lab on a Chip · doi:10.1039/c0lc00132e · Cited by 93

Microfluidic Cardiac Cell Culture Model (μCCCM)

Giridharan, G. A., Nguyen, M.-D., Estrada, R., Parichehreh, V., Hamid, T., Ismahil, M. A., Prabhu, S. D., & Sethu, P. (2010) · Analytical Chemistry · doi:10.1021/ac1012893 · Cited by 92

High-throughput single-molecule optofluidic analysis

Kim, S., Streets, A. M., Lin, R., Quake, S., Weiss, S., & Majumdar, D. (2011) · Nature Methods · doi:10.1038/nmeth.1569 · Cited by 92

Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip

Meier, M., Lucchetta, E. M., & Ismagilov, R. F. (2010) · Lab on a Chip · doi:10.1039/c004629a · Cited by 92

On-Chip Drop-to-Drop Liquid Microextraction Coupled with Real-Time Concentration Monitoring Technique

Wijethunga, P. A. L., Nanayakkara, Y. S., Kunchala, P., Armstrong, D. W., & Moon, H. (2011) · Analytical Chemistry · doi:10.1021/ac102716s · Cited by 92

Incubated Protein Reduction and Digestion on an Electrowetting-on-Dielectric Digital Microfluidic Chip for MALDI-MS

Nelson, W. C., Peng, I. X., Lee, G. A., Loo, J. A., Garrell, R. L., & Kim, C. (2010) · Analytical Chemistry · doi:10.1021/ac101833b · Cited by 91

Monolithic Integration of Two-Dimensional Liquid Chromatography−Capillary Electrophoresis and Electrospray Ionization on a Microfluidic Device

Chambers, A. G., Mellors, J. S., Henley, W. H., & Ramsey, J. M. (2011) · Analytical Chemistry · doi:10.1021/ac102437z · Cited by 91

A microfluidic platform for high-sensitivity, real-time drug screening on C. elegans and parasitic nematodes

Carr, J. A., Parashar, A., Gibson, R., Robertson, A. P., Martin, R. J., & Pandey, S. (2011) · Lab on a Chip · doi:10.1039/c1lc20170k · Cited by 91

An integrated microfluidic device for DNA purification and PCR amplification of STR fragments

Bienvenue, J. M., Legendre, L. A., Ferrance, J. P., & Landers, J. P. (2009) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2009.02.010 · Cited by 89

Detection of Proteins in Serum by Micromagnetic Aptamer PCR (MAP) Technology

Csordas, A. T., Gerdon, A. E., Adams, J. D., Qian, J., Oh, S. S., Xiao, Y., & Soh, H. T. (2009) · Angewandte Chemie · doi:10.1002/ange.200904846 · Cited by 87

Suspended microchannel resonators with piezoresistive sensors

Lee, J., Chunara, R., Shen, W., Payer, K. R., Babcock, K., Burg, T. P., & Manalis, S. R. (2010) · Lab on a Chip · doi:10.1039/c0lc00447b · Cited by 86

An automated microfluidic platform for calcium imaging of chemosensory neurons in Caenorhabditis elegans

Chokshi, T. V., Bazopoulou, D., & Chronis, N. (2010) · Lab on a Chip · doi:10.1039/c004658b · Cited by 85

Microfluidic Cell Culture and Metabolism Detection with Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometer

Gao, D., Wei, H., Guo, G., & Lin, J. (2010) · Analytical Chemistry · doi:10.1021/ac101370p · Cited by 85

Massively parallel concentration device for multiplexed immunoassays

Ko, S. H., Kim, S. J., Cheow, L. F., Li, L. D., Kang, K. H., & Han, J. (2011) · Lab on a Chip · doi:10.1039/c0lc00349b · Cited by 84

Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells

Torisawa, Y., Mosadegh, B., Bersano-Begey, T. F., Steele, J. M., Luker, K. E., Luker, G. D., & Takayama, S. (2010) · Integrative Biology · doi:10.1039/c0ib00041h · Cited by 84

3-Dimensional cell culture for on-chip differentiation of stem cells in embryoid body

