The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, Bolormaa, Youm, Yun-Hee, Ravussin, Anthony, Galgani, Jose E, Stadler, Krisztian, Mynatt, Randall L, Ravussin, Eric, Stephens, Jacqueline M +1 more·2011·Nature Medicine

Cited by (159)

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  10. Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances
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  11. Role of Innate Immune Response in Non-Alcoholic Fatty Liver Disease: Metabolic Complications and Therapeutic Tools
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  14. Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
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  17. G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus
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  18. Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation
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  19. Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity
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  20. Diet, Obesity, and Asthma
    Wood, Lisa G. · 2017 · Annals of the American Thoracic Society
  21. Inhibitory effects of toll-like receptor 4, NLRP3 inflammasome, and interleukin-1β on white adipocyte browning
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  22. Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle
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  24. Glycosylated haemoglobin for screening and diagnosis of gestational diabetes mellitus
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  25. Brief Report: Connecting Two Pathways Through Ca<sup>2+</sup> Signaling: NLRP3 Inflammasome Activation Induced by a Hypermorphic <i>PLCG2</i> Mutation
    Chae, Jae Jin, Park, Yong Hwan, Park, Chung, Hwang, Il‐Young, Hoffmann, Patrycja, Kehrl, John H., Aksentijevich, Ivona, Kastner, Daniel L. · 2015 · Arthritis &amp; Rheumatology
  26. Circulating NOD1 activators and hematopoietic NOD1 contribute to metabolic inflammation and insulin resistance
    Chan, Kenny L., Tam, Theresa H., Boroumand, Parastoo, Prescott, David, Costford, Sheila R., Escalante, Nichole K., Fine, Noah, Tu, YuShan, Robertson, Susan J., Prabaharan, Dilshaayee et al. · 2017 · Cell Reports
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  28. Nlrp3 Inflammasome Activation in Type 2 Diabetes: Is It Clinically Relevant?
    Dixit, Vishwa Deep · 2013 · Diabetes
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  30. Targeting inflammation in the treatment of type 2 diabetes
    Donath, M. Y. · 2013 · Diabetes, Obesity and Metabolism
  31. Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD
    Pierantonelli, Irene, Rychlicki, Chiara, Agostinelli, Laura, Giordano, Debora Maria, Gaggini, Melania, Fraumene, Cristina, Saponaro, Chiara, Manghina, Valeria, Sartini, Loris, Mingarelli, Eleonora et al. · 2017 · Scientific Reports
  32. Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome
    Mastrocola, Raffaella, Aragno, Manuela, Alloatti, Giuseppe, Collino, Massimo, Penna, Claudia, Pagliaro, Pasquale · 2018 · Current Medicinal Chemistry
  33. The implications of bone marrow adipose tissue on inflammaging
    Aaron, Nicole, Costa, Samantha, Rosen, Clifford J., Qiang, Li · 2022 · Frontiers in Endocrinology
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  35. DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding
    Ding, Y, Li, J, Liu, S, Zhang, L, Xiao, H, Li, J, Chen, H, Petersen, R B, Huang, K, Zheng, L · 2014 · International Journal of Obesity
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    Einer, Claudia, Hohenester, Simon, Wimmer, Ralf, Wottke, Lena, Artmann, Renate, Schulz, Sabine, Gosmann, Christian, Simmons, Alisha, Leitzinger, Christin, Eberhagen, Carola et al. · 2018 · Mitochondrion
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    Tung, Bui Thanh, Rodríguez-Bies, Elisabeth, Talero, Elena, Gamero-Estévez, Enrique, Motilva, Virginia, Navas, Plácido, López-Lluch, Guillermo · 2015 · Experimental Gerontology
  39. Pattern recognition receptor‐mediated inflammation in diabetic vascular complications
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  40. Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH
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  41. Alzheimer's disease: Innate immunity gone awry?
    VanItallie, Theodore B. · 2017 · Metabolism
  42. Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
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  43. Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance
    Yuzefovych, Larysa V., Pastukh, Viktor M., Ruchko, Mykhaylo V., Simmons, Jon D., Richards, William O., Rachek, Lyudmila I. · 2019 · PLOS ONE
  44. Age-associated inflammation and implications for skeletal muscle responses to exercise
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  45. Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice
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  48. PLIN2 inhibits insulin-induced glucose uptake in myoblasts through the activation of the NLRP3 inflammasome
    CHO, KYUNG-AH, KANG, PETER B. · 2015 · International Journal of Molecular Medicine
  49. Inflammation and metabolism: the role of adiposity in sarcopenic obesity
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  50. Targeting inflammation through a physical active lifestyle and pharmaceuticals for the treatment of type 2 diabetes
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