The DOI matches its Crossref record.
A forkhead-domain gene is mutated in a severe speech and language disorder
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
A high-coverage genome sequence from an archaic denisovan individual
Meyer, M., Kircher, M., Gansauge, M.-T., Li, H., Racimo, F., Mallick, S., Schraiber, J. G., Jay, F., Prüfer, K., de Filippo, C., et al. (2012) · Science · doi:10.1126/science.1224344 · Cited by 1,967
Molecular evolution of FOXP2, a gene involved in speech and language
Enard, W., Przeworski, M., Fisher, S. E., Lai, C. S. L., Wiebe, V., Kitano, T., Monaco, A. P., & Pääbo, S. (2002) · Nature · doi:10.1038/nature01025 · Cited by 1,603
Self-citationDurand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1933 · Cited by 1,602
A census of human transcription factors: function, expression and evolution
Vaquerizas, J. M., Kummerfeld, S. K., Teichmann, S. A., & Luscombe, N. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2538 · Cited by 1,573
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
O'Roak, B. J., Deriziotis, P., Lee, C., Vives, L., Schwartz, J. J., Girirajan, S., Karakoc, E., MacKenzie, A. P., Ng, S. B., Baker, C., et al. (2011) · Nature Genetics · doi:10.1038/ng.835 · Cited by 1,203
Self-citationMuhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207
Arbib, M. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000038 · Cited by 1,164
The Social Brain: Mind, Language, and Society in Evolutionary Perspective
Dunbar, R. I. M. (2003) · Annual Review of Anthropology · doi:10.1146/annurev.anthro.32.061002.093158 · Cited by 1,068
Evolution at Two Levels: On Genes and Form
Carroll, S. B. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030245 · Cited by 882
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776
Genetics of austim: complex aetiology for a heterogeneous disorder
Folstein, S. E., & Rosen-Sheidley, B. (2001) · Nature Reviews Genetics · doi:10.1038/35103559 · Cited by 771
Contribution of SHANK3 Mutations to Autism Spectrum Disorder
Moessner, R., Marshall, C. R., Sutcliffe, J. S., Skaug, J., Pinto, D., Vincent, J., Zwaigenbaum, L., Fernandez, B., Roberts, W., Szatmari, P., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/522590 · Cited by 681
A functional genetic link between distinct developmental language disorders
Vernes, S. C., Newbury, D. F., Abrahams, B. S., Winchester, L., Nicod, J., Groszer, M., Alarcón, M., Oliver, P. L., Davies, K. E., Geschwind, D. H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802828 · Cited by 676
Self-citationThe faculty of language: what's special about it?
Pinker, S., & Jackendoff, R. (2005) · Cognition · doi:10.1016/j.cognition.2004.08.004 · Cited by 631
Autism and pervasive developmental disorders
Volkmar, F. R., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1046/j.0021-9630.2003.00317.x · Cited by 616
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.041 · Cited by 605
Self-citationFitch, W. T. (2010) · doi:10.1017/cbo9780511817779 · Cited by 594
Tsao, F.-M., Liu, H.-M., & Kuhl, P. K. (2004) · Child Development · doi:10.1111/j.1467-8624.2004.00726.x · Cited by 588
Generalist Genes and Learning Disabilities.
Plomin, R., & Kovas, Y. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.592 · Cited by 534
Evolution of the Human Nervous System Function, Structure, and Development
Sousa, A. M. M., Meyer, K. A., Santpere, G., Gulden, F. O., & Sestan, N. (2017) · Cell · doi:10.1016/j.cell.2017.06.036 · Cited by 517
An association between mothers' speech clarity and infants' speech discrimination skills
Liu, H., Kuhl, P. K., & Tsao, F. (2003) · Developmental Science · doi:10.1111/1467-7687.00275 · Cited by 466
Convergent transcriptional specializations in the brains of humans and song-learning birds
Pfenning, A. R., Hara, E., Whitney, O., Rivas, M. V., Wang, R., Roulhac, P. L., Howard, J. T., Wirthlin, M., Lovell, P. V., Ganapathy, G., et al. (2014) · Science · doi:10.1126/science.1256846 · Cited by 463
“The FOXP2 transcription factor is required for vocal learning in both humans (20) and songbirds (21–24), which suggests that neural circuits for vocal learning across clades may have evolved overlapping molecular mechanisms.”