Kim, C., Lee, K. S., Bang, J. H., Kim, Y. E., Kim, M., Oh, K. W., Lee, S. H., & Kang, J. Y. (2011) · Lab on a Chip · doi:10.1039/c0lc00516a · Cited by 84

Circular compartmentalized microfluidic platform: Study of axon–glia interactions

Hosmane, S., Yang, I. H., Ruffin, A., Thakor, N. V., & Venkatesan, A. (2010) · Lab on a Chip · doi:10.1039/b918640a · Cited by 83

Breast Cancer Diagnosis Using a Microfluidic Multiplexed Immunohistochemistry Platform

Kim, M. S., Kim, T., Kong, S., Kwon, S., Bae, C. Y., Choi, J., Kim, C. H., Lee, E. S., & Park, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010441 · Cited by 82

Building and manipulating neural pathways with microfluidics

Berdichevsky, Y., Staley, K. J., & Yarmush, M. L. (2010) · Lab on a Chip · doi:10.1039/b922365g · Cited by 82

nanoLAB: An ultraportable, handheld diagnostic laboratory for global health

Gaster, R. S., Hall, D. A., & Wang, S. X. (2011) · Lab on a Chip · doi:10.1039/c0lc00534g · Cited by 81

Validation of a blood plasma separation system by biomarker detection

Kersaudy-Kerhoas, M., Kavanagh, D. M., Dhariwal, R. S., Campbell, C. J., & Desmulliez, M. P. Y. (2010) · Lab on a Chip · doi:10.1039/b926834k · Cited by 80

Nanoporous Elements in Microfluidics for Multiscale Manipulation of Bioparticles

Chen, G. D., Fachin, F., Fernández-Suárez, M., Wardle, B. L., & Toner, M. (2011) · Small · doi:10.1002/smll.201002076 · Cited by 79

Microfluidic Serial Dilution Cell-Based Assay for Analyzing Drug Dose Response over a Wide Concentration Range

Sugiura, S., Hattori, K., & Kanamori, T. (2010) · Analytical Chemistry · doi:10.1021/ac1017666 · Cited by 78

Chemotactic cell trapping in controlled alternating gradient fields

Meier, B., Zielinski, A., Weber, C. A., Arcizet, D., Youssef, S., Franosch, T., Rädler, J. O., & Heinrich, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014853108 · Cited by 77

Ultrafast microfluidic mixer with three-dimensional flow focusing for studies of biochemical kinetics

Gambin, Y., Simonnet, C., VanDelinder, V., Deniz, A. A., & Groisman, A. (2009) · Lab on a Chip · doi:10.1039/b914174j · Cited by 73

Selection of phage-displayed peptides on live adherent cells in microfluidic channels

Wang, J., Liu, Y., Teesalu, T., Sugahara, K. N., Kotamraju, V. R., Adams, J. D., Ferguson, B. S., Gong, Q., Oh, S. S., Csordas, A. T., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014753108 · Cited by 73

Microfluidic Western Blot

Pan, W., Chen, W., & Jiang, X. (2010) · Analytical Chemistry · doi:10.1021/ac1000493 · Cited by 70

An integrated microfluidic system for studying cell-microenvironmental interactions versatilely and dynamically

Liu, W., Li, L., Wang, X., Ren, L. M., Wang, X., Wang, J., Tu, Q., Huang, X., & Wang, J. (2010) · Lab on a Chip · doi:10.1039/c001049a · Cited by 70

Multichannel Capillary Electrophoresis Microdevice and Instrumentation for in Situ Planetary Analysis of Organic Molecules and Biomarkers

Benhabib, M., Chiesl, T. N., Stockton, A. M., Scherer, J. R., & Mathies, R. A. (2010) · Analytical Chemistry · doi:10.1021/ac9025994 · Cited by 68

Microfluidic Measurement of Antibody−Antigen Binding Kinetics from Low-Abundance Samples and Single Cells

Singhal, A., Haynes, C. A., & Hansen, C. L. (2010) · Analytical Chemistry · doi:10.1021/ac101956e · Cited by 67

Characterization of the interaction between fibroblasts and tumor cells on a microfluidic co‐culture device

Ma, H., Liu, T., Qin, J., & Lin, B. (2010) · Electrophoresis · doi:10.1002/elps.200900776 · Cited by 67

Device for co-culture of sympathetic neurons and cardiomyocytes using microfabrication.

