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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
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“Initially, FL-βAPP is cleaved near the cell surface in its extracellular domain either by β-secretase (to generate a membrane-bound 99-residue C-terminal stub, C99-βAPP”
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Metadata
- Authors
- Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y.-Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D.-S., Holmes, E., Milman, P., Liang, Y., Zhang, D. M., Xu, D. H., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L., Sorbi, S., Bruni, A., Fraser, P., & St George-Hyslop, P.
- Venue
- Nature
- Published
- 2000-09
- Volume
- 407
- Issue
- 6800
- Pages
- 48-54
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1626267121
- Cited by
- 911
- References
- 7
- FWCI
- 49.33
- Type
- journal article
- Language
- en
- Open access
- closed
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