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Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
Abstract
The functions of cortical areas depend on their inputs and outputs, but the detailed circuits made by long-range projections are unknown. We show that the light-gated channel channelrhodopsin-2 (ChR2) is delivered to axons in pyramidal neurons in vivo. In brain slices from ChR2-expressing mice, photostimulation of ChR2-positive axons can be transduced reliably into single action potentials. Combining photostimulation with whole-cell recordings of synaptic currents makes it possible to map circuits between presynaptic neurons, defined by ChR2 expression, and postsynaptic neurons, defined by targeted patching. We applied this technique, ChR2-assisted circuit mapping (CRACM), to map long-range callosal projections from layer (L) 2/3 of the somatosensory cortex. L2/3 axons connect with neurons in L5, L2/3 and L6, but not L4, in both ipsilateral and contralateral cortex. In both hemispheres the L2/3-to-L5 projection is stronger than the L2/3-to-L2/3 projection. Our results suggest that laminar specificity may be identical for local and long-range cortical projections.
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“Furthermore, the EPSCs persisted in the presence of tetradotoxin (TTX) and 4-aminopyridine (4AP), suggesting that they represent monosynaptic glutamate release from DRN DA terminals (Petreanu et al., 2007).”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Petreanu et al., 2007
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Metadata
- Authors
- Petreanu, L., Huber, D., Sobczyk, A., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Svoboda, Karel
- Venue
- Nature Neuroscience
- Published
- 2007-04-15
- Volume
- 10
- Issue
- 5
- Pages
- 663-668
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2163438163
- Cited by
- 930
- References
- 46
- Citations by year
- 2026: 38 · 2025: 38 · 2024: 56 · 2023: 44 · 2022: 56 · 2021: 49 · 2020: 44 · 2019: 40 · 2018: 50 · 2017: 52 · 2016: 54 · 2015: 55 · 2014: 58 · 2013: 57 · 2012: 56
- FWCI
- 15.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- channelrhodopsin-2, circuit mapping, somatosensory cortex, layer 2/3 pyramidal neurons, laminar specificity, cortical connectivity
- MeSH terms
- Animals, Animals, Newborn, Axons, Brain Mapping, Corpus Callosum, Embryo, Mammalian, Female, Functional Laterality, Membrane Potentials, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neural Pathways, Photic Stimulation, Pregnancy, Retinaldehyde, Rhodopsin, Somatosensory Cortex, Patch-Clamp Techniques, Mice, In Vitro Techniques
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