The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans
Sankararaman, S., Mallick, S., Patterson, N., & Reich, D. (2016) · Current Biology · doi:10.1016/j.cub.2016.03.037 · Cited by 465
Precise auditory–vocal mirroring in neurons for learned vocal communication
Prather, J. F., Peters, S., Nowicki, S., & Mooney, R. (2008) · Nature · doi:10.1038/nature06492 · Cited by 463
Identifying neurocognitive phenotypes in autism
Tager-Flusberg, H., & Joseph, R. M. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1198 · Cited by 460
Fox transcription factors: from development to disease
Golson, M. L., & Kaestner, K. H. (2016) · Development · doi:10.1242/dev.112672 · Cited by 406
Human-specific transcriptional regulation of CNS development genes by FOXP2
Konopka, G., Bomar, J. M., Winden, K., Coppola, G., Jonsson, Z. O., Gao, F., Peng, S., Preuss, T. M., Wohlschlegel, J. A., & Geschwind, D. H. (2009) · Nature · doi:10.1038/nature08549 · Cited by 390
Haesler, S., Rochefort, C., Georgi, B., Licznerski, P., Osten, P., & Scharff, C. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050321 · Cited by 364
From mouth to hand: Gesture, speech, and the evolution of right-handedness
Corballis, M. C. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03000062 · Cited by 357
Genes and the parsing of cognitive processes
Goldberg, T. E., & Weinberger, D. R. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.05.011 · Cited by 356
Language‐association cortex asymmetry in autism and specific language impairment
De Fossé, L., Hodge, S. M., Makris, N., Kennedy, D. N., Caviness, V. S., McGrath, L., Steele, S., Ziegler, D. A., Herbert, M. R., Frazier, J. A., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20275 · Cited by 339
From manual gesture to speech: A gradual transition.
Gentilucci, M., & Corballis, M. C. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.02.004 · Cited by 332
Common neural substrates for inhibition of spoken and manual responses
Xue, G., Aron, A. R., & Poldrack, R. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm220 · Cited by 280
Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
Vernes, S. C., Oliver, P. L., Spiteri, E., Lockstone, H. E., Puliyadi, R., Taylor, J. M., Ho, J., Mombereau, C., Brewer, A., Lowy, E., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002145 · Cited by 276
Gene Losses during Human Origins
Wang, X., Grus, W. E., & Zhang, J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040052 · Cited by 246
Fujita, E., Tanabe, Y., Shiota, A., Ueda, M., Suwa, K., Momoi, M. Y., & Momoi, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712298105 · Cited by 233
De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment
Hamdan, F. F., Daoud, H., Rochefort, D., Piton, A., Gauthier, J., Langlois, M., Foomani, G., Dobrzeniecka, S., Krebs, M.-O., Joober, R., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.09.017 · Cited by 235
Human brain evolution: insights from microarrays
Preuss, T. M., Cáceres, M., Oldham, M. C., & Geschwind, D. H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1469 · Cited by 215
The Human Condition—A Molecular Approach
Pääbo, S. (2014) · Cell · doi:10.1016/j.cell.2013.12.036 · Cited by 197
The Neural Basis of Language Development and Its Impairment
Friederici, A. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.12.002 · Cited by 194
Berg, J. S., Brunetti-Pierri, N., Peters, S. U., Kang, S.-H. L., Fong, C.-T., Salamone, J., Freedenberg, D., Hannig, V. L., Prock, L. A., Miller, D. T., et al. (2007) · Genetics in Medicine · doi:10.1097/gim.0b013e3180986192 · Cited by 193
Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders
Schaaf, C. P., Sabo, A., Sakai, Y., Crosby, J., Muzny, D., Hawes, A., Lewis, L., Akbar, H., Varghese, R., Boerwinkle, E., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr243 · Cited by 175
A Principal Components Analysis of the Autism Diagnostic Interview-Revised
Tadevosyan-leyfer, O., Dowd, M., Mankoski, R., Winklosky, B., Putnam, S., McGrath, L., Tager-flusberg, H., & Folstein, S. E. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046870.56865.90 · Cited by 173
Functional genetic analysis of mutations implicated in a human speech and language disorder
