The microglial sensome revealed by direct RNA sequencing

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Items 101–200 of 210

1. Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging
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2. The microglial ATP‐gated ion channel P2X7 as a CNS drug target
   Bhattacharya, Anindya, Biber, Knut · 2016 · Glia
3. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia
   Brownjohn, Philip W., Smith, James, Solanki, Ravi, Lohmann, Ebba, Houlden, Henry, Hardy, John, Dietmann, Sabine, Livesey, Frederick J. · 2018 · Stem Cell Reports
4. Transcriptional control of microglia phenotypes in health and disease
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5. Intersection of pathological tau and microglia at the synapse
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6. NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury
   Kumar, Alok, Barrett, James P., Alvarez-Croda, Dulce-Mariely, Stoica, Bogdan A., Faden, Alan I., Loane, David J. · 2016 · Brain Behavior and Immunity
7. APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
   Lee, Sangderk, Devanney, Nicholas A., Golden, Lesley R., Smith, Cathryn T., Schwartz, James L., Walsh, Adeline E., Clarke, Harrison A., Goulding, Danielle S., Allenger, Elizabeth J., Morillo-Segovia, Gabriella et al. · 2023 · Cell Reports
8. Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion
   Plemel, Jason R., Stratton, Jo Anne, Michaels, Nathan J., Rawji, Khalil S., Zhang, Eric, Sinha, Sarthak, Baaklini, Charbel S., Dong, Yifei, Ho, Madelene, Thorburn, Kevin et al. · 2020 · Science Advances
9. NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?
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10. Microglial immune checkpoint mechanisms
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11. Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes
    Kelley, Kevin W., Nakao-Inoue, Hiromi, Molofsky, Anna V., Oldham, Michael C. · 2018 · Nature Neuroscience
12. Microglia-dependent synapse loss in type I interferon-mediated lupus
    Bialas, Allison R., Presumey, Jessy, Das, Abhishek, van der Poel, Cees E., Lapchak, Peter H., Mesin, Luka, Victora, Gabriel, Tsokos, George C., Mawrin, Christian, Herbst, Ronald et al. · 2017 · Nature · Retracted
13. Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease
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14. Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration
    Pluvinage, John V., Wyss-Coray, Tony · 2020 · Nature Reviews Neuroscience
15. Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation
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16. β-amyloid, microglia, and the inflammasome in Alzheimer’s disease
    Gold, Maike, El Khoury, Joseph · 2015 · Seminars in Immunopathology
17. Targeting microglia for the treatment of Alzheimer’s Disease
    Wes, Paul D., Sayed, Faten A., Bard, Frédérique, Gan, Li · 2016 · Glia
18. Microglia in multiple sclerosis: protectors turn destroyers
    Yong, V. Wee · 2022 · Neuron
19. TREM2 in CNS homeostasis and neurodegenerative disease
    Painter, Meghan M., Atagi, Yuka, Liu, Chia-Chen, Rademakers, Rosa, Xu, Huaxi, Fryer, John D., Bu, Guojun · 2015 · Molecular Neurodegeneration
20. Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain
    Raj, Divya, Yin, Zhuoran, Breur, Marjolein, Doorduin, Janine, Holtman, Inge R., Olah, Marta, Mantingh-Otter, Ietje J., Van Dam, Debby, De Deyn, Peter P., den Dunnen, Wilfred et al. · 2017 · Frontiers in Molecular Neuroscience
21. Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
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22. NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease
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23. A new genetic strategy for targeting microglia in development and disease
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24. PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
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25. Nuclear Receptors License Phagocytosis by Trem2⁺Myeloid Cells in Mouse Models of Alzheimer's Disease
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26. <i><scp>APOE</scp></i>‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective
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27. Neuropharmacological Effects of Quercetin: A Literature-Based Review
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28. Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis
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29. Microglial TYROBP/DAP12 in Alzheimer's Disease: Transduction of Physiological and Pathological Signals Across TREM2
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30. Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy
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31. AD-linked R47H- <i>TREM2</i> mutation induces disease-enhancing microglial states via AKT hyperactivation
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32. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain
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33. Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease
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34. Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease
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35. Transcriptional profiling of microglia; current state of the art and future perspectives
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36. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation
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37. Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome
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38. Transcriptional and Epigenetic Regulation of Microglia in Health and Disease
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39. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept
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40. Aging microglia
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41. Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
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42. Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes—Activation and Age-Related Effects
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43. Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review
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44. Microglia: unique and common features with other tissue macrophages
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45. Microglial diversity by responses and responders
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46. Microglial priming in Alzheimer’s disease
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47. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice
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48. Microglia: A Central Player in Depression
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49. Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain
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50. Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia
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51. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
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52. APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice
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53. Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
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54. Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
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55. Microglial Priming as Trained Immunity in the Brain
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56. A limited capacity for microglial repopulation in the adult brain
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57. Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities
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58. Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury
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59. Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury
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60. Molecular Profiling of Resident and Infiltrating Mononuclear Phagocytes during Rapid Adult Retinal Degeneration Using Single-Cell RNA Sequencing
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61. <i>Cx3cr1-</i> deficient microglia exhibit a premature aging transcriptome
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62. Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks
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63. Microglial modulation of neuronal activity in the healthy brain
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64. ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
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65. Acute microglia ablation induces neurodegeneration in the somatosensory system
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66. A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s disease
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67. Microglia communication: parallels between aging and Alzheimer's disease
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68. Effect of neuroinflammation on the progression of Alzheimer’s disease and its significant ramifications for novel anti-inflammatory treatments
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69. Inflammasome-Induced IL-1β Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases
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70. The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology
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71. Oligodendroglial α‐synucleinopathy‐driven neuroinflammation in multiple system atrophy
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72. Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice
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73. Endothelial CD36 Contributes to Postischemic Brain Injury by Promoting Neutrophil Activation via CSF3
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74. Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
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75. Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
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76. Molecular Imaging of Neuroinflammation in Neurodegenerative Dementias: The Role of In Vivo PET Imaging
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77. A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation
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78. Mice deficient in NRROS show abnormal microglial development and neurological disorders
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79. Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2
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80. Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain
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81. Ischemia/reperfusion induces interferon stimulated gene expression in microglia
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82. Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia
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84. Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism
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85. Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity
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86. Microglia gone awry: linking immunometabolism to neurodegeneration
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87. Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup
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88. Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal
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89. Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease
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90. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer’s Disease Brains
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91. Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors
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92. Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain
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93. Direct and indirect effects of lipids on microglia function
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94. Development and maintenance of the brain’s immune toolkit: microglia and non-parenchymal brain macrophages
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95. Regulation of microglial physiology by the microbiota
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96. Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
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97. Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy During Epileptogenesis
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98. Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis
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99. Identification of a chronic non‐neurodegenerative microglia activation state in a mouse model of peroxisomal β‐oxidation deficiency
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100. Frequent Low-Dose Δ9-Tetrahydrocannabinol in Adolescence Disrupts Microglia Homeostasis and Disables Responses to Microbial Infection and Social Stress in Young Adulthood
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