Takeuchi, A., Nakafutami, S., Tani, H., Mori, M., Takayama, Y., Moriguchi, H., Kotani, K., Miwa, K., Lee, J.-K., Noshiro, M., et al. (2011) · Lab on a Chip · doi:10.1039/c0lc00327a · Cited by 64

High-throughput tracking of single yeast cells in a microfluidic imaging matrix

Falconnet, D., Niemistö, A., Taylor, R. J., Ricicova, M., Galitski, T., Shmulevich, I., & Hansen, C. L. (2010) · Lab on a Chip · doi:10.1039/c0lc00228c · Cited by 64

A microsystem-based assay for studying pollen tube guidance in plant reproduction

Yetisen, A. K., Jiang, L., Cooper, J., Qin, Y., Palanivelu, R., & Zohar, Y. (2011) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/21/5/054018 · Cited by 63

Flexible casting of modular self-aligning microfluidic assembly blocks

Langelier, S. M., Livak-Dahl, E., Manzo, A. J., Johnson, B. N., Walter, N. G., & Burns, M. A. (2011) · Lab on a Chip · doi:10.1039/c0lc00517g · Cited by 62

Decoding Circulating Nucleic Acids in Human Serum Using Microfluidic Single Molecule Spectroscopy

Liu, K. J., Brock, M. V., Shih, I., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja100342q · Cited by 59

Microfluidic fluorescence in situ hybridization and flow cytometry (μFlowFISH)

Liu, P., Meagher, R. J., Light, Y. K., Yilmaz, S., Chakraborty, R., Arkin, A. P., Hazen, T. C., & Singh, A. K. (2011) · Lab on a Chip · doi:10.1039/c1lc20151d · Cited by 59

Integrated Microfluidic and Imaging Platform for a Kinase Activity Radioassay to Analyze Minute Patient Cancer Samples

Fang, C., Wang, Y., Vu, N. T., Lin, W., Hsieh, Y., Rubbi, L., Phelps, M. E., Müschen, M., Kim, Y., Chatziioannou, A. F., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0851 · Cited by 59

Uniform Amplification of Phage with Different Growth Characteristics in Individual Compartments Consisting of Monodisperse Droplets

Derda, R., Tang, S. K. Y., & Whitesides, G. M. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201001143 · Cited by 56

Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals

Park, E. S., Brown, A. C., DiFeo, M. A., Barker, T. H., & Lu, H. (2009) · Lab on a Chip · doi:10.1039/b919294h · Cited by 55

Dynamics of Liquid Plugs of Buffer and Surfactant Solutions in a Micro-Engineered Pulmonary Airway Model

Tavana, H., Kuo, C.-H., Lee, Q. Y., et al. (2009) · Langmuir · doi:10.1021/la903038a · Cited by 53

How to embed three-dimensional flexible electrodes in microfluidic devices for cell culture applications

Pavesi, A., Piraino, F., Fiore, G. B., et al. (2011) · Lab on a Chip · doi:10.1039/c1lc20084d · Cited by 53

Electrochemically switchable platform for the micro-patterning and release of heterotypic cell sheets

Guillaume-Gentil, O. J., Gabi, M., Zenobi‐Wong, M., & Vörös, J. (2010) · Biomedical Microdevices · doi:10.1007/s10544-010-9487-1 · Cited by 53

Analysis of gene expression at the single-cell level using microdroplet-based microfluidic technology

Mary, P., Dauphinot, L., Bois, N., Potier, M., Studer, V., & Tabeling, P. (2011) · Biomicrofluidics · doi:10.1063/1.3596394 · Cited by 52