Vernes, S. C., Nicod, J., Elahi, F. M., Coventry, J. A., Kenny, N., Coupe, A.-M., Bird, L. E., Davies, K. E., & Fisher, S. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl392 · Cited by 167
FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution
Enard, W. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.008 · Cited by 149
Genetic Changes Shaping the Human Brain
Bae, B.-I., Jayaraman, D., & Walsh, C. A. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.035 · Cited by 135
Horn, D., Kapeller, J., Rivera-Brugués, N., Moog, U., Lorenz-Depiereux, B., Eck, S., Hempel, M., Wagenstaller, J., Gawthrope, A., Monaco, A. P., et al. (2010) · Human Mutation · doi:10.1002/humu.21362 · Cited by 140
Self-citationPoot, M., Beyer, V., Schwaab, I., Damatova, N., van’t Slot, R., Prothero, J., Holder, S. E., & Haaf, T. (2010) · neurogenetics · doi:10.1007/s10048-009-0205-1 · Cited by 137
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex
Kwan, K. Y., Lam, M. M. S., Johnson, M. B., Dube, U., Shim, S., Rašin, M.-R., Sousa, A. M. M., Fertuzinhos, S., Chen, J.-G., Arellano, J. I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.060 · Cited by 137
The Evolution of Language: A Comparative Review
Fitch, W. T. (2005) · Biology & Philosophy · doi:10.1007/s10539-005-5597-1 · Cited by 137
Hubisz, M. J., Williams, A. L., & Siepel, A. (2020) · PLOS Genetics · doi:10.1371/journal.pgen.1008895 · Cited by 130
Evidence for multiple loci from a genome scan of autism kindreds
Schellenberg, G. D., Dawson, G., Sung, Y. J., Estes, A., Munson, J., Rosenthal, E., Rothstein, J., Flodman, P., Smith, M., Coon, H., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001874 · Cited by 129
Comparative Genomics Search for Losses of Long-Established Genes on the Human Lineage
Zhu, J., Sanborn, J. Z., Diekhans, M., Lowe, C. B., Pringle, T. H., & Haussler, D. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030247 · Cited by 129
Rice, M. L., Smith, S. D., & Gayán, J. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9031-x · Cited by 122
Peter, B., Raskind, W. H., Matsushita, M., Lisowski, M., Vu, T., Berninger, V. W., Wijsman, E. M., & Brkanac, Z. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9065-0 · Cited by 117
Lessons from studying monogenic disease for common disease
Peltonen, L., Perola, M., Naukkarinen, J., & Palotie, A. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl060 · Cited by 105
FoxP influences the speed and accuracy of a perceptual decision in Drosophila
DasGupta, S., Ferreira, C. H., & Miesenböck, G. (2014) · Science · doi:10.1126/science.1252114 · Cited by 104
FOXP1 mutations cause intellectual disability and a recognizable phenotype
Le Fevre, A. K., Taylor, S., Malek, N. H., Horn, D., Carr, C. W., Abdul‐Rahman, O. A., O'Donnell, S., Burgess, T., Shaw, M., Gecz, J., et al. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36174 · Cited by 98
Genetic basis of human brain evolution
Vallender, E. J., Mekel-Bobrov, N., & Lahn, B. T. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.08.010 · Cited by 102
Stillman, A. A., Krsnik, Ž., Sun, J., Rašin, M., State, M. W., šestan, N., & Louvi, A. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21919 · Cited by 95
Visual mental imagery in congenital prosopagnosia
Grüter, T., Grüter, M., Bell, V., & Carbon, C.-C. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.021 · Cited by 92
The search for autism disease genes
Wassink, T. H., Brzustowicz, L. M., Bartlett, C. W., & Szatmari, P. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20041 · Cited by 89
Pickard, B. S., Malloy, M. P., Porteous, D. J., Blackwood, D. H. R., & Muir, W. J. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30204 · Cited by 89
Wang, J., Fröhlich, H., Torres, F. B., Silva, R. L., Poschet, G., Agarwal, A., & Rappold, G. A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112852119 · Cited by 81
The genetics of reading disabilities: from phenotypes to candidate genes.
Raskind, W. H., Peter, B., Richards, T., Eckert, M. M., & Berninger, V. W. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00601 · Cited by 71
Linking neurogenetics and individual differences in language learning: the dopamine hypothesis.