Microfluidic lipid membrane formation on microchamber arrays

Ota, S., Suzuki, H., & Takeuchi, S. (2011) · Lab on a Chip · doi:10.1039/c1lc20334g · Cited by 51

Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip

Hsu, T., Xiao, J., Tsao, Y.-W., Kao, Y.-L., Huang, S., Liao, W., & Lee, C. (2011) · Lab on a Chip · doi:10.1039/c1lc20090a · Cited by 51

Capillary Based Patterning of Cellular Communities in Laterally Open Channels

Lee, S. H., Heinz, A. J., Shin, S., Jung, Y., Choi, S., Park, W., Roe, J., & Kwon, S. (2010) · Analytical Chemistry · doi:10.1021/ac902903q · Cited by 47

Sampling from Nanoliter Plugs via Asymmetrical Splitting of Segmented Flow

Nie, J., & Kennedy, R. T. (2010) · Analytical Chemistry · doi:10.1021/ac101723x · Cited by 44

A bio-inspired micropump based on stomatal transpiration in plants

Li, J., Liu, C., Xu, Z., Zhang, K.-P., Ke, X., Li, C., & Wang, L. (2011) · Lab on a Chip · doi:10.1039/c1lc20313d · Cited by 44

Actuation of elastomeric microvalves in point-of-care settings using handheld, battery-powered instrumentation

Addae‐Mensah, K. A., Cheung, Y. K., Fekete, V., Rendely, M. S., & Sia, S. K. (2010) · Lab on a Chip · doi:10.1039/c002349c · Cited by 42

Controlled release of reagents in capillary-driven microfluidics using reagent integrators

Hitzbleck, M., Gervais, L., & Delamarche, E. (2011) · Lab on a Chip · doi:10.1039/c1lc20282k · Cited by 41

High throughput label-free platform for statistical bio-molecular sensing

Bosco, F. G., Hwu, E., Chen, C.-H., Keller, S. S., Bache, M., Jakobsen, M. H., Hwang, I., & Boisen, A. (2011) · Lab on a Chip · doi:10.1039/c1lc20116f · Cited by 41

A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces

Liu, L., Loutherback, K., Liao, D., Yeater, D. B., Lambert, G., Estevez‐Torres, A., Sturm, J. C., Getzenberg, R. H., & Austin, R. H. (2010) · Lab on a Chip · doi:10.1039/c003509b · Cited by 39

Direct Plate-Reader Measurement of Nitric Oxide Released from Hypoxic Erythrocytes Flowing through a Microfluidic Device

Halpin, S. T., & Spence, D. M. (2010) · Analytical Chemistry · doi:10.1021/ac101130s · Cited by 38

Multifunctional protein processing chip with integrated digestion, solid‐phase extraction, separation and electrospray

Wang, C., Jemere, A. B., & Harrison, D. J. (2010) · Electrophoresis · doi:10.1002/elps.201000317 · Cited by 38

Microenvironment array chip for cell culture environment screening

Hattori, K., Sugiura, S., & Kanamori, T. (2010) · Lab on a Chip · doi:10.1039/c0lc00390e · Cited by 35

Development of a Multiplexed Microfluidic Proteomic Reactor and Its Application for Studying Protein–Protein Interactions

Tian, R., Hoa, X. D., Lambert, J., Pezacki, J. P., Veres, T., & Figeys, D. (2011) · Analytical Chemistry · doi:10.1021/ac200194d · Cited by 35

Integrated Capillary Electrophoresis Microsystem for Multiplex Analysis of Human Respiratory Viruses

Thaitrong, N., Liu, P., Briese, T., Lipkin, W. I., Chiesl, T. N., Higa, Y., & Mathies, R. A. (2010) · Analytical Chemistry · doi:10.1021/ac1020744 · Cited by 33

A multi‐functional electrochemical sensing system using microfluidic technology for the detection of urea and creatinine

Huang, C.-J., Lin, J., Chen, P. H., et al. (2011) · Electrophoresis · doi:10.1002/elps.201000679 · Cited by 32