Wong, P. C. M., Morgan-Short, K., Ettlinger, M., & Zheng, J. (2012) · Cortex · doi:10.1016/j.cortex.2012.03.017 · Cited by 67
The evolutionary history of genes involved in spoken and written language: beyond FOXP2
Mozzi, A., Forni, D., Clerici, M., Pozzoli, U., Mascheretti, S., Guerini, F. R., Riva, S., Bresolin, N., Cagliani, R., & Sironi, M. (2016) · Scientific Reports · doi:10.1038/srep22157 · Cited by 67
Artificial Intelligence Technologies for COVID-19 De Novo Drug Design
Floresta, G., Zagni, C., Gentile, D., Patamia, V., & Rescifina, A. (2022) · doi:10.20944/preprints202203.0032.v1 · Cited by 67
Endocannabinoid signaling in social functioning: an RDoC perspective
Karhson, D. S., Hardan, A. Y., & Parker, K. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.169 · Cited by 62
FoxP2 in song-learning birds and vocal-learning mammals
Webb, D. M., & Zhang, J. (2005) · Journal of Heredity · doi:10.1093/jhered/esi025 · Cited by 61
New Frontiers in Animal Research of Psychiatric Illness
Kaffman, A., & Krystal, J. J. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-458-2_1 · Cited by 59
Smogavec, M., Cleall, A., Hoyer, J., Lederer, D., Nassogne, M.-C., Palmer, E. E., Deprez, M., Benoit, V., Maystadt, I., Noakes, C., et al. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2016-103880 · Cited by 56
The evolution of FOXP2 in the light of admixture
Kuhlwilm, M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.04.006 · Cited by 56
The Molecular Basis of Human Brain Evolution
Enard, W. (2016) · Current Biology · doi:10.1016/j.cub.2016.09.030 · Cited by 55
Harvey‐Girard, E., Giassi, A. C. C., Ellis, W., & Maler, L. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.23107 · Cited by 54
Evolution of language: Lessons from the genome
Fisher, S. E. (2017) · Psychonomic Bulletin & Review · doi:10.3758/s13423-016-1112-8 · Cited by 53
Self-citationPanaitof, S. C., Abrahams, B. S., Dong, H., Geschwind, D. H., & White, S. A. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22318 · Cited by 49
Neurogenetics: Advancing the “Next-Generation” of Brain Research
Zoghbi, H. Y., & Warren, S. T. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.015 · Cited by 48
MET Receptor Tyrosine Kinase as an Autism Genetic Risk Factor
Peng, Y., Huentelman, M., Smith, C., & Qiu, S. (2013) · International Review of Neurobiology · doi:10.1016/b978-0-12-418700-9.00005-8 · Cited by 49
Mechanisms Underlying Circuit Dysfunction in Neurodevelopmental Disorders
Exposito-Alonso, D., & Rico, B. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072820-023642 · Cited by 49
Characterization of Foxp2-expressing cells in the developing spinal cord
Morikawa, Y., Hisaoka, T., & Senba, E. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.022 · Cited by 33
A penny for your thoughts: children’s inner speech and its neuro-development
Geva, S., & Fernyhough, C. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01708 · Cited by 35
Evolution of regulatory signatures in primate cortical neurons at cell-type resolution
Kozlenkov, A., Vermunt, M. W., Apontes, P., Li, J., Hao, K., Sherwood, C. C., Hof, P. R., Ely, J. J., Wegner, M., Mukamel, E. A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011884117 · Cited by 30
The language-ready head: Evolutionary considerations
Boeckx, C. (2017) · Psychonomic Bulletin & Review · doi:10.3758/s13423-016-1087-5 · Cited by 23
From Transcriptional Regulation to Aggressive Behavior
D'Souza, U. M., Kel, A., & Sluyter, F. (2003) · Behavior Genetics · doi:10.1023/a:1025778817885 · Cited by 12
Specific Language Impairment in Families
Flax, J. F., Realpe-Bonilla, T., Hirsch, L. S., Brzustowicz, L. M., Bartlett, C. W., & Tallal, P. (2003) · Journal of Speech, Language, and Hearing Research · doi:10.1044/1092-4388(2003/043
Metadata
- Authors
- Lai, C. S. L., Fisher, S. E., Hurst, J. A., Vargha-Khadem, F., & Monaco, A. P.
- Venue
- Nature
- Published
- 2001-10-04
- Volume
- 413
- Issue
- 6855
- Pages
- 519-523
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1981147791
- Cited by
- 2,054
- References
- 0
- FWCI
- 40.72
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.