Quantification of Global MicroRNA Abundance by Selective Isotachophoresis

Persat, A., Chivukula, R. R., Mendell, J. T., & Santiago, J. G. (2010) · Analytical Chemistry · doi:10.1021/ac102496m · Cited by 32

Extensive adipogenic and osteogenic differentiation of patterned human mesenchymal stem cells in a microfluidic device

Tenstad, E. M., Tourovskaia, A., Folch, A., Myklebost, O., & Rian, E. (2010) · Lab on a Chip · doi:10.1039/b926738g · Cited by 28

Real-time monitoring of suspension cell–cell communication using an integrated microfluidics

Xu, T., Yue, W., Li, C., Yao, X., Cai, G., & Yang, M. (2010) · Lab on a Chip · doi:10.1039/c004844e · Cited by 27

A microfluidic microprocessor: controlling biomimetic containers and cells using hybrid integrated circuit/microfluidic chips

Issadore, D., Franke, T., Brown, K. A., et al. (2010) · Lab on a Chip · doi:10.1039/c0lc00092b · Cited by 26

Behavior of a Metabolic Cycling Population at the Single Cell Level as Visualized by Fluorescent Gene Expression Reporters

Laxman, S., Sutter, B. M., & Tu, B. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012595 · Cited by 25

2-layer based microfluidic concentration generator by hybrid serial and volumetric dilutions

Lee, K., Kim, C., Kim, Y., Jung, K., Ahn, B., Kang, J. Y., & Oh, K. W. (2010) · Biomedical Microdevices · doi:10.1007/s10544-009-9385-6 · Cited by 24

Passive recruitment of circulating leukocytes into capillary sprouts from existing capillaries in a microfluidic system

Forouzan, O., Burns, J. M., Robichaux, J. L., Murfee, W. L., & Shevkoplyas, S. S. (2011) · Lab on a Chip · doi:10.1039/c0lc00547a · Cited by 24

Electrical Control of Individual Droplet Breaking and Droplet Contents Extraction

Zeng, S., Pan, X., Zhang, Q., Lin, B., & Qin, J. (2011) · Analytical Chemistry · doi:10.1021/ac1028775 · Cited by 23

Detection of Circulating Endothelial Cells via a Microfluidic Disk

Chen, K.-C., Lee, T., Pan, Y.-C., Chiang, C., Chen, C., Yang, Y., Chiang, B., Lee, H., & Wo, A. M. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.157404 · Cited by 21

Kinetics of NF-κB nucleocytoplasmic transport probed by single-cell screening without imaging

Wang, J., Fei, B., Zhan, Y., Geahlen, R. L., & Lu, C. (2010) · Lab on a Chip · doi:10.1039/c0lc00094a · Cited by 17

Analysis of chemoresistance in lung cancer with a simple microfluidic device

Zhang, L., Wang, J., Zhao, L., Meng, Q., & Wang, Q. (2010) · Electrophoresis · doi:10.1002/elps.201000265 · Cited by 14

A microfluidic system for fast detection of mitochondrial DNA deletion

Chang, C.-M., Chiu, L.-F., Wang, P., Shieh, D.-B., & Lee, G. (2011) · Lab on a Chip · doi:10.1039/c1lc20317g · Cited by 11

An integrated micro-electro-fluidic and protein arraying system for parallel analysis of cell responses to controlled microenvironments

Yin, Z., Tao, S., Cheong, R., Zhu, H., & Levchenko, A. (2010) · Integrative Biology · doi:10.1039/c0ib00017e · Cited by 10

A Cell Programmable Assay (CPA) chip

Ju, J., Warrick, J. W., & Beebe, D. J. (2010) · Lab on a Chip · doi:10.1039/c005103a · Cited by 10

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

Halldorsson, S., Lucumi, E., Gómez-Sjöberg, R., & Fleming, R. M. T. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.029 · Cited by 1,027

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

Kim, J.-Y., Fluri, D. A., Marchan, R., Boonen, K., Mohanty, S., Singh, P., Hammad, S., Landuyt, B., Hengstler, J. G., Kelm, J. M., et al. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2015.01.003 · Cited by 126

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